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  1. Content type: Review

    Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, wh...

    Authors: Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2017 24:5

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  2. Content type: Research

    Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxi...

    Authors: Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz and Daria Mochly-Rosen

    Citation: Journal of Biomedical Science 2017 24:3

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  3. Content type: Research

    Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of vi...

    Authors: Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai and Jen-Yang Chen

    Citation: Journal of Biomedical Science 2017 24:2

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  4. Content type: Research

    Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on...

    Authors: Xiaochen Yan, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2017 24:1

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  5. Content type: Review

    Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resul...

    Authors: Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj

    Citation: Journal of Biomedical Science 2016 23:88

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  6. Content type: Research

    Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Authors: Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara

    Citation: Journal of Biomedical Science 2016 23:89

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  7. Content type: Review

    The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for adv...

    Authors: Bin-Chi Liao, Chia-Chi Lin, Jih-Hsiang Lee and James Chih-Hsin Yang

    Citation: Journal of Biomedical Science 2016 23:86

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  8. Content type: Research

    The dengue non-structural 3 (NS3) is a multifunctional protein, containing a serine-protease domain, located at the N-terminal portion, and helicase, NTPase and RTPase domains present in the C-terminal region....

    Authors: M. L. Hurtado-Melgoza, A. Ramos-Ligonio, L. M. Álvarez-Rodríguez, T. Meza-Menchaca and A. López-Monteon

    Citation: Journal of Biomedical Science 2016 23:85

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  9. Content type: Research

    As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a...

    Authors: Dong Zhang, Qing Zhao, Hao Sun, Lijuan Yin, Jiajun Wu, Jun Xu, Tianxiang He, Chunlei Yang and Chengwei Liang

    Citation: Journal of Biomedical Science 2016 23:82

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  10. Content type: Research

    Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM pat...

    Authors: Che-Chia Hsu, Wen-Chang Chang, Tsung-I Hsu, Jr-Jiun Liu, Shiu-Hwa Yeh, Jia-Yi Wang, Jing-Ping Liou, Chiung-Yuan Ko, Kwang-Yu Chang and Jian-Ying Chuang

    Citation: Journal of Biomedical Science 2016 23:81

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  11. Content type: Review

    The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Authors: Stacy L. McAllister, Katherine Sun and Eric R. Gross

    Citation: Journal of Biomedical Science 2016 23:80

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  12. Content type: Research

    In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP). Nevertheless, little is known about the ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, Euclides Avila, Fernando Larrea and Lorenza Díaz

    Citation: Journal of Biomedical Science 2016 23:78

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  13. Content type: Research

    miR-199a-3p was significantly downregulated in the majority of human hepatocellular carcinoma (HCC) tissues and HCC cell lines. Yes associated protein 1 (YAP1) was overexpressed in human HCC, which promoted HC...

    Authors: Kewei Ren, Tengfei Li, Wenzhe Zhang, Jianzhuang Ren, Zhen Li and Gang Wu

    Citation: Journal of Biomedical Science 2016 23:79

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  14. Content type: Review

    A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental...

    Authors: G. S. Sailaja, P. Ramesh, Sajith Vellappally, Sukumaran Anil and H. K. Varma

    Citation: Journal of Biomedical Science 2016 23:77

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  15. Content type: Review

    Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomod...

    Authors: Li-Tzu Wang, Chiao-Hsuan Ting, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, Kenneth K. Wu and B. Linju Yen

    Citation: Journal of Biomedical Science 2016 23:76

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  16. Content type: Review

    Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and...

    Authors: Andrew Yang, Emily Farmer, T. C. Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2016 23:75

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  17. Content type: Review

    MicroRNAs (miRNAs), which are small non-coding RNAs expressed by almost all metazoans, have key roles in the regulation of cell differentiation, organism development and gene expression. Thousands of miRNAs re...

    Authors: Chet Raj Ojha, Myosotys Rodriguez, Seth M. Dever, Rita Mukhopadhyay and Nazira El-Hage

    Citation: Journal of Biomedical Science 2016 23:74

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  18. Content type: Research

    In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitin...

    Authors: Cheng-Fu Chang, Yi-Chao Lee, Kuen-Haur Lee, Hui-Ching Lin, Chia-Ling Chen, Che-Kun James Shen and Chi-Chen Huang

    Citation: Journal of Biomedical Science 2016 23:72

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  19. Content type: Research

    The mechanism of Nova1’s role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 in HCC is unveiled. This study is aimed to make it clear the distribution, prognostic...

    Authors: Yi-An Zhang, Hai-Ning Liu, Ji-Min Zhu, Dan-Ying Zhang, Xi-Zhong Shen and Tao-Tao Liu

    Citation: Journal of Biomedical Science 2016 23:71

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  20. Content type: Review

    A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein...

    Authors: Hong-Tai Tzeng and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2016 23:70

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  21. Content type: Research

    Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liv...

    Authors: Yi-Jen Liao, Tzong-Shyuan Lee, Yuh-Ching Twu, Shih-Ming Hsu, Ching-Ping Yang, Chung-Kwe Wang, Yu-Chih Liang and Yi-Ming Arthur Chen

    Citation: Journal of Biomedical Science 2016 23:69

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  22. Content type: Research

    Chemokine receptor 4 (CXCR4) is a multifunctional G protein-coupled receptor that is activated by its natural ligand, C-X-C motif chemokine 12 (CXCL12). As a likely member of the lipopolysaccharide (LPS)-sensi...

    Authors: Semjon Seemann and Amelie Lupp

    Citation: Journal of Biomedical Science 2016 23:68

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  23. Content type: Review

    Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being hi...

    Authors: Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi and Jafar Majidi

    Citation: Journal of Biomedical Science 2016 23:66

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  24. Content type: Research

    Renal cell carcinoma (RCC) is an adult malignancy with 2:1 men-to-women ratio, which implies the possible role of sex hormones in RCC carcinogenesis. One of the predominant sex hormones in women before menopau...

    Authors: Sheng-Tang Wu, Wei-Chi Ku, Chi-Jung Huang, Yen-Chieh Wang, Chih-Ming Lin and Shao-Kuan Chen

    Citation: Journal of Biomedical Science 2016 23:67

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  25. Content type: Research

    Small ubiquitin-related modifier (SUMO) is a group of proteins that participates in post-translational modifications. One known SUMO target is the transcription factor nuclear factor-kB (NF-kB) that plays a pi...

    Authors: Ching-Yi Tsai, Faith C. H. Li, Carol H. Y. Wu, Alice Y. W. Chang and Samuel H. H. Chan

    Citation: Journal of Biomedical Science 2016 23:65

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  26. Content type: Research

    To better evaluate and improve the efficacy of dendritic cell (DC)-based cancer immunotherapy, we conducted a clinical study of patients with advanced colorectal cancer using carcinoembryonic antigen (CEA)-pul...

    Authors: Ko-Jiunn Liu, Tsu-Yi Chao, Jang-Yang Chang, Ann-Lii Cheng, Hui-Ju Ch’ang, Woei-Yau Kao, Yu-Chen Wu, Wei-Lan Yu, Tsai-Rong Chung and Jacqueline Whang-Peng

    Citation: Journal of Biomedical Science 2016 23:64

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  27. Content type: Review

    Vasoactive intestinal peptide (VIP) plays important roles in many biological functions, such as, stimulation of contractility in the heart, vasodilation, promoting neuroendocrine-immune communication, lowering...

    Authors: Wei Jiang, Hua Wang, Yu-sheng Li and Wei Luo

    Citation: Journal of Biomedical Science 2016 23:63

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  28. Content type: Review

    Alterations in tissue oxygen pressure contribute to a number of diseases, including rheumatoid arthritis (RA). Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it...

    Authors: Celia María Quiñonez-Flores, Susana Aideé González-Chávez and César Pacheco-Tena

    Citation: Journal of Biomedical Science 2016 23:62

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  29. Content type: Review

    The wsb1 gene has been identified to be important in developmental biology and cancer. A complex transcriptional regulation of wsb1 yields at least three functional transcripts. The major expressed isoform, WSB1 ...

    Authors: Moinul Haque, Joseph Keith Kendal, Ryan Matthew MacIsaac and Douglas James Demetrick

    Citation: Journal of Biomedical Science 2016 23:61

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  30. Content type: Research

    Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy and is essential to develop novel therapeutic regimens. Increasing studies indicated that tamoxifen, a selectiv...

    Authors: Sheng-Tang Wu, Guang-Huan Sun, Tai-Lung Cha, Chien-Chang Kao, Sun-Yran Chang, Sheng-Chu Kuo and Tzong-Der Way

    Citation: Journal of Biomedical Science 2016 23:60

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  31. Content type: Research

    The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis even in early-stage patients. We aimed to identify a prognostic panel with multiple DNA methylation biomarkers to pr...

    Authors: I-Ying Kuo, Jayu Jen, Lien-Huei Hsu, Han-Shui Hsu, Wu-Wei Lai and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2016 23:58

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  32. Content type: Research

    Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previousl...

    Authors: Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao and Yung-Jen Chuang

    Citation: Journal of Biomedical Science 2016 23:59

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  33. Content type: Research

    Autophagy participates in plaque formation and progression; however, its association with foam cells’ fate is unknown. To investigate autophagy features and its effect on the fate of different-stage macrophage...

    Authors: Xiaopeng Liu, Yue Tang, Yongchun Cui, Hong Zhang and Dong Zhang

    Citation: Journal of Biomedical Science 2016 23:57

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  34. Content type: Research

    The impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.

    Authors: Yue Fan, Kumi Futawaka, Rie Koyama, Yuki Fukuda, Misa Hayashi, Miyuki Imamoto, Takashi Miyawaki, Masato Kasahara, Tetsuya Tagami and Kenji Moriyama

    Citation: Journal of Biomedical Science 2016 23:56

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  35. Content type: Research

    Numerous studies have demonstrated that the NDV-mediated gene therapy is a promising new approach for treatment of cancers. P53 plays a vital role in tumor suppression and surveillance. Therefore, we hypothesi...

    Authors: Ying An, Tianyan Liu, Jinjiao He, Hongsong Wu, Rui Chen, Yunye Liu, Yunzhou Wu, Yin Bai, Xiaochen Guo, Qi Zheng, Chang Liu, Jiechao Yin, Deshan Li and Guiping Ren

    Citation: Journal of Biomedical Science 2016 23:55

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  36. Content type: Review

    Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, inclu...

    Authors: Jayu Jen and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2016 23:53

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  37. Content type: Research

    Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed ...

    Authors: Xiaoqin Wang, Zhengyu Zhang, Gang Wu, Changlong Nan, Wen Shen, Yimin Hua and Xupei Huang

    Citation: Journal of Biomedical Science 2016 23:51

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  38. Content type: Research

    The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer’s disease and people with mild cognitive impairment. However, the therapeutic potential ...

    Authors: Tzeng Tsai-Teng, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Lu Chung-Kuang, Shen Chien-Chang, Huang F. Chi-Ying, Chen Chien-Chih and Young-Ji Shiao

    Citation: Journal of Biomedical Science 2016 23:49

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  39. Content type: Research

    Recently, NAD+ has been considered as an essential factor, participating in nerve control of physiological functions and intercellular communication. NAD+ also has been supposed as endogenous activator of P1 a...

    Authors: Vladislav S. Kuzmin, Ksenia B. Pustovit and Denis V. Abramochkin

    Citation: Journal of Biomedical Science 2016 23:50

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  40. Content type: Research

    Down syndrome (DS), caused by triplication of human chromosome 21, is the most common aneuploidies. The main characteristic of DS patients is intellectual disability. MicroRNAs (miRNAs) play important regulato...

    Authors: Wei-li Shi, Zhong-zhen Liu, Hong-dan Wang, Dong Wu, Hui Zhang, Hai Xiao, Yan Chu, Qiao-fang Hou and Shi-xiu Liao

    Citation: Journal of Biomedical Science 2016 23:48

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  41. Content type: Research

    Resveratrol, a phytoalexin found in grapes and red wine, exhibits diverse pharmacological activities. However, relatively little is known about whether resveratrol modulates the ion channels in cortical neuron...

    Authors: Ya-Jean Wang, Ming-Huan Chan, Linyi Chen, Sheng-Nan Wu and Hwei-Hisen Chen

    Citation: Journal of Biomedical Science 2016 23:47

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  42. Content type: Research

    Healing of bone defects is a dynamic and orchestrated process that relies on multiple growth factors and cell types. Bone morphogenetic protein 2 (BMP2) is a key growth factor for bone healing, which stimulate...

    Authors: Hyuck Choi, Byung-Chul Jeong, Min-Suk Kook and Jeong-Tae Koh

    Citation: Journal of Biomedical Science 2016 23:45

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