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  1. Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth and resistance to conventional treatments. This is due for part to a decrease in the ...

    Authors: Karine Varini, Amal Benzaria, Nadira Taïeb, Coralie Di Scala, Amanda Azmi, Soraya Graoudi and Marc Maresca
    Citation: Journal of Biomedical Science 2012 19:10
  2. The effective therapies for oral cancer patients of stage III and IV are generally surgical excision and radiation combined with adjuvant chemotherapy using 5-Fu and Cisplatin. However, the five-year survival ...

    Authors: Ying-Ray Lee, Wei-Ching Wu, Wen-Tsai Ji, Jeff Yi-Fu Chen, Ya-Ping Cheng, Ming-Ko Chiang and Hau-Ren Chen
    Citation: Journal of Biomedical Science 2012 19:9
  3. Abnormal accumulation of neuronal intermediate filament (IF) is a pathological indicator of some neurodegenerative disorders. However, the underlying neuropathological mechanisms of neuronal IF accumulation re...

    Authors: Wen-Ching Lee, Yun-Yu Chen, Daphne Kan and Chung-Liang Chien
    Citation: Journal of Biomedical Science 2012 19:8
  4. Although recent studies indicate that renal ischemic preconditioning (IPC) protects the kidney from ischemia-reperfusion (I/R) injury, the precise protective mechanism remains unclear. In the current study, we...

    Authors: Asma Mahfoudh-Boussaid, Mohamed Amine Zaouali, Kaouther Hadj-Ayed, Abdel-Hédi Miled, Dalila Saidane-Mosbahi, Joan Rosello-Catafau and Hassen Ben Abdennebi
    Citation: Journal of Biomedical Science 2012 19:7
  5. To explore the feasibility of constructing engineered myocardial tissues (EMTs) in vivo, using polylactic acid -co-glycolic acid (PLGA) for scaffold and cardiomyocyte-like cells derived from bone marrow mesenchym...

    Authors: Yujie Xing, Anlin Lv, Li Wang, Xuebo Yan, Wei Zhao and Feng Cao
    Citation: Journal of Biomedical Science 2012 19:6
  6. Hypoxia exposure initiates low serum testosterone levels that could be attributed to downregulated androgen biosynthesizing genes such as StAR (steroidogenic acute regulatory protein) and 3-beta-HSD (3-beta-hy...

    Authors: Gui-Lai Liu, Feng Yu, De-Zai Dai, Guo-Lin Zhang, Can Zhang and Yin Dai
    Citation: Journal of Biomedical Science 2012 19:4
  7. Fat embolism syndrome (FES) associated with acute lung injury (ALI) is a clinical condition following long bone fracture. We have reported 14 victims due to ALI with FES. Our laboratory has developed an animal...

    Authors: Chia-Chih Lin, Pei-Hsin Liu, Shang Jyh Kao and Hsing I Chen
    Citation: Journal of Biomedical Science 2012 19:3
  8. One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid β protein (Aβ) within lesions known as senile plaques. Aβ is also deposited in the walls of cerebral blood ...

    Authors: Ramesh JL Kandimalla, Willayat Yousuf Wani, Binukumar BK and Kiran Dip Gill
    Citation: Journal of Biomedical Science 2012 19:2
  9. The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ni...

    Authors: Yi-Chen Hsieh, Sudha Seshadri, Wen-Ting Chung, Fang-I Hsieh, Yi-Hsiang Hsu, Huey-Juan Lin, Hung-Pin Tseng, Li-Ming Lien, Chyi-Huey Bai, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Chin-I Chen, Chia-Chen Yu and Hung-Yi Chiou
    Citation: Journal of Biomedical Science 2012 19:1
  10. The covalently closed-circular DNA (cccDNA) of hepatitis B virus (HBV) is associated with viral persistence in HBV-infected hepatocytes. However, the regulation of cccDNA and its transcription in the host cell...

    Authors: Chin-Liew Chong, Mong-Liang Chen, Yi-Chieh Wu, Kuen-Nan Tsai, Chien-Chiao Huang, Cheng-po Hu, King-Song Jeng, Yu-Chi Chou and Chungming Chang
    Citation: Journal of Biomedical Science 2011 18:96
  11. The aim of the present study was to assess the effect of dietary supplementation (copper or copper and resveratrol) on the intensity of carcinogenesis and the frequency of microsatellite instability in a widel...

    Authors: Barbara Bobrowska, Dorota Skrajnowska and Andrzej Tokarz
    Citation: Journal of Biomedical Science 2011 18:95
  12. Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inf...

    Authors: Wen-Chi Wei, Sheng-Yen Lin, Yi-Jyun Chen, Chih-Chun Wen, Chiung-Yao Huang, Arulselvan Palanisamy, Ning-Sun Yang and Jyh-Horng Sheu
    Citation: Journal of Biomedical Science 2011 18:94
  13. Platelet activation is relevant to a variety of coronary heart diseases. Our previous studies revealed that sesamol possesses potent antiplatelet activity through increasing cyclic AMP formation. Although plat...

    Authors: Chao-Chien Chang, Wan-Jung Lu, Eng-Thiam Ong, Cheng-Wen Chiang, Song-Chow Lin, Shih-Yi Huang and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2011 18:93
  14. Skin stem cells contribute to all three major lineages of epidermal appendages, i.e., the epidermis, the hair follicle, and the sebaceous gland. In hair follicles, highly proliferative committed progenitor cel...

    Authors: Lixin Kan, Yijie Liu, Tammy L McGuire, Michael A Bonaguidi and John A Kessler
    Citation: Journal of Biomedical Science 2011 18:92
  15. Phosphatidylcholine (PPC) formulation is used for lipolytic injection, even though its mechanism of action is not well understood.

    Authors: Hailan Li, Jong-Hyuk Lee, Su Yeon Kim, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Yoosik Yoon, Ji Hoon Jeong and Dong-Seok Kim
    Citation: Journal of Biomedical Science 2011 18:91
  16. Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system...

    Authors: Miriam D Neher, Sebastian Weckbach, Michael A Flierl, Markus S Huber-Lang and Philip F Stahel
    Citation: Journal of Biomedical Science 2011 18:90
  17. Morphine is used in clinical practice as a highly effective painkiller as well as the drug of choice for treatment of certain heart diseases. However, there is lack of information about its effect on protein e...

    Authors: Zdenka Drastichova, Jitka Skrabalova, Jan Neckar, Frantisek Kolar and Jiri Novotny
    Citation: Journal of Biomedical Science 2011 18:89
  18. The tazarotene-induced gene 1 (TIG1) is a putative tumor suppressor gene. We have recently demonstrated both TIG1A and TIG1B isoforms inhibited cell growth and induced the expression of G protein-coupled receptor...

    Authors: Fu-Ming Tsai, Chang-Chieh Wu, Rong-Yaun Shyu, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: Journal of Biomedical Science 2011 18:88
  19. Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal cells under appropriate cellular conditions and transplanted in brain injury and neurodegenerative diseases animal models for neurore...

    Authors: Min Gong, Yang Bi, Wei Jiang, Yun Zhang, Li Chen, Nali Hou, Youxue Liu, Xiaoping Wei, Jie Chen and Tingyu Li
    Citation: Journal of Biomedical Science 2011 18:87
  20. Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may pote...

    Authors: Pin-Zhir Chao, Ming-Shium Hsieh, Chao-Wen Cheng, Yung-Feng Lin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2011 18:86
  21. Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its se...

    Authors: You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen and Wun-Chang Ko
    Citation: Journal of Biomedical Science 2011 18:84
  22. Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction. We previously report...

    Authors: Sang Won Park, Xine Shen, Lu-Tai Tien, Richard Roman and Tangeng Ma
    Citation: Journal of Biomedical Science 2011 18:83
  23. Peripheral tissue inflammation initiates hyperalgesia accompanied by tissue acidosis, nociceptor activation, and inflammation mediators. Recent studies have suggested a significantly increased expression of ac...

    Authors: Wei-Hsin Chen, Ching-Liang Hsieh, Chun-Ping Huang, Tzu-Jou Lin, Jason TC Tzen, Tin-Yun Ho and Yi-Wen Lin
    Citation: Journal of Biomedical Science 2011 18:82
  24. MiR-1 (microRNA-1) has been used as a positive control in some microRNA experiments. We found that miR-1 transfection of nasopharyngeal carcinoma cells reveals a typical apoptotic process as shown by time-laps...

    Authors: Cheng-Der Wu, Yuan-Sung Kuo, Han-Chung Wu and Chin-Tarng Lin
    Citation: Journal of Biomedical Science 2011 18:80
  25. Ischemic postconditioning (IPO) has been demonstrated to attenuate ischemia/reperfusion (I/R) injury in the heart and brain, its roles to liver remain to be defined. The study was undertaken to determine if IP...

    Authors: Jia Y Guo, Tong Yang, Xiang G Sun, Ni Y Zhou, Fu S Li, Dan Long, Tao Lin, Ping Y Li and Li Feng
    Citation: Journal of Biomedical Science 2011 18:79
  26. A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model. We investigated the neuroprotective effects of ADNF-9 against al...

    Authors: Youssef Sari, Zaneer M Segu, Ahmed YoussefAgha, Jonathan A Karty and Dragan Isailovic
    Citation: Journal of Biomedical Science 2011 18:77
  27. Accumulation of amyloid β-peptide (Aβ) in the plaques is one of the major pathological features in Alzheimer's disease (AD). Sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme...

    Authors: Anne Jämsä, Oscar Belda, Michael Edlund and Erik Lindström
    Citation: Journal of Biomedical Science 2011 18:76
  28. Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem. C-phycocyanin (Cpc) i...

    Authors: Li-Chen Wu, Yu-Yun Lin, Szu-Yen Yang, Yu-Ting Weng and Yi-Ting Tsai
    Citation: Journal of Biomedical Science 2011 18:74
  29. The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant ...

    Authors: Jenher Lu, Tzuchun Tsai, Sielin Choo, Shuyu Yeh, Renbing Tang, Anhang Yang, Hsinyu Lee and Jennkan Lu
    Citation: Journal of Biomedical Science 2011 18:73
  30. Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drink...

    Authors: Yu-Jun Lai, Chung-Lieh Hung, Ray-Ching Hong, Ya-Ming Tseng, Cheng-I Lin, Yu-Shien Ko, Cheng-Ho Tsai and Hung-I Yeh
    Citation: Journal of Biomedical Science 2011 18:72
  31. Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway. Presuming a major role of complement as an effecter in peptid...

    Authors: Yu-Huei Liu, Lei Wan, Chwen-Tzuei Chang, Wen-Ling Liao, Wen-Chi Chen, Yuhsin Tsai, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2011 18:71
  32. β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos wit...

    Authors: Yi-Ting Wu, Che Yi Lin, Ming-Yuan Tsai, Yi-Hua Chen, Yu-Fen Lu, Chang-Jen Huang, Chao-Min Cheng and Sheng-Ping L Hwang
    Citation: Journal of Biomedical Science 2011 18:70
  33. Perinatal brain injury is the leading cause of subsequent neurological disability in both term and preterm baby. Glutamate excitotoxicity is one of the major factors involved in perinatal hypoxic-ischemic ence...

    Authors: Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Ching-Jung Lai, Pen Jung Wang and Ted H Chiu
    Citation: Journal of Biomedical Science 2011 18:69
  34. The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia ...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Pei-Hsuan Chen, Ching-Mei Hsu and Lee-Wei Chen
    Citation: Journal of Biomedical Science 2011 18:68
  35. Although recent studies have highlighted the role of epicardial cells during cardiac development and regeneration, their cardiomyogenic potential is still controversial due to the question of lineage tracing o...

    Authors: Bin Zeng, Xiao-feng Ren, Feng Cao, Xiao-yang Zhou and Jing Zhang
    Citation: Journal of Biomedical Science 2011 18:67
  36. Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therap...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai
    Citation: Journal of Biomedical Science 2011 18:65
  37. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2011 18:64
  38. Prostate cancer is the most frequently diagnosed non-cutaneous tumor of men in Western countries. While surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary ...

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su
    Citation: Journal of Biomedical Science 2011 18:63
  39. Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Authors: Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki, Yu Sogo, Atsuo Ito and Akira Matsumura
    Citation: Journal of Biomedical Science 2011 18:62
  40. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang
    Citation: Journal of Biomedical Science 2011 18:61
  41. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi
    Citation: Journal of Biomedical Science 2011 18:60
  42. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li
    Citation: Journal of Biomedical Science 2011 18:59
  43. Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. R...

    Authors: Shan-shan Liu, Xiang-mei Chen, Hong-xia Zheng, Shu-liang Shi and Yu Li
    Citation: Journal of Biomedical Science 2011 18:58
  44. High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...

    Authors: Ke Chen, ping jin, Hong-hui He, Yan-hong Xie, Xiao-yun Xie and Zhao-hui Mo
    Citation: Journal of Biomedical Science 2011 18:57

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