Articles

Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia

Both overproduction of nitric oxide (NO) and oxidative injury of cardiovascular and pulmonary systems contribute to fatal cardiovascular depression during endotoxemia. We investigated in the present study the ...

Authors: Yen-Chin Liu, Alice YW Chang, Yu-Chuan Tsai and Julie YH Chan

Requirement of focal adhesion kinase in branching tubulogenesis

We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integr...

Authors: Wei-Chun Wei, Anna K Kopec and Ming-Jer Tang

Molecular mechanisms of cell proliferation induced by low power laser irradiation

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiatio...

Authors: Xuejuan Gao and Da Xing

A novel 9-bp insertion detected in steroid 21-hydroxylase gene (CYP21A2): prediction of its structural and functional implications by computational methods

Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Detection of underlying mutations in CYP21A2 gene encoding steroid 21-hydroxylase enzyme is helpful both for con...

Authors: Sudhisha Dubey, Susan Idicula-Thomas, Mohammad Anwaruddin, Chinnaraj Saravanan, R Raveendra Varma and Anurupa Maitra

Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs

Cre/lox P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreER^T

Authors: Chih-Chia Liang, Li-Ru You, Junn-Liang Chang, Ting-Fen Tsai and Chun-Ming Chen

Journal of Biomedical Science, marking a new epoch: moving to open access in 2009

Authors: Michael MC Lai

Persistent H. pylori colonization in early acquisition age of mice related with higher gastric sialylated Lewis x, IL-10, but lower interferon-γ expressions

H. pylori infection is less prevalent in childhood. This study validated whether the rates of H. pylori colonization depend on different acquisition ages, and correlate with the different gastric Lewis antigens o...

Authors: Yao-Jong Yang, Hsiao-Bai Yang, Jiunn-Jong Wu and Bor-Shyang Sheu

Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer

Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers ...

Authors: Xiaolong Zou, Haiquan Qiao, Xian Jiang, Xuesong Dong, Hongchi Jiang and Xueying Sun