Whitsett JA, Wert SE, Trapnell BC. Genetic disorders influencing lung formation and function at birth. Hum Mol Genet. 2004;13(2):R207–15 Spec No.
Article
CAS
PubMed
Google Scholar
Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, et al. Lung organogenesis. Curr Top Dev Biol. 2010;90:73–158.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chao CM, Moiseenko A, Zimmer KP, Bellusci S. Alveologenesis: key cellular players and fibroblast growth factor 10 signaling. Mol Cell Pediatr. 2016;3(1):17.
Article
PubMed
PubMed Central
Google Scholar
Ntokou A, Klein F, Dontireddy D, Becker S, Bellusci S, Richardson WD, et al. Characterization of the platelet-derived growth factor receptor-alpha-positive cell lineage during murine late lung development. Am J Phys Lung Cell Mol Phys. 2015;309(9):L942–58.
CAS
Google Scholar
Branchfield K, Li R, Lungova V, Verheyden JM, McCulley D, Sun X. A three-dimensional study of alveologenesis in mouse lung. Dev Biol. 2016;409(2):429–41.
Article
CAS
PubMed
Google Scholar
Noskovicova N, Petrek M, Eickelberg O, Heinzelmann K. Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies. Am J Respir Cell Mol Biol. 2015;52(3):263–84.
Article
CAS
PubMed
Google Scholar
Funa K, Uramoto H. Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor. Acta Biochim Pol. 2003;50(3):647–58.
Article
CAS
PubMed
Google Scholar
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH. cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A. 1989;86(13):4917–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, et al. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science. 1989;243(4892):800–4.
Article
CAS
PubMed
Google Scholar
Heldin CH. Targeting the PDGF signaling pathway in tumor treatment. Cell Commun Signal. 2013;11:97.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010;141(7):1117–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, et al. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest. 2007;117(3):730–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Raffetto JD, Vasquez R, Goodwin DG, Menzoian JO. Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovasc Surg. 2006;40(1):59–66.
Article
Google Scholar
Cartel NJ, Liu J, Wang J, Post M. PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Am J Phys Lung Cell Mol Phys. 2001;281(4):L786–98.
CAS
Google Scholar
Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J, Abboud HE. PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Phys. 1997;273(6 Pt 2):F931–8.
CAS
Google Scholar
Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22(10):1276–312.
Article
CAS
PubMed
PubMed Central
Google Scholar
Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development. 1997;124(14):2691–700.
CAS
PubMed
Google Scholar
Lindahl P, Karlsson L, Hellstrom M, Gebre-Medhin S, Willetts K, Heath JK, et al. Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development. 1997;124(20):3943–53.
CAS
PubMed
Google Scholar
Bostrom H, Willetts K, Pekny M, Leveen P, Lindahl P, Hedstrand H, et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996;85(6):863–73.
Article
CAS
PubMed
Google Scholar
Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, et al. Epithelial notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016;113(29):8242–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lau M, Masood A, Yi M, Belcastro R, Li J, Tanswell AK. Long-term failure of alveologenesis after an early short-term exposure to a PDGF-receptor antagonist. Am J Phys Lung Cell Mol Phys. 2011;300(4):L534–47.
CAS
Google Scholar
Popova AP, Bentley JK, Cui TX, Richardson MN, Linn MJ, Lei J, et al. Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia. Am J Phys Lung Cell Mol Phys. 2014;307(3):L231–9.
CAS
Google Scholar
Lai YT, Su CK, Jiang ST, Chang YJ, Lai AC, Huang YS. Deficiency of CPEB2-confined choline Acetyltransferase expression in the dorsal motor nucleus of Vagus causes Hyperactivated parasympathetic signaling-associated bronchoconstriction. J Neurosci. 2016;36(50):12661–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen PJ, Huang YS. CPEB2-eEF2 interaction impedes HIF-1alpha RNA translation. EMBO J. 2012;31(4):959–71.
Article
PubMed
CAS
Google Scholar
Chen PJ, Weng JY, Hsu PH, Shew JY, Huang YS, Lee WH. NPGPx modulates CPEB2-controlled HIF-1alpha RNA translation in response to oxidative stress. Nucleic Acids Res. 2015;43(19):9393–404.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lu WH, Yeh NH, Huang YS. CPEB2 activates GRASP1 mRNA translation and promotes AMPA receptor surface expression, long-term potentiation, and memory. Cell Rep. 2017;21(7):1783–94.
Article
CAS
PubMed
Google Scholar
Chen HF, Hsu CM, Huang YS. CPEB2-dependent translation of long 3’-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue. EMBO J. 2018;37:20.
Google Scholar
Mahadeva R, Shapiro SD. Chronic obstructive pulmonary disease * 3: experimental animal models of pulmonary emphysema. Thorax. 2002;57(10):908–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Santos LM, de Brito Cervilha DA, Cabral LD, Garcia EK, Teixeira VP, Brito JM, et al. Bronchial responsiveness in an elastase-induced mouse model of emphysema. Respir Physiol Neurobiol. 2014;194:9–14.
Article
CAS
PubMed
Google Scholar
Inoue K, Koike E, Takano H. Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters. Int Immunopharmacol. 2010;10(11):1380–9.
Article
CAS
PubMed
Google Scholar
Cohen J, Van Marter LJ, Sun Y, Allred E, Leviton A, Kohane IS. Perturbation of gene expression of the chromatin remodeling pathway in premature newborns at risk for bronchopulmonary dysplasia. Genome Biol. 2007;8(10):R210.
Article
PubMed
PubMed Central
CAS
Google Scholar
Collins JJP, Lithopoulos MA, Dos Santos CC, Issa N, Mobius MA, Ito C, et al. Impaired Angiogenic supportive capacity and altered gene expression profile of resident CD146(+) Mesenchymal stromal cells isolated from Hyperoxia-injured neonatal rat lungs. Stem Cells Dev. 2018;27(16):1109–24.
Article
CAS
PubMed
Google Scholar
Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 1997;156(3 Pt 1):766–75.
Article
CAS
PubMed
Google Scholar
Dohi M, Tsukamoto S, Nagahori T, Shinagawa K, Saitoh K, Tanaka Y, et al. Noninvasive system for evaluating the allergen-specific airway response in a murine model of asthma. Lab Investig. 1999;79(12):1559–71.
CAS
PubMed
Google Scholar
Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, et al. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat Med. 2013;19(10):1297–304.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182(3):311–22.
Article
CAS
PubMed
Google Scholar
Li J, Li Y, He H, Liu C, Li W, Xie L, et al. Csk/Src/EGFR signaling regulates migration of myofibroblasts and alveolarization. Am J Phys Lung Cell Mol Phys. 2016;310(6):L562–71.
Google Scholar
Tang K, Rossiter HB, Wagner PD, Breen EC. Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol. 2004;97(4):1559–66 discussion 49.
Article
CAS
PubMed
Google Scholar
Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong SB, et al. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep. 2014;7(2):412–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Metzger DE, Stahlman MT, Shannon JM. Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol. 2008;320(1):149–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fineschi S, De Cunto G, Facchinetti F, Civelli M, Imbimbo BP, Carnini C, et al. Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice. Am J Respir Cell Mol Biol. 2013;48(2):164–71.
Article
CAS
PubMed
Google Scholar
Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, et al. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med. 2005;11(5):491–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S. Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mandeville I, Aubin J, LeBlanc M, Lalancette-Hebert M, Janelle MF, Tremblay GM, et al. Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol. 2006;169(4):1312–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, et al. Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Phys Lung Cell Mol Phys. 2005;288(4):L683–91.
CAS
Google Scholar
Rackley CR, Stripp BR. Building and maintaining the epithelium of the lung. J Clin Invest. 2012;122(8):2724–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Du Y, Guo M, Whitsett JA, Xu Y. 'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015;70(11):1092–4.
Article
PubMed
Google Scholar
Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, et al. Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol. 2005;167(2):419–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Y, Tang Z, Huang H, Li J, Wang Z, Yu Y, et al. Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. Proc Natl Acad Sci U S A. 2018;115(10):2407–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yadav S, Puri S, Linstedt AD. A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing. Mol Biol Cell. 2009;20(6):1728–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vyas-Read S, Wang W, Kato S, Colvocoresses-Dodds J, Fifadara NH, Gauthier TW, et al. Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition. Am J Phys Lung Cell Mol Phys. 2014;306(4):L326–40.
CAS
Google Scholar
Turrens JF, Freeman BA, Crapo JD. Hyperoxia increases H2O2 release by lung mitochondria and microsomes. Arch Biochem Biophys. 1982;217(2):411–21.
Article
CAS
PubMed
Google Scholar
Gouveia L, Betsholtz C, Andrae J. PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung. Development. 2018;145:7.
Article
CAS
Google Scholar
Bonello MR, Bobryshev YV, Khachigian LM. Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells. Am J Pathol. 2005;167(4):1149–59.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, et al. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014;392(2):324–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang N, Chan CW, Sanchez-Guerrero E, Khachigian LM. Repression of PDGF-R-alpha after cellular injury involves TNF-alpha, formation of a c-Fos-YY1 complex, and negative regulation by HDAC. Am J Phys Cell Physiol. 2012;302(11):C1590–8.
Article
CAS
Google Scholar
Wang P, Xu J, Hou Z, Wang F, Song Y, Wang J, et al. miRNA-34a promotes proliferation of human pulmonary artery smooth muscle cells by targeting PDGFRA. Cell Prolif. 2016;49(4):484–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ruiz-Camp J, Quantius J, Lignelli E, Arndt PF, Palumbo F, Nardiello C, et al. Targeting miR-34a/Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia. EMBO molecular medicine. 2019;11:3.
Article
CAS
Google Scholar
Wang YZ, Zhang P, Rice AB, Bonner JC. Regulation of interleukin-1beta -induced platelet-derived growth factor receptor-alpha expression in rat pulmonary myofibroblasts by p38 mitogen-activated protein kinase. J Biol Chem. 2000;275(29):22550–7.
Article
CAS
PubMed
Google Scholar
Deng X, Jin K, Li Y, Gu W, Liu M, Zhou L. Platelet-derived growth factor and transforming growth factor beta1 regulate ARDS-associated lung fibrosis through distinct signaling pathways. Cell Physiol Biochem. 2015;36(3):937–46.
Article
CAS
PubMed
Google Scholar
Ingram JL, Rice AB, Geisenhoffer K, Madtes DK, Bonner JC. IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha. FASEB J. 2004;18(10):1132–4.
Article
CAS
PubMed
Google Scholar
Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, et al. Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clin Cancer Res. 2006;12(9):2676–88.
Article
CAS
PubMed
Google Scholar