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  1. When used in overdoses, acetaminophen (APAP) is a common cause of morbidity and mortality in humans. At present, N-acetylcysteine (NAC) is the antidote of choice for acetaminophen overdoses. Prompt administrat...

    Authors: Miteshkumar Acharya and Cesar A Lau-Cam

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S35

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  2. Poly(ADP-ribose) is a NAD+-requiring, DNA-repairing, enzyme playing a central role in pancreatic β-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation ...

    Authors: Kashyap G Pandya, Maulik R Patel and Cesar A Lau-Cam

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S16

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  3. Acute ethanol administration leads to massive apoptotic neurodegeneration in the developing central nervous system. We studied whether taurine is neuroprotective in ethanol-induced apoptosis in the mouse cereb...

    Authors: Andrey G Taranukhin, Elena Y Taranukhina, Pirjo Saransaari, Irina M Podkletnova, Markku Pelto-Huikko and Simo S Oja

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S12

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  4. Taurine (T) was first noted as beneficial for stroke and cardiovascular diseases (CVD) prevention in genetic rat models, stroke-prone spontaneously hypertensive rats (SHRSP). The preventive mechanisms of T wer...

    Authors: Yukio Yamori, Takashi Taguchi, Atsumi Hamada, Kazuhiro Kunimasa, Hideki Mori and Mari Mori

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S6

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  5. Taurine participates in a number of different physiologic and biologic processes in the kidney, often reflected by urinary excretion patterns. The kidney is key to aspects of taurine body pool size and homeost...

    Authors: Russell W Chesney, Xiaobin Han and Andrea B Patters

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S4

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  6. Taurine (aminoethane sulfonic acid) is an ubiquitous compound, found in very high concentrations in heart and muscle. Although taurine is classified as an amino acid, it does not participate in peptide bond fo...

    Authors: Stephen W Schaffer, Chian Ju Jong, Ramila KC and Junichi Azuma

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S2

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  7. Parkinson's disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. Genetic association studies have linked 13 h...

    Authors: Shahrooz Vahedi, Mehrnoosh Rajabian, Arman Misaghian, Daniel Grbec, Horst H Simon and Kambiz N Alavian

    Citation: Journal of Biomedical Science 2010 17:66

    Content type: Research

    Published on:

  8. Enterovirus type 71 (EV71) 2A protease exhibited strong transcriptional activity in yeast cells. The transcriptional activity of 2A protease was independent of its protease activity. EV71 2A protease retained ...

    Authors: Chee-Hing Yang, Hui-Chun Li, Jeng-Geng Jiang, Che-Fang Hsu, Yi-Jen Wang, Meng-Jiun Lai, Yue-Li Juang and Shih-Yen Lo

    Citation: Journal of Biomedical Science 2010 17:65

    Content type: Research

    Published on:

  9. To overcome loss of stem-like properties and spontaneous differentiation those hinder the expansion and application of human mesenchymal stem cells (hMSCs), we have clonally isolated permanent and stable human...

    Authors: Chih-Chien Tsai, Chun-Li Chen, Hwa-Chung Liu, Yi-Ting Lee, Hsei-Wei Wang, Lein-Tuan Hou and Shih-Chieh Hung

    Citation: Journal of Biomedical Science 2010 17:64

    Content type: Research

    Published on:

  10. Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present...

    Authors: Paola Cuccarolo, Francesca Barbieri, Monica Sancandi, Silvia Viaggi and Paolo Degan

    Citation: Journal of Biomedical Science 2010 17:63

    Content type: Research

    Published on:

  11. Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of ...

    Authors: Youssef Sari, Anne L Prieto, Scott J Barton, Benjamin R Miller and George V Rebec

    Citation: Journal of Biomedical Science 2010 17:62

    Content type: Research

    Published on:

  12. Ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. Advanced ovarian cancers are difficult to cure with the current available chemotherapy, which has ma...

    Authors: Daejin Kim, Talia Hoory, Archana Monie, Annie Wu, Wei-Ting Hsueh, Sara I Pai and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2010 17:61

    Content type: Research

    Published on:

  13. Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttle...

    Authors: Hongxing Gui, Chi-Wei Lu, Sandra Adams, Victor Stollar and Mei-Ling Li

    Citation: Journal of Biomedical Science 2010 17:59

    Content type: Research

    Published on:

  14. The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical is...

    Authors: Ai-Sheng Ho, Chun-Chia Cheng, Shui-Cheng Lee, Meng-Lun Liu, Jing-Ying Lee, Wen-Ming Wang and Chia-Chi Wang

    Citation: Journal of Biomedical Science 2010 17:58

    Content type: Research

    Published on:

  15. The treatment of AIDS remains a serious challenge owing to high genetic variation of Human Immunodeficiency Virus type 1 (HIV-1). The use of different antiretroviral drugs (ARV) is significantly limited by sev...

    Authors: Lakshmi N Ramana, Swaminathan Sethuraman, Udaykumar Ranga and Uma M Krishnan

    Citation: Journal of Biomedical Science 2010 17:57

    Content type: Research

    Published on:

  16. Islet transplantation provides a promising cure for Type 1 diabetes; however it is limited by a shortage of pancreas donors. Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells ...

    Authors: Hsiao-Yun Lin, Chih-Chien Tsai, Ling-Lan Chen, Shih-Hwa Chiou, Yng-Jiin Wang and Shih-Chieh Hung

    Citation: Journal of Biomedical Science 2010 17:56

    Content type: Research

    Published on:

  17. Paraplegia remains a potential complication of spinal cord ischemic reperfusion injury (IRI) in which oxidative stress induced cyclooxygenase activities may contribute to ischemic neuronal damage. Prolonged ad...

    Authors: Mohamed D Morsy, Ossama A Mostafa and Waleed N Hassan

    Citation: Journal of Biomedical Science 2010 17:55

    Content type: Research

    Published on:

  18. MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however...

    Authors: Genesio M Karere, Jeremy P Glenn, John L VandeBerg and Laura A Cox

    Citation: Journal of Biomedical Science 2010 17:54

    Content type: Research

    Published on:

  19. Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells...

    Authors: Rasmus O Bak and Jacob G Mikkelsen

    Citation: Journal of Biomedical Science 2010 17:53

    Content type: Review

    Published on:

  20. Open reading frame l0045 in the pathogenic island of enterohemorrhagic Escherichia coli O157:H7 has been predicted to encode a lytic transglycosylase that is homologous to two different gene products encoded by t...

    Authors: Yen-Chi Yu, Ching-Nan Lin, Shao-Hung Wang, Swee-Chuan Ng, Wensi S Hu and Wan-Jr Syu

    Citation: Journal of Biomedical Science 2010 17:52

    Content type: Research

    Published on:

  21. RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like par...

    Authors: Meng-Ing Chou, Yu-Fan Hsieh, Meilin Wang, Jinghua Tsai Chang, Deching Chang, Moncef Zouali and Gregory J Tsay

    Citation: Journal of Biomedical Science 2010 17:51

    Content type: Research

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  22. Communication between the SR (sarcoplasmic reticulum, SR) and mitochondria is important for cell survival and apoptosis. The SR supplies Ca2+ directly to mitochondria via inositol 1,4,5-trisphosphate receptors (I...

    Authors: Fang-hao Lu, Zhiliang Tian, Wei-hua Zhang, Ya-jun Zhao, Hu-lun Li, Huan Ren, Hui-shuang Zheng, Chong Liu, Guang-xia Hu, Ye Tian, Bao-feng Yang, Rui Wang and Chang-qing Xu

    Citation: Journal of Biomedical Science 2010 17:50

    Content type: Research

    Published on:

  23. The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-li...

    Authors: Hsiang-Ping Tsai, Li-Wei Lin, Zhi-Yang Lai, Jui-Yu Wu, Chiao-En Chen, Jaulang Hwang, Chien-Shu Chen and Chun-Mao Lin

    Citation: Journal of Biomedical Science 2010 17:49

    Content type: Research

    Published on:

  24. Major burn is associated with decreased gut barrier function and increased bacterial translocation (BT). This study is to investigate whether commensal microflora induce host defense and decrease BT in burn mice.

    Authors: Lee-Wei Chen, Wei-Jung Chang, Pei-Hsuan Chen and Ching-Mei Hsu

    Citation: Journal of Biomedical Science 2010 17:48

    Content type: Research

    Published on:

  25. The transcription factor p63 plays a pivotal role in the development and maintenance of epithelial tissues, including the ocular surface. In an effort to gain insight into the pathogenesis of keratitis caused ...

    Authors: László Orosz, Éva Gallyas, Lajos Kemény, Yvette Mándi, Andrea Facskó and Klára Megyeri

    Citation: Journal of Biomedical Science 2010 17:47

    Content type: Research

    Published on:

  26. Abuse of addictive substances is a serious problem that has a significant impact on areas such as health, the economy, and public safety. Heroin use among young women of reproductive age has drawn much attenti...

    Authors: Yao-Chang Chiang, Tsai-Wei Hung, Cynthia Wei-Sheng Lee, Jia-Ying Yan and Ing-Kang Ho

    Citation: Journal of Biomedical Science 2010 17:46

    Content type: Research

    Published on:

  27. 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their...

    Authors: Ye-Ming Lee, Wei-Fan Chen, Duen-Suey Chou, Thanasekaran Jayakumar, Ssu-Yu Hou, Jie-Jen Lee, George Hsiao and Joen-Rong Sheu

    Citation: Journal of Biomedical Science 2010 17:45

    Content type: Research

    Published on:

  28. Gene transfer into many cell types has been successfully used to develop alternative and adjunct approaches to conventional medical treatment. However, effective transfection of postmitotic neurons remains a c...

    Authors: Chung-Ren Lin, Kuan-Hung Chen, Chien-Hui Yang, Jiin-Tsuey Cheng, Shyr-Ming Sheen-Chen, Chih-Hsien Wu, Wei-Dih Sy and Yi-Shen Chen

    Citation: Journal of Biomedical Science 2010 17:44

    Content type: Research

    Published on:

  29. Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties. This study aims at evaluating the effect of curc...

    Authors: T Peeyush Kumar, Sherin Antony, G Gireesh, Naijil George and CS Paulose

    Citation: Journal of Biomedical Science 2010 17:43

    Content type: Research

    Published on:

  30. Liver fibrosis ranks as the second cause of death in México's productive-age population. This pathology is characterized by acummulation of fibrillar proteins in hepatic parenchyma causing synthetic and metabo...

    Authors: Francisco J Gálvez-Gastélum, Aida A Segura-Flores, María D Senties-Gomez, Jose F Muñoz-Valle and Juan S Armendáriz-Borunda

    Citation: Journal of Biomedical Science 2010 17:42

    Content type: Research

    Published on:

  31. Several molecular changes occur following axotomy, such as gene up-regulation and down-regulation. In our previous study using Affymetrix arrays, it was found that after the axotomy of sciatic nerve, there wer...

    Authors: Kuan-Hung Chen, Chien-Hui Yang, Jiin-Tsuey Cheng, Chih-Hsien Wu, Wei-Dih Sy and Chung-Ren Lin

    Citation: Journal of Biomedical Science 2010 17:41

    Content type: Research

    Published on:

  32. Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitoc...

    Authors: Bor-Show Tzang, Der-Yuan Chen, Chun-Chou Tsai, Szu-Yi Chiang, Tsung-Ming Lin and Tsai-Ching Hsu

    Citation: Journal of Biomedical Science 2010 17:40

    Content type: Research

    Published on:

  33. The interaction between prM and E proteins in flavivirus-infected cells is a major driving force for the assembly of flavivirus particles. We used site-directed mutagenesis to study the potential role of the t...

    Authors: Ying-Ju Lin, Jia-Guan Peng and Suh-Chin Wu

    Citation: Journal of Biomedical Science 2010 17:39

    Content type: Research

    Published on:

  34. Excitatory amino acid release and subsequent biochemical cascades following traumatic brain injury (TBI) have been well documented, especially glutamate-related excitotoxicity. The effects of TBI on the essent...

    Authors: Cynthia J Gibson, Rebecca C Meyer and Robert J Hamm

    Citation: Journal of Biomedical Science 2010 17:38

    Content type: Research

    Published on:

  35. Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are locate...

    Authors: Ching-Hsiung Lin, Kun-Tu Yeh, Ya-Sian Chang, Nicholas C Hsu and Jan-Gowth Chang

    Citation: Journal of Biomedical Science 2010 17:37

    Content type: Research

    Published on:

  36. It is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the proteolytic activity ...

    Authors: Hsiang-Ling Huang, Hsiang-Wei Hsing, Tzu-Chia Lai, Yi-Wen Chen, Tian-Ren Lee, Hsin-Tsu Chan, Ping-Chiang Lyu, Chieh-Lin Wu, Ying-Chieh Lu, Szu-Ting Lin, Cheng-Wen Lin, Chih-Ho Lai, Hao-Teng Chang, Hsiu-Chuan Chou and Hong-Lin Chan

    Citation: Journal of Biomedical Science 2010 17:36

    Content type: Research

    Published on:

  37. Protein Kinase C (PKC) is a serine/threonine kinase that involved in controlling of many cellular processes such as cell proliferation and differentiation. We have observed previously that TPA (12-O-tetradecan...

    Authors: Chao-Wei Chiang, Yi Huang, Ka-Wai Leong, Lih-Chyang Chen, Hua-Chien Chen, Shu-Jen Chen and Chen-Kung Chou

    Citation: Journal of Biomedical Science 2010 17:35

    Content type: Research

    Published on:

  38. X-ray crystal structure determination of agglutinin from abrus precatorius in Taiwan is presented. The crystal structure of agglutinin, a type II ribosome-inactivating protein (RIP) from the seeds of Abrus precat...

    Authors: Jack Cheng, Tian-Huey Lu, Chao-Lin Liu and Jung-Yaw Lin

    Citation: Journal of Biomedical Science 2010 17:34

    Content type: Research

    Published on:

  39. Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecul...

    Authors: Anna M Czarnecka, Jerzy S Czarnecki, Wojciech Kukwa, Francesco Cappello, Anna Ścińska and Andrzej Kukwa

    Citation: Journal of Biomedical Science 2010 17:31

    Content type: Review

    Published on:

  40. The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder ...

    Authors: Jen-Chuang Kung, Tsung-Chieh Chen, Bai-Chuang Shyu, Sigmund Hsiao and Andrew Chih Wei Huang

    Citation: Journal of Biomedical Science 2010 17:29

    Content type: Research

    Published on:

  41. Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dep...

    Authors: Shiou-Lan Chen, Hsin-I Ma, Jun-Ming Han, Ru-Band Lu, Pao-Luh Tao, Ping-Yee Law and Horace H Loh

    Citation: Journal of Biomedical Science 2010 17:28

    Content type: Research

    Published on:

  42. We observed previously that cisplatin-resistant HeLa cells were cross-resistant to UV light due to accumulation of DDB2, a protein implicated in DNA repair. More recently, we found that cFLIP, which represents...

    Authors: Nian-Kang Sun, Chun-Ling Sun, Chia-Hua Lin, Li-Mai Pai and Chuck CK Chao

    Citation: Journal of Biomedical Science 2010 17:27

    Content type: Research

    Published on:

  43. Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations...

    Authors: Jin-Ok Choi, Mi Hee Lee, Hae-Young Park and Sung-Chul Jung

    Citation: Journal of Biomedical Science 2010 17:26

    Content type: Research

    Published on:

  44. The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candid...

    Authors: Ahmed S Abdel-Moneim, Ahmad E Abdel-Ghany and Salama AS Shany

    Citation: Journal of Biomedical Science 2010 17:25

    Content type: Research

    Published on:

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