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  1. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasio...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra

    Citation: Journal of Biomedical Science 2010 17:10

    Content type: Review

    Published on:

  2. Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well establish...

    Authors: Chieh-Sen Chuang, Hong-Lin Su, Fu-Chou Cheng, Shan-hui Hsu, Chi-Fen Chuang and Chin-San Liu

    Citation: Journal of Biomedical Science 2010 17:9

    Content type: Research

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  3. Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, ou...

    Authors: A Luquita, L Urli, MJ Svetaz, AM Gennaro, ME Giorgetti, G Pistone, R Volpintesta, S Palatnik and M Rasia

    Citation: Journal of Biomedical Science 2010 17:8

    Content type: Research

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  4. Glucose homeostasis in humans is an important factor for the functioning of nervous system. Hypoglycemia and hyperglycemia is found to be associated with central and peripheral nerve system dysfunction. Change...

    Authors: Sherin Antony, Peeyush Kumar T, Jobin Mathew, TR Anju and CS Paulose

    Citation: Journal of Biomedical Science 2010 17:7

    Content type: Research

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  5. Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC...

    Authors: Qifeng Jiang, Renjian Huang, Shaoxi Cai and Chih-Lueh A Wang

    Citation: Journal of Biomedical Science 2010 17:6

    Content type: Research

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  6. Androgen ablation is one of the viable therapeutic options for patients with primary hormone (androgen)-dependent prostate cancer. However, an antibiotic brefeldin A (BFA) has been shown to exhibit the growth ...

    Authors: Srinivas Rajamahanty, Catherine Alonzo, Shahrad Aynehchi, Muhammad Choudhury and Sensuke Konno

    Citation: Journal of Biomedical Science 2010 17:5

    Content type: Research

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  7. Caffeine, a nonselective adenosine A1 and A2A receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact...

    Authors: Chih W Hsu, Chin S Wang and Ted H Chiu

    Citation: Journal of Biomedical Science 2010 17:4

    Content type: Research

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  8. The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of...

    Authors: Paul Gutwein, Anja Schramme, Mohamed Sadek Abdel-Bakky, Kai Doberstein, Ingeborg A Hauser, Andreas Ludwig, Peter Altevogt, Stefan Gauer, Anja Hillmann, Thomas Weide, Christine Jespersen, Wolfgang Eberhardt and Josef Pfeilschifter

    Citation: Journal of Biomedical Science 2010 17:3

    Content type: Research

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  9. Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be con...

    Authors: Jurandir F Comar, Fumie Suzuki-Kemmelmeier, Jorgete Constantin and Adelar Bracht

    Citation: Journal of Biomedical Science 2010 17:1

    Content type: Research

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  10. Several lines of evidence point to a particularly important role of the left atrium (LA) in initiating and maintaining atrial fibrillation (AF). This role may be related to the location of pulmonary veins (PVs...

    Authors: Yue-Xia Loh, Kuo-Ho Wu, Yao-Chang Chen, Chih-Hsiung Hsu, Jeng Wei and Cheng-I Lin

    Citation: Journal of Biomedical Science 2009 16:114

    Content type: Research

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  11. The uptake of abortion-inducing pathogens by trophoblast giant (TG) cells is a key event in infectious abortion. However, little is known about phagocytic functions of TG cells against the pathogens. Here we s...

    Authors: Kenta Watanabe, Masato Tachibana, Suk Kim and Masahisa Watarai

    Citation: Journal of Biomedical Science 2009 16:113

    Content type: Research

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  12. An important role in atherogenesis is played by oxidative stress, which may be induced by common risk factors. Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidenc...

    Authors: Paolo Puddu, Giovanni M Puddu, Eleonora Cravero, Susanna De Pascalis and Antonio Muscari

    Citation: Journal of Biomedical Science 2009 16:112

    Content type: Review

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  13. After publication of our article, it was noted that we inadvertently failed to include the complete list of authors. The full list, including co-authors, has now been added and the Authors' contributions and C...

    Authors: Sang Soo Hah, Paul T Henderson and Kenneth W Turteltaub

    Citation: Journal of Biomedical Science 2009 16:111

    Content type: Erratum

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    The original article was published in Journal of Biomedical Science 2009 16:54

  14. Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing ...

    Authors: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger and Ching-Shih Chen

    Citation: Journal of Biomedical Science 2009 16:110

    Content type: Research

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  15. Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve ...

    Authors: Anuradha Subramanian, Uma Maheswari Krishnan and Swaminathan Sethuraman

    Citation: Journal of Biomedical Science 2009 16:108

    Content type: Review

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  16. Human cytomegalovirus (HCMV) is known to induce chromosome aberrations in infected cells, which can lead to congenital abnormalities in infected fetuses. HCMV UL76 belongs to a conserved protein family from he...

    Authors: Voon-Kwan Siew, Chang-Yih Duh and Shang-Kwei Wang

    Citation: Journal of Biomedical Science 2009 16:107

    Content type: Research

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  17. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang

    Citation: Journal of Biomedical Science 2009 16:106

    Content type: Research

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  18. Epithelial-mesenchymal transition (EMT) is an important process in tumor metastasis. The EMT-related events associated with metastasis of NPC in the absence of EBV have not been elucidated. We established an E...

    Authors: Jung-Chung Lin, Shuen-Kuei Liao, En-Huei Lee, Man-Shan Hung, Yiyang Sayion, Hung-Chang Chen, Chen-Chen Kang, Liang-Sheng Huang and Jaw-Ming Cherng

    Citation: Journal of Biomedical Science 2009 16:105

    Content type: Research

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  19. Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paral...

    Authors: Jing-Yi Lin, Tzu-Chun Chen, Kuo-Feng Weng, Shih-Cheng Chang, Li-Lien Chen and Shin-Ru Shih

    Citation: Journal of Biomedical Science 2009 16:103

    Content type: Review

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  20. Anaemia is a frequent complication of infection with the human immunodeficiency virus (HIV) and may have multiple causes. The objective of this study was to find out if blood haemoglobin measurement could be u...

    Authors: Christian Obirikorang and Francis A Yeboah

    Citation: Journal of Biomedical Science 2009 16:102

    Content type: Research

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  21. The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillator...

    Authors: Mario Vassalle, John N Catanzaro, Michael P Nett and Marcello Rota

    Citation: Journal of Biomedical Science 2009 16:101

    Content type: Research

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  22. The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have establish...

    Authors: Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai and Jeng-Fan Lo

    Citation: Journal of Biomedical Science 2009 16:100

    Content type: Research

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  23. Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotr...

    Authors: Savitha Balakrishnan, Peeyush Kumar T and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:99

    Content type: Research

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  24. Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from m...

    Authors: Yuanbin Liu and David R Schubert

    Citation: Journal of Biomedical Science 2009 16:98

    Content type: Research

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  25. To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (h PSCs). Human cho...

    Authors: Shin-Han Tsai, Ming-Thau Sheu, Yu-Chih Liang, Hsiu-Tan Cheng, Sheng-Shiung Fang and Chien-Ho Chen

    Citation: Journal of Biomedical Science 2009 16:97

    Content type: Research

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  26. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intri...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang

    Citation: Journal of Biomedical Science 2009 16:96

    Content type: Review

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  27. The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by gl...

    Authors: Yi-Ruu Lin, Hwei-Hsien Chen, Yu-Chin Lin, Chien-Hsin Ko and Ming-Huan Chan

    Citation: Journal of Biomedical Science 2009 16:94

    Content type: Research

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  28. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De

    Citation: Journal of Biomedical Science 2009 16:93

    Content type: Review

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  29. Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogeneis, we took a novel approach based on phenotype chan...

    Authors: Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye and Bing Sun

    Citation: Journal of Biomedical Science 2009 16:92

    Content type: Research

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  30. Bacterial adherence to epithelial cells is a key virulence trait of pathogenic bacteria. The type 1 fimbriae and the P-fimbriae of uropathogenic Escherichia coli (UPEC) have both been described to be important fo...

    Authors: Kun-Wei Tsai, Hong-Thih Lai, Tzung-Chieh Tsai, Yi-Chien Wu, Ya-Ting Yang, Kwei-Yi Chen, Chun-Ming Chen, Yi-Shuan J Li and Cheng-Nan Chen

    Citation: Journal of Biomedical Science 2009 16:91

    Content type: Research

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  31. Envelope (E) glycoprotein E2 of the hepatitis C virus (HCV) mediates binding of the virus to target cell receptors. Nevertheless, the precise role of E1 in viral entry remains elusive.

    Authors: Hsiao-Fen Li, Chia-Hsuan Huang, Li-Shuang Ai, Chin-Kai Chuang and Steve SL Chen

    Citation: Journal of Biomedical Science 2009 16:89

    Content type: Research

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  32. Trophoblast differentiation and formation of the placenta are important events linked to post-implantation embryonic development. Models mimicking the biology of trophoblast differentiation in a post-implantat...

    Authors: Kavitha Sivasubramaiyan, Swapnil Totey, Vijay Bhat, Satish M Totey and Kaushik Deb

    Citation: Journal of Biomedical Science 2009 16:88

    Content type: Research

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  33. Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiat...

    Authors: Yan Huang, Zhong-Quan Dai, Shu-Kuan Ling, Hong-Yu Zhang, Yu-Min Wan and Ying-Hui Li

    Citation: Journal of Biomedical Science 2009 16:87

    Content type: Research

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  34. Application of superparamagnetic iron oxide nanoparticles (SPIOs) as the contrast agent has improved the quality of magnetic resonance (MR) imaging. Low efficiency of loading the commercially available iron ox...

    Authors: Huey-Chung Huang, Po-Yuan Chang, Karen Chang, Chao-Yu Chen, Chung-Wu Lin, Jyh-Horng Chen, Chung-Yuan Mou, Zee-Fen Chang and Fu-Hsiung Chang

    Citation: Journal of Biomedical Science 2009 16:86

    Content type: Research

    Published on:

  35. Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs). Egr-EF, an expression vector pCIneo containing Egr-1 promoter cloned upstream...

    Authors: Nan Du, Xuetao Pei, Jinming Zhou, Hui Zhao, Xiaosong Li, Yan Fu and Yixin Hao

    Citation: Journal of Biomedical Science 2009 16:85

    Content type: Research

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  36. Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the ...

    Authors: Fan-Ching Shen, Ih-Jen Su, Han-Chieh Wu, Yi-Hsuan Hsieh, Wei-Jen Yao, Kung-Chia Young, Tsung-Chuan Chang, Hui-Chuan Hsieh, Han-Ni Tsai and Wenya Huang

    Citation: Journal of Biomedical Science 2009 16:84

    Content type: Research

    Published on:

  37. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour

    Citation: Journal of Biomedical Science 2009 16:82

    Content type: Research

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  38. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski

    Citation: Journal of Biomedical Science 2009 16:81

    Content type: Research

    Published on:

  39. To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...

    Authors: Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang and Shih-Yen Lo

    Citation: Journal of Biomedical Science 2009 16:80

    Content type: Research

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  40. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek

    Citation: Journal of Biomedical Science 2009 16:79

    Content type: Research

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  41. Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on ...

    Authors: Ting-Chun Weng, Chien-Chang Shen, Yung-Tsung Chiu, Yun-Lian Lin, Cheng-Deng Kuo and Yi-Tsau Huang

    Citation: Journal of Biomedical Science 2009 16:78

    Content type: Research

    Published on:

  42. In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin sign...

    Authors: Jiung-Pang Huang, Shiang-Suo Huang, Jen-Ying Deng and Li-Man Hung

    Citation: Journal of Biomedical Science 2009 16:77

    Content type: Research

    Published on:

  43. Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented s...

    Authors: Hung-Chuan Pan, Dar-Yu Yang, Shu-Peng Ho, Meei-Ling Sheu, Chung-Jung Chen, Shiaw-Min Hwang, Ming-Hong Chang and Fu-Chou Cheng

    Citation: Journal of Biomedical Science 2009 16:75

    Content type: Research

    Published on:

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