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  1. The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical is...

    Authors: Ai-Sheng Ho, Chun-Chia Cheng, Shui-Cheng Lee, Meng-Lun Liu, Jing-Ying Lee, Wen-Ming Wang and Chia-Chi Wang
    Citation: Journal of Biomedical Science 2010 17:58
    Content type: Research Published on:

  2. The treatment of AIDS remains a serious challenge owing to high genetic variation of Human Immunodeficiency Virus type 1 (HIV-1). The use of different antiretroviral drugs (ARV) is significantly limited by sev...

    Authors: Lakshmi N Ramana, Swaminathan Sethuraman, Udaykumar Ranga and Uma M Krishnan
    Citation: Journal of Biomedical Science 2010 17:57
    Content type: Research Published on:

  3. Islet transplantation provides a promising cure for Type 1 diabetes; however it is limited by a shortage of pancreas donors. Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells ...

    Authors: Hsiao-Yun Lin, Chih-Chien Tsai, Ling-Lan Chen, Shih-Hwa Chiou, Yng-Jiin Wang and Shih-Chieh Hung
    Citation: Journal of Biomedical Science 2010 17:56
    Content type: Research Published on:

  4. Paraplegia remains a potential complication of spinal cord ischemic reperfusion injury (IRI) in which oxidative stress induced cyclooxygenase activities may contribute to ischemic neuronal damage. Prolonged ad...

    Authors: Mohamed D Morsy, Ossama A Mostafa and Waleed N Hassan
    Citation: Journal of Biomedical Science 2010 17:55
    Content type: Research Published on:

  5. MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however...

    Authors: Genesio M Karere, Jeremy P Glenn, John L VandeBerg and Laura A Cox
    Citation: Journal of Biomedical Science 2010 17:54
    Content type: Research Published on:

  6. Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells...

    Authors: Rasmus O Bak and Jacob G Mikkelsen
    Citation: Journal of Biomedical Science 2010 17:53
    Content type: Review Published on:

  7. Open reading frame l0045 in the pathogenic island of enterohemorrhagic Escherichia coli O157:H7 has been predicted to encode a lytic transglycosylase that is homologous to two different gene products encoded by t...

    Authors: Yen-Chi Yu, Ching-Nan Lin, Shao-Hung Wang, Swee-Chuan Ng, Wensi S Hu and Wan-Jr Syu
    Citation: Journal of Biomedical Science 2010 17:52
    Content type: Research Published on:

  8. RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like par...

    Authors: Meng-Ing Chou, Yu-Fan Hsieh, Meilin Wang, Jinghua Tsai Chang, Deching Chang, Moncef Zouali and Gregory J Tsay
    Citation: Journal of Biomedical Science 2010 17:51
    Content type: Research Published on:

  9. Communication between the SR (sarcoplasmic reticulum, SR) and mitochondria is important for cell survival and apoptosis. The SR supplies Ca2+ directly to mitochondria via inositol 1,4,5-trisphosphate receptors (I...

    Authors: Fang-hao Lu, Zhiliang Tian, Wei-hua Zhang, Ya-jun Zhao, Hu-lun Li, Huan Ren, Hui-shuang Zheng, Chong Liu, Guang-xia Hu, Ye Tian, Bao-feng Yang, Rui Wang and Chang-qing Xu
    Citation: Journal of Biomedical Science 2010 17:50
    Content type: Research Published on:

  10. The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-li...

    Authors: Hsiang-Ping Tsai, Li-Wei Lin, Zhi-Yang Lai, Jui-Yu Wu, Chiao-En Chen, Jaulang Hwang, Chien-Shu Chen and Chun-Mao Lin
    Citation: Journal of Biomedical Science 2010 17:49
    Content type: Research Published on:

  11. Major burn is associated with decreased gut barrier function and increased bacterial translocation (BT). This study is to investigate whether commensal microflora induce host defense and decrease BT in burn mice.

    Authors: Lee-Wei Chen, Wei-Jung Chang, Pei-Hsuan Chen and Ching-Mei Hsu
    Citation: Journal of Biomedical Science 2010 17:48
    Content type: Research Published on:

  12. The transcription factor p63 plays a pivotal role in the development and maintenance of epithelial tissues, including the ocular surface. In an effort to gain insight into the pathogenesis of keratitis caused ...

    Authors: László Orosz, Éva Gallyas, Lajos Kemény, Yvette Mándi, Andrea Facskó and Klára Megyeri
    Citation: Journal of Biomedical Science 2010 17:47
    Content type: Research Published on:

  13. Abuse of addictive substances is a serious problem that has a significant impact on areas such as health, the economy, and public safety. Heroin use among young women of reproductive age has drawn much attenti...

    Authors: Yao-Chang Chiang, Tsai-Wei Hung, Cynthia Wei-Sheng Lee, Jia-Ying Yan and Ing-Kang Ho
    Citation: Journal of Biomedical Science 2010 17:46
    Content type: Research Published on:

  14. 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their...

    Authors: Ye-Ming Lee, Wei-Fan Chen, Duen-Suey Chou, Thanasekaran Jayakumar, Ssu-Yu Hou, Jie-Jen Lee, George Hsiao and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2010 17:45
    Content type: Research Published on:

  15. Gene transfer into many cell types has been successfully used to develop alternative and adjunct approaches to conventional medical treatment. However, effective transfection of postmitotic neurons remains a c...

    Authors: Chung-Ren Lin, Kuan-Hung Chen, Chien-Hui Yang, Jiin-Tsuey Cheng, Shyr-Ming Sheen-Chen, Chih-Hsien Wu, Wei-Dih Sy and Yi-Shen Chen
    Citation: Journal of Biomedical Science 2010 17:44
    Content type: Research Published on:

  16. Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties. This study aims at evaluating the effect of curc...

    Authors: T Peeyush Kumar, Sherin Antony, G Gireesh, Naijil George and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:43
    Content type: Research Published on:

  17. Liver fibrosis ranks as the second cause of death in México's productive-age population. This pathology is characterized by acummulation of fibrillar proteins in hepatic parenchyma causing synthetic and metabo...

    Authors: Francisco J Gálvez-Gastélum, Aida A Segura-Flores, María D Senties-Gomez, Jose F Muñoz-Valle and Juan S Armendáriz-Borunda
    Citation: Journal of Biomedical Science 2010 17:42
    Content type: Research Published on:

  18. Several molecular changes occur following axotomy, such as gene up-regulation and down-regulation. In our previous study using Affymetrix arrays, it was found that after the axotomy of sciatic nerve, there wer...

    Authors: Kuan-Hung Chen, Chien-Hui Yang, Jiin-Tsuey Cheng, Chih-Hsien Wu, Wei-Dih Sy and Chung-Ren Lin
    Citation: Journal of Biomedical Science 2010 17:41
    Content type: Research Published on:

  19. Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitoc...

    Authors: Bor-Show Tzang, Der-Yuan Chen, Chun-Chou Tsai, Szu-Yi Chiang, Tsung-Ming Lin and Tsai-Ching Hsu
    Citation: Journal of Biomedical Science 2010 17:40
    Content type: Research Published on:

  20. The interaction between prM and E proteins in flavivirus-infected cells is a major driving force for the assembly of flavivirus particles. We used site-directed mutagenesis to study the potential role of the t...

    Authors: Ying-Ju Lin, Jia-Guan Peng and Suh-Chin Wu
    Citation: Journal of Biomedical Science 2010 17:39
    Content type: Research Published on:

  21. Excitatory amino acid release and subsequent biochemical cascades following traumatic brain injury (TBI) have been well documented, especially glutamate-related excitotoxicity. The effects of TBI on the essent...

    Authors: Cynthia J Gibson, Rebecca C Meyer and Robert J Hamm
    Citation: Journal of Biomedical Science 2010 17:38
    Content type: Research Published on:

  22. Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are locate...

    Authors: Ching-Hsiung Lin, Kun-Tu Yeh, Ya-Sian Chang, Nicholas C Hsu and Jan-Gowth Chang
    Citation: Journal of Biomedical Science 2010 17:37
    Content type: Research Published on:

  23. It is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the proteolytic activity ...

    Authors: Hsiang-Ling Huang, Hsiang-Wei Hsing, Tzu-Chia Lai, Yi-Wen Chen, Tian-Ren Lee, Hsin-Tsu Chan, Ping-Chiang Lyu, Chieh-Lin Wu, Ying-Chieh Lu, Szu-Ting Lin, Cheng-Wen Lin, Chih-Ho Lai, Hao-Teng Chang, Hsiu-Chuan Chou and Hong-Lin Chan
    Citation: Journal of Biomedical Science 2010 17:36
    Content type: Research Published on:

  24. Protein Kinase C (PKC) is a serine/threonine kinase that involved in controlling of many cellular processes such as cell proliferation and differentiation. We have observed previously that TPA (12-O-tetradecan...

    Authors: Chao-Wei Chiang, Yi Huang, Ka-Wai Leong, Lih-Chyang Chen, Hua-Chien Chen, Shu-Jen Chen and Chen-Kung Chou
    Citation: Journal of Biomedical Science 2010 17:35
    Content type: Research Published on:

  25. X-ray crystal structure determination of agglutinin from abrus precatorius in Taiwan is presented. The crystal structure of agglutinin, a type II ribosome-inactivating protein (RIP) from the seeds of Abrus precat...

    Authors: Jack Cheng, Tian-Huey Lu, Chao-Lin Liu and Jung-Yaw Lin
    Citation: Journal of Biomedical Science 2010 17:34
    Content type: Research Published on:

  28. Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecul...

    Authors: Anna M Czarnecka, Jerzy S Czarnecki, Wojciech Kukwa, Francesco Cappello, Anna Ścińska and Andrzej Kukwa
    Citation: Journal of Biomedical Science 2010 17:31
    Content type: Review Published on:

  30. The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder ...

    Authors: Jen-Chuang Kung, Tsung-Chieh Chen, Bai-Chuang Shyu, Sigmund Hsiao and Andrew Chih Wei Huang
    Citation: Journal of Biomedical Science 2010 17:29
    Content type: Research Published on:

  31. Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dep...

    Authors: Shiou-Lan Chen, Hsin-I Ma, Jun-Ming Han, Ru-Band Lu, Pao-Luh Tao, Ping-Yee Law and Horace H Loh
    Citation: Journal of Biomedical Science 2010 17:28
    Content type: Research Published on:

  32. We observed previously that cisplatin-resistant HeLa cells were cross-resistant to UV light due to accumulation of DDB2, a protein implicated in DNA repair. More recently, we found that cFLIP, which represents...

    Authors: Nian-Kang Sun, Chun-Ling Sun, Chia-Hua Lin, Li-Mai Pai and Chuck CK Chao
    Citation: Journal of Biomedical Science 2010 17:27
    Content type: Research Published on:

  33. Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations...

    Authors: Jin-Ok Choi, Mi Hee Lee, Hae-Young Park and Sung-Chul Jung
    Citation: Journal of Biomedical Science 2010 17:26
    Content type: Research Published on:

  34. The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candid...

    Authors: Ahmed S Abdel-Moneim, Ahmad E Abdel-Ghany and Salama AS Shany
    Citation: Journal of Biomedical Science 2010 17:25
    Content type: Research Published on:

  36. The association of TGF β1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The p...

    Authors: Yongzheng Wang, Xuwei Hou and Yuliang Li
    Citation: Journal of Biomedical Science 2010 17:23
    Content type: Research Published on:

  37. The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms ...

    Authors: Wei Sun, Wen-Wen Shen, Shuang Yang, Fen Hu, Yang Gao, Yu-Huan Qiao and Tian-Hui Zhu
    Citation: Journal of Biomedical Science 2010 17:22
    Content type: Research Published on:

  38. Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need of alternative cancer therapies. Moreover, the success of novel cancer therapies depends on their se...

    Authors: S Patyar, R Joshi, DS Prasad Byrav, A Prakash, B Medhi and BK Das
    Citation: Journal of Biomedical Science 2010 17:21
    Content type: Review Published on:

  39. Pulmonary veins (PVs) are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation. Elimination...

    Authors: Yung-Kuo Lin, Yen-Yu Lu, Yao-Chang Chen, Yi-Jen Chen and Shih-Ann Chen
    Citation: Journal of Biomedical Science 2010 17:20
    Content type: Research Published on:

  40. Diffuse noxious inhibitory controls (DNIC) can be produced by different types of conditioning stimuli, but the analgesic properties and underlying mechanisms remain unclear. The aim of this study was to differ...

    Authors: Yeong-Ray Wen, Chia-Chuan Wang, Geng-Chang Yeh, Sheng-Feng Hsu, Yung-Jen Huang, Yen-Li Li and Wei-Zen Sun
    Citation: Journal of Biomedical Science 2010 17:19
    Content type: Research Published on:

  41. Akt regulates various cellular processes, including cell growth, survival, and metabolism. Recently, Akt's role in neurite outgrowth has also emerged. We thus aimed to identify neuronal function-related genes ...

    Authors: Young-Tae Ro, Bo-Kwang Jang, Chan Young Shin, Eui U Park, Chul Geun Kim and Sung-Il Yang
    Citation: Journal of Biomedical Science 2010 17:18
    Content type: Research Published on:

  42. As the origin of a life-and-death signal detected from systemic arterial pressure, which sequentially increases (pro-life) and decreases (pro-death) to reflect progressive dysfunction of central cardiovascular...

    Authors: Samuel HH Chan, Enya YH Sun and Alice YW Chang
    Citation: Journal of Biomedical Science 2010 17:17
    Content type: Research Published on:

  43. Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Rece...

    Authors: Gang Wu, Changlong Nan, Johnathon C Rollo, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2010 17:16
    Content type: Research Published on:

  44. Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expres...

    Authors: Kou-Gi Shyu, Bao-Wei Wang, Chiu-Mei Lin and Hang Chang
    Citation: Journal of Biomedical Science 2010 17:15
    Content type: Research Published on:

  45. Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magneti...

    Authors: Maria A Macri, Nicola D'Alessandro, Camillo Di Giulio, Patrizia Di Iorio, Silvano Di Luzio, Patricia Giuliani, Ennio Esposito and Mieczyslaw Pokorski
    Citation: Journal of Biomedical Science 2010 17:14
    Content type: Research Published on:

  46. Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious pu...

    Authors: Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Wen-Fang Tang, Ming-sian Wu, Jiann-Yih Yeh, Yu-Sheng Chao, John TA Hsu, Hsing-Pang Hsieh and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2010 17:13
    Content type: Research Published on:

  47. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction,...

    Authors: Chyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau and Wen-Harn Pan
    Citation: Journal of Biomedical Science 2010 17:12
    Content type: Research Published on:

  48. Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of ...

    Authors: Bertrand Chin-Ming Tan, Hsuan Liu, Chih-Li Lin and Sheng-Chung Lee
    Citation: Journal of Biomedical Science 2010 17:11
    Content type: Research Published on:

  49. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasio...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra
    Citation: Journal of Biomedical Science 2010 17:10
    Content type: Review Published on:

  50. Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well establish...

    Authors: Chieh-Sen Chuang, Hong-Lin Su, Fu-Chou Cheng, Shan-hui Hsu, Chi-Fen Chuang and Chin-San Liu
    Citation: Journal of Biomedical Science 2010 17:9
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127