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  1. Content type: Review

    Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Authors: Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri

    Citation: Journal of Biomedical Science 2017 24:56

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  2. Content type: Research

    Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG’s effect on warts...

    Authors: Yu-Wen Chu, Shu-Ting Liu, Ya-Lan Yang, Shih-Ming Huang and Wei-Ming Wang

    Citation: Journal of Biomedical Science 2017 24:55

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  3. Content type: Research

    An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cy...

    Authors: Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto and Lien-I Hor

    Citation: Journal of Biomedical Science 2017 24:54

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  4. Content type: Research

    Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary ar...

    Authors: Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao and Liangxing Wang

    Citation: Journal of Biomedical Science 2017 24:52

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  5. Content type: Research

    Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...

    Authors: Yu-Tang Chin, Le-Ming Wang, Meng-Ti Hsieh, Ya-Jung Shih, André Wendindondé Nana, Chun A. Changou, Yu-Chen S. H. Yang, Hsien-Chung Chiu, Earl Fu, Paul J. Davis, Heng-Yuan Tang and Hung-Yun Lin

    Citation: Journal of Biomedical Science 2017 24:51

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  6. Content type: Review

    Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence show...

    Authors: Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu and Christopher W. K. Lai

    Citation: Journal of Biomedical Science 2017 24:50

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  7. Content type: Review

    B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified with...

    Authors: Shin-Huei Fu, Li-Tzu Yeh, Chin-Chen Chu, B. Lin-Ju Yen and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2017 24:49

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  8. Content type: Review

    Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with cognitive impairment. AD is the most common neurodegenerative disease worldwide,...

    Authors: Shih-Ya Hung and Wen-Mei Fu

    Citation: Journal of Biomedical Science 2017 24:47

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  9. Content type: Research

    Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human...

    Authors: Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang and Sheng-Ping L. Hwang

    Citation: Journal of Biomedical Science 2017 24:45

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  10. Content type: Research

    The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate ...

    Authors: Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger and Marcel A. G. van der Heyden

    Citation: Journal of Biomedical Science 2017 24:44

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  11. Content type: Research

    Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythr...

    Authors: Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu and Wei-Chiao Chang

    Citation: Journal of Biomedical Science 2017 24:43

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  12. Content type: Review

    Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects periphe...

    Authors: Peggy Sfyri and Antonios Matsakas

    Citation: Journal of Biomedical Science 2017 24:42

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  13. Content type: Research

    Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF...

    Authors: Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara and Masafumi Kawamura

    Citation: Journal of Biomedical Science 2017 24:41

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  14. Content type: Research

    Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. ...

    Authors: Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin and Hui-Yee Chee

    Citation: Journal of Biomedical Science 2017 24:40

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  15. Content type: Research

    Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Authors: Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu

    Citation: Journal of Biomedical Science 2017 24:38

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  16. Content type: Review

    Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung cancer. Late stage of diagnosis and lack of effec...

    Authors: Chantal Hoi Yin Cheung and Hsueh-Fen Juan

    Citation: Journal of Biomedical Science 2017 24:37

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  17. Content type: Review

    The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial fo...

    Authors: Pey Yee Lee, Siok-Fong Chin, Hui-min Neoh and Rahman Jamal

    Citation: Journal of Biomedical Science 2017 24:36

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  18. Content type: Review

    Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effect...

    Authors: Hwei-Fang Tsai and Ping-Ning Hsu

    Citation: Journal of Biomedical Science 2017 24:35

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  19. Content type: Research

    Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears ...

    Authors: May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang and Henrich Cheng

    Citation: Journal of Biomedical Science 2017 24:34

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  20. Content type: Research

    The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen

    Citation: Journal of Biomedical Science 2017 24:33

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  21. Content type: Research

    In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Authors: Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon

    Citation: Journal of Biomedical Science 2017 24:31

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  22. Content type: Research

    The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen

    Citation: Journal of Biomedical Science 2017 24:30

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  23. Content type: Research

    Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Authors: Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2017 24:29

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  24. Content type: Research

    Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate

    Citation: Journal of Biomedical Science 2017 24:27

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  25. Content type: Review

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Authors: Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Citation: Journal of Biomedical Science 2017 24:26

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  26. Content type: Research

    Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Authors: Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Citation: Journal of Biomedical Science 2017 24:25

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  27. Content type: Research

    Malfunctioning of the serotonergic system in Parkinson’s disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 re...

    Authors: Kryspin Andrzejewski, Katarzyna Kaczyńska and Małgorzata Zaremba

    Citation: Journal of Biomedical Science 2017 24:24

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  28. Content type: Research

    GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Citation: Journal of Biomedical Science 2017 24:23

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  29. Content type: Review

    Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Authors: Susan Marqus, Elena Pirogova and Terrence J. Piva

    Citation: Journal of Biomedical Science 2017 24:21

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  30. Content type: Research

    The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Authors: Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo

    Citation: Journal of Biomedical Science 2017 24:20

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  31. Content type: Research

    Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-...

    Authors: Mei-Yi Lee, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng, Ming-Huan Chan and Hwei-Hsien Chen

    Citation: Journal of Biomedical Science 2017 24:18

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  32. Content type: Review

    Multi voxel magnetic resonance spectroscopic imaging (MRSI) is an important imaging tool that combines imaging and spectroscopic techniques. MRSI of the human brain has been beneficially applied to different c...

    Authors: Oun Al-iedani, Jeannette Lechner-Scott, Karen Ribbons and Saadallah Ramadan

    Citation: Journal of Biomedical Science 2017 24:17

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  33. Content type: Research

    Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulce...

    Authors: Manish Suthar, Saniya Gupta, Suhail Bukhari and Venkatesh Ponemone

    Citation: Journal of Biomedical Science 2017 24:16

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  34. Content type: Review

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    Authors: S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Citation: Journal of Biomedical Science 2017 24:15

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  35. Content type: Review

    Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Authors: Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini

    Citation: Journal of Biomedical Science 2017 24:14

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  36. Content type: Review

    Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Authors: Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov

    Citation: Journal of Biomedical Science 2017 24:13

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  37. Content type: Research

    Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Authors: Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf

    Citation: Journal of Biomedical Science 2017 24:12

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  38. Content type: Review

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Authors: Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Citation: Journal of Biomedical Science 2017 24:10

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  39. Content type: Review

    Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Authors: Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee

    Citation: Journal of Biomedical Science 2017 24:9

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  40. Content type: Research

    Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynam...

    Authors: Sean P. Nassoiy, Kenneth L. Byron and Matthias Majetschak

    Citation: Journal of Biomedical Science 2017 24:8

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  41. Content type: Review

    Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils ar...

    Authors: Bill Cheng, H. C. Chen, I. W. Chou, Tony W. H. Tang and Patrick C. H. Hsieh

    Citation: Journal of Biomedical Science 2017 24:7

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