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1065 result(s) for 'antibody' within Journal of Biomedical Science

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  1. Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing ...

    Authors: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger and Ching-Shih Chen
    Citation: Journal of Biomedical Science 2009 16:110
    Content type: Research Published on:

  2. Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen
    Citation: Journal of Biomedical Science 2009 16:35
    Content type: Research Published on:

  3. Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10) contributes to distant migration of PDAC. The role of KLF1...

    Authors: Yi-Chih Tsai, Kung Hung Cheng, Shih Sheng Jiang, John R. Hawse, Shun En Chuang, Su Liang Chen, Tze-Sing Huang and Hui-Ju Ch’ang
    Citation: Journal of Biomedical Science 2023 30:39
    Content type: Research Published on:

  4. Open-access databases were utilized to examine the association of PTX3 expression and the fibroblast signature in colon cancer. Loss-of-function assays, including studies in tamoxifen-induced Ptx3...knockout mice...

    Authors: Feng-Wei Chen, Yung-Ling Wu, Chao-Chun Cheng, Yu-Wei Hsiao, Jhih-Ying Chi, Liang-Yi Hung, Chih-Peng Chang, Ming-Derg Lai and Ju-Ming Wang
    Citation: Journal of Biomedical Science 2024 31:10
    Content type: Research Published on:

  5. Dystonia musculorum (dt) is an autosomal recessive hereditary neuropathy with a characteristic uncoordinated movement and is caused by a defect in the bullous pemphigoid antigen 1 (BPAG1) gene. The neural isoform...

    Authors: Kuang-Wen Tseng, Mei-Lin Peng, Yang-Cheng Wen, Kang-Jen Liu and Chung-Liang Chien
    Citation: Journal of Biomedical Science 2011 18:9
    Content type: Research Published on:

  7. Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immuni...

    Authors: Patricia Ruiz-Limon, Maria Lourdes Ladehesa-Pineda, Maria del Carmen Castro-Villegas, Maria del Carmen Abalos-Aguilera, Clementina Lopez-Medina, Chary Lopez-Pedrera, Nuria Barbarroja, Daniel Espejo-Peralbo, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Carlos Perez-Sanchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Pilar Font-Ugalde and Yolanda Jimenez-Gomez
    Citation: Journal of Biomedical Science 2020 27:54
    Content type: Research Published on:

  8. Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate...

    Authors: Neha Pandey, Meghana Rastogi and Sunit K. Singh
    Citation: Journal of Biomedical Science 2021 28:52
    Content type: Research Published on:

  9. Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been i...

    Authors: Mohamed Fouda Salama, Henry K Bayele and Surjit SK Srai
    Citation: Journal of Biomedical Science 2012 19:83
    Content type: Research Published on:

  10. Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosine (m6A) modification is a type of RNA modification that regulates metabolism of mRNAs. Pre...

    Authors: Dipayan Bose, Xiang Lin, Le Gao, Zhi Wei, Yonggang Pei and Erle S. Robertson
    Citation: Journal of Biomedical Science 2023 30:18
    Content type: Research Published on:

  11. Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each yea...

    Authors: Saumya Sinha, Kinjal Singh, Y. S. Ravi Kumar, Riya Roy, Sushant Phadnis, Varsha Meena, Sankar Bhattacharyya and Bhupendra Verma
    Citation: Journal of Biomedical Science 2024 31:43
    Content type: Review Published on:

  12. Mainstay haemophilia treatment, namely intravenous factor replacement, poses several clinical challenges including frequent injections due to the short half-life of recombinant factors, intravenous administrat...

    Authors: Dide Okaygoun, Danielle D. Oliveira, Sooriya Soman and Riccardo Williams
    Citation: Journal of Biomedical Science 2021 28:64
    Content type: Review Published on:

  13. Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functio...

    Authors: Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan and Eng-King Tan
    Citation: Journal of Biomedical Science 2024 31:24
    Content type: Research Published on:

  14. In the present study, we explore the role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced apoptosis in human lung adenocarcinoma (A549) cells. Denbinobin-induced cell apoptosis was attenua...

    Authors: Chen-Tzu Kuo, Bing-Chang Chen, Chung-Chi Yu, Chih-Ming Weng, Ming-Jen Hsu, Chien-Chih Chen, Mei-Chieh Chen, Che-Ming Teng, Shiow-Lin Pan, Mauo-Ying Bien, Chung-Hung Shih and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2009 16:43
    Content type: Research Published on:

  15. The three test phytochemicals considerably increased the expression of DAMPs including HSP70, HSP90 and HMGB1, but had no effect on expression of calreticulin (CRT). DC vaccines pulsed with MDA-treated tumor cell...

    Authors: Chih-Chun Wen, Hui-Ming Chen, Swey-Shen Chen, Li-Ting Huang, Wei-Ting Chang, Wen-Chi Wei, Li-Chen Chou, Palanisamy Arulselvan, Jin-Bin Wu, Sheng-Chu Kuo and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2011 18:44
    Content type: Research Published on:

  16. Sustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly activated by cAMP (Epac1 and Epac2) as key mediators. This study aimed to e...

    Authors: Yi-Hsin Chan, Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen and Yung-Hsin Yeh
    Citation: Journal of Biomedical Science 2023 30:55
    Content type: Research Published on:

  17. Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial–mesenchymal transition (EMT) process. Centrosome is an organelle that functions as the ma...

    Authors: Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou and Tang K. Tang
    Citation: Journal of Biomedical Science 2022 29:24
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2024 31:35

  18. High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw
    Citation: Journal of Biomedical Science 2009 16:51
    Content type: Research Published on:

  19. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to s...

    Authors: María Victoria Castro, Gastón Alexis Barbero, María Belén Villanueva, Luca Grumolato, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada and Pablo Lopez-Bergami
    Citation: Journal of Biomedical Science 2021 28:76
    Content type: Research Published on:

  20. Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with exten...

    Authors: Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng and Che Ma
    Citation: Journal of Biomedical Science 2020 27:33
    Content type: Review Published on:

  21. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2011 18:64
    Content type: Research Published on:

  22. RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like par...

    Authors: Meng-Ing Chou, Yu-Fan Hsieh, Meilin Wang, Jinghua Tsai Chang, Deching Chang, Moncef Zouali and Gregory J Tsay
    Citation: Journal of Biomedical Science 2010 17:51
    Content type: Research Published on:

  23. Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttle...

    Authors: Hongxing Gui, Chi-Wei Lu, Sandra Adams, Victor Stollar and Mei-Ling Li
    Citation: Journal of Biomedical Science 2010 17:59
    Content type: Research Published on:

  24. The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The mol...

    Authors: Chia-Hsiang Hsueh, Wen-Pin Chen, Jiunn-Lee Lin, Chia-Ti Tsai, Yen-Bin Liu, Jyh-Ming Juang, Hsuan-Ming Tsao, Ming-Jai Su and Ling-Ping Lai
    Citation: Journal of Biomedical Science 2009 16:23
    Content type: Research Published on:

  25. Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection is well associated with NPC and has been implicated in its pathogenesis. Moreover, var...

    Authors: Peter Han-Chung Yee and Sai-Peng Sim
    Citation: Journal of Biomedical Science 2010 17:77
    Content type: Research Published on:

  28. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. However, the mechanisms of miR-155 functions as an oncomiR are mainly unknown. In this study, the aims ...

    Authors: Chun-Mei Zhang, Jing Zhao and Hua-Yu Deng
    Citation: Journal of Biomedical Science 2013 20:79
    Content type: Research Published on:

  29. Pancreatic β-cells release insulin via an electrogenic response triggered by an increase in plasma glucose concentrations. The critical plasma glucose concentration has been determined to be ~3 mM, at which ti...

    Authors: William J L’Amoreaux, Christina Cuttitta, Allison Santora, Jonathan F Blaize, Janto Tachjadi and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S11
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  30. Japanese encephalitis (JE) virus is the most common cause of epidemic viral encephalitis in the world. The virus mainly infects neuronal cells and causes an inflammatory response after invasion of the parenchyma ...

    Authors: Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang and Wei-June Chen
    Citation: Journal of Biomedical Science 2011 18:20
    Content type: Research Published on:

  31. Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages an...

    Authors: Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang and Robert Anderson
    Citation: Journal of Biomedical Science 2018 25:77
    Content type: Review Published on:

  33. In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor...

    Authors: Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2019 26:78
    Content type: Review Published on:

  34. CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the...

    Authors: Francesca Rusconi, Hrishikesh Thakur, Jinliang Li and Michael S Kapiloff
    Citation: Journal of Biomedical Science 2013 20:56
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2014 21:45

  35. Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic ...

    Authors: Zhenyu Tang, Zongming Gong and Xiaoliang Sun
    Citation: Journal of Biomedical Science 2018 25:4
    Content type: Research Published on:

  36. Maternal epileptic seizures during pregnancy can affect the hippocampal neurons in the offspring. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is expressed in the developing central nervo...

    Authors: Aliakbar Rajabzadeh, Alireza Ebrahimzadeh Bideskan, Alireza Fazel, Mojtaba Sankian, Houshang Rafatpanah and Hossein Haghir
    Citation: Journal of Biomedical Science 2012 19:56
    Content type: Research Published on:

  37. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski
    Citation: Journal of Biomedical Science 2009 16:81
    Content type: Research Published on:

  38. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek
    Citation: Journal of Biomedical Science 2009 16:79
    Content type: Research Published on:

  39. PUMA protein and mRNA were up-regulated in the shunt group as compared with sham group. The increased PUMA protein expression and apoptosis induced by shunt was reversed by treatment with atorvastatin at 30 mg/kg...

    Authors: Wen-Pin Cheng, Gong-Jhe Wu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2012 19:72
    Content type: Research Published on:

  40. Metastatic renal cell carcinoma (RCC) is highly resistant to systemic chemotherapy. Unfortunately, nearly all patients die of the metastatic and chemoresistant RCC. Recent studies have shown the atypical PKCζ ...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Jyue-Yu Chen, Wang-Yi Kang, Ying-Chu Lin, Yu-Shiang Shiu, Shu-Ju Chuang, Hong-Jeng Yu, Ming-Kuen Lai, Yu-Chieh Tsai, Wen-Jeng Wu and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2012 19:39
    Content type: Research Published on:

  41. N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in m...

    Authors: Tsung-Chieh Chen, José Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh and Bai-Chuang Shyu
    Citation: Journal of Biomedical Science 2012 19:55
    Content type: Research Published on:

  44. Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutama...

    Authors: MS Nandhu, Jes Paul, Korah P Kuruvilla, Anitha Malat, Chinthu Romeo and CS Paulose
    Citation: Journal of Biomedical Science 2011 18:5
    Content type: Research Published on:

  45. H-rev107, also called HRASLS3 or PLA2G16, is a member of the HREV107 type II tumor suppressor gene family. Previous studies showed that H-rev107 exhibits phospholipase A/acyltransferase (PLA/AT) activity and d...

    Authors: Chun-Hua Wang, Rong-Yaun Shyu, Chang-Chieh Wu, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2014 21:36
    Content type: Research Published on:

  47. Esophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility....

    Authors: Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and Hung-Chi Cheng
    Citation: Journal of Biomedical Science 2020 27:102
    Content type: Research Published on:

  48. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
    Content type: Research Published on:

  49. Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evide...

    Authors: Shih-Ron Hsieh, Chen-Sen Hsu, Chen-Hua Lu, Wei-Cheng Chen, Chun-Hwei Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2013 20:86
    Content type: Research Published on:

  50. Mutation in the Wiskott-Aldrich syndrome Protein (WASP) causes Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN). The majority of missense mutations caus...

    Authors: Neeraj Jain, Jun Hou Tan, Shijin Feng, Bhawana George and Thirumaran Thanabalu
    Citation: Journal of Biomedical Science 2014 21:91
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127