Skip to main content

Articles

Page 25 of 33

  1. Daidzein, a phytoestrogen found in isoflavone, is known to exert neurotrophic and neuroprotective effects on the nervous system. Using primary rat dorsal root ganglion (DRG) neuronal cultures, we have examined...

    Authors: Shih-Hung Yang, Chih-Chen Liao, Ying Chen, Jhih-Pu Syu, Chung-Jiuan Jeng and Seu-Mei Wang
    Citation: Journal of Biomedical Science 2012 19:80
    Content type: Research Published on:

  2. Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly...

    Authors: Li-Jing Chen, Seh Hong Lim, Yi-Ting Yeh, Sheng-Chieh Lien and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2012 19:79
    Content type: Review Published on:

  3. Epilepsy is a neurological disorder produced by an imbalance between excitatory and inhibitory neurotransmission, in which transporters of both glutamate and GABA have been implicated. Hence, at different time...

    Authors: Laura Medina-Ceja, Flavio Sandoval-García, Alberto Morales-Villagrán and Silvia J López-Pérez
    Citation: Journal of Biomedical Science 2012 19:78
    Content type: Research Published on:

  5. Estrogen acts on the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ER)β-dependent mechanism. We investigated in...

    Authors: Kay LH Wu, Chen-Hsiu Chen and Cheng-Dean Shih
    Citation: Journal of Biomedical Science 2012 19:76
    Content type: Research Published on:

  6. TRPM7 (T ransient R eceptor P otential of the M elastatin subfamily) proteins are highly expressed in the heart, however, electrophysiological studies, demonstrating and characterizing these channels in human car...

    Authors: Regina Macianskiene, Irma Martisiene, Danguole Zablockaite and Vida Gendviliene
    Citation: Journal of Biomedical Science 2012 19:75
    Content type: Research Published on:

  7. Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a...

    Authors: Kaiyu Zhou, Gang Wu, Yifei Li, Liang Zhao, Rong Zhou, Qi Zhu, Xupei Huang, Dezhi Mu and Yimin Hua
    Citation: Journal of Biomedical Science 2012 19:74
    Content type: Research Published on:

  8. Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalitie...

    Authors: Jun-Xia Deng, Xiao-Jing Nie, Ying-Feng Lei, Chao-Feng Ma, Dong-Liang Xu, Biao Li, Zhi-Kai Xu and Guo-Cheng Zhang
    Citation: Journal of Biomedical Science 2012 19:73
    Content type: Research Published on:

  9. PUMA (p53-up-regulated modulator of apoptosis), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of PUMA in cardiomyocytes under mechanical stress is little k...

    Authors: Wen-Pin Cheng, Gong-Jhe Wu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2012 19:72
    Content type: Research Published on:

  10. Endoplasmic reticulum (ER) and mitochondria have been implicated in the pathology of renal ischemia/reperfusion (I/R). In the present study, we investigated whether the use of ischemic postconditioning (IPostC...

    Authors: Asma Mahfoudh-Boussaid, Mohamed Amine Zaouali, Thierry Hauet, Kaouther Hadj-Ayed, Abdel-Hédi Miled, Sonia Ghoul-Mazgar, Dalila Saidane-Mosbahi, Joan Rosello-Catafau and Hassen Ben Abdennebi
    Citation: Journal of Biomedical Science 2012 19:71
    Content type: Research Published on:

  12. Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This stud...

    Authors: Ching-Hua Hsieh, Cheng-Shyuan Rau, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng and Johnson Chia-Shen Yang
    Citation: Journal of Biomedical Science 2012 19:69
    Content type: Research Published on:

  13. The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.

    Authors: Luciano da Silva Lopes, Rosemarie Brandin Marques, Heliana Barros Fernandes, Sergio da Silva Pereira, Mariane CC Ayres, Mariana Helena Chaves and Fernanda RC Almeida
    Citation: Journal of Biomedical Science 2012 19:68
    Content type: Research Published on:

  15. The roles of circulating endothelial progenitor cell (EPC) and mononuclear cell apoptosis (MCA) in liver cirrhosis (LC) patients are unknown. Moreover, vascular endothelial growth factor (VEGF) and stromal cel...

    Authors: Chih-Hung Chen, Li-Teh Chang, Wei-Chih Tung, Yung-Lung Chen, Chia-Lo Chang, Steve Leu, Cheuk-Kwan Sun, Tzu-Hsien Tsai, I-Ting Tsai, Hsueh-Wen Chang and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2012 19:66
    Content type: Research Published on:

  16. Cancer is an international health problem, and the search for effective treatments is still in progress. Peptide therapy is focused on the development of short peptides with strong tumoricidal activity and low...

    Authors: Nahlah M Almansour, Elena Pirogova, Peter J Coloe, Irena Cosic and Taghrid S Istivan
    Citation: Journal of Biomedical Science 2012 19:65
    Content type: Research Published on:

  17. Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen spe...

    Authors: Shih-Hung Chan, Ushio Kikkawa, Hidenori Matsuzaki, Jyh-Hong Chen and Wen-Chang Chang
    Citation: Journal of Biomedical Science 2012 19:64
    Content type: Research Published on:

  18. Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome.

    Authors: Tzu-Chun Tsai, Jen-Kann Lu, Sie-Lin Choo, Shu-Yu Yeh, Ren-Bing Tang, Hsin-Yu Lee and Jen-Her Lu
    Citation: Journal of Biomedical Science 2012 19:63
    Content type: Research Published on:

  20. Rabies is known to be lethal in human. Treatment with passive immunity for the rabies is effective only when the patients have not shown the central nerve system (CNS) signs. The blood–brain barrier (BBB) is a...

    Authors: Pi-Hung Liao, Hui-Hua Yang, Ping-Tse Chou, Ming-Hseng Wang, Po-Chun Chu, Hao-Li Liu and Li-Kuang Chen
    Citation: Journal of Biomedical Science 2012 19:61
    Content type: Research Published on:

  21. Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for tr...

    Authors: Kyung-Ae Lee, Jung-Il Chae and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2012 19:60
    Content type: Research Published on:

  22. The phosphoinositide 3-kinases (PI3K/Akt) dependent signaling pathway plays an important role in cardiac function, specifically cardiac contractility. We have reported that sepsis decreases myocardial Akt acti...

    Authors: Bridget M Graves, Thomas Simerly, Chuanfu Li, David L Williams and Robert Wondergem
    Citation: Journal of Biomedical Science 2012 19:59
    Content type: Research Published on:

  23. Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections. This research evaluates how probiotic lac...

    Authors: R Doug Wagner and Shemedia J Johnson
    Citation: Journal of Biomedical Science 2012 19:58
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:84

  24. Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis ...

    Authors: Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung and Hsuan Liu
    Citation: Journal of Biomedical Science 2012 19:57
    Content type: Research Published on:

  25. Maternal epileptic seizures during pregnancy can affect the hippocampal neurons in the offspring. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is expressed in the developing central nervo...

    Authors: Aliakbar Rajabzadeh, Alireza Ebrahimzadeh Bideskan, Alireza Fazel, Mojtaba Sankian, Houshang Rafatpanah and Hossein Haghir
    Citation: Journal of Biomedical Science 2012 19:56
    Content type: Research Published on:

  26. N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in m...

    Authors: Tsung-Chieh Chen, José Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh and Bai-Chuang Shyu
    Citation: Journal of Biomedical Science 2012 19:55
    Content type: Research Published on:

  27. The Aim of this study is to study the minimum zinc dependent metalloprotease catalytic folding motif, helix B Met loop-helix C, with proteolytic catalytic activities in metzincin super family. The metzincin su...

    Authors: Wei-Hsuan Yu, Po-Tsang Huang, Kuo-Long Lou, Shuan-Su C Yu and Chen Lin
    Citation: Journal of Biomedical Science 2012 19:54
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:87

  28. We aimed to examine the expression level of Nucleophosmin (NPM1) protein in colon cancer tissues and to investigate the potential role of NPM1 in the regulation of cell migration and invasiveness.

    Authors: Yan Liu, Fei Zhang, Xiao-fang Zhang, Li-sha Qi, Lei Yang, Hua Guo and Ning Zhang
    Citation: Journal of Biomedical Science 2012 19:53
    Content type: Research Published on:

  29. Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulatio...

    Authors: Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen and Horng-Dar Wang
    Citation: Journal of Biomedical Science 2012 19:52
    Content type: Research Published on:

  31. Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has demonstrated various pharmacological activities, including antimicrobial, antihyperlipidemic, antithrombotic, and anticancer eff...

    Authors: Yung Hyun Choi and Hyun Soo Park
    Citation: Journal of Biomedical Science 2012 19:50
    Content type: Research Published on:

  32. In the present study we identified a novel gene, Homo Sapiens Chromosome 1 ORF109 (c1orf109, GenBank ID: NM_017850.1), which encodes a substrate of CK2. We analyzed the regulation mode of the gene, the expression...

    Authors: Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He, Yang Yu, You-peng Qu, Lei Yue, Yao Zhang and Yu Li
    Citation: Journal of Biomedical Science 2012 19:49
    Content type: Research Published on:

  33. Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome syste...

    Authors: Carol HY Wu, Julie YH Chan, Jimmy Li-Jer Chou, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:48
    Content type: Research Published on:

  34. Although diabetes mellitus (DM) can be treated with islet transplantation, a scarcity of donors limits the utility of this technique. This study investigated whether human mesenchymal stem cells (MSCs) from um...

    Authors: Pei-Jiun Tsai, Hwai-Shi Wang, Yi-Ming Shyr, Zen-Chung Weng, Ling-Chen Tai, Jia-Fwu Shyu and Tien-Hua Chen
    Citation: Journal of Biomedical Science 2012 19:47
    Content type: Research Published on:

  36. Microglial cells are the predominant immune cells in malignant brain tumors, but tumors may release some factors to reduce their defensive functions. Restoration of the anti-cancer function of microglia has be...

    Authors: Tsung-Lang Chiu, Mei-Jan Wang and Chin-Cheng Su
    Citation: Journal of Biomedical Science 2012 19:45
    Content type: Research Published on:

  37. Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of vir...

    Authors: Szu-Cheng Kuo, Ying-Ju Chen, Yu-Ming Wang, Pei-Yi Tsui, Ming-Der Kuo, Tzong-Yuan Wu and Szecheng J Lo
    Citation: Journal of Biomedical Science 2012 19:44
    Content type: Research Published on:

  38. The aim of the study was to investigate the effect of dietary supplementation with zinc and polyphenol compounds, i.e. resveratrol and genistein, on the effectiveness of chemically induced mammary cancer and t...

    Authors: Barbara Bobrowska-Korczak, Dorota Skrajnowska and Andrzej Tokarz
    Citation: Journal of Biomedical Science 2012 19:43
    Content type: Research Published on:

  39. Shikonin, a phytochemical purified from Lithospermum erythrorhizon, has been shown to confer diverse pharmacological activities, including accelerating granuloma formation, wound healing, anti-inflammation and ot...

    Authors: Hui-Ming Chen, Pi-Hsueh Wang, Kandan Aravindaram, Yun-Hsiang Chen, Hsiu-Hui Yu, Wen-Chin Yang and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2012 19:42
    Content type: Research Published on:

  41. The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic sign...

    Authors: Gordana Đorđević, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac and Nives Jonjić
    Citation: Journal of Biomedical Science 2012 19:40
    Content type: Research Published on:

  42. Metastatic renal cell carcinoma (RCC) is highly resistant to systemic chemotherapy. Unfortunately, nearly all patients die of the metastatic and chemoresistant RCC. Recent studies have shown the atypical PKCζ ...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Jyue-Yu Chen, Wang-Yi Kang, Ying-Chu Lin, Yu-Shiang Shiu, Shu-Ju Chuang, Hong-Jeng Yu, Ming-Kuen Lai, Yu-Chieh Tsai, Wen-Jeng Wu and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2012 19:39
    Content type: Research Published on:

  43. Human olfactomedin 4 (OLFM4) gene is a secreted glycoprotein more commonly known as the anti-apoptotic molecule GW112. OLFM4 is found to be frequently up-regulated in many types of human tumors including gastr...

    Authors: Rui-hua Liu, Mei-hua Yang, Hua Xiang, Li-ming Bao, Hua-an Yang, Li-wen Yue, Xue Jiang, Na Ang, Li-ya Wu and Yi Huang
    Citation: Journal of Biomedical Science 2012 19:38
    Content type: Research Published on:

  45. Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging induces bone loss due to decreased osteoblastic bone formation and increased osteocl...

    Authors: Masayoshi Yamaguchi
    Citation: Journal of Biomedical Science 2012 19:36
    Content type: Review Published on:

  46. In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr-Abl and clinically used for chronic myelogenous leukemia) and TNF-related apoptosis-...

    Authors: Duen-Yi Huang, Yee Chao, Ming-Hui Tai, Yang-Hao Yu and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2012 19:35
    Content type: Research Published on:

  47. Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity....

    Authors: Yi-Heng Li, Cheng-Hsiang Kuo, Guey-Yueh Shi and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2012 19:34
    Content type: Review Published on:

  48. Both Neurofibromatosis type I (NF1) and inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) are autosomal dominant genetic disorders. These two diseases are fully penetran...

    Authors: Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2012 19:33
    Content type: Review Published on:

  49. Excessive oxidative stress and lipid peroxidation have been demonstrated to play important roles in the production of liver damage. L-carnitine is a natural substance and acts as a carrier for fatty acids acro...

    Authors: Jin-Lian Li, Qiao-Yun Wang, Hai-Yun Luan, Ze-Chun Kang and Chun-Bo Wang
    Citation: Journal of Biomedical Science 2012 19:32
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 9.0
    5-year Journal Impact Factor: 10.7
    Source Normalized Impact per Paper (SNIP): 2.014
    SCImago Journal Rank (SJR): 2.606

    Speed 2023
    Submission to first editorial decision (median days): 14
    Submission to acceptance (median days): 107

    Usage 2023
    Downloads: 1,698,723
    Altmetric mentions: 3,813

Journal of Biomedical Science

ISSN: 1423-0127