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  1. Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations b...

    Authors: Fadwa S. Albalawi, Maha H. Daghestani, Mazin H. Daghestani, Abdelmoneim Eldali and Arjumand S. Warsy
    Citation: Journal of Biomedical Science 2018 25:50
    Content type: Research Published on:

  2. Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, a...

    Authors: Ching-Huang Lin, Yi-Ting Hsu, Cheng-Chung Yen, Hsin-Hung Chen, Ching-Jiunn Tseng, Yuk-Keung Lo and Julie Y. H. Chan
    Citation: Journal of Biomedical Science 2018 25:49
    Content type: Research Published on:

  3. Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals link...

    Authors: Robert F. Hillary and Una FitzGerald
    Citation: Journal of Biomedical Science 2018 25:48
    Content type: Review Published on:

  4. Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...

    Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang
    Citation: Journal of Biomedical Science 2018 25:47
    Content type: Research Published on:

  6. Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulat...

    Authors: Lorenz S. Neuwirth, Greg R. Phillips and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2018 25:45
    Content type: Research Published on:

  7. Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca

    Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang and Rong-Chi Huang
    Citation: Journal of Biomedical Science 2018 25:44
    Content type: Research Published on:

  8. The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in embryonic development to adult brain plasticity and the inf...

    Authors: Mohamed El Amri, Una Fitzgerald and Gerhard Schlosser
    Citation: Journal of Biomedical Science 2018 25:43
    Content type: Review Published on:

  9. Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...

    Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2018 25:42
    Content type: Research Published on:

  10. Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with...

    Authors: Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar and Omar Šerý
    Citation: Journal of Biomedical Science 2018 25:41
    Content type: Research Published on:

  11. Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in gly...

    Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang and Jessica Nealon
    Citation: Journal of Biomedical Science 2018 25:40
    Content type: Research Published on:

  12. Whether hepatic progenitor cells (HPCs)/oval cells regenerate liver mass upon chronic liver injury is controversial in mice and has not been conclusively proven in humans and rats. In this study, we examined w...

    Authors: Chin-Sung Chien, Ya-Hui Chen, Hui-Ling Chen, Chiu-Ping Wang, Shang-Hsin Wu, Shu-Li Ho, Wen-Cheng Huang, Chun-Hsien Yu and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2018 25:39
    Content type: Research Published on:

  13. Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclast...

    Authors: Hsiao-Hsuan Wang, Yu-Hsiang Hsu and Ming-Shi Chang
    Citation: Journal of Biomedical Science 2018 25:38
    Content type: Review Published on:

  15. Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are de...

    Authors: Pramod K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Shilpa Prasad, Ashutosh N. Pandey and Shail K. Chaube
    Citation: Journal of Biomedical Science 2018 25:36
    Content type: Review Published on:

  16. The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity....

    Authors: Satish Kumar Devarapu and Hans-Joachim Anders
    Citation: Journal of Biomedical Science 2018 25:35
    Content type: Review Published on:

  17. SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family. Very recently, we showed that SP110b, an SP110 isoform, controls host innate immunity to Mycobacterium tuberculosis infecti...

    Authors: Jia-Shiun Leu, So-Yi Chang, Chia-Yu Mu, Mei-Ling Chen and Bo-Shiun Yan
    Citation: Journal of Biomedical Science 2018 25:34
    Content type: Research Published on:

  18. Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieve...

    Authors: Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin and Liudmila M. Tsybalova
    Citation: Journal of Biomedical Science 2018 25:33
    Content type: Research Published on:

  19. During metastasis, cancer cells require anokis resistant mechanism to survive until reach the distant secondary tissues. As anoikis sensitization may benefit for cancer therapy, this study demonstrated the pot...

    Authors: Arisara Prateep, Somruethai Sumkhemthong, Wiranpat Karnsomwan, Wanchai De-Eknamkul, Supakarn Chamni, Pithi Chanvorachote and Chatchai Chaotham
    Citation: Journal of Biomedical Science 2018 25:32
    Content type: Research Published on:

  21. Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen
    Citation: Journal of Biomedical Science 2018 25:30
    Content type: Review Published on:

  22. Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad
    Citation: Journal of Biomedical Science 2018 25:29
    Content type: Review Published on:

  23. Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanis...

    Authors: I-Ting Tsai, Ching-Chuan Kuo, Jing-Ping Liou and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2018 25:28
    Content type: Research Published on:

  24. β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee
    Citation: Journal of Biomedical Science 2018 25:27
    Content type: Research Published on:

  25. Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision makin...

    Authors: Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini and Silmar Teixeira
    Citation: Journal of Biomedical Science 2018 25:26
    Content type: Review Published on:

  27. Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses...

    Authors: Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu and Shih-Torng Ding
    Citation: Journal of Biomedical Science 2018 25:24
    Content type: Research Published on:

  28. Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression ...

    Authors: Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang and Yunfu Cui
    Citation: Journal of Biomedical Science 2018 25:23
    Content type: Review Published on:

  29. Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major...

    Authors: Ricardo Leão, Joana Dias Apolónio, Donghyun Lee, Arnaldo Figueiredo, Uri Tabori and Pedro Castelo-Branco
    Citation: Journal of Biomedical Science 2018 25:22
    Content type: Review Published on:

  30. Pericytes are multipotent cells present in every vascularized tissue in the body. Despite the fact that they are well-known for more than a century, pericytes are still representing cells with intriguing prope...

    Authors: C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov and Vladislav Volarevic
    Citation: Journal of Biomedical Science 2018 25:21
    Content type: Review Published on:

  31. Cancer stem cells (CSCs) are subpopulations of cancer cells sharing similar characteristics as normal stem or progenitor cells such as self-renewal ability and multi-lineage differentiation to drive tumour gro...

    Authors: Ain Zubaidah Ayob and Thamil Selvee Ramasamy
    Citation: Journal of Biomedical Science 2018 25:20
    Content type: Review Published on:

  32. In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of...

    Authors: Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang and Bing-Chang Chen
    Citation: Journal of Biomedical Science 2018 25:19
    Content type: Research Published on:

  33. LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined.

    Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong and Jian Zhang
    Citation: Journal of Biomedical Science 2018 25:18
    Content type: Research Published on:

  34. Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed 99mT...

    Authors: Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr
    Citation: Journal of Biomedical Science 2018 25:17
    Content type: Research Published on:

  35. Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed ...

    Authors: Lan Zhao, Alvin H. W. Fong, Na Liu and William C. S. Cho
    Citation: Journal of Biomedical Science 2018 25:16
    Content type: Research Published on:

  36. Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has dev...

    Authors: Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam and Shamala Devi Sekaran
    Citation: Journal of Biomedical Science 2018 25:15
    Content type: Research Published on:

  37. Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastic...

    Authors: Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu and Meei Jyh Jiang
    Citation: Journal of Biomedical Science 2018 25:14
    Content type: Research Published on:

  38. Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated. In the present study, t...

    Authors: Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen and Shenghai Huang
    Citation: Journal of Biomedical Science 2018 25:13
    Content type: Research Published on:

  39. Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mec...

    Authors: Sajal K. Ghosh, Abhishek Ganta and Remco A. Spanjaard
    Citation: Journal of Biomedical Science 2018 25:12
    Content type: Research Published on:

  40. Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms of lncRNA H19 in vascular sm...

    Authors: Lei Zhang, Hailing Cheng, Yuxia Yue, Shuangzhan Li, Daping Zhang and Ruili He
    Citation: Journal of Biomedical Science 2018 25:11
    Content type: Research Published on:

  41. Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tole...

    Authors: Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Zu-Min Xing, Han-Wen Chen and Yi-Wen Zhang
    Citation: Journal of Biomedical Science 2018 25:10
    Content type: Research Published on:

  42. Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) i...

    Authors: Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2018 25:9
    Content type: Research Published on:

  43. Intake of ethanol (alcohol) has been shown to influence cardiovascular function; the underlying brain mechanism remains unclear. Noting that nitric oxide (NO) system in the CNS is involved in the regulation of...

    Authors: Jiro Hasegawa Situmorang, Hsun-Hsun Lin, Hsuan Lo and Chih-Chia Lai
    Citation: Journal of Biomedical Science 2018 25:8
    Content type: Research Published on:

  44. Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrade...

    Authors: Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen and Marianne M. Stanford
    Citation: Journal of Biomedical Science 2018 25:7
    Content type: Research Published on:

  45. Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essenti...

    Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and Lee-Young Chau
    Citation: Journal of Biomedical Science 2018 25:6
    Content type: Research Published on:

  46. Mesenchymal stem cells (MSC) are used for several therapeutic applications to improve the functions of bone, cardiac, nervous tissue as well as to facilitate the repopulation of hematopoietic stem cells. MSC g...

    Authors: Chinnapaka Somaiah, Atul Kumar, Renu Sharma, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, Sewali Deka Talukdar and Bithiah Grace Jaganathan
    Citation: Journal of Biomedical Science 2018 25:5
    Content type: Research Published on:

  47. Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic ...

    Authors: Zhenyu Tang, Zongming Gong and Xiaoliang Sun
    Citation: Journal of Biomedical Science 2018 25:4
    Content type: Research Published on:

  48. Alzheimer’s disease (AD) is characterized by progressive memory and neuronal loss culminating in cognitive impairment that not only affects a person’s living ability but also becomes a society’s as well as a f...

    Authors: Ya-Hsin Hsiao, Chih-Hua Chang and Po-Wu Gean
    Citation: Journal of Biomedical Science 2018 25:3
    Content type: Review Published on:

  49. The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling me...

    Authors: Yu-Tzu Shih and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2018 25:2
    Content type: Review Published on:

  50. Atherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their co...

    Authors: Tung-Lin Yang, Pei-Ling Lee, Ding-Yu Lee, Wei-Li Wang, Shu-Yi Wei, Chih-I Lee and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2018 25:1
    Content type: Research Published on:
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Journal of Biomedical Science

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