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  1. The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders.

    Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo and John H. Zhang
    Citation: Journal of Biomedical Science 2020 27:61
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:71

  2. Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic ...

    Authors: Shaw-Min Hou, Chih-Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Marappan Velusamy and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2020 27:60
    Content type: Research Published on:

  3. Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological ...

    Authors: Tse-Chun Kuo, Hsing-Jien Kung and Jing-Wen Shih
    Citation: Journal of Biomedical Science 2020 27:59
    Content type: Review Published on:

  4. Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression, it can be hypothesized that STF can improve the efficacy of ...

    Authors: Jing Zhang, Yanlin Deng and Bee Luan Khoo
    Citation: Journal of Biomedical Science 2020 27:58
    Content type: Review Published on:

  5. O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of nuclear or cytoplasmic proteins by O-GlcN...

    Authors: Yi-Hsuan Chang, Chia-Lin Weng and Kuo-I Lin
    Citation: Journal of Biomedical Science 2020 27:57
    Content type: Review Published on:

  6. Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major chal...

    Authors: Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim and Seungkwon You
    Citation: Journal of Biomedical Science 2020 27:56
    Content type: Research Published on:

  7. Very few studies have identified receptor molecules for dengue virus (DENV) on neural cells. This study was designed to identify putative receptor/(s) involved in entry of DENV-3 in human neural cells of vario...

    Authors: Amita Sharma, Ravi Vasanthapuram, Manjunatha M Venkataswamy and Anita Desai
    Citation: Journal of Biomedical Science 2020 27:55
    Content type: Research Published on:

  8. Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immuni...

    Authors: Patricia Ruiz-Limon, Maria Lourdes Ladehesa-Pineda, Maria del Carmen Castro-Villegas, Maria del Carmen Abalos-Aguilera, Clementina Lopez-Medina, Chary Lopez-Pedrera, Nuria Barbarroja, Daniel Espejo-Peralbo, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Carlos Perez-Sanchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Pilar Font-Ugalde and Yolanda Jimenez-Gomez
    Citation: Journal of Biomedical Science 2020 27:54
    Content type: Research Published on:

  9. Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss...

    Authors: Shao-Hsuan Hsia, Jainn-Jim Lin, Oi-Wa Chan and Tzou-Yien Lin
    Citation: Journal of Biomedical Science 2020 27:53
    Content type: Review Published on:

  10. Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause ab...

    Authors: Yen-Ting Lai, Hsu-Wen Chao, Alan Chuan-Ying Lai, Shu-Hui Lin, Ya-Jen Chang and Yi-Shuian Huang
    Citation: Journal of Biomedical Science 2020 27:52
    Content type: Research Published on:

  11. The emergence of Zika virus (ZV) in tropical and subtropical areas of the world has created an urgent need for vaccines against ZV. However, approved vaccines that prevent ZV infection are not available. To de...

    Authors: Mei-Yu Chen, Kit Man Chai, Chen-Yi Chiang, Chiao-Chieh Wu, Guann-Yi Yu, Shih-Jen Liu and Hsin-Wei Chen
    Citation: Journal of Biomedical Science 2020 27:51
    Content type: Research Published on:

  12. The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied.

    Authors: Ayesha Wijesinghe, Jayani Gamage, Hemantha Goonewardena, Laksiri Gomes, Deshni Jayathilaka, Dulharie T. Wijeratne, Ruklanthi de Alwis, Chandima Jeewandara, Ananda Wijewickrama, Graham S. Ogg and Gathsaurie Neelika Malavige
    Citation: Journal of Biomedical Science 2020 27:50
    Content type: Research Published on:

  14. With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcrib...

    Authors: Chih-Fan Yeh, Yu-Chen Eugene Chang, Cheng-Yuan Lu, Chin-Feng Hsuan, Wei-Tien Chang and Kai-Chien Yang
    Citation: Journal of Biomedical Science 2020 27:48
    Content type: Review Published on:

  15. Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an...

    Authors: Tsai-Teng Tzeng, Po-Ling Chen, Tsai-Chuan Weng, Shin-Yi Tsai, Chia-Chun Lai, Hsin-I Chou, Pin-Wen Chen, Chia-Chun Lu, Ming-Tsan Liu, Wang-Chou Sung, Min-Shi Lee and Alan Yung-Chih Hu
    Citation: Journal of Biomedical Science 2020 27:47
    Content type: Research Published on:

  16. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2020 27:46
    Content type: Research Published on:

  17. Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents....

    Authors: Yu-Wen Wu, Cheng-Chain Huang, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran and Thierry Burnouf
    Citation: Journal of Biomedical Science 2020 27:45
    Content type: Research Published on:

  19. Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem c...

    Authors: Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai and Sung-Jan Lin
    Citation: Journal of Biomedical Science 2020 27:43
    Content type: Review Published on:

  20. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang
    Citation: Journal of Biomedical Science 2020 27:42
    Content type: Research Published on:

  21. Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Cas...

    Authors: Mel Campbell and Yoshihiro Izumiya
    Citation: Journal of Biomedical Science 2020 27:41
    Content type: Review Published on:

  22. The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to explore the mechanism by which MALAT1 regulates aquap...

    Authors: Hongwei Wang, Xiaoxiao Zheng, Jing Jin, Li Zheng, Ting Guan, Yangfan Huo, Shufen Xie, Ying Wu and Wei Chen
    Citation: Journal of Biomedical Science 2020 27:40
    Content type: Research Published on:

  25. Aerobically-grown bacteria can be challenged by hydrogen peroxide stress from endogenous aerobic metabolism and exogenously generated reactive oxygen species. Catalase (Kat), alkyl hydroperoxidase (Ahp), and g...

    Authors: Li-Hua Li, Yung-Luen Shih, Jing-Yun Huang, Chao-Jung Wu, Yi-Wei Huang, Hsin-Hui Huang, Yu-Chieh Tsai and Tsuey-Ching Yang
    Citation: Journal of Biomedical Science 2020 27:37
    Content type: Research Published on:

  26. Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Fo...

    Authors: Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou and Wen-Tai Chiu
    Citation: Journal of Biomedical Science 2020 27:36
    Content type: Research Published on:

  27. Spinal cord injury (SCI) is a highly debilitating pathology without curative treatment. One of the most promising disease modifying strategies consists in the implantation of stem cells to reduce inflammation ...

    Authors: Lorenzo Romero-Ramírez, Siyu Wu, Johannes de Munter, Erik Ch. Wolters, Boris W. Kramer and Jörg Mey
    Citation: Journal of Biomedical Science 2020 27:35
    Content type: Research Published on:

  28. In the past years evidence has been growing about the interconnection of chronic kidney disease and acute kidney injury. The underlying pathophysiological mechanisms remain unclear. We hypothesized, that a thr...

    Authors: Alexander Holderied, Franziska Kraft, Julian Aurelio Marschner, Marc Weidenbusch and Hans-Joachim Anders
    Citation: Journal of Biomedical Science 2020 27:34
    Content type: Research Published on:

  29. Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with exten...

    Authors: Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng and Che Ma
    Citation: Journal of Biomedical Science 2020 27:33
    Content type: Review Published on:

  30. Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously,...

    Authors: Yu-Hsun Chang, Tang-Yuan Chu and Dah-Ching Ding
    Citation: Journal of Biomedical Science 2020 27:32
    Content type: Research Published on:

  31. X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of th...

    Authors: Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng and Euphemia Leung
    Citation: Journal of Biomedical Science 2020 27:31
    Content type: Review Published on:

  32. The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence is a leading clinical bottleneck in NPC. Revealing the mechanism of NPC radioresistance wi...

    Authors: Panpan Zhang, Xiaomin Li, Qiuping He, Lulu Zhang, Keqing Song, Xiaojing Yang, Qingmei He, Yaqin Wang, Xiaohong Hong, Jun Ma and Na Liu
    Citation: Journal of Biomedical Science 2020 27:30
    Content type: Research Published on:

  35. Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpec...

    Authors: Muhammad Izzuddin Mohd Ropidi, Ahmad Suhail Khazali, Nurshamimi Nor Rashid and Rohana Yusof
    Citation: Journal of Biomedical Science 2020 27:27
    Content type: Review Published on:

  36. Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protei...

    Authors: Dan Nie, Yue Hu, Zhou Chen, Mingkai Li, Zheng Hou, Xiaoxing Luo, Xinggang Mao and Xiaoyan Xue
    Citation: Journal of Biomedical Science 2020 27:26
    Content type: Review Published on:

  37. Dengue presents a wide clinical spectrum. Most patients recover following a self-limiting non-severe clinical course. A small proportion of patients progress to severe disease, mostly characterized by plasma l...

    Authors: Harsha Hapugaswatta, Pubudu Amarasena, Ranjan Premaratna, Kapila N. Seneviratne and Nimanthi Jayathilaka
    Citation: Journal of Biomedical Science 2020 27:25
    Content type: Research Published on:

  39. Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosi...

    Authors: Yu-An Hsu, Ching-Yao Chang, Joung-Liang Lan, Ju-Pi Li, Hui-Ju Lin, Chih-Sheng Chen, Lei Wan and Fu-Tong Liu
    Citation: Journal of Biomedical Science 2020 27:24
    Content type: Research Published on:

  40. Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CS...

    Authors: Han-Shui Hsu, Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Anna Fen-Yau Li and Shih-Chieh Hung
    Citation: Journal of Biomedical Science 2020 27:5
    Content type: Research Published on:

  41. Enterovirus 71 (EV-A71) is one of the major causative agents of hand, foot, and mouth disease. EV-A71 infection is sometimes associated with severe neurological diseases such as acute encephalitis, acute flacc...

    Authors: Kyousuke Kobayashi and Satoshi Koike
    Citation: Journal of Biomedical Science 2020 27:23
    Content type: Review Published on:

  42. Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA,...

    Authors: Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo and Lih-Chu Chiou
    Citation: Journal of Biomedical Science 2020 27:7
    Content type: Research Published on:

  43. Upon EV-A71 infection of a host cell, EV-A71 RNA is translated into a viral polyprotein. Although EV-A71 can use the cellular translation machinery to produce viral proteins, unlike cellular translation, which...

    Authors: Ming-Chih Lai, Han-Hsiang Chen, Peng Xu and Robert Y. L. Wang
    Citation: Journal of Biomedical Science 2020 27:22
    Content type: Review Published on:

  44. Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for speci...

    Authors: Cheng-Chung Lee, Yu-Cheng Su, Tzu-Ping Ko, Li-Ling Lin, Chih-Ya Yang, Stanley Shi-Chung Chang, Steve R. Roffler and Andrew H.-J. Wang
    Citation: Journal of Biomedical Science 2020 27:12
    Content type: Research Published on:

  45. Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal muc...

    Authors: Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han and Sei-Jung Lee
    Citation: Journal of Biomedical Science 2020 27:21
    Content type: Research Published on:

  46. Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progres...

    Authors: María Belén Vecchione, Natalia Laufer, Omar Sued, Marcelo Corti, Horacio Salomon and Maria Florencia Quiroga
    Citation: Journal of Biomedical Science 2020 27:20
    Content type: Research Published on:

  47. The FDA approved drug granulocyte-colony stimulating factor (G-CSF) displays anti-apoptotic and immunomodulatory properties with neurogenesis and angiogenic functions. It is known to demonstrate neuroprotectiv...

    Authors: Jigar Modi, Janet Menzie-Suderam, Hongyuan Xu, Paola Trujillo, Kristen Medley, Michael L. Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2020 27:19
    Content type: Research Published on:

  48. Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Prese...

    Authors: Li-Kai Huang, Shu-Ping Chao and Chaur-Jong Hu
    Citation: Journal of Biomedical Science 2020 27:18
    Content type: Review Published on:

  49. Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replicati...

    Authors: Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2020 27:17
    Content type: Research Published on:

  50. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang
    Citation: Journal of Biomedical Science 2020 27:11
    Content type: Research Published on:
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Journal of Biomedical Science

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