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  1. Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosi...

    Authors: Yu-An Hsu, Ching-Yao Chang, Joung-Liang Lan, Ju-Pi Li, Hui-Ju Lin, Chih-Sheng Chen, Lei Wan and Fu-Tong Liu
    Citation: Journal of Biomedical Science 2020 27:24
    Content type: Research Published on:

  2. Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CS...

    Authors: Han-Shui Hsu, Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Anna Fen-Yau Li and Shih-Chieh Hung
    Citation: Journal of Biomedical Science 2020 27:5
    Content type: Research Published on:

  3. Enterovirus 71 (EV-A71) is one of the major causative agents of hand, foot, and mouth disease. EV-A71 infection is sometimes associated with severe neurological diseases such as acute encephalitis, acute flacc...

    Authors: Kyousuke Kobayashi and Satoshi Koike
    Citation: Journal of Biomedical Science 2020 27:23
    Content type: Review Published on:

  4. Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA,...

    Authors: Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo and Lih-Chu Chiou
    Citation: Journal of Biomedical Science 2020 27:7
    Content type: Research Published on:

  5. Upon EV-A71 infection of a host cell, EV-A71 RNA is translated into a viral polyprotein. Although EV-A71 can use the cellular translation machinery to produce viral proteins, unlike cellular translation, which...

    Authors: Ming-Chih Lai, Han-Hsiang Chen, Peng Xu and Robert Y. L. Wang
    Citation: Journal of Biomedical Science 2020 27:22
    Content type: Review Published on:

  6. Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for speci...

    Authors: Cheng-Chung Lee, Yu-Cheng Su, Tzu-Ping Ko, Li-Ling Lin, Chih-Ya Yang, Stanley Shi-Chung Chang, Steve R. Roffler and Andrew H.-J. Wang
    Citation: Journal of Biomedical Science 2020 27:12
    Content type: Research Published on:

  7. Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal muc...

    Authors: Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han and Sei-Jung Lee
    Citation: Journal of Biomedical Science 2020 27:21
    Content type: Research Published on:

  8. Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progres...

    Authors: María Belén Vecchione, Natalia Laufer, Omar Sued, Marcelo Corti, Horacio Salomon and Maria Florencia Quiroga
    Citation: Journal of Biomedical Science 2020 27:20
    Content type: Research Published on:

  9. The FDA approved drug granulocyte-colony stimulating factor (G-CSF) displays anti-apoptotic and immunomodulatory properties with neurogenesis and angiogenic functions. It is known to demonstrate neuroprotectiv...

    Authors: Jigar Modi, Janet Menzie-Suderam, Hongyuan Xu, Paola Trujillo, Kristen Medley, Michael L. Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2020 27:19
    Content type: Research Published on:

  10. Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Prese...

    Authors: Li-Kai Huang, Shu-Ping Chao and Chaur-Jong Hu
    Citation: Journal of Biomedical Science 2020 27:18
    Content type: Review Published on:

  11. Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replicati...

    Authors: Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2020 27:17
    Content type: Research Published on:

  12. Over-stimulation of dopamine signaling is thought to underlie the pathophysiology of a list of mental disorders, such as psychosis, mania and attention-deficit/hyperactivity disorder. These disorders are frequ...

    Authors: Pi-Kai Chang, Jung Chu, Ya-Ting Tsai, Yan-Heng Lai and Jin-Chung Chen
    Citation: Journal of Biomedical Science 2020 27:16
    Content type: Research Published on:

  14. Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections...

    Authors: Wen-Chun Huang, Chung-Yen Lin, Masayuki Hashimoto, Jiunn-Jong Wu, Ming-Cheng Wang, Wei-Hung Lin, Chang-Shi Chen and Ching-Hao Teng
    Citation: Journal of Biomedical Science 2020 27:14
    Content type: Research Published on:

  15. Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to d...

    Authors: Torsten Voigtländer, Jochen Metzger, Holger Husi, Martha M. Kirstein, Martin Pejchinovski, Agnieszka Latosinska, Maria Frantzi, William Mullen, Thorsten Book, Harald Mischak and Michael P. Manns
    Citation: Journal of Biomedical Science 2020 27:13
    Content type: Research Published on:

  16. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang
    Citation: Journal of Biomedical Science 2020 27:11
    Content type: Research Published on:

  19. Bacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host. In ...

    Authors: Haejeong Lee, Juyoun Shin, Yeun-Jun Chung, Myungseo Park, Kyeong Jin Kang, Jin Yang Baek, Dongwoo Shin, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2020 27:8
    Content type: Research Published on:

  20. Today, the treatment of bacterial infections is a major challenge, due to growing rate of multidrug-resistant bacteria, complication of treatment and increased healthcare costs. Moreover, new treatments for ba...

    Authors: Shima Afrasiabi, Maryam Pourhajibagher, Reza Raoofian, Maryam Tabarzad and Abbas Bahador
    Citation: Journal of Biomedical Science 2020 27:6
    Content type: Review Published on:

  21. Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal and there is currently no effective antiviral agent or vaccine. The only licensed vaccine, Dengvaxia, has low efficacy...

    Authors: Rui Rui Wong, Noraini Abd-Aziz, Sarah Affendi and Chit Laa Poh
    Citation: Journal of Biomedical Science 2020 27:4
    Content type: Review Published on:

  22. Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated in several solid tumors. We have prev...

    Authors: Jing-You Guo, Chu-Hsuan Chiu, Mei-Jung Wang, Fu-An Li and Jeou-Yuan Chen
    Citation: Journal of Biomedical Science 2020 27:2
    Content type: Research Published on:

  23. It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatica...

    Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li and Han-Chung Wu
    Citation: Journal of Biomedical Science 2020 27:1
    Content type: Review Published on:

  24. In the original publication of this article [1] the name of the fifth author is uncorrect. The correct name of the fifth author should be Wei-Chiao Chang rather than Wei-Chao Chang. The original publication ha...

    Authors: Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang and Yun Yen
    Citation: Journal of Biomedical Science 2019 26:98
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2019 26:96

  25. Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodie...

    Authors: Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2019 26:97
    Content type: Research Published on:

  26. Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic...

    Authors: Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang and Yun Yen
    Citation: Journal of Biomedical Science 2019 26:96
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:98

  28. Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain ...

    Authors: Yu-Jia Wang, Henry Sung-Ching Wong, Chung-Che Wu, Yung-Hsiao Chiang, Wen-Ta Chiu, Kai-Yun Chen and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2019 26:94
    Content type: Research Published on:

  29. Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and Chi...

    Authors: An-Ting Liou, Chun-Che Liao, Shu-Fan Chou, Ya-Shu Chang, Chih-Shin Chang and Chiaho Shih
    Citation: Journal of Biomedical Science 2019 26:93
    Content type: Research Published on:

  30. Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms a...

    Authors: Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori, Mehrnaz Mehrabani and Saeedeh Salimi
    Citation: Journal of Biomedical Science 2019 26:92
    Content type: Research Published on:

  31. Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, wit...

    Authors: Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2019 26:91
    Content type: Research Published on:

  32. Toll-like receptors (TLRs) are well known as critical pattern recognition receptors that trigger innate immune responses. In addition, TLRs are expressed in neurons and may act as the gears in the neuronal det...

    Authors: Chiung-Ya Chen, Yi-Chun Shih, Yun-Fen Hung and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2019 26:90
    Content type: Review Published on:

  33. Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying stra...

    Authors: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum and Thierry Burnouf
    Citation: Journal of Biomedical Science 2019 26:89
    Content type: Research Published on:

  34. Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review intr...

    Authors: Jyong-Huei Lee, Kuan-Lun Ho and Shih-Kang Fan
    Citation: Journal of Biomedical Science 2019 26:88
    Content type: Review Published on:

  35. The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based d...

    Authors: Ching-Ying Huang, Chun-Lin Liu, Chien-Yu Ting, Yueh-Ting Chiu, Yu-Che Cheng, Martin W. Nicholson and Patrick C. H. Hsieh
    Citation: Journal of Biomedical Science 2019 26:87
    Content type: Review Published on:

  39. Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and ...

    Authors: María Ángeles JIMÉNEZ-SOUSA, José Luis JIMÉNEZ, Amanda FERNÁNDEZ-RODRÍGUEZ, José María BELLÓN, Carmen RODRÍGUEZ, Melchor RIERA, Joaquín PORTILLA, Ángeles CASTRO, María Ángeles MUÑOZ-FERNÁNDEZ and Salvador RESINO
    Citation: Journal of Biomedical Science 2019 26:83
    Content type: Research Published on:

  40. MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and identified as an upstream activator of the MAPK J...

    Authors: Huai-Chia Chuang and Tse-Hua Tan
    Citation: Journal of Biomedical Science 2019 26:82
    Content type: Review Published on:

  42. Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degr...

    Authors: Ruey-Hwa Chen, Yu-Hsuan Chen and Tzu-Yu Huang
    Citation: Journal of Biomedical Science 2019 26:80
    Content type: Review Published on:

  44. In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor...

    Authors: Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2019 26:78
    Content type: Review Published on:

  45. Intratumor subsets with tumor-initiating features in glioblastoma are likely to survive treatment. Our goal is to identify the key factor in the process by which cells develop temozolomide (TMZ) resistance.

    Authors: Chia-Hung Chien, Jian-Ying Chuang, Shun-Tai Yang, Wen-Bin Yang, Pin-Yuan Chen, Tsung-I Hsu, Chih-Yuan Huang, Wei-Lun Lo, Ka-Yen Yang, Ming-Sheng Liu, Jui-Mei Chu, Pei-Hsuan Chung, Jr-Jiun Liu, Shao-Wen Chou, Shang-Hung Chen and Kwang-Yu Chang
    Citation: Journal of Biomedical Science 2019 26:77
    Content type: Research Published on:

  46. The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses ...

    Authors: Daria Mezhenskaya, Irina Isakova-Sivak and Larisa Rudenko
    Citation: Journal of Biomedical Science 2019 26:76
    Content type: Review Published on:

  47. Enterovirus A71 (EV-A71) is one of the common causative pathogens for hand foot and mouth disease (HFMD) affecting young children. HFMD outbreak can result in a substantial pediatric hospitalization and burden...

    Authors: Jiratchaya Puenpa, Nasamon Wanlapakorn, Sompong Vongpunsawad and Yong Poovorawan
    Citation: Journal of Biomedical Science 2019 26:75
    Content type: Review Published on:

  48. Complex regional pain syndrome (CRPS) is related to microcirculation impairment caused by tissue hypoxia and peripheral cytokine overproduction in the affected human limb and chronic post-ischemic pain (CPIP) ...

    Authors: Hung-Tsung Hsiao, Yuan-Yuarn Liu, Jeffrey Chi-Fei Wang, Ya-Chi Lin and Yen-Chin Liu
    Citation: Journal of Biomedical Science 2019 26:74
    Content type: Research Published on:

  49. Soft materials have been developed very rapidly in the biomedical field over the past 10 years because of advances in medical devices, cell therapy, and 3D printing for precision medicine. Smart polymers are o...

    Authors: Hung-Jin Huang, Yu-Liang Tsai, Shih-Ho Lin and Shan-hui Hsu
    Citation: Journal of Biomedical Science 2019 26:73
    Content type: Review Published on:

  50. Transforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis. Currently, there are no effective agents targeting TGF-β s...

    Authors: Ying-Jen Chen, Shih-Ming Huang, Ming-Cheng Tai, Jiann-Torng Chen and Chang-Min Liang
    Citation: Journal of Biomedical Science 2019 26:72
    Content type: Research Published on:
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ISSN: 1423-0127