Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...