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  1. Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen
    Citation: Journal of Biomedical Science 2018 25:30
    Content type: Review Published on:

  2. Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad
    Citation: Journal of Biomedical Science 2018 25:29
    Content type: Review Published on:

  3. Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanis...

    Authors: I-Ting Tsai, Ching-Chuan Kuo, Jing-Ping Liou and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2018 25:28
    Content type: Research Published on:

  4. β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee
    Citation: Journal of Biomedical Science 2018 25:27
    Content type: Research Published on:

  5. Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision makin...

    Authors: Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini and Silmar Teixeira
    Citation: Journal of Biomedical Science 2018 25:26
    Content type: Review Published on:

  7. Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses...

    Authors: Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu and Shih-Torng Ding
    Citation: Journal of Biomedical Science 2018 25:24
    Content type: Research Published on:

  8. Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression ...

    Authors: Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang and Yunfu Cui
    Citation: Journal of Biomedical Science 2018 25:23
    Content type: Review Published on:

  9. Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major...

    Authors: Ricardo Leão, Joana Dias Apolónio, Donghyun Lee, Arnaldo Figueiredo, Uri Tabori and Pedro Castelo-Branco
    Citation: Journal of Biomedical Science 2018 25:22
    Content type: Review Published on:

  10. Pericytes are multipotent cells present in every vascularized tissue in the body. Despite the fact that they are well-known for more than a century, pericytes are still representing cells with intriguing prope...

    Authors: C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov and Vladislav Volarevic
    Citation: Journal of Biomedical Science 2018 25:21
    Content type: Review Published on:

  11. Cancer stem cells (CSCs) are subpopulations of cancer cells sharing similar characteristics as normal stem or progenitor cells such as self-renewal ability and multi-lineage differentiation to drive tumour gro...

    Authors: Ain Zubaidah Ayob and Thamil Selvee Ramasamy
    Citation: Journal of Biomedical Science 2018 25:20
    Content type: Review Published on:

  12. In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of...

    Authors: Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang and Bing-Chang Chen
    Citation: Journal of Biomedical Science 2018 25:19
    Content type: Research Published on:

  13. LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined.

    Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong and Jian Zhang
    Citation: Journal of Biomedical Science 2018 25:18
    Content type: Research Published on:

  14. Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed 99mT...

    Authors: Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr
    Citation: Journal of Biomedical Science 2018 25:17
    Content type: Research Published on:

  15. Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed ...

    Authors: Lan Zhao, Alvin H. W. Fong, Na Liu and William C. S. Cho
    Citation: Journal of Biomedical Science 2018 25:16
    Content type: Research Published on:

  16. Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has dev...

    Authors: Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam and Shamala Devi Sekaran
    Citation: Journal of Biomedical Science 2018 25:15
    Content type: Research Published on:

  17. Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastic...

    Authors: Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu and Meei Jyh Jiang
    Citation: Journal of Biomedical Science 2018 25:14
    Content type: Research Published on:

  18. Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated. In the present study, t...

    Authors: Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen and Shenghai Huang
    Citation: Journal of Biomedical Science 2018 25:13
    Content type: Research Published on:

  19. Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mec...

    Authors: Sajal K. Ghosh, Abhishek Ganta and Remco A. Spanjaard
    Citation: Journal of Biomedical Science 2018 25:12
    Content type: Research Published on:

  20. Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms of lncRNA H19 in vascular sm...

    Authors: Lei Zhang, Hailing Cheng, Yuxia Yue, Shuangzhan Li, Daping Zhang and Ruili He
    Citation: Journal of Biomedical Science 2018 25:11
    Content type: Research Published on:

  21. Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tole...

    Authors: Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Zu-Min Xing, Han-Wen Chen and Yi-Wen Zhang
    Citation: Journal of Biomedical Science 2018 25:10
    Content type: Research Published on:

  22. Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) i...

    Authors: Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2018 25:9
    Content type: Research Published on:

  23. Intake of ethanol (alcohol) has been shown to influence cardiovascular function; the underlying brain mechanism remains unclear. Noting that nitric oxide (NO) system in the CNS is involved in the regulation of...

    Authors: Jiro Hasegawa Situmorang, Hsun-Hsun Lin, Hsuan Lo and Chih-Chia Lai
    Citation: Journal of Biomedical Science 2018 25:8
    Content type: Research Published on:

  24. Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrade...

    Authors: Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen and Marianne M. Stanford
    Citation: Journal of Biomedical Science 2018 25:7
    Content type: Research Published on:

  25. Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essenti...

    Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and Lee-Young Chau
    Citation: Journal of Biomedical Science 2018 25:6
    Content type: Research Published on:

  26. Mesenchymal stem cells (MSC) are used for several therapeutic applications to improve the functions of bone, cardiac, nervous tissue as well as to facilitate the repopulation of hematopoietic stem cells. MSC g...

    Authors: Chinnapaka Somaiah, Atul Kumar, Renu Sharma, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, Sewali Deka Talukdar and Bithiah Grace Jaganathan
    Citation: Journal of Biomedical Science 2018 25:5
    Content type: Research Published on:

  27. Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic ...

    Authors: Zhenyu Tang, Zongming Gong and Xiaoliang Sun
    Citation: Journal of Biomedical Science 2018 25:4
    Content type: Research Published on:

  29. The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling me...

    Authors: Yu-Tzu Shih and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2018 25:2
    Content type: Review Published on:

  30. Atherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their co...

    Authors: Tung-Lin Yang, Pei-Ling Lee, Ding-Yu Lee, Wei-Li Wang, Shu-Yi Wei, Chih-I Lee and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2018 25:1
    Content type: Research Published on:

  31. Numerous studies have shown that Id-1 (Inhibitor of differentiation 1) is upregulated in several cancers and associated with tumor malignant characters. However, the clinical significance and biological role o...

    Authors: Jie Li, Yingjie Li, Bin Wang, Yongfu Ma and Ping Chen
    Citation: Journal of Biomedical Science 2017 24:95
    Content type: Research Published on:

  32. Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and cerebrospinal fluid of infected patients with brainst...

    Authors: Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang and Shun-Hua Chen
    Citation: Journal of Biomedical Science 2017 24:94
    Content type: Research Published on:

  34. Beta-thalassemia is common in the Mediterranean area as well as the Middle East and India. Official report in Iran revealed the average prevalence rate of carriers about 4%. More than 20 restriction fragment l...

    Authors: Mohammad Bagher Hashemi-Soteh, Seyed Saeed Mousavi and Alireza Tafazoli
    Citation: Journal of Biomedical Science 2017 24:92
    Content type: Research Published on:

  35. A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical man...

    Authors: Hiroya Matsumura, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Shunsuke Tomomori, Chikaaki Motoda, Michitaka Amioka, Naoya Hironobe, Masaaki Toshishige, Shinya Takahashi, Katsuhiko Imai, Taijiro Sueda, Kazuaki Chayama and Yasuki Kihara
    Citation: Journal of Biomedical Science 2017 24:91
    Content type: Research Published on:

  36. Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytoki...

    Authors: Isela Martínez-Reza, Lorenza Díaz and Rocío García-Becerra
    Citation: Journal of Biomedical Science 2017 24:90
    Content type: Review Published on:

  37. MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for...

    Authors: Che-Chung Yeh, Yanying Fan, Yi-Lin Yang and Michael J. Mann
    Citation: Journal of Biomedical Science 2017 24:89
    Content type: Research Published on:

  38. The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enh...

    Authors: Lorrany dos Santos Franco, Paloma Oliveira Vidal and Jaime Henrique Amorim
    Citation: Journal of Biomedical Science 2017 24:88
    Content type: Research Published on:

  39. Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellula...

    Authors: Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal and Stephen Myers
    Citation: Journal of Biomedical Science 2017 24:87
    Content type: Review Published on:

  41. This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascula...

    Authors: Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen and Li-Chin Sung
    Citation: Journal of Biomedical Science 2017 24:85
    Content type: Research Published on:

  42. Blood pressure control with renin-angiotensin system (RAS) blockade has remained the gold standard for treating patients with proteinuric chronic kidney disease (CKD) up to date. Nevertheless, RAS blockade slo...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin and Tun-Jun Tsai
    Citation: Journal of Biomedical Science 2017 24:84
    Content type: Review Published on:

  43. Cells adapt to hypoxia by transcriptional induction of genes that participate in regulation of angiogenesis, glucose metabolism and cell proliferation. The primary factors mediating cell response to low oxygen...

    Authors: Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Anna Lipińska, Lech Pomorski, Marek Wieczorek, Magdalena Bryś, Ewa Forma and Anna Krześlak
    Citation: Journal of Biomedical Science 2017 24:83
    Content type: Research Published on:

  44. Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric infl...

    Authors: Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2017 24:82
    Content type: Research Published on:

  45. Luteinizing hormone-releasing hormone (LH-RH) agonists are the standard for androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. Current guidelines recommend serum testosterone measurement to ...

    Authors: Juan Morote, Imma Comas, Roser Ferrer, Jacques Planas, Anna Celma and Lucas Regis
    Citation: Journal of Biomedical Science 2017 24:81
    Content type: Research Published on:

  47. Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+

    Authors: Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya
    Citation: Journal of Biomedical Science 2017 24:79
    Content type: Research Published on:

  48. Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely...

    Authors: Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G. Weiss, Daniela Panáková and Stéphanie Lucas
    Citation: Journal of Biomedical Science 2017 24:78
    Content type: Research Published on:

  49. Several tumour necrosis factor (TNF) based therapeutics have already been approved for human use and several others are emerging. Therefore, we determined the mRNA expression levels of the TNF superfamily liga...

    Authors: Satish Kumar Devarapu, Julia Felicitas Grill, Junhui Xie, Marc Weidenbusch, Mohsen Honarpisheh, Volker Vielhauer, Hans-Joachim Anders and Shrikant R. Mulay
    Citation: Journal of Biomedical Science 2017 24:77
    Content type: Research Published on:

  50. Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer’s disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, R...

    Authors: Waqar Ahmad, Bushra Ijaz, Khadija Shabbiri, Fayyaz Ahmed and Sidra Rehman
    Citation: Journal of Biomedical Science 2017 24:76
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127