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  2. Zinc finger protein 179 (Znf179), also known as ring finger protein 112 (Rnf112), is a member of the RING finger protein family and plays an important role in neuronal differentiation. To investigate novel mec...

    Authors: Ding-Yen Lin, Chi-Chen Huang, Ya-Ting Hsieh, Hsin-Chuan Lin, Ping-Chieh Pao, Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Hung, Ju-Ming Wang, Wen-Chang Chang and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2013 20:98
    Content type: Research Published on:

  3. CDC4, which encodes an F-box protein that is a member of the Skp1-Cdc53/Cul1-F-box (SCF) ubiquitin E3 ligase, was initially identified in the budding yeast Saccharomyces cerevisiae as an essential gene for progre...

    Authors: Chuen Chin, Wei-Chung Lai, Tai-Lin Lee, Tzu-Ling Tseng and Jia-Ching Shieh
    Citation: Journal of Biomedical Science 2013 20:97
    Content type: Research Published on:

  4. MicroRNA (miRNA) emerges as important player in drug abuse. Yet, their expression profile in neurological disorder of cocaine abuse has not been well characterized. Here, we explored the changes of miRNA expre...

    Authors: Chun-Lin Chen, Hailin Liu and Xiaowei Guan
    Citation: Journal of Biomedical Science 2013 20:96
    Content type: Research Published on:

  5. Infertility, spontaneous abortion and conception of trisomic offspring increase exponentially with age in mammals but in women there is an apparent acceleration in the rate from about age 37. The problems most...

    Authors: Judith H Ford
    Citation: Journal of Biomedical Science 2013 20:93
    Content type: Review Published on:

  6. DNA transposons are primitive genetic elements which have colonized living organisms from plants to bacteria and mammals. Through evolution such parasitic elements have shaped their host genomes by replicating...

    Authors: Kristian Alsbjerg Skipper, Peter Refsing Andersen, Nynne Sharma and Jacob Giehm Mikkelsen
    Citation: Journal of Biomedical Science 2013 20:92
    Content type: Review Published on:

  7. Noise induced injury of the cochlea causes shifts in activation thresholds and changes of frequency response in the inferior colliculus (IC). Noise overexposure also induces pathological changes in the cochlea...

    Authors: Feng Wang, Li Zuo, Bo Hong, Dongyi Han, Ethan M Range, Lingyun Zhao, Yanan Sui, Weiwei Guo and Liangfa Liu
    Citation: Journal of Biomedical Science 2013 20:91
    Content type: Research Published on:

  8. The roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood. Here, we investigate hippocampal...

    Authors: Tsai-Teng Tzeng, Huey-Jen Tsay, Luping Chang, Chia-Lin Hsu, Tzu-Hsuan Lai, Fong-Lee Huang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:90
    Content type: Research Published on:

  10. Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making ...

    Authors: Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2013 20:88
    Content type: Review Published on:

  11. Long non-coding RNAs (lncRNAs) have different functions in cells. They work as signals, decoys, guides, and scaffolds. Altered lncRNA levels can affect the expression of gene products. There are seldom studies...

    Authors: Yu Qi Qiao, Mei Lan Huang, An Tao Xu, Di Zhao, Zhi Hua Ran and Jun Shen
    Citation: Journal of Biomedical Science 2013 20:87
    Content type: Research Published on:

  12. Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evide...

    Authors: Shih-Ron Hsieh, Chen-Sen Hsu, Chen-Hua Lu, Wei-Cheng Chen, Chun-Hwei Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2013 20:86
    Content type: Research Published on:

  13. Clinical and experimental evidence demonstrates that sleep and epilepsy reciprocally affect each other. Previous studies indicated that epilepsy alters sleep homeostasis; in contrast, sleep disturbance deterio...

    Authors: Pei-Lu Yi, Chin-Yu Lu, Chiung-Hsiang Cheng, Yi-Fong Tsai, Chung-Tien Lin and Fang-Chia Chang
    Citation: Journal of Biomedical Science 2013 20:85
    Content type: Research Published on:

  14. Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis, has been used to treat septic shock, hepatitis and venom poisoning in traditional Chinese medicines. The objective of the study was to eluci...

    Authors: Fang Yuan, Jie Chen, Ping-ping Sun, Su Guan and Jing Xu
    Citation: Journal of Biomedical Science 2013 20:84
    Content type: Research Published on:

  15. Two isoforms of Rho-associated protein kinase (ROCK), ROCKI and ROCKII, play a pivotal role in regulation of cytoskeleton and are involved in multiple cellular processes in mammalian cells. Knockout mice exper...

    Authors: Hsiang-Hao Chuang, Shao-Wei Liang, Zee-Fen Chang and Hsiao-Hui Lee
    Citation: Journal of Biomedical Science 2013 20:83
    Content type: Research Published on:

  16. This study investigated the association between innate immune reaction and myocardial damage after acute myocardial infarction (AMI) and anti-inflammatory role of tacrolimus in reducing infarct size. Male mini...

    Authors: Jiunn-Jye Sheu, Pei-Hsun Sung, Steve Leu, Han-Tan Chai, Yen-Yi Zhen, Yi-Ching Chen, Sarah Chua, Yung-Lung Chen, Tzu-Hsien Tsai, Fan-Yen Lee, Hsueh-Wen Chang, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2013 20:82
    Content type: Research Published on:

  17. Tamsulosin, an α1-adrenoceptor antagonist, and sildenafil, a phosphodiesterase (PDE) inhibitor, are reported to improve lower urinary tract symptoms including overactive bladder (OAB). This study is aimed at i...

    Authors: Sung-Eun Kim, Il-Gyu Ko, Lakkyong Hwang, In-Young Choi, Mal-Soon Shin, Chang-Ju Kim and Khae-Hawn Kim
    Citation: Journal of Biomedical Science 2013 20:81
    Content type: Research Published on:

  18. Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to...

    Authors: Shania Abbas, Syed Tasleem Raza, Faisal Ahmed, Absar Ahmad, Saliha Rizvi and Farzana Mahdi
    Citation: Journal of Biomedical Science 2013 20:80
    Content type: Review Published on:

  19. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. However, the mechanisms of miR-155 functions as an oncomiR are mainly unknown. In this study, the aims ...

    Authors: Chun-Mei Zhang, Jing Zhao and Hua-Yu Deng
    Citation: Journal of Biomedical Science 2013 20:79
    Content type: Research Published on:

  20. The specific role of microglia on Aβ-mediated neurotoxicity is difficult to assign in vivo due to their complicated environment in the brain. Therefore, most of the current microglia-related studies employed the ...

    Authors: Huey-Jen Tsay, Yung-Cheng Huang, Fong-Lee Huang, Chia-Ping Chen, Yu-Chun Tsai, Ying-Hsiu Wang, Mine-Fong Wu, Feng-Yi Chiang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:78
    Content type: Research Published on:

  21. The exact mechanisms of morphine-induced dependence and withdrawal symptoms remain unclear. In order to identify an agent that can prevent withdrawal syndrome, many studies have been performed. This study was ...

    Authors: Sabah Moradi, Mohammad Charkhpour, Hamed Ghavimi, Rasoul Motahari, Majid Ghaderi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2013 20:77
    Content type: Research Published on:

  22. Tamoxifen is the most widely used anti-estrogen for the treatment of breast cancer. Studies show that the combination therapy with other substances that helps the activity of tamoxifen. The objective of this s...

    Authors: Sara Darakhshan and Ali Ghanbari
    Citation: Journal of Biomedical Science 2013 20:76
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:89

  23. Early diagnosis of dengue virus infection during the febrile stage is essential for adjusting appropriate management. This study is to identify the predictive markers of clinical and laboratory findings in the...

    Authors: Tzong-Shiann Ho, Shih-Min Wang, Yee-Shin Lin and Ching-Chuan Liu
    Citation: Journal of Biomedical Science 2013 20:75
    Content type: Research Published on:

  25. Hematological and biochemical abnormalities are among the most common clinicopathological manifestations of HIV patients on ART. Consequently, the development and assessment of indigenous antiretroviral drugs ...

    Authors: Bartholomew Okecuhukwu Ibeh, Olushola D Omodamiro, Urenna Ibeh and Josiah Bitrus Habu
    Citation: Journal of Biomedical Science 2013 20:73
    Content type: Research Published on:

  26. The microRNAs let-7 g and miR-221 have been demonstrated to be related to the glucose metabolism. This study assessed the serum levels of these two microRNAs in subjects with and without metabolic syndrome (Me...

    Authors: Yu-Ting Wang, Pei-Chien Tsai, Yi-Chu Liao, Chung-Y Hsu and Suh-Hang Hank Juo
    Citation: Journal of Biomedical Science 2013 20:72
    Content type: Research Published on:

  27. Mesenchymal Stem Cells (MSC) are important candidates for therapeutic applications due to their ex vivo proliferation and differentiation capacity. MSC differentiation is controlled by both intrinsic and extri...

    Authors: Himangshu Sonowal, Atul Kumar, Jina Bhattacharyya, Pabitra Kumar Gogoi and Bithiah Grace Jaganathan
    Citation: Journal of Biomedical Science 2013 20:71
    Content type: Research Published on:

  28. Xeroderma Pigmentosum (XP) is a rare skin disorder characterized by skin hypersensitivity to sunlight and abnormal pigmentation. The aim of this study was to investigate the genetic cause of a severe XP phenot...

    Authors: Muhammad Nasir, Nafees Ahmad, Christian MK Sieber, Amir Latif, Salman Akbar Malik and Abdul Hameed
    Citation: Journal of Biomedical Science 2013 20:70
    Content type: Research Published on:

  29. Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and...

    Authors: Miroslava Majzunova, Ima Dovinova, Miroslav Barancik and Julie YH Chan
    Citation: Journal of Biomedical Science 2013 20:69
    Content type: Review Published on:

  30. Epithelial barrier dysfunction is associated with the pathogenesis of a number of immune inflammations; the etiology is not fully understood. The fusion of endosome/lysosome is a critical process in the degrad...

    Authors: Yu-Wei Liao, Xing-Mao Wu, Jia Jia, Xiao-Lei Wu, Tao Hong, Ling-Xin Meng and Xiu-Ying Wu
    Citation: Journal of Biomedical Science 2013 20:68
    Content type: Research Published on:

  31. Among viral enzymes, the human HIV-1 protease comprises the most interesting target for drug discovery. There are increasing efforts focused on designing more effective inhibitors for HIV-1 protease in order t...

    Authors: Mohammad Reza Dayer and Mohammad Saaid Dayer
    Citation: Journal of Biomedical Science 2013 20:67
    Content type: Research Published on:

  32. Hematopoietic stem/progenitor cells (HSPCs) maintain the hematopoietic system by balancing their self-renewal and differentiation events. Hematopoietic stem cells also migrate to various sites and interact wit...

    Authors: Bithiah Grace Jaganathan, Fernando Anjos-Afonso, Atul Kumar and Dominique Bonnet
    Citation: Journal of Biomedical Science 2013 20:66
    Content type: Research Published on:

  33. We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. This study intended to clarify whether DV infection c...

    Authors: Ying-Ray Lee, Hsuan-Yun Hu, Szu-Han Kuo, Huan-Yao Lei, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2013 20:65
    Content type: Research Published on:

  34. The lack of noninvasive biomarkers of rejection remains a challenge in the accurate monitoring of deeply buried nerve allografts and precludes optimization of therapeutic intervention. This study aimed to esta...

    Authors: Cheng-Shyuan Rau, Johnson Chia-Shen Yang, Shao-Chun Wu, Yi-Chun Chen, Tsu-Hsiang Lu, Ming-Wei Lin, Yi-Chan Wu, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:64
    Content type: Research Published on:

  35. The efficiency of regenerative medicine can be ameliorated by improving the biological performances of stem cells before their transplantation. Several ex-vivo protocols of non-damaging cell hypoxia have been ...

    Authors: Claudio Muscari, Emanuele Giordano, Francesca Bonafè, Marco Govoni, Alice Pasini and Carlo Guarnieri
    Citation: Journal of Biomedical Science 2013 20:63
    Content type: Review Published on:

  36. Knockout of either toll-like receptor 4 (TLR4) or 2 (TLR2) had been reported to delay the Wallerian degeneration after peripheral nerve injury by deterring the recruitment of the macrophages and clearance of m...

    Authors: Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng, Yi-Chun Chen and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:62
    Content type: Research Published on:

  37. Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir ...

    Authors: Premila Abraham, Hemalatha Ramamoorthy and Bina Isaac
    Citation: Journal of Biomedical Science 2013 20:61
    Content type: Research Published on:

  38. The NKG2D receptor confers important activating signals to NK cells via ligands expressed during cellular stress and viral infection. This receptor has generated great interest because not only is it expressed...

    Authors: Mariel Garcia-Chagollan, Luis F Jave-Suarez, Jesse Haramati, Pedro E Sanchez-Hernandez, Adriana Aguilar-Lemarroy, Miriam R Bueno-Topete, Ana L Pereira-Suarez, Mary Fafutis-Morris, Angel Cid-Arregui and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2013 20:60
    Content type: Research Published on:

  39. Although donor age-related effects of characteristics of mesenchymal stem cells (MSC), such as a decrease in the proliferation and differentiation capacity and an increase of senescence and apoptosis, are evid...

    Authors: Dah-Ching Ding, Hsiang-Lan Chou, Wei-Ting Hung, Hwan-Wun Liu and Tang-Yuan Chu
    Citation: Journal of Biomedical Science 2013 20:59
    Content type: Research Published on:

  40. The relevance of recurrent molecular abnormalities in cytogenetically normal (CN) acute myeloid leukemia (AML) was recently acknowledged by the inclusion of molecular markers such as NPM1, FLT3, and CEBPA as a co...

    Authors: Wen-Chi Yang, Wan-Chi Tsai, Pai-Mei Lin, Ming-Yu Yang, Yi-Chang Liu, Chao-Sung Chang, Wen-Hui Yu and Sheng-Fung Lin
    Citation: Journal of Biomedical Science 2013 20:58
    Content type: Research Published on:

  41. Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleot...

    Authors: Alessandro Tonacci, Andrea Borghini, Antonella Mercuri, Giovanni Pioggia and Maria Grazia Andreassi
    Citation: Journal of Biomedical Science 2013 20:57
    Content type: Research Published on:

  42. CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the...

    Authors: Francesca Rusconi, Hrishikesh Thakur, Jinliang Li and Michael S Kapiloff
    Citation: Journal of Biomedical Science 2013 20:56
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2014 21:45

  43. Microglial inflammation may significantly contribute to the pathology of Alzheimer’s disease. To examine the potential of Cudrania cochinchinensis to ameliorate amyloid β protein (Aβ)-induced microglia activation...

    Authors: Chung-Jen Wang, Chien-Chih Chen, Huey-Jen Tsay, Feng-Yi Chiang, Mine-Fong Wu and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:55
    Content type: Research Published on:

  44. Insufficient clearance of soluble oligomeric amyloid-β peptide (oAβ) in the central nervous system leads to the synaptic and memory deficits in Alzheimer's disease (AD). Previously we have identified scavenger...

    Authors: Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie and Huey-Jen Tsay
    Citation: Journal of Biomedical Science 2013 20:54
    Content type: Research Published on:

  45. Antioxidants have been shown to enhance the proliferation of adipose-derived mesenchymal stem cells (ADMSCs) in vitro, although the detailed mechanism(s) and potential side effects are not fully understood.

    Authors: Li-Yi Sun, Cheng-Yoong Pang, Dian-Kun Li, Chia-Hsin Liao, Wei-Chao Huang, Chao-Chuan Wu, Yi-Yo Chou, Wei Wu Li, Shin-Yuan Chen, Hwan-Wun Liu, Yao-Jen Chang and Ching-Feng Cheng
    Citation: Journal of Biomedical Science 2013 20:53
    Content type: Research Published on:

  46. Cancer cell differentiation is an important characteristic of malignant tumor and has a great impact on prognosis and therapeutic decision for patients. The N-myc downstream regulated gene 1 (NDRG1), a putativ...

    Authors: Lin-Lin Han, Lin Hou, Ming-Jin Zhou, Zhong-liang Ma, Dong-Liang Lin, Li Wu and Yin-lin Ge
    Citation: Journal of Biomedical Science 2013 20:52
    Content type: Research Published on:

  47. Wound healing is a complex biologic process that involves the integration of inflammation, mitosis, angiogenesis, synthesis, and remodeling of the extracellular matrix. However, some wounds fail to heal proper...

    Authors: Sheng-Ping Huang, Chun-Hsiang Huang, Jia-Fwu Shyu, Herng-Sheng Lee, Shyi-Gen Chen, James Yi-Hsin Chan and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2013 20:51
    Content type: Research Published on:

  48. The expression of myocardin, a cardiac-restricted gene, increases during environmental stress. How mechanical stretch affects the regulation of myocardin in vascular smooth muscle cells (VSMCs) is not fully un...

    Authors: Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2013 20:50
    Content type: Research Published on:

  50. Oxidative stress increases the cytosolic content of calcium in the cytoplasm through a combination of effects on calcium pumps, exchangers, channels and binding proteins. In this study, oxidative stress was pr...

    Authors: Tso-Hao Tang, Chiung-Tan Chang, Hsiu-Jen Wang, Joshua D Erickson, Rhett A Reichard, Alexis G Martin, Erica K Shannon, Adam L Martin, Yue-Wern Huang and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:48
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127