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792 result(s) for 'cancer' within Journal of Biomedical Science

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  1. Houttuynia cordata...Thunb (HCT) is commonly used in Taiwan and other Asian countries as an anti-inflammatory, antibacterial and antiviral herbal medicine. In this study, we investigated the anti-human lung cancer

    Authors: Yuh-Fung Chen, Jai-Sing Yang, Wen-Shin Chang, Shih-Chang Tsai, Shu-Fen Peng and Yuan-Ru Zhou
    Citation: Journal of Biomedical Science 2013 20:18
    Content type: Research Published on:

  2. Somatic mutations of the epidermal growth factor receptor (EGFR...) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the...

    Authors: Tiffany Ng Shi Yeen, Rajadurai Pathmanathan, Mohd Sidik Shiran, Fattah Azman Ahmad Zaid and Yoke Kqueen Cheah
    Citation: Journal of Biomedical Science 2013 20:22
    Content type: Research Published on:

  3. Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the ... -1BBL) vaccine on the development of colorectal cancers and the potential immune mechanisms in rat...

    Authors: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
    Citation: Journal of Biomedical Science 2013 20:8
    Content type: Research Published on:

  4. We found that two cis-acting elements within the crucial region of the c1orf109 promoter, one TATA box and one CAAT box, are required for maximal transcription of the c1orf109 gene. The 5′ flanking region of the

    Authors: Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He, Yang Yu, You-peng Qu, Lei Yue, Yao Zhang and Yu Li
    Citation: Journal of Biomedical Science 2012 19:49
    Content type: Research Published on:

  5. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. However, the mechanisms of miR-155 ... and cell apoptosis of ERalpha (+) breast cancer cells and to verify...

    Authors: Chun-Mei Zhang, Jing Zhao and Hua-Yu Deng
    Citation: Journal of Biomedical Science 2013 20:79
    Content type: Research Published on:

  6. Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to...DNMT1 enzyme ...

    Authors: Nader Mansour Samaei, Yaghoub Yazdani, Reza Alizadeh-Navaei, Hossein Azadeh and Touraj Farazmandfar
    Citation: Journal of Biomedical Science 2014 21:73
    Content type: Research Published on:

  7. Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...

    Authors: Xia Wang, Yadi Wang, Yue Wang, Jian Cheng, Yanyun Wang and Minwen Ha
    Citation: Journal of Biomedical Science 2013 20:5
    Content type: Research Published on:

  8. Epidermal growth factor receptor (EGFR...) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of...EGFR genes in a singl...

    Authors: Ching-Hsiung Lin, Kun-Tu Yeh, Ya-Sian Chang, Nicholas C Hsu and Jan-Gowth Chang
    Citation: Journal of Biomedical Science 2010 17:37
    Content type: Research Published on:

  10. Androgen ablation is one of the viable therapeutic options for patients with primary hormone (androgen)-dependent prostate cancer. However, an antibiotic brefeldin A (BFA ... to exhibit the growth inhibitory effe...

    Authors: Srinivas Rajamahanty, Catherine Alonzo, Shahrad Aynehchi, Muhammad Choudhury and Sensuke Konno
    Citation: Journal of Biomedical Science 2010 17:5
    Content type: Research Published on:

  11. Sensitivity of cancer cells to recombinant arginine deiminase (rADI) ... RNA interfering of AS in sensitizing the resistant cancer cells to rADI, the down regulation of...

    Authors: Fe-Lin Lin Wu, Yu-Fen Liang, Yuan-Chen Chang, Hao-Hsin Yo, Ming-Feng Wei and Li-Jiuan Shen
    Citation: Journal of Biomedical Science 2011 18:25
    Content type: Research Published on:

  12. Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis...have been reported to be enriched in colorectal cancer (CRC) in multiple studies...

    Authors: Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang and Ling-Hui Li
    Citation: Journal of Biomedical Science 2022 29:88
    Content type: Research Published on:

  13. A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated....

    Authors: Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu and Kun-Huei Yeh
    Citation: Journal of Biomedical Science 2021 28:75
    Content type: Research Published on:

  14. The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product re...

    Authors: Marcella Martinelli, Luca Scapoli, Francesca Cura, Maria Teresa Rodia, Giampaolo Ugolini, Isacco Montroni and Rossella Solmi
    Citation: Journal of Biomedical Science 2014 21:89
    Content type: Research Published on:

  15. Helicobacter pylori-mediated gastric carcinogenesis is initiated by a plethora of signaling events in the infected gastric epithelial cells (GECs). The E3 ubiquitin ligase seven in absentia homolog 2 (Siah2) is i...

    Authors: Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh and Asima Bhattacharyya
    Citation: Journal of Biomedical Science 2021 28:12
    Content type: Research Published on:

  16. A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies...+...T cells, and to investigate its effect on CAR-T cells against colorectal cancer.

    Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye and Ping Lan
    Citation: Journal of Biomedical Science 2023 30:47
    Content type: Research Published on:

  17. The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the...

    Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2012 19:91
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:21

  18. Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR ... of AR to promote tumor growth in prostate cancer and are candidate therapeutic targets to overcome...

    Authors: Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung and Wen-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:29
    Content type: Research Published on:

  19. Tamoxifen is the most widely used anti-estrogen for the treatment of breast cancer. Studies show that the combination therapy with ... used in combination with tranilast on human breast cancer cells.

    Authors: Sara Darakhshan and Ali Ghanbari
    Citation: Journal of Biomedical Science 2013 20:76
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:89

  20. Placenta growth factor (PlGF), a dimeric glycoprotein with 53% homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and may function by modulating VEGF activity. We previously h...

    Authors: Shu-Chen Wei, Po-Nien Tsao, Meng-Tzu Weng, Zhifang Cao and Jau-Min Wong
    Citation: Journal of Biomedical Science 2013 20:39
    Content type: Research Published on:

  21. Dysregulated epidermal growth factor receptor (EGFR)-phosphoinositide-3-kinase (PI3K)-AKT signaling is considered pivotal for oral cancer, and the pathway is a potential candidate...

    Authors: Kwang-Yu Chang, Shan-Yin Tsai, Shang-Hung Chen, Hsiao-Hui Tsou, Chia-Jui Yen, Ko-Jiunn Liu, Hsun-Lang Fang, Hung-Chang Wu, Bin-Fay Chuang, Shao-Wen Chou, Careen K Tang, Shyun-Yeu Liu, Pei-Jung Lu, Ching-Yu Yen and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2013 20:43
    Content type: Research Published on:

  22. The development of drug resistance in oral squamous cell carcinoma (OSCC) that frequently leads to recurrence and metastasis after initial treatment remains an unresolved challenge. Presence of cancer stem cells ...

    Authors: Te-Hsuan Jang, Wei-Chieh Huang, Shiao-Lin Tung, Sheng-Chieh Lin, Po-Ming Chen, Chun-Yu Cho, Ya-Yu Yang, Tzu-Chen Yen, Guo-Hsuen Lo, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:42
    Content type: Research Published on:

  23. Sotorasib is the first KRASG12C inhibitor approved by the US Food and Drug Administration for treating KRASG12C-mutant non-small-cell lung cancer (NSCLC). Clinical trials on the therapeutic use of sotorasib for cancer

    Authors: Li-Wen Chiou, Chien-Hui Chan, Yu-Ling Jhuang, Ching-Yao Yang and Yung-Ming Jeng
    Citation: Journal of Biomedical Science 2023 30:50
    Content type: Research Published on:

  24. The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We...

    Authors: Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Chien-Min Chen, Pei-Yi Chu, Kun-Tu Yeh, Pearlly S Yan, Yu-Sun Chang, Tim H-M Huang and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:12
    Content type: Research Published on:

  25. Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This subtype accounts for the ... in expression coincides with increas...

    Authors: Arpita Poddar, Farah Ahmady, Sushma R. Rao, Revati Sharma, George Kannourakis, Prashanth Prithviraj and Aparna Jayachandran
    Citation: Journal of Biomedical Science 2024 31:23
    Content type: Review Published on:

  26. We demonstrated that deregulated miR-30a and miR-379 could represent a mechanism for the silencing of ADHFE1 and ALDH1A2 in OSCC through targeting DNMT3B. Ectopic expression of miR-30a and miR-379 could induce re...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2020 27:46
    Content type: Research Published on:

  27. Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) and improving immune surve...

    Authors: Li-Mei Chen, Pao-Pao Yang, Aushia Tanzih Al Haq, Pai-An Hwang, You-Chen Lai, Yueh-Shan Weng, Michelle Audrey Chen and Hsin-Ling Hsu
    Citation: Journal of Biomedical Science 2022 29:70
    Content type: Research Published on:

  28. In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr ... agent) in leukemia, colon, and prostate cancer cells.

    Authors: Duen-Yi Huang, Yee Chao, Ming-Hui Tai, Yang-Hao Yu and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2012 19:35
    Content type: Research Published on:

  29. ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to the tumorigenesis of lung cancer, however, ...

    Authors: Chantal Hoi Yin Cheung, Chia-Lang Hsu, Tsai-Yu Lin, Wei-Ting Chen, Yi-Ching Wang, Hsuan-Cheng Huang and Hsueh-Fen Juan
    Citation: Journal of Biomedical Science 2020 27:75
    Content type: Research Published on:

  30. The tazarotene-induced gene 1 (TIG1...) is a putative tumor suppressor gene. We have recently demonstrated both TIG1A and TIG1B isoforms inhibited cell growth and induced the expression of G protein-coupled recep...

    Authors: Fu-Ming Tsai, Chang-Chieh Wu, Rong-Yaun Shyu, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: Journal of Biomedical Science 2011 18:88
    Content type: Research Published on:

  31. Enzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion prot...

    Authors: Katrin P Guillen, Carla Kurkjian and Roger G Harrison
    Citation: Journal of Biomedical Science 2014 21:65
    Content type: Research Published on:

  32. The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular ... of the immune landscape along th...

    Authors: Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin and Hsing-Chen Tsai
    Citation: Journal of Biomedical Science 2023 30:3
    Content type: Review Published on:

  34. N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein.....

    Authors: Ying-Nai Wang, Heng-Huan Lee, Jennifer L. Hsu, Dihua Yu and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2020 27:77
    Content type: Review Published on:

  35. Among gynecological cancers, ovarian carcinoma has the highest mortality rate ... , and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to ... migration, which plays a...

    Authors: Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou and Wen-Tai Chiu
    Citation: Journal of Biomedical Science 2020 27:36
    Content type: Research Published on:

  36. Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the micro...

    Authors: Ali Jangjou, Amir Hossein Meisami, Kazem Jamali, Mohammad Hadi Niakan, Milad Abbasi, Mostafa Shafiee, Majid Salehi, Ahmad Hosseinzadeh, Ali Mohammad Amani and Ahmad Vaez
    Citation: Journal of Biomedical Science 2021 28:49
    Content type: Review Published on:

  37. The root bark of Paeonia suffruticosa...Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and anti-i...

    Authors: Hyeong Sim Choi, Hye-Sook Seo, Ji Hye Kim, Jae-Young Um, Yong Cheol Shin and Seong-Gyu Ko
    Citation: Journal of Biomedical Science 2012 19:82
    Content type: Research Published on:

  38. Astrocytomas are cancers of the brain in which high levels ... mislocalization in astrocytoma cells. Although non-astrocytoma cancers express EAATs, the localization of EAATs and...

    Authors: Karine Varini, Amal Benzaria, Nadira Taïeb, Coralie Di Scala, Amanda Azmi, Soraya Graoudi and Marc Maresca
    Citation: Journal of Biomedical Science 2012 19:10
    Content type: Research Published on:

  39. Prostate cancer is the most frequently diagnosed non-cutaneous ... surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary treatment for metastatic prostate cancer

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su
    Citation: Journal of Biomedical Science 2011 18:63
    Content type: Review Published on:

  40. Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be elu...

    Authors: Wenbin Zhou, Hong Pan, Tiansong Xia, Jinqiu Xue, Lin Cheng, Ping Fan, Yifen Zhang, Weidong Zhu, Yi Xue, Xiaoan Liu, Qiang Ding, Yun Liu and Shui Wang
    Citation: Journal of Biomedical Science 2014 21:97
    Content type: Research Published on:

  42. Cancer susceptibility germline mutations are associated with pancreatic...

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
    Content type: Research Published on:

  43. In the study, we found that H-rev107 was co-localized with prostaglandin D2 synthase (PTGDS) and enhanced the activity of PTGDS, resulting in increase of PGD2 production in testis cells. Furthermore, when H-rev10...

    Authors: Rong-Yaun Shyu, Chang-Chieh Wu, Chun-Hua Wang, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2013 20:30
    Content type: Research Published on:

  44. Circular RNAs (circRNAs) have caught increasing attentions and interests for their important involvement in cancer initiation and progression. This study aims to ... circNOL10 and its potential molecular mechanis...

    Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu
    Citation: Journal of Biomedical Science 2021 28:4
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2021 28:31

  45. Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers inc...

    Authors: Xiaolong Zou, Haiquan Qiao, Xian Jiang, Xuesong Dong, Hongchi Jiang and Xueying Sun
    Citation: Journal of Biomedical Science 2008 16:33
    Content type: Research Published on:

  47. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here ... and plasma membrane prohibitin (PHB) affects ovarian cancer stemness and chemotherapy resistance.

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang
    Citation: Journal of Biomedical Science 2020 27:42
    Content type: Research Published on:

  48. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this...vs. microsatellite stability (MSS) in Taiwanese sporadic CRCs.

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen
    Citation: Journal of Biomedical Science 2011 18:36
    Content type: Research Published on:

  49. G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in...

    Authors: Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard and Tao Jia
    Citation: Journal of Biomedical Science 2024 31:50
    Content type: Research Published on:

  50. Docetaxel has been approved by USFDA as a first-line treatment for castration-resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation ... growth, the migration and invasion of prostate

    Authors: Yu-Ke Fu, Bi-Juan Wang, Jen-Chih Tseng, Shih-Han Huang, Ching-Yu Lin, Ying-Yu Kuo, Tzyh-Chyuan Hour and Chih-Pin Chuu
    Citation: Journal of Biomedical Science 2022 29:16
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127