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  1. Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to possess an insulin-like property in diabetes. In...

    Authors: Chih-Chun Chang, Chieh-Yu Chang, Yang-Tzu Wu, Jiung-Pang Huang, Tzung-Hai Yen and Li-Man Hung
    Citation: Journal of Biomedical Science 2011 18:47
    Content type: Research Published on:

  2. Methionine Sulfoxide Reductase A (MsrA), an enzyme in the Msr gene family, is important in the cellular anti-oxidative stress defense mechanism. It acts by reducing the oxidized methionine sulfoxide in protein...

    Authors: Pingping Jia, Chi Zhang, Yuanyuan Jia, Keith A Webster, Xupei Huang, Andrei A Kochegarov, Sharon L Lemanski and Larry F Lemanski
    Citation: Journal of Biomedical Science 2011 18:46
    Content type: Research Published on:

  3. Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling path...

    Authors: Karen F Chambers, Joanna F Pearson, Davide Pellacani, Naveed Aziz, Miodrag Gužvić, Christoph A Klein and Shona H Lang
    Citation: Journal of Biomedical Science 2011 18:45
    Content type: Research Published on:

  4. Damage-associated molecular patterns (DAMPs) are associated with immunogenic cell death and have the ability to enhance maturation and antigen presentation of dendritic cells (DCs). Specific microtubule-depoly...

    Authors: Chih-Chun Wen, Hui-Ming Chen, Swey-Shen Chen, Li-Ting Huang, Wei-Ting Chang, Wen-Chi Wei, Li-Chen Chou, Palanisamy Arulselvan, Jin-Bin Wu, Sheng-Chu Kuo and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2011 18:44
    Content type: Research Published on:

  5. Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteina...

    Authors: Ta-Liang Chen, Yung-Feng Lin, Chao-Wen Cheng, Shi-Yun Chen, Ming-Thau Sheu, Ting-Kai Leung, Cheng-Hong Qin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2011 18:43
    Content type: Research Published on:

  6. The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally ...

    Authors: Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh and Li-Mei Pai
    Citation: Journal of Biomedical Science 2011 18:42
    Content type: Research Published on:

  7. The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden. Two seasons existed, one of increased deprivation...

    Authors: Pa T Ngom, Juan Solon, Sophie E Moore, Gareth Morgan, Andrew M Prentice and Richard Aspinall
    Citation: Journal of Biomedical Science 2011 18:41
    Content type: Research Published on:

  8. Carbon monoxide (CO) is a toxic gas, which also acts in the organism as a neurotransmitter. It is generated as a by-product of heme breakdown catalyzed by heme oxygenase. We have investigated changes in electr...

    Authors: Denis V Abramochkin, Nail N Haertdinov, Maria V Porokhnya, Andrew L Zefirov and Gusel F Sitdikova
    Citation: Journal of Biomedical Science 2011 18:40
    Content type: Research Published on:

  9. Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact ro...

    Authors: Ling-fang He, Ting-ting Wang, Qian-ying Gao, Guang-feng Zhao, Ya-hong Huang, Li-ke Yu and Ya-yi Hou
    Citation: Journal of Biomedical Science 2011 18:39
    Content type: Research Published on:

  10. Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one ...

    Authors: Lorenzo A Calò, Luciana Bordin, Paul A Davis, Elisa Pagnin, Lucia Dal Maso, Gian Paolo Rossi, Achille C Pessina and Giulio Clari
    Citation: Journal of Biomedical Science 2011 18:38
    Content type: Research Published on:

  11. It is of growing interest to develop novel approaches to initiate differentiation of mesenchymal stem cells (MSCs) into cardiomyocytes. The purpose of this investigation was to determine if Sphingosine-1-phosp...

    Authors: Zhenqiang Zhao, Zhibin Chen, Xiubo Zhao, Fang Pan, Meihua Cai, Tan Wang, Henggui Zhang, Jian R Lu and Ming Lei
    Citation: Journal of Biomedical Science 2011 18:37
    Content type: Research Published on:

  12. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as repr...

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen
    Citation: Journal of Biomedical Science 2011 18:36
    Content type: Research Published on:

  13. Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to prote...

    Authors: Jian Xiao, Xiaoyan Zhu, Bin He, Yufeng Zhang, Bo Kang, Zhinong Wang and Xin Ni
    Citation: Journal of Biomedical Science 2011 18:35
    Content type: Research Published on:

  14. Mu opioid receptor (MOR), which plays key roles in analgesia and also has effects on learning and memory, was reported to distribute abundantly in the patches of the neostriatum. The marginal division (MrD) of...

    Authors: Chuanxing Wang, Si Yun Shu, Zhouyi Guo, Ye Feng Cai, Xinmin Bao, Changchun Zeng, Bingyi Wu, Ziyou Hu and Xuemei Liu
    Citation: Journal of Biomedical Science 2011 18:34
    Content type: Research Published on:

  16. Adrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS). We previously demonstrated...

    Authors: David HT Yen, Lih-Chi Chen, Yuh-Chiang Shen, Ying-Chen Chiu, I-Chun Ho, Ya-Jou Lou, I-Chin Chen and Jiin-Cherng Yen
    Citation: Journal of Biomedical Science 2011 18:32
    Content type: Research Published on:

  17. Hypoxia during the first week of life can induce neuronal death in vulnerable brain regions usually associated with an impairment of cognitive function that can be detected later in life. The neurobiological c...

    Authors: Thoppil R Anju, Sadanandan Jayanarayanan and Cheramadatikudiyil S Paulose
    Citation: Journal of Biomedical Science 2011 18:31
    Content type: Research Published on:

  19. NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex...

    Authors: Hsin-Yu Liu, Pin-Chao Liao, Kai-Tun Chuang and Mou-Chieh Kao
    Citation: Journal of Biomedical Science 2011 18:29
    Content type: Research Published on:

  20. Natural products have played a significant role in drug discovery and development. Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been suggested to conn...

    Authors: I-Ni Hsieh, Anita Shin-Yuan Chang, Che-Ming Teng, Chien-Chih Chen and Chia-Ron Yang
    Citation: Journal of Biomedical Science 2011 18:28
    Content type: Research Published on:

  21. Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effect...

    Authors: Bao-Wei Wang, Chiu-Mei Lin, Gong-Jhe Wu and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2011 18:27
    Content type: Research Published on:

  22. Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients ...

    Authors: Wei S Lian, Heng Lin, Winston TK Cheng, Tateki Kikuchi and Ching F Cheng
    Citation: Journal of Biomedical Science 2011 18:26
    Content type: Research Published on:

  23. Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand t...

    Authors: Fe-Lin Lin Wu, Yu-Fen Liang, Yuan-Chen Chang, Hao-Hsin Yo, Ming-Feng Wei and Li-Jiuan Shen
    Citation: Journal of Biomedical Science 2011 18:25
    Content type: Research Published on:

  24. Artemin (ARTN) is a neurotrophic factor belonging to the glial cell-derived neurotrophic factor family of ligands. To develop potential therapy targeting ARTN, we studied the roles of miR-223 in the migration ...

    Authors: Shujun Li, Zhigang Li, Fengjie Guo, Xuebo Qin, Bin Liu, Zhe Lei, Zuoqing Song, Liya Sun, Hong-Tao Zhang, Jiacong You and Qinghua Zhou
    Citation: Journal of Biomedical Science 2011 18:24
    Content type: Research Published on:

  26. Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken ...

    Authors: Bin He, Jian Xiao, An-Jing Ren, Yu-Feng Zhang, Hao Zhang, Min Chen, Bing Xie, Xiao-Gang Gao and Ying-Wei Wang
    Citation: Journal of Biomedical Science 2011 18:22
    Content type: Research Published on:

  27. Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dim...

    Authors: Shiwen Peng, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu
    Citation: Journal of Biomedical Science 2011 18:21
    Content type: Research Published on:

  28. Japanese encephalitis (JE) virus is the most common cause of epidemic viral encephalitis in the world. The virus mainly infects neuronal cells and causes an inflammatory response after invasion of the parenchy...

    Authors: Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang and Wei-June Chen
    Citation: Journal of Biomedical Science 2011 18:20
    Content type: Research Published on:

  29. In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA rec...

    Authors: Hwei-Hsien Chen, Pei-Fei Liao and Ming-Huan Chan
    Citation: Journal of Biomedical Science 2011 18:19
    Content type: Research Published on:

  30. Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptor...

    Authors: Hong-zhu Li, Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang…
    Citation: Journal of Biomedical Science 2011 18:18
    Content type: Research Published on:

  31. Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental ...

    Authors: Se Jin Jeon, Jung Eun Seo, Sung-Il Yang, Ji Woong Choi, David Wells, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2011 18:17
    Content type: Research Published on:

  32. The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery (PA) is unknown.

    Authors: Guang-wei Li, Qiu-shi Wang, Jing-hui Hao, Wen-jing Xing, Jin Guo, Hong-zhu Li, Shu-zhi Bai, Hong-xia Li, Wei-hua Zhang, Bao-feng Yang, Guang-dong Yang, Ling-yun Wu, Rui Wang and Chang-qing Xu
    Citation: Journal of Biomedical Science 2011 18:16
    Content type: Research Published on:

  33. Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in...

    Authors: Xiaomin Zhang, Gohar Azhar, Scott A Helms and Jeanne Y Wei
    Citation: Journal of Biomedical Science 2011 18:15
    Content type: Research Published on:

  34. Aging is a progressive process related to the accumulation of oxidative damage and neuroinflammation. We tried to find the anti-amnesic effect of the Scutellaria baicalens Georgia (SBG) ethanol extract and its ma...

    Authors: Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee…
    Citation: Journal of Biomedical Science 2011 18:14
    Content type: Research Published on:

  35. Traumatic spinal cord injury (SCI) forms a disadvantageous microenvironment for tissue repair at the lesion site. To consider an appropriate time window for giving a promising therapeutic treatment for subacut...

    Authors: Chih-Yen Wang, Jen-Kun Chen, Yi-Ting Wu, May-Jywan Tsai, Song-Kun Shyue, Chung-Shi Yang and Shun-Fen Tzeng
    Citation: Journal of Biomedical Science 2011 18:13
    Content type: Research Published on:

  36. The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We...

    Authors: Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Chien-Min Chen, Pei-Yi Chu, Kun-Tu Yeh, Pearlly S Yan, Yu-Sun Chang, Tim H-M Huang and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:12
    Content type: Research Published on:

  37. Taurine has chemical structure similar to an inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Previous studies on GABA in the stomach suggest GABAergic neuron is involved in acid secretion, but the eff...

    Authors: Kai-Han Huang, Chia-Chieh Chang, Jau-Der Ho, Ruey-Hwa Lu and Li Hsueh Tsai
    Citation: Journal of Biomedical Science 2011 18:11
    Content type: Research Published on:

  38. Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) ...

    Authors: Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund and Thomas G Jensen
    Citation: Journal of Biomedical Science 2011 18:10
    Content type: Review Published on:

  39. Dystonia musculorum (dt) is an autosomal recessive hereditary neuropathy with a characteristic uncoordinated movement and is caused by a defect in the bullous pemphigoid antigen 1 (BPAG1) gene. The neural isoform...

    Authors: Kuang-Wen Tseng, Mei-Lin Peng, Yang-Cheng Wen, Kang-Jen Liu and Chung-Liang Chien
    Citation: Journal of Biomedical Science 2011 18:9
    Content type: Research Published on:

  40. Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acety...

    Authors: Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai and Yih Ho
    Citation: Journal of Biomedical Science 2011 18:8
    Content type: Research Published on:

  41. The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and d...

    Authors: Halina Z Malina
    Citation: Journal of Biomedical Science 2011 18:7
    Content type: Research Published on:

  42. Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly un...

    Authors: Han-Hsin Chang, Bo-Yie Chen, Chia-Yung Wu, Zih-Jay Tsao, Ying-Yu Chen, Chin-Pao Chang, Chi-Rei Yang and David Pei-Cheng Lin
    Citation: Journal of Biomedical Science 2011 18:6
    Content type: Research Published on:

  43. Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutama...

    Authors: MS Nandhu, Jes Paul, Korah P Kuruvilla, Anitha Malat, Chinthu Romeo and CS Paulose
    Citation: Journal of Biomedical Science 2011 18:5
    Content type: Research Published on:

  44. There are three apolipoprotein E (apoE) isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166) peptides that are tailored to lack domain interactions ar...

    Authors: Yi-Hui Hsieh and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2011 18:4
    Content type: Research Published on:

  45. Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors az...

    Authors: Yi-Shiuan Lin, Arthur Y Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim HM Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:3
    Content type: Research Published on:

  47. Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin,...

    Authors: Chung-Yin Wu, Chih-Ta Lin, Min-Zu Wu and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2011 18:1
    Content type: Research Published on:

  49. The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope g...

    Authors: Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon and Pierre Castelnau
    Citation: Journal of Biomedical Science 2010 17:91
    Content type: Research Published on:

  50. Cytochrome b5 performs central roles in various biological electron transfer reactions, where difference in the redox potential of two reactant proteins provides the driving force. Redox potentials of cytochromes...

    Authors: Tomomi Aono, Yoichi Sakamoto, Masahiro Miura, Fusako Takeuchi, Hiroshi Hori and Motonari Tsubaki
    Citation: Journal of Biomedical Science 2010 17:90
    Content type: Research Published on:
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Journal of Biomedical Science

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