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  1. Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations...

    Authors: Jin-Ok Choi, Mi Hee Lee, Hae-Young Park and Sung-Chul Jung
    Citation: Journal of Biomedical Science 2010 17:26
  2. The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candid...

    Authors: Ahmed S Abdel-Moneim, Ahmad E Abdel-Ghany and Salama AS Shany
    Citation: Journal of Biomedical Science 2010 17:25
  3. The association of TGF β1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The p...

    Authors: Yongzheng Wang, Xuwei Hou and Yuliang Li
    Citation: Journal of Biomedical Science 2010 17:23
  4. The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms ...

    Authors: Wei Sun, Wen-Wen Shen, Shuang Yang, Fen Hu, Yang Gao, Yu-Huan Qiao and Tian-Hui Zhu
    Citation: Journal of Biomedical Science 2010 17:22
  5. Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need of alternative cancer therapies. Moreover, the success of novel cancer therapies depends on their se...

    Authors: S Patyar, R Joshi, DS Prasad Byrav, A Prakash, B Medhi and BK Das
    Citation: Journal of Biomedical Science 2010 17:21
  6. Pulmonary veins (PVs) are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation. Elimination...

    Authors: Yung-Kuo Lin, Yen-Yu Lu, Yao-Chang Chen, Yi-Jen Chen and Shih-Ann Chen
    Citation: Journal of Biomedical Science 2010 17:20
  7. Diffuse noxious inhibitory controls (DNIC) can be produced by different types of conditioning stimuli, but the analgesic properties and underlying mechanisms remain unclear. The aim of this study was to differ...

    Authors: Yeong-Ray Wen, Chia-Chuan Wang, Geng-Chang Yeh, Sheng-Feng Hsu, Yung-Jen Huang, Yen-Li Li and Wei-Zen Sun
    Citation: Journal of Biomedical Science 2010 17:19
  8. Akt regulates various cellular processes, including cell growth, survival, and metabolism. Recently, Akt's role in neurite outgrowth has also emerged. We thus aimed to identify neuronal function-related genes ...

    Authors: Young-Tae Ro, Bo-Kwang Jang, Chan Young Shin, Eui U Park, Chul Geun Kim and Sung-Il Yang
    Citation: Journal of Biomedical Science 2010 17:18
  9. As the origin of a life-and-death signal detected from systemic arterial pressure, which sequentially increases (pro-life) and decreases (pro-death) to reflect progressive dysfunction of central cardiovascular...

    Authors: Samuel HH Chan, Enya YH Sun and Alice YW Chang
    Citation: Journal of Biomedical Science 2010 17:17
  10. Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Rece...

    Authors: Gang Wu, Changlong Nan, Johnathon C Rollo, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2010 17:16
  11. Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expres...

    Authors: Kou-Gi Shyu, Bao-Wei Wang, Chiu-Mei Lin and Hang Chang
    Citation: Journal of Biomedical Science 2010 17:15
  12. Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magneti...

    Authors: Maria A Macri, Nicola D'Alessandro, Camillo Di Giulio, Patrizia Di Iorio, Silvano Di Luzio, Patricia Giuliani, Ennio Esposito and Mieczyslaw Pokorski
    Citation: Journal of Biomedical Science 2010 17:14
  13. Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious pu...

    Authors: Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Wen-Fang Tang, Ming-sian Wu, Jiann-Yih Yeh, Yu-Sheng Chao, John TA Hsu, Hsing-Pang Hsieh and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2010 17:13
  14. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction,...

    Authors: Chyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau and Wen-Harn Pan
    Citation: Journal of Biomedical Science 2010 17:12
  15. Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of ...

    Authors: Bertrand Chin-Ming Tan, Hsuan Liu, Chih-Li Lin and Sheng-Chung Lee
    Citation: Journal of Biomedical Science 2010 17:11
  16. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasio...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra
    Citation: Journal of Biomedical Science 2010 17:10
  17. Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well establish...

    Authors: Chieh-Sen Chuang, Hong-Lin Su, Fu-Chou Cheng, Shan-hui Hsu, Chi-Fen Chuang and Chin-San Liu
    Citation: Journal of Biomedical Science 2010 17:9
  18. Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, ou...

    Authors: A Luquita, L Urli, MJ Svetaz, AM Gennaro, ME Giorgetti, G Pistone, R Volpintesta, S Palatnik and M Rasia
    Citation: Journal of Biomedical Science 2010 17:8
  19. Glucose homeostasis in humans is an important factor for the functioning of nervous system. Hypoglycemia and hyperglycemia is found to be associated with central and peripheral nerve system dysfunction. Change...

    Authors: Sherin Antony, Peeyush Kumar T, Jobin Mathew, TR Anju and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:7
  20. Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC...

    Authors: Qifeng Jiang, Renjian Huang, Shaoxi Cai and Chih-Lueh A Wang
    Citation: Journal of Biomedical Science 2010 17:6
  21. Androgen ablation is one of the viable therapeutic options for patients with primary hormone (androgen)-dependent prostate cancer. However, an antibiotic brefeldin A (BFA) has been shown to exhibit the growth ...

    Authors: Srinivas Rajamahanty, Catherine Alonzo, Shahrad Aynehchi, Muhammad Choudhury and Sensuke Konno
    Citation: Journal of Biomedical Science 2010 17:5
  22. Caffeine, a nonselective adenosine A1 and A2A receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact...

    Authors: Chih W Hsu, Chin S Wang and Ted H Chiu
    Citation: Journal of Biomedical Science 2010 17:4
  23. The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of...

    Authors: Paul Gutwein, Anja Schramme, Mohamed Sadek Abdel-Bakky, Kai Doberstein, Ingeborg A Hauser, Andreas Ludwig, Peter Altevogt, Stefan Gauer, Anja Hillmann, Thomas Weide, Christine Jespersen, Wolfgang Eberhardt and Josef Pfeilschifter
    Citation: Journal of Biomedical Science 2010 17:3
  24. Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be con...

    Authors: Jurandir F Comar, Fumie Suzuki-Kemmelmeier, Jorgete Constantin and Adelar Bracht
    Citation: Journal of Biomedical Science 2010 17:1
  25. Several lines of evidence point to a particularly important role of the left atrium (LA) in initiating and maintaining atrial fibrillation (AF). This role may be related to the location of pulmonary veins (PVs...

    Authors: Yue-Xia Loh, Kuo-Ho Wu, Yao-Chang Chen, Chih-Hsiung Hsu, Jeng Wei and Cheng-I Lin
    Citation: Journal of Biomedical Science 2009 16:114
  26. The uptake of abortion-inducing pathogens by trophoblast giant (TG) cells is a key event in infectious abortion. However, little is known about phagocytic functions of TG cells against the pathogens. Here we s...

    Authors: Kenta Watanabe, Masato Tachibana, Suk Kim and Masahisa Watarai
    Citation: Journal of Biomedical Science 2009 16:113
  27. An important role in atherogenesis is played by oxidative stress, which may be induced by common risk factors. Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidenc...

    Authors: Paolo Puddu, Giovanni M Puddu, Eleonora Cravero, Susanna De Pascalis and Antonio Muscari
    Citation: Journal of Biomedical Science 2009 16:112
  28. After publication of our article, it was noted that we inadvertently failed to include the complete list of authors. The full list, including co-authors, has now been added and the Authors' contributions and C...

    Authors: Sang Soo Hah, Paul T Henderson and Kenneth W Turteltaub
    Citation: Journal of Biomedical Science 2009 16:111

    The original article was published in Journal of Biomedical Science 2009 16:54

  29. Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing ...

    Authors: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger and Ching-Shih Chen
    Citation: Journal of Biomedical Science 2009 16:110
  30. Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve ...

    Authors: Anuradha Subramanian, Uma Maheswari Krishnan and Swaminathan Sethuraman
    Citation: Journal of Biomedical Science 2009 16:108
  31. Human cytomegalovirus (HCMV) is known to induce chromosome aberrations in infected cells, which can lead to congenital abnormalities in infected fetuses. HCMV UL76 belongs to a conserved protein family from he...

    Authors: Voon-Kwan Siew, Chang-Yih Duh and Shang-Kwei Wang
    Citation: Journal of Biomedical Science 2009 16:107
  32. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2009 16:106
  33. Epithelial-mesenchymal transition (EMT) is an important process in tumor metastasis. The EMT-related events associated with metastasis of NPC in the absence of EBV have not been elucidated. We established an E...

    Authors: Jung-Chung Lin, Shuen-Kuei Liao, En-Huei Lee, Man-Shan Hung, Yiyang Sayion, Hung-Chang Chen, Chen-Chen Kang, Liang-Sheng Huang and Jaw-Ming Cherng
    Citation: Journal of Biomedical Science 2009 16:105
  34. Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paral...

    Authors: Jing-Yi Lin, Tzu-Chun Chen, Kuo-Feng Weng, Shih-Cheng Chang, Li-Lien Chen and Shin-Ru Shih
    Citation: Journal of Biomedical Science 2009 16:103
  35. Anaemia is a frequent complication of infection with the human immunodeficiency virus (HIV) and may have multiple causes. The objective of this study was to find out if blood haemoglobin measurement could be u...

    Authors: Christian Obirikorang and Francis A Yeboah
    Citation: Journal of Biomedical Science 2009 16:102
  36. The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillator...

    Authors: Mario Vassalle, John N Catanzaro, Michael P Nett and Marcello Rota
    Citation: Journal of Biomedical Science 2009 16:101
  37. The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have establish...

    Authors: Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai and Jeng-Fan Lo
    Citation: Journal of Biomedical Science 2009 16:100
  38. Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotr...

    Authors: Savitha Balakrishnan, Peeyush Kumar T and CS Paulose
    Citation: Journal of Biomedical Science 2009 16:99
  39. Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from m...

    Authors: Yuanbin Liu and David R Schubert
    Citation: Journal of Biomedical Science 2009 16:98
  40. To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (h PSCs). Human cho...

    Authors: Shin-Han Tsai, Ming-Thau Sheu, Yu-Chih Liang, Hsiu-Tan Cheng, Sheng-Shiung Fang and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2009 16:97
  41. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intri...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang
    Citation: Journal of Biomedical Science 2009 16:96
  42. The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by gl...

    Authors: Yi-Ruu Lin, Hwei-Hsien Chen, Yu-Chin Lin, Chien-Hsin Ko and Ming-Huan Chan
    Citation: Journal of Biomedical Science 2009 16:94
  43. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De
    Citation: Journal of Biomedical Science 2009 16:93
  44. Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogeneis, we took a novel approach based on phenotype chan...

    Authors: Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye and Bing Sun
    Citation: Journal of Biomedical Science 2009 16:92
  45. Bacterial adherence to epithelial cells is a key virulence trait of pathogenic bacteria. The type 1 fimbriae and the P-fimbriae of uropathogenic Escherichia coli (UPEC) have both been described to be important fo...

    Authors: Kun-Wei Tsai, Hong-Thih Lai, Tzung-Chieh Tsai, Yi-Chien Wu, Ya-Ting Yang, Kwei-Yi Chen, Chun-Ming Chen, Yi-Shuan J Li and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2009 16:91

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