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1065 result(s) for 'antibody' within Journal of Biomedical Science

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  1. Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DU...

    Authors: Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan and Yi-Rong Chen
    Citation: Journal of Biomedical Science 2022 29:40
    Content type: Research Published on:

  2. Extraintestinal pathogenic E. coli (ExPEC) is a common gram-negative organism causing various infections, including urinary tract infections (UTIs), bacteremia, and neonatal meningitis. The cjrABC-senB gene clust...

    Authors: Wen-Chun Huang, Yi-Jyun Liao, Masayuki Hashimoto, Kuan-Fu Chen, Chishih Chu, Po-Chuen Hsu, Shuying Wang and Ching-Hao Teng
    Citation: Journal of Biomedical Science 2020 27:86
    Content type: Research Published on:

  3. The specific role of microglia on Aβ-mediated neurotoxicity is difficult to assign in vivo due to their complicated environment in the brain. Therefore, most of the current microglia-related studies employed the ...

    Authors: Huey-Jen Tsay, Yung-Cheng Huang, Fong-Lee Huang, Chia-Ping Chen, Yu-Chun Tsai, Ying-Hsiu Wang, Mine-Fong Wu, Feng-Yi Chiang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:78
    Content type: Research Published on:

  4. Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable disease flares and organ damage. This research investigates the potential of aberrant sign...

    Authors: Chin-Man Wang, Yeong-Jian Jan Wu, Jian-Wen Zheng, Li Yu Huang, Keng Poo Tan and Ji-Yih Chen
    Citation: Journal of Biomedical Science 2024 31:41
    Content type: Research Published on:

  6. The polymorphic species Candida albicans is the major cause of candidiasis in humans. The secreted aspartyl proteinases (Saps) of C. albicans, encoded by a family of 10 SAP genes, have been investigated as the vi...

    Authors: Leh-Miauh Buu and Yee-Chun Chen
    Citation: Journal of Biomedical Science 2013 20:101
    Content type: Research Published on:

  7. Zinc finger protein 179 (Znf179), also known as ring finger protein 112 (Rnf112), is a member of the RING finger protein family and plays an important role in neuronal differentiation. To investigate novel mec...

    Authors: Ding-Yen Lin, Chi-Chen Huang, Ya-Ting Hsieh, Hsin-Chuan Lin, Ping-Chieh Pao, Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Hung, Ju-Ming Wang, Wen-Chang Chang and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2013 20:98
    Content type: Research Published on:

  8. Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear. Decidualization is critical for the establishment and maintenance of norma...

    Authors: Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang and Meirong Du
    Citation: Journal of Biomedical Science 2022 29:101
    Content type: Research Published on:

  9. The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We ...

    Authors: Chih-Hsu Chang, Shu-Fan Chou and Chiaho Shih
    Citation: Journal of Biomedical Science 2021 28:82
    Content type: Research Published on:

  10. The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved ...

    Authors: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau and Ruey-Bing Yang
    Citation: Journal of Biomedical Science 2023 30:33
    Content type: Review Published on:

  11. Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter...

    Authors: Chun-Yang Lin, Meng-Cen Shih, Hung-Chun Chang, Kuan-Jung Lin, Lin-Fang Chen, Sheng-Wen Huang, Mei-Lin Yang, Sheng-Kai Ma, Ai-Li Shiau, Jen-Ren Wang, Kuan-Ru Chen and Pin Ling
    Citation: Journal of Biomedical Science 2021 28:66
    Content type: Research Published on:

  12. The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and d...

    Authors: Halina Z Malina
    Citation: Journal of Biomedical Science 2011 18:7
    Content type: Research Published on:

  13. Androgenetic alopecia (AGA) is a genetic disorder caused by dihydrotestosterone (DHT), accompanied by the senescence of androgen-sensitive dermal papilla cells (DPCs) located in the base of hair follicles. DHT...

    Authors: Young Hyun Jung, Chang Woo Chae, Gee Euhn Choi, Him Cha Shin, Jae Ryong Lim, Han Seung Chang, Joonmo Park, Ji Hyeon Cho, Mo Ran Park, Hyun Jik Lee and Ho Jae Han
    Citation: Journal of Biomedical Science 2022 29:17
    Content type: Research Published on:

  14. Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer the...

    Authors: Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska and Łukasz Opaliński
    Citation: Journal of Biomedical Science 2021 28:69
    Content type: Research Published on:

  15. Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial...

    Authors: Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2022 29:95
    Content type: Research Published on:

  16. Arsenic exposure induces overproduction of reactive nitrogen species (RNS) in brain tissue and results in nucleic acid damage to the nerve cells. The 8-nitroguanine is one of the major products formed by the r...

    Authors: Ning Ma, Mikio Sasoh, Shosuke Kawanishi, Hiromichi Sugiura and Fengyuan Piao
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  17. One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid β protein (Aβ) within lesions known as senile plaques. Aβ is also deposited in the walls of cerebral blood ...

    Authors: Ramesh JL Kandimalla, Willayat Yousuf Wani, Binukumar BK and Kiran Dip Gill
    Citation: Journal of Biomedical Science 2012 19:2
    Content type: Research Published on:

  18. Ex vivo...analysis showed 2.1 ± 0.4%, 37.6 ± 6.3% and 38.5 ± 6.2% injected dose/g accumulated in the tumors at 15 min, 24 h and 48 h respectively. Tumor uptake was significantly decreased in pretreated with exces...

    Authors: Bishnuhari Paudyal, Pramila Paudyal, Dilip Shah, Hideyuki Tominaga, Yoshito Tsushima and Keigo Endo
    Citation: Journal of Biomedical Science 2014 21:35
    Content type: Research Published on:

  19. Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one ...

    Authors: Lorenzo A Calò, Luciana Bordin, Paul A Davis, Elisa Pagnin, Lucia Dal Maso, Gian Paolo Rossi, Achille C Pessina and Giulio Clari
    Citation: Journal of Biomedical Science 2011 18:38
    Content type: Research Published on:

  20. The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer’s disease and people with mild cognitive impairment. However, the therapeutic potential ...

    Authors: Tzeng Tsai-Teng, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Lu Chung-Kuang, Shen Chien-Chang, Huang F. Chi-Ying, Chen Chien-Chih and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2016 23:49
    Content type: Research Published on:

  21. The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during ch...

    Authors: Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee and Simanti Datta
    Citation: Journal of Biomedical Science 2022 29:97
    Content type: Research Published on:

  22. Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-t...

    Authors: Yu-Ling Tseng, Po-Chao Lu, Chi-Chang Lee, Ruei-Yu He, Yung-An Huang, Yin-Chen Tseng, Ting-Jen Rachel Cheng, Joseph Jen-Tse Huang and Jim-Min Fang
    Citation: Journal of Biomedical Science 2023 30:27
    Content type: Research Published on:

  23. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2020 27:46
    Content type: Research Published on:

  24. H-rev107 is a member of the HREV107 type II tumor suppressor gene family which includes H-REV107, RIG1, and HRASLS. H-REV107 has been shown to express at high levels in differentiated tissues of post-meiotic t...

    Authors: Rong-Yaun Shyu, Chang-Chieh Wu, Chun-Hua Wang, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2013 20:30
    Content type: Research Published on:

  25. Hepatitis D virus (HDV) infection may induce fulminant hepatitis in chronic hepatitis B patients (CHB) or rapid progression of CHB to cirrhosis or hepatocellular carcinoma. There is no effective treatment for ...

    Authors: Yuh-Jin Liang, Cheng-Pu Sun, Yu-Chen Hsu, Yi-Wen Chen, I-An Wang, Chien-Wei Su, Mi-Hua Tao and Jaw-Ching Wu
    Citation: Journal of Biomedical Science 2020 27:65
    Content type: Research Published on:

  27. Coronavirus membrane (M) proteins are capable of interacting with nucleocapsid (N) and envelope (E) proteins. Severe acute respiratory syndrome coronavirus (SARS-CoV) M co-expression with either N or E is suff...

    Authors: Ying-Tzu Tseng, Shiu-Mei Wang, Kuo-Jung Huang and Chin-Tien Wang
    Citation: Journal of Biomedical Science 2014 21:34
    Content type: Research Published on:

  28. Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) si...

    Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo and Hee-Sook Jun
    Citation: Journal of Biomedical Science 2022 29:31
    Content type: Research Published on:

  29. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of ce...

    Authors: Dilip Shah, Nidhi Mahajan, Sangita Sah, Swapan K Nath and Bishnuhari Paudyal
    Citation: Journal of Biomedical Science 2014 21:23
    Content type: Review Published on:

  30. Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis within 5 years after the initial diagnosis. Therefore, a deeper understanding of the p...

    Authors: Shih-Hsuan Chan, Wen-Hung Kuo and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2023 30:93
    Content type: Research Published on:

  31. Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fi...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2021 28:38
    Content type: Research Published on:

  32. Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis ...

    Authors: Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung and Hsuan Liu
    Citation: Journal of Biomedical Science 2012 19:57
    Content type: Research Published on:

  33. Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly id...

    Authors: Guan-Lin Lee, Tsai-Lien Liao, Jing-Yiing Wu, Kenneth K. Wu and Cheng-Chin Kuo
    Citation: Journal of Biomedical Science 2021 28:74
    Content type: Research Published on:

  34. The global burden of invasive fungal infections (IFIs) has shown an upsurge in recent years due to the higher load of immunocompromised patients suffering from various diseases. The role of early and accurate ...

    Authors: Wenjie Fang, Junqi Wu, Mingrong Cheng, Xinlin Zhu, Mingwei Du, Chang Chen, Wanqing Liao, Kangkang Zhi and Weihua Pan
    Citation: Journal of Biomedical Science 2023 30:42
    Content type: Review Published on:

  35. Sudden cardiac death (SCD) is the clinical outcome of a lethal arrhythmia that can develop on the background of unrecognized channelopathies or cardiomyopathies. Several susceptibility genes have been identifi...

    Authors: Vincenzo Lariccia, Annamaria Assunta Nasti, Federica Alessandrini, Mauro Pesaresi, Santo Gratteri, Adriano Tagliabracci and Salvatore Amoroso
    Citation: Journal of Biomedical Science 2014 21:58
    Content type: Research Published on:

  36. Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is ess...

    Authors: Chung-Yu Hsieh, Huai-Yu Hsiao, Wan-Yi Wu, Ching-Ann Liu, Yu-Chih Tsai, Yuen-Jen Chao, Danny L Wang and Hsyue-Jen Hsieh
    Citation: Journal of Biomedical Science 2009 16:12
    Content type: Research Published on:

  37. Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). However, th...

    Authors: Wan-Ting Kuo, I-Ying Kuo, Hung-Chia Hsieh, Ssu-Ting Wu, Wu-Chou Su and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2024 31:20
    Content type: Research Published on:

  38. T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that ...

    Authors: I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu
    Citation: Journal of Biomedical Science 2024 31:33
    Content type: Research Published on:

  39. Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse ...

    Authors: Ioannis P. Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E. Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N. Pavlakis and Meletios A. Dimopoulos
    Citation: Journal of Biomedical Science 2021 28:9
    Content type: Review Published on:

  40. The Maillard reaction is a chemical reaction occurring between a reducing sugar and an amino acid, generally requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and...

    Authors: Jung-Il Chae, RaHam Lee, JinHyoung Cho, JinTae Hong and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2014 21:4
    Content type: Research Published on:

  41. Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we s...

    Authors: Kou-Gi Shyu, Su-Kiat Chua, Bao-Wai Wang and Peiliang Kuan
    Citation: Journal of Biomedical Science 2009 16:50
    Content type: Research Published on:

  42. The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery (PA) is unknown.

    Authors: Guang-wei Li, Qiu-shi Wang, Jing-hui Hao, Wen-jing Xing, Jin Guo, Hong-zhu Li, Shu-zhi Bai, Hong-xia Li, Wei-hua Zhang, Bao-feng Yang, Guang-dong Yang, Ling-yun Wu, Rui Wang and Chang-qing Xu
    Citation: Journal of Biomedical Science 2011 18:16
    Content type: Research Published on:

  43. Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to b...

    Authors: Tzer-Min Kuo, Cheng-po Hu, Ya-Ling Chen, Ming-Hsiang Hong, King-Song Jeng, Chun-Chin T Liang, Mong-Liang Chen and Chungming Chang
    Citation: Journal of Biomedical Science 2009 16:41
    Content type: Research Published on:

  44. Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and Chi...

    Authors: An-Ting Liou, Chun-Che Liao, Shu-Fan Chou, Ya-Shu Chang, Chih-Shin Chang and Chiaho Shih
    Citation: Journal of Biomedical Science 2019 26:93
    Content type: Research Published on:

  45. Naturally occurring pre-S deletion mutants have been identified in hepatitis B carriers and shown to be associated with the development of hepatocellular carcinoma. The phenotypes of these pre-S deletion genom...

    Authors: Chih-Ming Lin, Gen-Ming Wang, Guey-Mei Jow and Bing-Fang Chen
    Citation: Journal of Biomedical Science 2012 19:17
    Content type: Research Published on:

  46. In the present study we identified a novel gene, Homo Sapiens Chromosome 1 ORF109 (c1orf109, GenBank ID: NM_017850.1), which encodes a substrate of CK2. We analyzed the regulation mode of the gene, the expression...

    Authors: Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He, Yang Yu, You-peng Qu, Lei Yue, Yao Zhang and Yu Li
    Citation: Journal of Biomedical Science 2012 19:49
    Content type: Research Published on:

  47. Transgenic models, including those of zebrafish, have been employed to elucidate the mechanisms by which tau protein causes neurodegeneration. In this study, a transient expression system was established to expre...

    Authors: Bo-Kai Wu, Rey-Yue Yuan, Huang-Wei Lien, Chin-Chun Hung, Pung-Pung Hwang, Rita Pei-Yeh Chen, Chun-Che Chang, Yung-Feng Liao and Chang-Jen Huang
    Citation: Journal of Biomedical Science 2016 23:25
    Content type: Research Published on:

  48. Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated. In the present study, t...

    Authors: Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen and Shenghai Huang
    Citation: Journal of Biomedical Science 2018 25:13
    Content type: Research Published on:

  49. The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang
    Citation: Journal of Biomedical Science 2018 25:76
    Content type: Research Published on:

  50. The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen
    Citation: Journal of Biomedical Science 2017 24:30
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127