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  1. The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair t...

    Authors: Chiao-Chi V Chen, Yu-Chen Chen, Han-Yun Hsiao, Chen Chang and Yijuang Chern
    Citation: Journal of Biomedical Science 2013 20:47
    Content type: Review Published on:

  2. Prostate smooth muscle tone is regulated by α1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outs...

    Authors: Martin Hennenberg, Frank Strittmatter, Henning Schmetkamp, Beata Rutz, Sebastian Walther, Christian G Stief and Christian Gratzke
    Citation: Journal of Biomedical Science 2013 20:46
    Content type: Research Published on:

  3. Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mi...

    Authors: Xuemei Zhang, Chao Wang, Guangyao Song, Kexin Gan, Dexian Kong, Qian Nie and Luping Ren
    Citation: Journal of Biomedical Science 2013 20:45
    Content type: Research Published on:

  4. gp340, a member of scavenger receptor cysteine rich family encoded by Deleted in Malignant Brain Tumors 1 (DMBT1), is an important component in innate immune defense. The first scavenger receptor cysteine rich do...

    Authors: Ying Chu, Jiahuang Li, Xilin Wu, Zichun Hua and Zhiwei Wu
    Citation: Journal of Biomedical Science 2013 20:44
    Content type: Research Published on:

  5. Dysregulated epidermal growth factor receptor (EGFR)-phosphoinositide-3-kinase (PI3K)-AKT signaling is considered pivotal for oral cancer, and the pathway is a potential candidate for therapeutic targeting.

    Authors: Kwang-Yu Chang, Shan-Yin Tsai, Shang-Hung Chen, Hsiao-Hui Tsou, Chia-Jui Yen, Ko-Jiunn Liu, Hsun-Lang Fang, Hung-Chang Wu, Bin-Fay Chuang, Shao-Wen Chou, Careen K Tang, Shyun-Yeu Liu, Pei-Jung Lu, Ching-Yu Yen and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2013 20:43
    Content type: Research Published on:

  6. Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in t...

    Authors: Yung-Chun Chuang, Shu-Ying Wang, Yee-Shin Lin, Hong-Ru Chen and Trai-Ming Yeh
    Citation: Journal of Biomedical Science 2013 20:42
    Content type: Review Published on:

  7. In non-excitable cells, one major route for calcium entry is through store-operated calcium (SOC) channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ store. STIM1 a...

    Authors: I-Hui Yang, Yao-Ting Tsai, Siou-Jin Chiu, Li-Teh Liu, Hsuan-Hung Lee, Ming-Feng Hou, Wen-Li Hsu, Ben-Kuen Chen and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2013 20:41
    Content type: Research Published on:

  8. Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, invo...

    Authors: Tsung-Ting Tsai, Yi-Jui Chuang, Yee-Shin Lin, Shu-Wen Wan, Chia-Ling Chen and Chiou-Feng Lin
    Citation: Journal of Biomedical Science 2013 20:40
    Content type: Review Published on:

  9. Placenta growth factor (PlGF), a dimeric glycoprotein with 53% homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and may function by modulating VEGF activity. We previousl...

    Authors: Shu-Chen Wei, Po-Nien Tsao, Meng-Tzu Weng, Zhifang Cao and Jau-Min Wong
    Citation: Journal of Biomedical Science 2013 20:39
    Content type: Research Published on:

  10. Effective and validated animal models are valuable to investigate the pathogenesis and potential therapeutics for human diseases. There is much concern for diabetic retinopathy (DR) in that it affects substant...

    Authors: Dong Hyun Jo, Chang Sik Cho, Jin Hyoung Kim, Hyoung Oh Jun and Jeong Hun Kim
    Citation: Journal of Biomedical Science 2013 20:38
    Content type: Review Published on:

  11. Dengue is one of the most important emerging vector-borne viral diseases. There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-thre...

    Authors: Shu-Wen Wan, Chiou-Feng Lin, Shuying Wang, Yu-Hung Chen, Trai-Ming Yeh, Hsiao-Sheng Liu, Robert Anderson and Yee-Shin Lin
    Citation: Journal of Biomedical Science 2013 20:37
    Content type: Review Published on:

  13. Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to...

    Authors: Murat Topuzogullari, Rabia Cakir Koc, Sevil Dincer Isoglu, Melahat Bagirova, Zeynep Akdeste, Serhat Elcicek, Olga N Oztel, Serap Yesilkir Baydar, Sezen Canim Ates and Adil M Allahverdiyev
    Citation: Journal of Biomedical Science 2013 20:35
    Content type: Research Published on:

  15. TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range ...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng and Che-Kun James Shen
    Citation: Journal of Biomedical Science 2013 20:33
    Content type: Research Published on:

  16. To characterize single nucleotide polymorphisms (SNPs) within the promoter region of the estrogen receptor beta (ERβ) gene and to analyze the association of ERβ SNPs with susceptibility to breast cancer. Genot...

    Authors: Li Chen, Yan Liang, Juhui Qiu, Lingling Zhang, Xianchun Chen, Xiangdong Luo and Jun Jiang
    Citation: Journal of Biomedical Science 2013 20:32
    Content type: Research Published on:

  17. Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due to lack of understanding in OA pathology. To better understand ...

    Authors: Jinsoo Song, Dongkyun Kim, Chang Hoon Lee, Myeung Su Lee, Churl-Hong Chun and Eun-Jung Jin
    Citation: Journal of Biomedical Science 2013 20:31
    Content type: Research Published on:

  18. H-rev107 is a member of the HREV107 type II tumor suppressor gene family which includes H-REV107, RIG1, and HRASLS. H-REV107 has been shown to express at high levels in differentiated tissues of post-meiotic t...

    Authors: Rong-Yaun Shyu, Chang-Chieh Wu, Chun-Hua Wang, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2013 20:30
    Content type: Research Published on:

  19. Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant.

    Authors: Raúl Teruel, Irene Martínez-Martínez, José A Guerrero, Rocío González-Conejero, María E de la Morena-Barrio, Salam Salloum-Asfar, Ana B Arroyo, Sonia Águila, Nuria García-Barberá, Antonia Miñano, Vicente Vicente, Javier Corral and Constantino Martínez
    Citation: Journal of Biomedical Science 2013 20:29
    Content type: Research Published on:

  20. Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and dev...

    Authors: Abdolhamid Meimandi-Parizi, Ahmad Oryan and Ali Moshiri
    Citation: Journal of Biomedical Science 2013 20:28
    Content type: Research Published on:

  21. Antibodies against spliceosome Sm proteins (anti-Sm autoantibodies) are specific to the autoimmune disease systemic lupus erythematosus (SLE). Anti-Sm autosera have been reported to specifically recognize Sm D...

    Authors: Hong-How Chang, Huan-Hsuan Hu, Yu-Jen Lee, Hung-Ming Wei, Ming-Chun Fan-June, Tsai-Ching Hsu, Gregory J Tsay and Chuan Li
    Citation: Journal of Biomedical Science 2013 20:27
    Content type: Research Published on:

  23. Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substituti...

    Authors: Hiroko Terui, Kiwamu Akagi, Hiroshi Kawame and Kei Yura
    Citation: Journal of Biomedical Science 2013 20:25
    Content type: Research Published on:

  24. mTOR is a genetically conserved serine/threonine protein kinase, which controls cell growth, proliferation, and survival. A multifunctional protein CAD, catalyzing the initial three steps in de novo pyrimidine sy...

    Authors: Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa and Kazuyoshi Yonezawa
    Citation: Journal of Biomedical Science 2013 20:24
    Content type: Research Published on:

  25. Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...

    Authors: Yih-Fung Chen, Ying-Ting Chen, Wen-Tai Chiu and Meng-Ru Shen
    Citation: Journal of Biomedical Science 2013 20:23
    Content type: Review Published on:

  26. Somatic mutations of the epidermal growth factor receptor (EGFR) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the mu...

    Authors: Tiffany Ng Shi Yeen, Rajadurai Pathmanathan, Mohd Sidik Shiran, Fattah Azman Ahmad Zaid and Yoke Kqueen Cheah
    Citation: Journal of Biomedical Science 2013 20:22
    Content type: Research Published on:

  27. Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2013 20:21
    Content type: Erratum Published on:

    The original article was published in Journal of Biomedical Science 2012 19:91

  28. A recessive mutation “c” in the Mexican axolotl, Ambystoma mexicanum, results in the failure of normal heart development. In homozygous recessive embryos, the hearts do not have organized myofibrils and fail to b...

    Authors: Andrei Kochegarov, Ashley Moses, William Lian, Jessica Meyer, Michael C Hanna and Larry F Lemanski
    Citation: Journal of Biomedical Science 2013 20:20
    Content type: Research Published on:

  29. Influenza virus has antigen drift and antigen shift effect, vaccination with some influenza vaccine might not induce sufficient immunity for host to the threat of other influenza virus strains. S-OIV H1N1 and ...

    Authors: Hui-Tsu Lin, Chuan-Chang Chuang, Hsieh-Ling Wu, Der-Ming Chu and Yeau-Ching Wang
    Citation: Journal of Biomedical Science 2013 20:19
    Content type: Research Published on:

  31. Houttuynia cordata Thunb (HCT) is commonly used in Taiwan and other Asian countries as an anti-inflammatory, antibacterial and antiviral herbal medicine. In this study, we investigated the anti-human lung cancer ...

    Authors: Yuh-Fung Chen, Jai-Sing Yang, Wen-Shin Chang, Shih-Chang Tsai, Shu-Fen Peng and Yuan-Ru Zhou
    Citation: Journal of Biomedical Science 2013 20:18
    Content type: Research Published on:

  32. Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not cl...

    Authors: Chien-Jung Chang, Yao-Chang Chen, Yung-Kuo Lin, Jen-Hung Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:17
    Content type: Research Published on:

  33. Targeted therapy of human cancers is an attractive approach and has been investigated with limited success. We have developed novel cytotoxic agents for targeted therapy of human cancers based on the extracell...

    Authors: Derek V Chan, Rahul Sharma, Chiao-Ying A Ju, Steve R Roffler and Shyr-Te Ju
    Citation: Journal of Biomedical Science 2013 20:16
    Content type: Research Published on:

  34. MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to invol...

    Authors: Pravin Kumar Singh, Ajay Vir Singh and Devendra Singh Chauhan
    Citation: Journal of Biomedical Science 2013 20:14
    Content type: Review Published on:

  35. In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and ...

    Authors: Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Luis F Jave-Suárez, Ruth De Célis-Carrillo, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomeli and Pablo Cesar Ortiz-Lazareno
    Citation: Journal of Biomedical Science 2013 20:13
    Content type: Research Published on:

  36. Several studies have demonstrated a fundamental role for the HLA in the susceptibility of, or protection to, type 1 diabetes mellitus (T1DM). However, this has not been adequately studied in Asian Indian popul...

    Authors: Oindrila Raha, Biswanath Sarkar, Bhaskar VKS Lakkakula, Veerraju Pasumarthy, Sudhakar Godi, Subhankar Chowdhury, Pradip Raychaudhuri and Raghavendra Rao Vadlamudi
    Citation: Journal of Biomedical Science 2013 20:12
    Content type: Research Published on:

  37. Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autono...

    Authors: Hsiu-Jen Wang, Alexis G Martin, Po-Kuan Chao, Rhett A Reichard, Adam L Martin, Yue-wern Huang, Ming-Huan Chan and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:11
    Content type: Research Published on:

  38. The central molecule in the pathogenesis of Alzheimer’s disease (AD) is believed to be a small-sized polypeptide – beta amyloid (Aβ) which has an ability to assemble spontaneously into oligomers. Various studi...

    Authors: Indre Dalgediene, Rita Lasickiene, Rima Budvytyte, Gintaras Valincius, Ramune Morkuniene, Vilmante Borutaite and Aurelija Zvirbliene
    Citation: Journal of Biomedical Science 2013 20:10
    Content type: Research Published on:

  39. MicroRNAs (miRNAs), a class of highly conserved small non-coding RNA molecules, are known to play essential roles in central nervous system (CNS) by causing post-transcriptional gene silencing. There is much e...

    Authors: Si Yun Shu, Di Qing, Bin Wang, Qi-yi Zeng, Yan-chen Chen, Ying Jin, Chang-chun Zeng and Rong Bao
    Citation: Journal of Biomedical Science 2013 20:9
    Content type: Research Published on:

  40. Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of...

    Authors: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
    Citation: Journal of Biomedical Science 2013 20:8
    Content type: Research Published on:

  42. Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. A complex network of transcription factors and signaling molecules are required ...

    Authors: Mohammad Mahdi Forghanifard, Meysam Moghbeli, Reza Raeisossadati, Alireza Tavassoli, Afsaneh Javdani Mallak, Samaneh Boroumand-Noughabi and Mohammad Reza Abbaszadegan
    Citation: Journal of Biomedical Science 2013 20:6
    Content type: Research Published on:

  43. Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...

    Authors: Xia Wang, Yadi Wang, Yue Wang, Jian Cheng, Yanyun Wang and Minwen Ha
    Citation: Journal of Biomedical Science 2013 20:5
    Content type: Research Published on:

  45. IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and i...

    Authors: Wei-Chien Huang and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2013 20:3
    Content type: Review Published on:

  46. Previously, we had identified a specific whole blood–derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was des...

    Authors: Ching-Hua Hsieh, Johnson Chia-Shen Yang, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Siou-Ling Tzeng, Yi-Chan Wu, Chia-Jung Wu and Cheng-Shyuan Rau
    Citation: Journal of Biomedical Science 2013 20:2
    Content type: Research Published on:

  47. Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell different...

    Authors: Jing-Yi Lin, Jau-Shiuh Chen, Pei-Chun Chen, Ming-Hui Chung, Ching-Yi Liu, Shi-Chuen Miaw and Li-Fang Wang
    Citation: Journal of Biomedical Science 2013 20:1
    Content type: Research Published on:

  48. Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicit...

    Authors: Md Golam Sharoar, Arjun Thapa, Mohammad Shahnawaz, Vijay Sankar Ramasamy, Eun-Rhan Woo, Song Yub Shin and Il-Seon Park
    Citation: Journal of Biomedical Science 2012 19:104
    Content type: Research Published on:

  49. Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially...

    Authors: Varinder K Lall, Mathias Dutschmann, Jim Deuchars and Susan A Deuchars
    Citation: Journal of Biomedical Science 2012 19:103
    Content type: Research Published on:

  50. Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-...

    Authors: Ya-Ping Tsai and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2012 19:102
    Content type: Review Published on:
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Journal of Biomedical Science

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