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  1. The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have establish...

    Authors: Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai and Jeng-Fan Lo
    Citation: Journal of Biomedical Science 2009 16:100
    Content type: Research Published on:

  2. Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotr...

    Authors: Savitha Balakrishnan, Peeyush Kumar T and CS Paulose
    Citation: Journal of Biomedical Science 2009 16:99
    Content type: Research Published on:

  3. Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from m...

    Authors: Yuanbin Liu and David R Schubert
    Citation: Journal of Biomedical Science 2009 16:98
    Content type: Research Published on:

  4. To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (h PSCs). Human cho...

    Authors: Shin-Han Tsai, Ming-Thau Sheu, Yu-Chih Liang, Hsiu-Tan Cheng, Sheng-Shiung Fang and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2009 16:97
    Content type: Research Published on:

  5. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intri...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang
    Citation: Journal of Biomedical Science 2009 16:96
    Content type: Review Published on:

  7. The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by gl...

    Authors: Yi-Ruu Lin, Hwei-Hsien Chen, Yu-Chin Lin, Chien-Hsin Ko and Ming-Huan Chan
    Citation: Journal of Biomedical Science 2009 16:94
    Content type: Research Published on:

  8. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De
    Citation: Journal of Biomedical Science 2009 16:93
    Content type: Review Published on:

  9. Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogeneis, we took a novel approach based on phenotype chan...

    Authors: Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye and Bing Sun
    Citation: Journal of Biomedical Science 2009 16:92
    Content type: Research Published on:

  10. Bacterial adherence to epithelial cells is a key virulence trait of pathogenic bacteria. The type 1 fimbriae and the P-fimbriae of uropathogenic Escherichia coli (UPEC) have both been described to be important fo...

    Authors: Kun-Wei Tsai, Hong-Thih Lai, Tzung-Chieh Tsai, Yi-Chien Wu, Ya-Ting Yang, Kwei-Yi Chen, Chun-Ming Chen, Yi-Shuan J Li and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2009 16:91
    Content type: Research Published on:

  12. Envelope (E) glycoprotein E2 of the hepatitis C virus (HCV) mediates binding of the virus to target cell receptors. Nevertheless, the precise role of E1 in viral entry remains elusive.

    Authors: Hsiao-Fen Li, Chia-Hsuan Huang, Li-Shuang Ai, Chin-Kai Chuang and Steve SL Chen
    Citation: Journal of Biomedical Science 2009 16:89
    Content type: Research Published on:

  13. Trophoblast differentiation and formation of the placenta are important events linked to post-implantation embryonic development. Models mimicking the biology of trophoblast differentiation in a post-implantat...

    Authors: Kavitha Sivasubramaiyan, Swapnil Totey, Vijay Bhat, Satish M Totey and Kaushik Deb
    Citation: Journal of Biomedical Science 2009 16:88
    Content type: Research Published on:

  14. Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiat...

    Authors: Yan Huang, Zhong-Quan Dai, Shu-Kuan Ling, Hong-Yu Zhang, Yu-Min Wan and Ying-Hui Li
    Citation: Journal of Biomedical Science 2009 16:87
    Content type: Research Published on:

  15. Application of superparamagnetic iron oxide nanoparticles (SPIOs) as the contrast agent has improved the quality of magnetic resonance (MR) imaging. Low efficiency of loading the commercially available iron ox...

    Authors: Huey-Chung Huang, Po-Yuan Chang, Karen Chang, Chao-Yu Chen, Chung-Wu Lin, Jyh-Horng Chen, Chung-Yuan Mou, Zee-Fen Chang and Fu-Hsiung Chang
    Citation: Journal of Biomedical Science 2009 16:86
    Content type: Research Published on:

  16. Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs). Egr-EF, an expression vector pCIneo containing Egr-1 promoter cloned upstream...

    Authors: Nan Du, Xuetao Pei, Jinming Zhou, Hui Zhao, Xiaosong Li, Yan Fu and Yixin Hao
    Citation: Journal of Biomedical Science 2009 16:85
    Content type: Research Published on:

  17. Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the ...

    Authors: Fan-Ching Shen, Ih-Jen Su, Han-Chieh Wu, Yi-Hsuan Hsieh, Wei-Jen Yao, Kung-Chia Young, Tsung-Chuan Chang, Hui-Chuan Hsieh, Han-Ni Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2009 16:84
    Content type: Research Published on:

  19. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2009 16:82
    Content type: Research Published on:

  20. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski
    Citation: Journal of Biomedical Science 2009 16:81
    Content type: Research Published on:

  21. To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...

    Authors: Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang and Shih-Yen Lo
    Citation: Journal of Biomedical Science 2009 16:80
    Content type: Research Published on:

  22. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek
    Citation: Journal of Biomedical Science 2009 16:79
    Content type: Research Published on:

  23. Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on ...

    Authors: Ting-Chun Weng, Chien-Chang Shen, Yung-Tsung Chiu, Yun-Lian Lin, Cheng-Deng Kuo and Yi-Tsau Huang
    Citation: Journal of Biomedical Science 2009 16:78
    Content type: Research Published on:

  24. In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin sign...

    Authors: Jiung-Pang Huang, Shiang-Suo Huang, Jen-Ying Deng and Li-Man Hung
    Citation: Journal of Biomedical Science 2009 16:77
    Content type: Research Published on:

  26. Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented s...

    Authors: Hung-Chuan Pan, Dar-Yu Yang, Shu-Peng Ho, Meei-Ling Sheu, Chung-Jung Chen, Shiaw-Min Hwang, Ming-Hong Chang and Fu-Chou Cheng
    Citation: Journal of Biomedical Science 2009 16:75
    Content type: Research Published on:

  27. Mesenchymal stem cells (MSCs)-based regenerative therapy is currently regarded as an alternative approach to salvage the acute myocardial infarcted hearts. However, the efficiency of MSCs transplantation is li...

    Authors: Yongwei Yao, Fumin Zhang, Liansheng Wang, Guohui Zhang, Zhaojun Wang, Jianmei Chen and Xiang Gao
    Citation: Journal of Biomedical Science 2009 16:74
    Content type: Research Published on:

  28. The application of a subset of single nucleotide polymorphisms, the tagSNPs, can be useful in capturing untyped SNPs information in a genomic region. TagSNP transferability from the HapMap dataset to admixed p...

    Authors: Tulio C Lins, Breno S Abreu and Rinaldo W Pereira
    Citation: Journal of Biomedical Science 2009 16:73
    Content type: Research Published on:

  29. The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) we...

    Authors: Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang and Che-Se Tung
    Citation: Journal of Biomedical Science 2009 16:72
    Content type: Research Published on:

  30. Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and au...

    Authors: Feng-Cheng Chou and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2009 16:71
    Content type: Research Published on:

  31. Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isola...

    Authors: Vilmante Borutaite, Ramune Morkuniene, Odeta Arandarcikaite, Aiste Jekabsone, Jurgita Barauskaite and Guy C Brown
    Citation: Journal of Biomedical Science 2009 16:70
    Content type: Research Published on:

  32. Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications ...

    Authors: Chien-Der Lee, Yao-Pei Yan, Shu-Mei Liang and Ting-Fang Wang
    Citation: Journal of Biomedical Science 2009 16:69
    Content type: Research Published on:

  33. Diabetes Mellitus is a chronic disease and many patients of which require frequent subcutaneous insulin injection to maintain proper blood glucose levels. Due to the inconvenience of insulin administration, an...

    Authors: Henry J Tsai and Shan-Yen Chou
    Citation: Journal of Biomedical Science 2009 16:68
    Content type: Research Published on:

  34. Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts...

    Authors: Shyan-Yuan Kao
    Citation: Journal of Biomedical Science 2009 16:67
    Content type: Research Published on:

  36. In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellul...

    Authors: Jiang Liuyun, Li Yubao and Xiong Chengdong
    Citation: Journal of Biomedical Science 2009 16:65
    Content type: Research Published on:

  37. This study aimed to investigate if food components that exert anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA). The cytokine profile and...

    Authors: Yong-Han Hong, Wen-Wan Chao, Miaw-Ling Chen and Bi-Fong Lin
    Citation: Journal of Biomedical Science 2009 16:64
    Content type: Research Published on:

  38. Parkinson's disease (PD) is a neurodegenerative disorder. The diagnosis of Parkinsonism is challenging because currently none of the clinical tests have been proven to help in diagnosis. PD may produce charact...

    Authors: Shiek SSJ Ahmed, Winkins Santosh, Suresh Kumar and Hema T Thanka Christlet
    Citation: Journal of Biomedical Science 2009 16:63
    Content type: Research Published on:

  39. The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and accurate determinati...

    Authors: Ping Qiu, Xiao-Yan Cai, Wei Ding, Qing Zhang, Ellie D Norris and Jonathan R Greene
    Citation: Journal of Biomedical Science 2009 16:62
    Content type: Research Published on:

  40. Oxidative stress induced by the production of reactive oxygen species may play a critical role in the stimulation of HIV replication and the development of immunodeficiency. This study was conducted as there a...

    Authors: DR Suresh, Vamseedhar Annam, K Pratibha and BV Maruti Prasad
    Citation: Journal of Biomedical Science 2009 16:61
    Content type: Research Published on:

  41. Apart from their well-known peripheral cardiovascular effects, emerging evidence indicates that estrogen acts as a modulator in the brain to regulate cardiovascular functions. The underlying mechanisms of estr...

    Authors: Cheng-Dean Shih
    Citation: Journal of Biomedical Science 2009 16:60
    Content type: Research Published on:

  42. During apoptosis several mitochondrial proteins are released. Some of them participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF) and endonuclease G (endoG). Ano...

    Authors: Miroslav Vařecha, Michal Zimmermann, Jana Amrichová, Vladimír Ulman, Pavel Matula and Michal Kozubek
    Citation: Journal of Biomedical Science 2009 16:59
    Content type: Research Published on:

  43. Airborne particulate matter, from cooking oil, smoking, engine exhaust and other sources, is associated with the development of atherosclerosis and myocardial infarction. In order to explore the cellular and m...

    Authors: Li Ping-Chia, Lai I-Ju, Lin Yu-Ching, Chang Li-Ching and Chen Wen-Chung
    Citation: Journal of Biomedical Science 2009 16:58
    Content type: Research Published on:

  44. Lysophosphatidylcholine (LPC), an atherogenic component of oxidized low-density lipoprotein, has been shown to induce the attenuation of endothelium-dependent vascular relaxation. Although benidipine, a dihydr...

    Authors: Makoto Takayama, Kozo Yao and Michihito Wada
    Citation: Journal of Biomedical Science 2009 16:57
    Content type: Research Published on:

  45. RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDIβ plays a previously undefined role in regulat...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, I-Chang Chang, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang
    Citation: Journal of Biomedical Science 2009 16:56
    Content type: Research Published on:

  46. Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge
    Citation: Journal of Biomedical Science 2009 16:55
    Content type: Research Published on:

  47. The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah
    Citation: Journal of Biomedical Science 2009 16:54
    Content type: Review Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  48. Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf
    Citation: Journal of Biomedical Science 2009 16:53
    Content type: Research Published on:

  50. High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw
    Citation: Journal of Biomedical Science 2009 16:51
    Content type: Research Published on:
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Journal of Biomedical Science

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