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356 result(s) for 'screening test' within Journal of Biomedical Science

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  3. Global ischemia is the resulting effect of a cardiopulmonary arrest (CPA). Presently there is no effective treatment to address neurological deficits in patients who survived a CPA. Granulocyte-colony stimulat...

    Authors: Janet M. Menzie-Suderam, Jigar Modi, Hongyaun Xu, Andrew Bent, Paula Trujillo, Kristen Medley, Eugenia Jimenez, Jessica Shen, Michael Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2020 27:99
    Content type: Research Published on:

  4. Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biom...

    Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2019 26:20
    Content type: Research Published on:

  6. MicroRNAs (miRNAs), a class of highly conserved small non-coding RNA molecules, are known to play essential roles in central nervous system (CNS) by causing post-transcriptional gene silencing. There is much e...

    Authors: Si Yun Shu, Di Qing, Bin Wang, Qi-yi Zeng, Yan-chen Chen, Ying Jin, Chang-chun Zeng and Rong Bao
    Citation: Journal of Biomedical Science 2013 20:9
    Content type: Research Published on:

  7. The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. T...

    Authors: Jaung-Geng Lin, Guan-Jhong Huang and Yi-Chang Su
    Citation: Journal of Biomedical Science 2023 30:30
    Content type: Review Published on:

  8. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li
    Citation: Journal of Biomedical Science 2011 18:59
    Content type: Research Published on:

  9. mTOR is a genetically conserved serine/threonine protein kinase, which controls cell growth, proliferation, and survival. A multifunctional protein CAD, catalyzing the initial three steps in de novo pyrimidine sy...

    Authors: Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa and Kazuyoshi Yonezawa
    Citation: Journal of Biomedical Science 2013 20:24
    Content type: Research Published on:

  10. O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible modification is catalysed by a uniq...

    Authors: Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud and Patrick Pagesy
    Citation: Journal of Biomedical Science 2022 29:64
    Content type: Review Published on:

  11. Pigmentation in human skin is an important defense mechanism against sunlight or oxidative stress. Despite the protective role of melanin, abnormal hyperpigmentation such as freckles and chloasma sometimes can...

    Authors: Ji Sun Yu and An Keun Kim
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S45
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  12. Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss...

    Authors: Shao-Hsuan Hsia, Jainn-Jim Lin, Oi-Wa Chan and Tzou-Yien Lin
    Citation: Journal of Biomedical Science 2020 27:53
    Content type: Review Published on:

  13. The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publication...

    Authors: Carlotta Camilli, Alexandra E. Hoeh, Giulia De Rossi, Stephen E. Moss and John Greenwood
    Citation: Journal of Biomedical Science 2022 29:6
    Content type: Review Published on:

  14. Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of vir...

    Authors: Szu-Cheng Kuo, Ying-Ju Chen, Yu-Ming Wang, Pei-Yi Tsui, Ming-Der Kuo, Tzong-Yuan Wu and Szecheng J Lo
    Citation: Journal of Biomedical Science 2012 19:44
    Content type: Research Published on:

  15. Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to...

    Authors: Hyang-Min Byun, Kyu Heo, Kasey J Mitchell and Allen S Yang
    Citation: Journal of Biomedical Science 2012 19:13
    Content type: Research Published on:

  16. A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 20...

    Authors: Min-Han Lin, Shang-Ju Chuang, Chiao-Che Chen, Shu-Chun Cheng, Kai-Wen Cheng, Chao-Hsiung Lin, Chiao-Yin Sun and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2014 21:54
    Content type: Research Published on:

  17. Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio...

    Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, Fei-Yun Chen, Hsin-Yi Chen and Ruey-Hwa Chen
    Citation: Journal of Biomedical Science 2022 29:30
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:59

  18. Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodie...

    Authors: Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2019 26:97
    Content type: Research Published on:

  19. The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang
    Citation: Journal of Biomedical Science 2018 25:76
    Content type: Research Published on:

  20. Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells...

    Authors: Rasmus O Bak and Jacob G Mikkelsen
    Citation: Journal of Biomedical Science 2010 17:53
    Content type: Review Published on:

  21. Obesity is nowadays considered a pandemic which prevalence’s has been steadily increasingly in western countries. It is a dynamic, complex, and multifactorial disease which propitiates the development of sever...

    Authors: José Antônio Fagundes Assumpção, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martín Hernan Bonamino and Kelly Grace Magalhães
    Citation: Journal of Biomedical Science 2022 29:12
    Content type: Review Published on:

  22. Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation...

    Authors: Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang and Hai Hu
    Citation: Journal of Biomedical Science 2023 30:44
    Content type: Research Published on:

  23. Enzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion p...

    Authors: Katrin P Guillen, Carla Kurkjian and Roger G Harrison
    Citation: Journal of Biomedical Science 2014 21:65
    Content type: Research Published on:

  24. Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major chal...

    Authors: Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim and Seungkwon You
    Citation: Journal of Biomedical Science 2020 27:56
    Content type: Research Published on:

  25. Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regene...

    Authors: Ih-Jen Su, Lily Hui-Ching Wang, Wen-Chuan Hsieh, Han-Chieh Wu, Chiao-Fang Teng, Hung-Wen Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2014 21:98
    Content type: Review Published on:

  26. Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and l...

    Authors: Alexandra Tikhomirova, Emmylee R. McNabb, Luca Petterlin, Georgia L. Bellamy, Kyaw H. Lin, Christopher A. Santoso, Ella S. Daye, Fatimah M. Alhaddad, Kah Peng Lee and Anna Roujeinikova
    Citation: Journal of Biomedical Science 2024 31:45
    Content type: Review Published on:

  27. The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts a...

    Authors: Lucia Sophie Kilian, Jakob Voran, Derk Frank and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2021 28:33
    Content type: Review Published on:

  28. The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in ...

    Authors: Zhengquan Wu, Bernd Uhl, Olivier Gires and Christoph A. Reichel
    Citation: Journal of Biomedical Science 2023 30:21
    Content type: Research Published on:

  29. The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a s...

    Authors: Valentina Arrè, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro
    Citation: Journal of Biomedical Science 2023 30:90
    Content type: Review Published on:

  30. Curiosity on toxin–antitoxin modules has increased intensely over recent years as it is ubiquitously present in many bacterial genomes, including pathogens like Methicillin-resistant Staphylococcus aureus (MRSA)....

    Authors: Sonia Jain, Arghya Bhowmick, Bohyun Jeong, Taeok Bae and Abhrajyoti Ghosh
    Citation: Journal of Biomedical Science 2022 29:28
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily...

    Authors: Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha
    Citation: Journal of Biomedical Science 2021 28:39
    Content type: Review Published on:

  32. Lymphangiogenesis is one of the major causes of corneal graft rejection. Among the lymphangiogenic factors, vascular endothelial growth factor (VEGF)-C and -D are considered to be the most potent. Both bind to...

    Authors: Minkoo Seo, Jun-Sub Choi, Chang Rae Rho, Choun-Ki Joo and Suk Kyeong Lee
    Citation: Journal of Biomedical Science 2015 22:3
    Content type: Research Published on:

  33. Developing brain is a major target for alcohol’s actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies ha...

    Authors: Amanjot Kaur Riar, Madhusudhanan Narasimhan, Mary Latha Rathinam, George I. Henderson and Lenin Mahimainathan
    Citation: Journal of Biomedical Science 2016 23:6
    Content type: Research Published on:

  34. Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney ...

    Authors: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen and Shuei-Liong Lin
    Citation: Journal of Biomedical Science 2021 28:73
    Content type: Research Published on:

  35. The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence is a leading clinical bottleneck in NPC. Revealing the mechanism of NPC radioresistance wi...

    Authors: Panpan Zhang, Xiaomin Li, Qiuping He, Lulu Zhang, Keqing Song, Xiaojing Yang, Qingmei He, Yaqin Wang, Xiaohong Hong, Jun Ma and Na Liu
    Citation: Journal of Biomedical Science 2020 27:30
    Content type: Research Published on:

  36. Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genet...

    Authors: Yu-Wen Hsu, Henry Sung-Ching Wong, Wan-Chen Huang, Yi-Hung Yeh, Chwan-Deng Hsiao, Wei-Chiao Chang and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:43
    Content type: Research Published on:

  37. Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as...

    Authors: Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung and David K. Ann
    Citation: Journal of Biomedical Science 2023 30:32
    Content type: Research Published on:

  38. Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying stra...

    Authors: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum and Thierry Burnouf
    Citation: Journal of Biomedical Science 2019 26:89
    Content type: Research Published on:

  39. Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/o...

    Authors: Patience Shumba, Thomas Sura, Kirsten Moll, Bhavya Chakrakodi, Lea A. Tölken, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
    Citation: Journal of Biomedical Science 2023 30:52
    Content type: Research Published on:

  40. Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications.

    Authors: Huixin Chen, Patchara Phuektes, Li Sze Yeo, Yi Hao Wong, Regina Ching Hua Lee, Bowen Yi, Xinjun Hou, Sen Liu, Yu Cai and Justin Jang Hann Chu
    Citation: Journal of Biomedical Science 2024 31:8
    Content type: Research Published on:

  41. Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

    Authors: Hong-Yi Chang, Hsin-Mei Chang, Tsung-Jung Wu, Chang-Yao Chaing, Tzong-Shin Tzai, Hong-Lin Cheng, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2017 24:61
    Content type: Research Published on:

  42. The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally ...

    Authors: Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh and Li-Mei Pai
    Citation: Journal of Biomedical Science 2011 18:42
    Content type: Research Published on:

  43. Psychological investigations and functional imaging technology have been used to describe neural correlations of different types of memory with various stimuli. Memory with limited storage capacity and a short...

    Authors: Jingxin Nie, Zengqiang Zhang, Bin Wang, Hong Li, Jianghua Xu, Sheng Wu, Chunhua Zhu, Xin Yang, Bin Liu, Yongming Wu, Sheng Tan, Zhibo Wen, Jinlong Zheng, Siyun Shu and Lin Ma
    Citation: Journal of Biomedical Science 2019 26:22
    Content type: Research Published on:

  44. Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood–brain barrier (BBB) activity. A panel of sesamin ...

    Authors: Chien-Wei Hou, Yi-Ling Chen, Shih-Hsien Chuang, Jen-Shu Wang and Kee-Ching Jeng
    Citation: Journal of Biomedical Science 2014 21:15
    Content type: Research Published on:

  45. The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.

    Authors: Luciano da Silva Lopes, Rosemarie Brandin Marques, Heliana Barros Fernandes, Sergio da Silva Pereira, Mariane CC Ayres, Mariana Helena Chaves and Fernanda RC Almeida
    Citation: Journal of Biomedical Science 2012 19:68
    Content type: Research Published on:

  46. Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with exten...

    Authors: Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng and Che Ma
    Citation: Journal of Biomedical Science 2020 27:33
    Content type: Review Published on:

  48. Post-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent addition of a small chemi...

    Authors: Prithviraj Manohar Vijaya Shetty, Ashraf Yusuf Rangrez and Norbert Frey
    Citation: Journal of Biomedical Science 2020 27:98
    Content type: Review Published on:

  49. Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate immunity to viral nucleic acids mediates ...

    Authors: Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing and Zhiqiang Zhang
    Citation: Journal of Biomedical Science 2022 29:55
    Content type: Research Published on:

  50. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub...

    Authors: Mi-Hyun Lee, Hye Lin Kim, Hyejun Seo, Sangkwon Jung and Bum-Joon Kim
    Citation: Journal of Biomedical Science 2023 30:95
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127