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1065 result(s) for 'antibody' within Journal of Biomedical Science

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  1. A host intracellular filamentous cytoskeletal protein vimentin was identified by immunoprecipitation and LC-MS/MS analysis following chemical cross-linking on Vero E6 cells that were pre-incubated with the SARS-C...

    Authors: Yvonne Ting-Chun Yu, Ssu-Chia Chien, I-Yin Chen, Chia-Tsen Lai, Yeou-Guang Tsay, Shin C. Chang and Ming-Fu Chang
    Citation: Journal of Biomedical Science 2016 23:14
    Content type: Research Published on:

  2. Although taurine and glutamate are the most abundant amino acids conducting neural signals in the central nervous system, the communication between these two neurotransmitters is largely unknown. This study explo...

    Authors: Simon Bulley and Wen Shen
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S5
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  3. Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the cellular events in UVA-treated retinal pigment epithelial (RPE) cells.

    Authors: Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2023 30:91
    Content type: Research Published on:

  4. Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells ...

    Authors: Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne and Shaw-Fang Yet
    Citation: Journal of Biomedical Science 2022 29:25
    Content type: Research Published on:

  5. Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucosi...

    Authors: Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le, Tsai-Chen Yang, Chou-Yu Kuo, Ai-Feng Feng, Kwok-Kong Tony Mong and Chun-Hung Lin
    Citation: Journal of Biomedical Science 2024 31:44
    Content type: Research Published on:

  6. We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. This study intended to clarify whether DV infection c...

    Authors: Ying-Ray Lee, Hsuan-Yun Hu, Szu-Han Kuo, Huan-Yao Lei, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2013 20:65
    Content type: Research Published on:

  7. The levels of the protein TEM1 are elevated in both hypertrophic scars and keloids in comparison to normal skin. A re-analysis of scRNA-seq datasets reveals that a major profibrotic subpopulation of keloid and...

    Authors: Yi-Kai Hong, Yu-Chen Lin, Tsung-Lin Cheng, Chao-Han Lai, Yi-Han Chang, Yu-Lun Huang, Chia-Yi Hung, Chen-Han Wu, Kuo-Shu Hung, Ya-Chu Ku, Yen-Ting Ho, Ming-Jer Tang, Shu-Wha Lin, Guey-Yueh Shi, John A. McGrath, Hua-Lin Wu…
    Citation: Journal of Biomedical Science 2024 31:12
    Content type: Research Published on:

  8. Twenty clinical CV-B isolates were tested on CaCo-2 cell line using anti-DAF (BRIC216) and anti-CAR (RmcB) antibodies. CV-B3 Nancy prototype strain and a...

    Authors: Samira Riabi, Rafik Harrath, Imed Gaaloul, Lamjed Bouslama, Dorsaf Nasri, Mahjoub Aouni, Sylvie Pillet and Bruno Pozzetto
    Citation: Journal of Biomedical Science 2014 21:50
    Content type: Research Published on:

  9. Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as...

    Authors: Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung and David K. Ann
    Citation: Journal of Biomedical Science 2023 30:32
    Content type: Research Published on:

  10. Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona...

    Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin
    Citation: Journal of Biomedical Science 2021 28:65
    Content type: Research Published on:

  11. Excessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte lipid droplets represent key organelles coordinating lipid storage and m...

    Authors: Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz and María M. Malagón
    Citation: Journal of Biomedical Science 2024 31:2
    Content type: Research Published on:

  12. Traumatic spinal cord injury (SCI) forms a disadvantageous microenvironment for tissue repair at the lesion site. To consider an appropriate time window for giving a promising therapeutic treatment for subacut...

    Authors: Chih-Yen Wang, Jen-Kun Chen, Yi-Ting Wu, May-Jywan Tsai, Song-Kun Shyue, Chung-Shi Yang and Shun-Fen Tzeng
    Citation: Journal of Biomedical Science 2011 18:13
    Content type: Research Published on:

  13. p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation or inactivating interactions with viral or cellular proteins. The uncertainties around the link bet...

    Authors: James Yi-Hsin Chan, Ying-Chuan Chen, Shu-Ting Liu, Wei-Yuan Chou, Ching-Liang Ho and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2014 21:40
    Content type: Research Published on:

  14. Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro ...

    Authors: Tsui-Hwa Tseng, Chien-Heng Shen, Wen-Shih Huang, Cheng-Nan Chen, Wen-Hai Liang, Tseng-Hsi Lin and Hsing-Chun Kuo
    Citation: Journal of Biomedical Science 2014 21:61
    Content type: Research Published on:

  15. Sodium/iodide symporter (NIS) mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be crit...

    Authors: Chia-Cheng Li, Tin-Yun Ho, Chia-Hung Kao, Shih-Lu Wu, Ji-An Liang and Chien-Yun Hsiang
    Citation: Journal of Biomedical Science 2010 17:89
    Content type: Research Published on:

  16. The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical is...

    Authors: Ai-Sheng Ho, Chun-Chia Cheng, Shui-Cheng Lee, Meng-Lun Liu, Jing-Ying Lee, Wen-Ming Wang and Chia-Chi Wang
    Citation: Journal of Biomedical Science 2010 17:58
    Content type: Research Published on:

  17. Enterovirus type 71 (EV71) 2A protease exhibited strong transcriptional activity in yeast cells. The transcriptional activity of 2A protease was independent of its protease activity. EV71 2A protease retained ...

    Authors: Chee-Hing Yang, Hui-Chun Li, Jeng-Geng Jiang, Che-Fang Hsu, Yi-Jen Wang, Meng-Jiun Lai, Yue-Li Juang and Shih-Yen Lo
    Citation: Journal of Biomedical Science 2010 17:65
    Content type: Research Published on:

  18. Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for...

    Authors: S. M. Chiavenna, J. P. Jaworski and A. Vendrell
    Citation: Journal of Biomedical Science 2017 24:15
    Content type: Review Published on:

  19. BALB/c mice were immunized with the recombinant protein NS3-DEN3 via intraperitoneal and with plasmid pcDNA3/NS3-DEN3 intramuscularly and the immune response was evaluated. The activity of T lymphocytes was analy...

    Authors: M. L. Hurtado-Melgoza, A. Ramos-Ligonio, L. M. Álvarez-Rodríguez, T. Meza-Menchaca and A. López-Monteon
    Citation: Journal of Biomedical Science 2016 23:85
    Content type: Research Published on:

  21. Methionine, an essential amino acid, is required for protein synthesis and normal cell metabolism. The transmethylation pathway and methionine salvage pathway (MTA cycle) are two major pathways regulating meth...

    Authors: He-Yen Chou, Yu-Hung Lin, Guan-Lin Shiu, Hsiang-Yu Tang, Mei-Ling Cheng, Ming-Shi Shiao and Li-Mei Pai
    Citation: Journal of Biomedical Science 2014 21:64
    Content type: Research Published on:

  22. Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In th...

    Authors: Alireza Tahamtan, Amir Ghaemi, Ali Gorji, Hamid R Kalhor, Azadeh Sajadian, Alijan Tabarraei, Abdolvahab Moradi, Fatemeh Atyabi and Mishar Kelishadi
    Citation: Journal of Biomedical Science 2014 21:69
    Content type: Research Published on:

  24. Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit o...

    Authors: Masanobu Tsubaki, Makiko Komai, Tatsuki Itoh, Motohiro Imano, Kotaro Sakamoto, Hirotaka Shimaoka, Tomoya Takeda, Naoki Ogawa, Kenji Mashimo, Daiichiro Fujiwara, Junji Mukai, Katsuhiko Sakaguchi, Takao Satou and Shozo Nishida
    Citation: Journal of Biomedical Science 2014 21:10
    Content type: Research Published on:

  25. Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious pu...

    Authors: Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Wen-Fang Tang, Ming-sian Wu, Jiann-Yih Yeh, Yu-Sheng Chao, John TA Hsu, Hsing-Pang Hsieh and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2010 17:13
    Content type: Research Published on:

  26. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2009 16:82
    Content type: Research Published on:

  27. Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an ...

    Authors: Chunfang Zhang, Jinyong Peng, Shan Wu, Yue Jin, Fan Xia, Changyuan Wang, Kexin Liu, Huijun Sun and Mozhen Liu
    Citation: Journal of Biomedical Science 2014 21:30
    Content type: Research Published on:

  28. The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publication...

    Authors: Carlotta Camilli, Alexandra E. Hoeh, Giulia De Rossi, Stephen E. Moss and John Greenwood
    Citation: Journal of Biomedical Science 2022 29:6
    Content type: Review Published on:

  29. Diabetes and stress stimulate hippocampal 5-HT synthesis, metabolism and release. The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the ...

    Authors: Pretty Mary Abraham, Korah P Kuruvilla, Jobin Mathew, Anitha Malat, Shilpa Joy and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:78
    Content type: Research Published on:

  30. Helicobacter pylori-mediated gastric carcinogenesis is initiated by a plethora of signaling events in the infected gastric epithelial cells (GECs). The E3 ubiquitin ligase seven in absentia homolog 2 (Siah2) is i...

    Authors: Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh and Asima Bhattacharyya
    Citation: Journal of Biomedical Science 2021 28:12
    Content type: Research Published on:

  31. TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range ...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng and Che-Kun James Shen
    Citation: Journal of Biomedical Science 2013 20:33
    Content type: Research Published on:

  32. NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Neverthe...

    Authors: Moloud Aflaki Sooreshjani, Mohini Kamra, Amina Zoubeidi and Kavita Shah
    Citation: Journal of Biomedical Science 2021 28:68
    Content type: Research Published on:

  33. Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer patients remain refractory to the ICB therapy, which is largely attributed...

    Authors: Ning Ma, Rong Hua, Yang Yang, Zhi-Chao Liu, Jie Pan, Bo-Yao Yu, Yi-Feng Sun, Dong Xie, Yan Wang and Zhi-Gang Li
    Citation: Journal of Biomedical Science 2023 30:20
    Content type: Research Published on:

  34. The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell research initiatives and provide a platform for researchers interested in utilizing induced pluripotent...

    Authors: Ching-Ying Huang, Ling-Hui Li, Wan-Tseng Hsu, Yu-Che Cheng, Martin W. Nicholson, Chun-Lin Liu, Chien-Yu Ting, Hui-Wen Ko, Shih-Han Syu, Cheng-Hao Wen, Zhuge Yan, Hsiang-Po Huang, Hong-Lin Su, Po-Min Chiang, Chia-Ning Shen, Hsin-Fu Chen…
    Citation: Journal of Biomedical Science 2020 27:92
    Content type: Research Published on:

  35. Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation ...

    Authors: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe and Ilo Jou
    Citation: Journal of Biomedical Science 2021 28:51
    Content type: Research Published on:

  36. G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) genome. Howev...

    Authors: Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard and Tao Jia
    Citation: Journal of Biomedical Science 2024 31:50
    Content type: Research Published on:

  37. Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiat...

    Authors: Yan Huang, Zhong-Quan Dai, Shu-Kuan Ling, Hong-Yu Zhang, Yu-Min Wan and Ying-Hui Li
    Citation: Journal of Biomedical Science 2009 16:87
    Content type: Research Published on:

  38. Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involvi...

    Authors: Tsung-Ting Tsai, Yi-Jui Chuang, Yee-Shin Lin, Shu-Wen Wan, Chia-Ling Chen and Chiou-Feng Lin
    Citation: Journal of Biomedical Science 2013 20:40
    Content type: Review Published on:

  39. Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mo...

    Authors: Yumay Chen, Huai-Chin Chiang, Patricia Litchfield, Michelle Pena, Charity Juang and Daniel J Riley
    Citation: Journal of Biomedical Science 2014 21:63
    Content type: Research Published on:

  40. In congestive heart failure the balance between cell death and cell survival in cardiomyocytes is compromised. Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against is...

    Authors: Tse-Min Lu, Jia-Yun Tsai, Yen-Chung Chen, Chun-Yang Huang, Hung-Lung Hsu, Chi-Feng Weng, Chun-Che Shih and Chiao-Po Hsu
    Citation: Journal of Biomedical Science 2014 21:57
    Content type: Research Published on:

  41. Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative ...

    Authors: Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson and Jorge Goldstein
    Citation: Journal of Biomedical Science 2019 26:16
    Content type: Research Published on:

  42. Histone acetyltransferases (HATs), p300 and cAMP response element binding protein (CREB)-binding protein (CBP) are two structurally related transcriptional co-activators that activate expression of many eukary...

    Authors: Guozhen Chen, Jing Zhu, Tiewei Lv, Gang Wu, Huichao Sun, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2009 16:24
    Content type: Research Published on:

  43. The transcription factor p63 plays a pivotal role in the development and maintenance of epithelial tissues, including the ocular surface. In an effort to gain insight into the pathogenesis of keratitis caused ...

    Authors: László Orosz, Éva Gallyas, Lajos Kemény, Yvette Mándi, Andrea Facskó and Klára Megyeri
    Citation: Journal of Biomedical Science 2010 17:47
    Content type: Research Published on:

  44. Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however, the underlying mechanism by whic...

    Authors: Guo-Zhen Liu, Xu-Wen Xu, Shu-Hui Tao, Ming-Jian Gao and Zhou-Hua Hou
    Citation: Journal of Biomedical Science 2021 28:67
    Content type: Research Published on:

  45. Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been s...

    Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang and Hongsheng Wang
    Citation: Journal of Biomedical Science 2022 29:58
    Content type: Research Published on:

  46. Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications.

    Authors: Huixin Chen, Patchara Phuektes, Li Sze Yeo, Yi Hao Wong, Regina Ching Hua Lee, Bowen Yi, Xinjun Hou, Sen Liu, Yu Cai and Justin Jang Hann Chu
    Citation: Journal of Biomedical Science 2024 31:8
    Content type: Research Published on:

  47. Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these patho...

    Authors: Sue-Jane Lin, Ming Lo, Rei-Lin Kuo, Shin-Ru Shih, David M Ojcius, Jean Lu, Chien-Kuo Lee, Hui-Chen Chen, Meei Yun Lin, Chuen-Miin Leu, Chia-Ni Lin and Ching-Hwa Tsai
    Citation: Journal of Biomedical Science 2014 21:99
    Content type: Research Published on:

  48. Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found ...

    Authors: Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin and Chiaho Shih
    Citation: Journal of Biomedical Science 2022 29:44
    Content type: Research Published on:

  49. CYP11A1 is a protein located in the inner membrane of mitochondria catalyzing the first step of steroid synthesis. As a marker gene for steroid-producing cells, the abundance of CYP11A1 characterizes the exten...

    Authors: Karen G. Rosal, Wei-Yi Chen and Bon-chu Chung
    Citation: Journal of Biomedical Science 2022 29:61
    Content type: Research Published on:

  50. We aimed to examine the expression level of Nucleophosmin (NPM1) protein in colon cancer tissues and to investigate the potential role of NPM1 in the regulation of cell migration and invasiveness.

    Authors: Yan Liu, Fei Zhang, Xiao-fang Zhang, Li-sha Qi, Lei Yang, Hua Guo and Ning Zhang
    Citation: Journal of Biomedical Science 2012 19:53
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127