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222 result(s) for 'genetics' within Journal of Biomedical Science

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  1. Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes causing...

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees
    Citation: Journal of Biomedical Science 2018 25:82
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:31

  2. MicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy...

    Authors: Roshni Roy, Navonil De Sarkar, Sandip Ghose, Ranjan R Paul, Anindita Ray, Indranil Mukhopadhyay and Bidyut Roy
    Citation: Journal of Biomedical Science 2014 21:48
    Content type: Research Published on:

  3. The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms ...

    Authors: Wei Sun, Wen-Wen Shen, Shuang Yang, Fen Hu, Yang Gao, Yu-Huan Qiao and Tian-Hui Zhu
    Citation: Journal of Biomedical Science 2010 17:22
    Content type: Research Published on:

  4. The treatment of AIDS remains a serious challenge owing to high genetic variation of Human Immunodeficiency Virus type 1 (HIV-1). The use of different antiretroviral drugs (ARV) is significantly limited by sev...

    Authors: Lakshmi N Ramana, Swaminathan Sethuraman, Udaykumar Ranga and Uma M Krishnan
    Citation: Journal of Biomedical Science 2010 17:57
    Content type: Research Published on:

  5. Several studies have demonstrated a fundamental role for the HLA in the susceptibility of, or protection to, type 1 diabetes mellitus (T1DM). However, this has not been adequately studied in Asian Indian popul...

    Authors: Oindrila Raha, Biswanath Sarkar, Bhaskar VKS Lakkakula, Veerraju Pasumarthy, Sudhakar Godi, Subhankar Chowdhury, Pradip Raychaudhuri and Raghavendra Rao Vadlamudi
    Citation: Journal of Biomedical Science 2013 20:12
    Content type: Research Published on:

  6. Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.

    Authors: Lukkana Suksanpaisan, Tharinee Susantad and Duncan R Smith
    Citation: Journal of Biomedical Science 2009 16:17
    Content type: Research Published on:

  7. Artemin (ARTN) is a neurotrophic factor belonging to the glial cell-derived neurotrophic factor family of ligands. To develop potential therapy targeting ARTN, we studied the roles of miR-223 in the migration ...

    Authors: Shujun Li, Zhigang Li, Fengjie Guo, Xuebo Qin, Bin Liu, Zhe Lei, Zuoqing Song, Liya Sun, Hong-Tao Zhang, Jiacong You and Qinghua Zhou
    Citation: Journal of Biomedical Science 2011 18:24
    Content type: Research Published on:

  8. Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development ...

    Authors: Yu-Huei Liu, Cheng-Hsu Chen, Shih-Yin Chen, Ying-Ju Lin, Wen-Ling Liao, Chang-Hai Tsai, Lei Wan and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:81
    Content type: Research Published on:

  9. Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of...

    Authors: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
    Citation: Journal of Biomedical Science 2013 20:8
    Content type: Research Published on:

  10. GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23). Here, we identify three novel mutations in the GLB1 gene from tw...

    Authors: Chi-Fan Yang, Jer-Yuarn Wu and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:79
    Content type: Research Published on:

  11. In the present study we identified a novel gene, Homo Sapiens Chromosome 1 ORF109 (c1orf109, GenBank ID: NM_017850.1), which encodes a substrate of CK2. We analyzed the regulation mode of the gene, the expression...

    Authors: Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He, Yang Yu, You-peng Qu, Lei Yue, Yao Zhang and Yu Li
    Citation: Journal of Biomedical Science 2012 19:49
    Content type: Research Published on:

  12. MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however...

    Authors: Genesio M Karere, Jeremy P Glenn, John L VandeBerg and Laura A Cox
    Citation: Journal of Biomedical Science 2010 17:54
    Content type: Research Published on:

  13. Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based...

    Authors: Pablo Matar, Laura Alaniz, Viviana Rozados, Jorge B Aquino, Mariana Malvicini, Catalina Atorrasagasti, Manuel Gidekel, Marcelo Silva, O Graciela Scharovsky and Guillermo Mazzolini
    Citation: Journal of Biomedical Science 2009 16:30
    Content type: Review Published on:

  14. Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and furt...

    Authors: Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng and Shang-Hsun Yang
    Citation: Journal of Biomedical Science 2021 28:59
    Content type: Review Published on:

  15. With the advancement of next generation sequencing technologies (NGS), whole-genome sequencing (WGS) has been deployed to a wide range of clinical scenarios. Rapid and accurate classification of drug-resistant My...

    Authors: Ming-Chih Yu, Ching-Sheng Hung, Chun-Kai Huang, Cheng-Hui Wang, Yu-Chih Liang and Jung-Chun Lin
    Citation: Journal of Biomedical Science 2021 28:86
    Content type: Research Published on:

  16. The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product re...

    Authors: Marcella Martinelli, Luca Scapoli, Francesca Cura, Maria Teresa Rodia, Giampaolo Ugolini, Isacco Montroni and Rossella Solmi
    Citation: Journal of Biomedical Science 2014 21:89
    Content type: Research Published on:

  17. Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/o...

    Authors: Patience Shumba, Thomas Sura, Kirsten Moll, Bhavya Chakrakodi, Lea A. Tölken, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
    Citation: Journal of Biomedical Science 2023 30:52
    Content type: Research Published on:

  18. The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse l...

    Authors: Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu and Ting-Fen Tsai
    Citation: Journal of Biomedical Science 2022 29:53
    Content type: Research Published on:

  19. Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each yea...

    Authors: Saumya Sinha, Kinjal Singh, Y. S. Ravi Kumar, Riya Roy, Sushant Phadnis, Varsha Meena, Sankar Bhattacharyya and Bhupendra Verma
    Citation: Journal of Biomedical Science 2024 31:43
    Content type: Review Published on:

  21. Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA ...

    Authors: Chia-Ling Hsu, Shin Yen Chong, Chia-Yeh Lin and Cheng-Fu Kao
    Citation: Journal of Biomedical Science 2021 28:48
    Content type: Review Published on:

  22. Bactericidal activity of traditional titanium dioxide (TiO2) photocatalyst is effective only upon irradiation by ultraviolet light, which restricts the potential applications of TiO2 for use in our living environ...

    Authors: Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang
    Citation: Journal of Biomedical Science 2009 16:7
    Content type: Research Published on:

  23. Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells...

    Authors: Rasmus O Bak and Jacob G Mikkelsen
    Citation: Journal of Biomedical Science 2010 17:53
    Content type: Review Published on:

  24. The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, belong to a family of neurological disorders that cause blindness, seizures, loss of motor function and cognitive ability, and prema...

    Authors: Robert J. Huber
    Citation: Journal of Biomedical Science 2020 27:64
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:94

  25. Maternal epileptic seizures during pregnancy can affect the hippocampal neurons in the offspring. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is expressed in the developing central nervo...

    Authors: Aliakbar Rajabzadeh, Alireza Ebrahimzadeh Bideskan, Alireza Fazel, Mojtaba Sankian, Houshang Rafatpanah and Hossein Haghir
    Citation: Journal of Biomedical Science 2012 19:56
    Content type: Research Published on:

  26. In non-excitable cells, one major route for calcium entry is through store-operated calcium (SOC) channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ store. STIM1 a...

    Authors: I-Hui Yang, Yao-Ting Tsai, Siou-Jin Chiu, Li-Teh Liu, Hsuan-Hung Lee, Ming-Feng Hou, Wen-Li Hsu, Ben-Kuen Chen and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2013 20:41
    Content type: Research Published on:

  27. Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infe...

    Authors: Lea A. Tölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers and Nikolai Siemens
    Citation: Journal of Biomedical Science 2024 31:26
    Content type: Research Published on:

  29. Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpos...

    Authors: Yu-Huei Liu, Ching-Chu Chen, Li-Ling Liao, Lei Wan, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2012 19:97
    Content type: Research Published on:

  30. Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) ...

    Authors: Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund and Thomas G Jensen
    Citation: Journal of Biomedical Science 2011 18:10
    Content type: Review Published on:

  31. Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they ...

    Authors: Roy A. Wise and Chloe J. Jordan
    Citation: Journal of Biomedical Science 2021 28:83
    Content type: Review Published on:

  32. Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio...

    Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, Fei-Yun Chen, Hsin-Yi Chen and Ruey-Hwa Chen
    Citation: Journal of Biomedical Science 2022 29:30
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:59

  33. Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Cas...

    Authors: Mel Campbell and Yoshihiro Izumiya
    Citation: Journal of Biomedical Science 2020 27:41
    Content type: Review Published on:

  37. The fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants have been identified in fusiform intracranial aneurysms, the molecular...

    Authors: Li Hao, Xiaolong Ya, Jiaye Wu, Chuming Tao, Ruochen Ma, Zhiyao Zheng, Siqi Mou, Yiming Ling, Yingxi Yang, Jiguang Wang, Yan Zhang, Qing Lin and Jizong Zhao
    Citation: Journal of Biomedical Science 2024 31:51
    Content type: Research Published on:

  38. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
    Content type: Research Published on:

  39. Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended t...

    Authors: Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang and Yong-Qing Yang
    Citation: Journal of Biomedical Science 2009 16:46
    Content type: Research Published on:

  40. CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing...

    Authors: Guzide Bender, Rezan Fahrioglu Yamaci and Bahar Taneri
    Citation: Journal of Biomedical Science 2021 28:77
    Content type: Review Published on:

  41. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2020 27:46
    Content type: Research Published on:

  42. Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells ...

    Authors: Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne and Shaw-Fang Yet
    Citation: Journal of Biomedical Science 2022 29:25
    Content type: Research Published on:

  43. Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood...

    Authors: Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu…
    Citation: Journal of Biomedical Science 2023 30:13
    Content type: Research Published on:

  44. Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major chal...

    Authors: Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim and Seungkwon You
    Citation: Journal of Biomedical Science 2020 27:56
    Content type: Research Published on:

  45. Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acety...

    Authors: Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai and Yih Ho
    Citation: Journal of Biomedical Science 2011 18:8
    Content type: Research Published on:

  46. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang
    Citation: Journal of Biomedical Science 2011 18:61
    Content type: Research Published on:

  47. With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcrib...

    Authors: Chih-Fan Yeh, Yu-Chen Eugene Chang, Cheng-Yuan Lu, Chin-Feng Hsuan, Wei-Tien Chang and Kai-Chien Yang
    Citation: Journal of Biomedical Science 2020 27:48
    Content type: Review Published on:

  48. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang
    Citation: Journal of Biomedical Science 2020 27:11
    Content type: Research Published on:

  50. Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological ...

    Authors: Tse-Chun Kuo, Hsing-Jien Kung and Jing-Wen Shih
    Citation: Journal of Biomedical Science 2020 27:59
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127