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  1. Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly un...

    Authors: Han-Hsin Chang, Bo-Yie Chen, Chia-Yung Wu, Zih-Jay Tsao, Ying-Yu Chen, Chin-Pao Chang, Chi-Rei Yang and David Pei-Cheng Lin
    Citation: Journal of Biomedical Science 2011 18:6
  2. Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutama...

    Authors: MS Nandhu, Jes Paul, Korah P Kuruvilla, Anitha Malat, Chinthu Romeo and CS Paulose
    Citation: Journal of Biomedical Science 2011 18:5
  3. There are three apolipoprotein E (apoE) isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166) peptides that are tailored to lack domain interactions ar...

    Authors: Yi-Hui Hsieh and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2011 18:4
  4. Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors az...

    Authors: Yi-Shiuan Lin, Arthur Y Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim HM Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:3
  5. Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin,...

    Authors: Chung-Yin Wu, Chih-Ta Lin, Min-Zu Wu and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2011 18:1
  6. The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope g...

    Authors: Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon and Pierre Castelnau
    Citation: Journal of Biomedical Science 2010 17:91
  7. Cytochrome b5 performs central roles in various biological electron transfer reactions, where difference in the redox potential of two reactant proteins provides the driving force. Redox potentials of cytochromes...

    Authors: Tomomi Aono, Yoichi Sakamoto, Masahiro Miura, Fusako Takeuchi, Hiroshi Hori and Motonari Tsubaki
    Citation: Journal of Biomedical Science 2010 17:90
  8. Sodium/iodide symporter (NIS) mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be crit...

    Authors: Chia-Cheng Li, Tin-Yun Ho, Chia-Hung Kao, Shih-Lu Wu, Ji-An Liang and Chien-Yun Hsiang
    Citation: Journal of Biomedical Science 2010 17:89
  9. Effective vaccination against human papillomavirus (HPV) represents an opportunity to control cervical cancer. Peptide-based vaccines targeting HPV E6 and/or E7 antigens while safe, will most likely require ad...

    Authors: Chao-Yi Wu, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu
    Citation: Journal of Biomedical Science 2010 17:88
  10. Melanomas, highly malignant tumors arise from the melanocytes which originate as multipotent neural crest cells during neural tube genesis. The purpose of this study is to assess the pattern of neural differen...

    Authors: Bhanu Iyengar and Avantika V Singh
    Citation: Journal of Biomedical Science 2010 17:87
  11. Bacillus thuringiensis (Bt), an ubiquitous gram-positive spore-forming bacterium forms parasporal proteins during the stationary phase of its growth. Recent findings of selective human cancer cell-killing activit...

    Authors: Kanakeswary Krishnan, Jeremy Er An Ker, Shar Mariam Mohammed and Vishna Devi Nadarajah
    Citation: Journal of Biomedical Science 2010 17:86
  12. Prenatal ethanol exposure during pregnancy induces a spectrum of mental and physical disorders called fetal alcohol spectrum disorder (FASD). The central nervous system is the main organ influenced by FASD, an...

    Authors: Ki Chan Kim, Hyo Sang Go, Hae Rang Bak, Chang Soon Choi, Inha Choi, Pitna Kim, Seol-Heui Han, So Min Han, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2010 17:85
  13. Plumbagin is found in many herbal plants and inhibits the growth of various bacteria. Escherichia coli strains are relatively resistant to this drug. The mechanism of resistance is not clear. Previous findings sh...

    Authors: Ching-Nan Lin, Wan-Jr Syu, Wei-Sheng W Sun, Jenn-Wei Chen, Tai-Hung Chen, Ming-Jaw Don and Shao-Hung Wang
    Citation: Journal of Biomedical Science 2010 17:84
  14. To assess the effects of Glycine tomentella Hayata (GTH), a traditional herbal medicine for treatment of rheumatic diseases on the expression of the proinflammatory cytokines and on the clearance of apoptotic cel...

    Authors: Jia-Hau Yen, Deng-Jye Yang, Meng-Chi Chen, Yu-Fan Hsieh, Yu-Shu Sun and Gregory J Tsay
    Citation: Journal of Biomedical Science 2010 17:83
  15. Multicellular organisms are characterized by a remarkable diversity of morphologically distinct and functionally specialized cell types. Transgenic techniques for the manipulation of gene expression in specifi...

    Authors: Gerard Honig, Angela Liou, Miles Berger, Michael S German and Laurence H Tecott
    Citation: Journal of Biomedical Science 2010 17:82
  16. Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development ...

    Authors: Yu-Huei Liu, Cheng-Hsu Chen, Shih-Yin Chen, Ying-Ju Lin, Wen-Ling Liao, Chang-Hai Tsai, Lei Wan and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:81
  17. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with diverse cytoprotective effects, and reported to have an important role in angiogenesis recently. Here we investigated whether HO-1 transduced by mesenc...

    Authors: Bin Zeng, Guosheng Lin, Xiaofeng Ren, Yan Zhang and Honglei Chen
    Citation: Journal of Biomedical Science 2010 17:80
  18. GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23). Here, we identify three novel mutations in the GLB1 gene from tw...

    Authors: Chi-Fan Yang, Jer-Yuarn Wu and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:79
  19. Diabetes and stress stimulate hippocampal 5-HT synthesis, metabolism and release. The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the ...

    Authors: Pretty Mary Abraham, Korah P Kuruvilla, Jobin Mathew, Anitha Malat, Shilpa Joy and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:78
  20. Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection is well associated with NPC and has been implicated in its pathogenesis. Moreover, var...

    Authors: Peter Han-Chung Yee and Sai-Peng Sim
    Citation: Journal of Biomedical Science 2010 17:77
  21. We postulated that combining high-dose simvastatin with bone marrow derived-mesenchymal stem cells (MSCs) delivery may give better prognosis in a mouse hindlimb ischemia model.

    Authors: Yong Li, Dingguo Zhang, Yuqing Zhang, Guoping He and Fumin Zhang
    Citation: Journal of Biomedical Science 2010 17:75
  22. Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal ad...

    Authors: Xiaojun Liu, Min Zhang, Vay Liang W Go and Shen Hu
    Citation: Journal of Biomedical Science 2010 17:74
  23. Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, t...

    Authors: Aleksandra Klemba, Magdalena Kowalewska, Wojciech Kukwa, Katarzyna Tonska, Aleksandra Szybinska, Malgorzata Mossakowska, Anna Scinska, Paweł Golik, Kamil Koper, Jakub Radziszewski, Andrzej Kukwa, Anna M Czarnecka and Ewa Bartnik
    Citation: Journal of Biomedical Science 2010 17:73
  24. Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem de...

    Authors: Kuang-Yu Dai, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2010 17:72
  25. l-Dopa has been used for Parkinson's disease management for a long time. However, its wide variety in the rate and the extent of absorption remained challenge in designing suitable therapeutic regime. We report.....

    Authors: Chun-Li Wang, Yang-Bin Fan, Hsiao-Hwa Lu, Tung-Hu Tsai, Ming-Cheng Tsai and Hui-Po Wang
    Citation: Journal of Biomedical Science 2010 17:71
  26. Arsenic is a strong stimulus of heme oxygenase (HO)-1 expression in experimental studies in response to oxidative stress caused by a stimulus. A functional GT-repeat polymorphism in the HO-1 gene promoter was ...

    Authors: Meei-Maan Wu, Hung-Yi Chiou, Te-Chang Lee, Chi-Ling Chen, Ling-I Hsu, Yuan-Hung Wang, Wen-Ling Huang, Yi-Chen Hsieh, Tse-Yen Yang, Cheng-Yeh Lee, Ping-Keung Yip, Chih-Hao Wang, Yu-Mei Hsueh and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2010 17:70
  27. It has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabet...

    Authors: Shumei Lin, Jiancheng Yang, Gaofeng Wu, Mei Liu, Xinhong Luan, Qiufeng Lv, He Zhao and Jianmin Hu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S46

    This article is part of a Supplement: Volume 17 Supplement 1

  28. Calculus Bovis (:C.Bovis) is one of the most precious and commonly-used medicinal materials in Japan and China. As the natural occurrence is very rare, a source of supply for C. Bovis is far behind the actual nee...

    Authors: Kyoko Takahashi, Yuko Azuma, Kayoko Shimada, Tadashi Saito, Masaya Kawase and Stephen W Schaffer
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S44

    This article is part of a Supplement: Volume 17 Supplement 1

  29. Lotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in...

    Authors: Huan Du, Jeong-Soon You, Xu Zhao, Ji-Yeon Park, Sung-Hoon Kim and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S42

    This article is part of a Supplement: Volume 17 Supplement 1

  30. The purpose of this study was to investigate the dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students.

    Authors: Ji-Yeon Park, Jeong-Soon You and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S40

    This article is part of a Supplement: Volume 17 Supplement 1

  31. In 1889 Dr. John Bland-Sutton, a prominent London surgeon, was consulted about fatal rickets in over 20 successive litters of lion cubs born at the London Zoo. He evaluated the diet and found the cause of rick...

    Authors: Russell W Chesney and Gail Hedberg
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S36

    This article is part of a Supplement: Volume 17 Supplement 1

  32. Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination f...

    Authors: Atsumi Hamada, Mari Mori, Hideki Mori, Alfa Muhihi, Marina Njelekela, Zablon Masesa, Jacob Mtabaji and Yukio Yamori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S34

    This article is part of a Supplement: Volume 17 Supplement 1

  33. Perinatal taurine exposure influences renal function in adult female offspring. This study tests the hypothesis that prenatal rather than postnatal taurine exposure alters renal function in adult conscious mal...

    Authors: Sanya Roysommuti, Pisamai Malila, Dusit Jirakulsomchok and J Michael Wyss
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S31

    This article is part of a Supplement: Volume 17 Supplement 1

  34. Perinatal taurine exposure has long-term effects on the arterial pressure and renal function. This study tests its influence on renal potassium excretion in young adult, conscious rats. Female Sprague-Dawley r...

    Authors: Sanya Roysommuti, Pisamai Malila, Wichaporn Lerdweeraphon, Dusit Jirakulsomchok and J Michael Wyss
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S29

    This article is part of a Supplement: Volume 17 Supplement 1

  35. Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. We have demonstrated that cisplatin down-regulates the expression of the taurine transporter gene (Ta...

    Authors: Xiaobin Han and Russell W Chesney
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S28

    This article is part of a Supplement: Volume 17 Supplement 1

  36. Adiponectin greatly stimulated the expression of matrix metalloproteinases (MMPs) in fibroblast-like synoviocytes (FLSs) as did IL-1β. We wondered whether taurine chloramine (TauCl) inhibits the production of ...

    Authors: Kyoung Soo Kim, Hyun-Mi Choi, Da Hee Oh, Chaekyun Kim, Jin Seok Jeong, Myung Chul Yoo and Hyung-In Yang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S27

    This article is part of a Supplement: Volume 17 Supplement 1

  37. The β-amino acid, taurine, is a nutritional requirement in some species. In these species, the depletion of intracellular stores of taurine leads to the development of severe organ dysfunction. The basis under...

    Authors: Chian Ju Jong, Takashi Ito, Mahmood Mozaffari, Junichi Azuma and Stephen Schaffer
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S25

    This article is part of a Supplement: Volume 17 Supplement 1

  38. The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Tauri...

    Authors: Svend Høime Hansen, Mogens Larsen Andersen, Claus Cornett, Robert Gradinaru and Niels Grunnet
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S23

    This article is part of a Supplement: Volume 17 Supplement 1

  39. Since taurine (T) administration was proven to decrease blood pressure (BP) and stroke mortality in stroke-prone spontaneously hypertension rates (SHRSP) in the 1980’s and our WHO-coordinated CARDIAC (Cardiova...

    Authors: Yukio Yamori, Takashi Taguchi, Hideki Mori and Mari Mori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S21

    This article is part of a Supplement: Volume 17 Supplement 1

  40. Taurine is a free amino acid present in high concentrations in a variety of organs of mammalians. As an antioxidant, taurine has been found to protect cells against oxidative stress, but the underlying mechani...

    Authors: Chunliu Pan, Grace S Giraldo, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S17

    This article is part of a Supplement: Volume 17 Supplement 1

  41. Fragile X Syndrome is the most common known genetic cause of autism. The Fmr1-KO mouse, lacks the fragile X mental retardation protein (FMRP), and is used as a model of the syndrome. The core behavioral deficits ...

    Authors: Abdeslem El Idrissi, Lorenz S Neuwirth and William L’Amoreaux
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S15

    This article is part of a Supplement: Volume 17 Supplement 1

  42. Taurine and zinc exert neurotrophic effects in the central nervous system. Current studies demonstrate that Na+/Cl- dependent neurotransmitter transporters, similar to that of taurine, are modulated by micromolar...

    Authors: Sonia Nusetti, Mary Urbina and Lucimey Lima
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S13

    This article is part of a Supplement: Volume 17 Supplement 1

  43. Pancreatic β-cells release insulin via an electrogenic response triggered by an increase in plasma glucose concentrations. The critical plasma glucose concentration has been determined to be ~3 mM, at which ti...

    Authors: William J L’Amoreaux, Christina Cuttitta, Allison Santora, Jonathan F Blaize, Janto Tachjadi and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S11

    This article is part of a Supplement: Volume 17 Supplement 1

  44. It has been demonstrated that taurine is one of the most abundant free amino acids in the male reproductive system, and can be biosynthesized by male reproductive organs. But the effect of taurine on male repr...

    Authors: Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lv, Shumei Lin and Jianmin Hu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S9

    This article is part of a Supplement: Volume 17 Supplement 1

  45. Arsenic exposure induces overproduction of reactive nitrogen species (RNS) in brain tissue and results in nucleic acid damage to the nerve cells. The 8-nitroguanine is one of the major products formed by the r...

    Authors: Ning Ma, Mikio Sasoh, Shosuke Kawanishi, Hiromichi Sugiura and Fengyuan Piao
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S7

    This article is part of a Supplement: Volume 17 Supplement 1

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