Skip to main content

Articles

Page 26 of 32

  1. The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ni...

    Authors: Yi-Chen Hsieh, Sudha Seshadri, Wen-Ting Chung, Fang-I Hsieh, Yi-Hsiang Hsu, Huey-Juan Lin, Hung-Pin Tseng, Li-Ming Lien, Chyi-Huey Bai, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Chin-I Chen, Chia-Chen Yu and Hung-Yi Chiou
    Citation: Journal of Biomedical Science 2012 19:1
    Content type: Research Published on:

  2. The covalently closed-circular DNA (cccDNA) of hepatitis B virus (HBV) is associated with viral persistence in HBV-infected hepatocytes. However, the regulation of cccDNA and its transcription in the host cell...

    Authors: Chin-Liew Chong, Mong-Liang Chen, Yi-Chieh Wu, Kuen-Nan Tsai, Chien-Chiao Huang, Cheng-po Hu, King-Song Jeng, Yu-Chi Chou and Chungming Chang
    Citation: Journal of Biomedical Science 2011 18:96
    Content type: Research Published on:

  3. The aim of the present study was to assess the effect of dietary supplementation (copper or copper and resveratrol) on the intensity of carcinogenesis and the frequency of microsatellite instability in a widel...

    Authors: Barbara Bobrowska, Dorota Skrajnowska and Andrzej Tokarz
    Citation: Journal of Biomedical Science 2011 18:95
    Content type: Research Published on:

  4. Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inf...

    Authors: Wen-Chi Wei, Sheng-Yen Lin, Yi-Jyun Chen, Chih-Chun Wen, Chiung-Yao Huang, Arulselvan Palanisamy, Ning-Sun Yang and Jyh-Horng Sheu
    Citation: Journal of Biomedical Science 2011 18:94
    Content type: Research Published on:

  5. Platelet activation is relevant to a variety of coronary heart diseases. Our previous studies revealed that sesamol possesses potent antiplatelet activity through increasing cyclic AMP formation. Although plat...

    Authors: Chao-Chien Chang, Wan-Jung Lu, Eng-Thiam Ong, Cheng-Wen Chiang, Song-Chow Lin, Shih-Yi Huang and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2011 18:93
    Content type: Research Published on:

  6. Skin stem cells contribute to all three major lineages of epidermal appendages, i.e., the epidermis, the hair follicle, and the sebaceous gland. In hair follicles, highly proliferative committed progenitor cel...

    Authors: Lixin Kan, Yijie Liu, Tammy L McGuire, Michael A Bonaguidi and John A Kessler
    Citation: Journal of Biomedical Science 2011 18:92
    Content type: Research Published on:

  7. Phosphatidylcholine (PPC) formulation is used for lipolytic injection, even though its mechanism of action is not well understood.

    Authors: Hailan Li, Jong-Hyuk Lee, Su Yeon Kim, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Yoosik Yoon, Ji Hoon Jeong and Dong-Seok Kim
    Citation: Journal of Biomedical Science 2011 18:91
    Content type: Research Published on:

  8. Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system...

    Authors: Miriam D Neher, Sebastian Weckbach, Michael A Flierl, Markus S Huber-Lang and Philip F Stahel
    Citation: Journal of Biomedical Science 2011 18:90
    Content type: Review Published on:

  9. Morphine is used in clinical practice as a highly effective painkiller as well as the drug of choice for treatment of certain heart diseases. However, there is lack of information about its effect on protein e...

    Authors: Zdenka Drastichova, Jitka Skrabalova, Jan Neckar, Frantisek Kolar and Jiri Novotny
    Citation: Journal of Biomedical Science 2011 18:89
    Content type: Research Published on:

  10. The tazarotene-induced gene 1 (TIG1) is a putative tumor suppressor gene. We have recently demonstrated both TIG1A and TIG1B isoforms inhibited cell growth and induced the expression of G protein-coupled receptor...

    Authors: Fu-Ming Tsai, Chang-Chieh Wu, Rong-Yaun Shyu, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: Journal of Biomedical Science 2011 18:88
    Content type: Research Published on:

  11. Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal cells under appropriate cellular conditions and transplanted in brain injury and neurodegenerative diseases animal models for neurore...

    Authors: Min Gong, Yang Bi, Wei Jiang, Yun Zhang, Li Chen, Nali Hou, Youxue Liu, Xiaoping Wei, Jie Chen and Tingyu Li
    Citation: Journal of Biomedical Science 2011 18:87
    Content type: Research Published on:

  12. Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may pote...

    Authors: Pin-Zhir Chao, Ming-Shium Hsieh, Chao-Wen Cheng, Yung-Feng Lin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2011 18:86
    Content type: Research Published on:

  14. Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its se...

    Authors: You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen and Wun-Chang Ko
    Citation: Journal of Biomedical Science 2011 18:84
    Content type: Research Published on:

  15. Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction. We previously report...

    Authors: Sang Won Park, Xine Shen, Lu-Tai Tien, Richard Roman and Tangeng Ma
    Citation: Journal of Biomedical Science 2011 18:83
    Content type: Research Published on:

  16. Peripheral tissue inflammation initiates hyperalgesia accompanied by tissue acidosis, nociceptor activation, and inflammation mediators. Recent studies have suggested a significantly increased expression of ac...

    Authors: Wei-Hsin Chen, Ching-Liang Hsieh, Chun-Ping Huang, Tzu-Jou Lin, Jason TC Tzen, Tin-Yun Ho and Yi-Wen Lin
    Citation: Journal of Biomedical Science 2011 18:82
    Content type: Research Published on:

  18. MiR-1 (microRNA-1) has been used as a positive control in some microRNA experiments. We found that miR-1 transfection of nasopharyngeal carcinoma cells reveals a typical apoptotic process as shown by time-laps...

    Authors: Cheng-Der Wu, Yuan-Sung Kuo, Han-Chung Wu and Chin-Tarng Lin
    Citation: Journal of Biomedical Science 2011 18:80
    Content type: Research Published on:

  19. Ischemic postconditioning (IPO) has been demonstrated to attenuate ischemia/reperfusion (I/R) injury in the heart and brain, its roles to liver remain to be defined. The study was undertaken to determine if IP...

    Authors: Jia Y Guo, Tong Yang, Xiang G Sun, Ni Y Zhou, Fu S Li, Dan Long, Tao Lin, Ping Y Li and Li Feng
    Citation: Journal of Biomedical Science 2011 18:79
    Content type: Research Published on:

  21. A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model. We investigated the neuroprotective effects of ADNF-9 against al...

    Authors: Youssef Sari, Zaneer M Segu, Ahmed YoussefAgha, Jonathan A Karty and Dragan Isailovic
    Citation: Journal of Biomedical Science 2011 18:77
    Content type: Research Published on:

  22. Accumulation of amyloid β-peptide (Aβ) in the plaques is one of the major pathological features in Alzheimer's disease (AD). Sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme...

    Authors: Anne Jämsä, Oscar Belda, Michael Edlund and Erik Lindström
    Citation: Journal of Biomedical Science 2011 18:76
    Content type: Research Published on:

  24. Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem. C-phycocyanin (Cpc) i...

    Authors: Li-Chen Wu, Yu-Yun Lin, Szu-Yen Yang, Yu-Ting Weng and Yi-Ting Tsai
    Citation: Journal of Biomedical Science 2011 18:74
    Content type: Research Published on:

  25. The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant ...

    Authors: Jenher Lu, Tzuchun Tsai, Sielin Choo, Shuyu Yeh, Renbing Tang, Anhang Yang, Hsinyu Lee and Jennkan Lu
    Citation: Journal of Biomedical Science 2011 18:73
    Content type: Research Published on:

  26. Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drink...

    Authors: Yu-Jun Lai, Chung-Lieh Hung, Ray-Ching Hong, Ya-Ming Tseng, Cheng-I Lin, Yu-Shien Ko, Cheng-Ho Tsai and Hung-I Yeh
    Citation: Journal of Biomedical Science 2011 18:72
    Content type: Research Published on:

  27. Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway. Presuming a major role of complement as an effecter in peptid...

    Authors: Yu-Huei Liu, Lei Wan, Chwen-Tzuei Chang, Wen-Ling Liao, Wen-Chi Chen, Yuhsin Tsai, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2011 18:71
    Content type: Research Published on:

  28. β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos wit...

    Authors: Yi-Ting Wu, Che Yi Lin, Ming-Yuan Tsai, Yi-Hua Chen, Yu-Fen Lu, Chang-Jen Huang, Chao-Min Cheng and Sheng-Ping L Hwang
    Citation: Journal of Biomedical Science 2011 18:70
    Content type: Research Published on:

  29. Perinatal brain injury is the leading cause of subsequent neurological disability in both term and preterm baby. Glutamate excitotoxicity is one of the major factors involved in perinatal hypoxic-ischemic ence...

    Authors: Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Ching-Jung Lai, Pen Jung Wang and Ted H Chiu
    Citation: Journal of Biomedical Science 2011 18:69
    Content type: Research Published on:

  30. The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia ...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Pei-Hsuan Chen, Ching-Mei Hsu and Lee-Wei Chen
    Citation: Journal of Biomedical Science 2011 18:68
    Content type: Research Published on:

  31. Although recent studies have highlighted the role of epicardial cells during cardiac development and regeneration, their cardiomyogenic potential is still controversial due to the question of lineage tracing o...

    Authors: Bin Zeng, Xiao-feng Ren, Feng Cao, Xiao-yang Zhou and Jing Zhang
    Citation: Journal of Biomedical Science 2011 18:67
    Content type: Research Published on:

  33. Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therap...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai
    Citation: Journal of Biomedical Science 2011 18:65
    Content type: Research Published on:

  34. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2011 18:64
    Content type: Research Published on:

  35. Prostate cancer is the most frequently diagnosed non-cutaneous tumor of men in Western countries. While surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary ...

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su
    Citation: Journal of Biomedical Science 2011 18:63
    Content type: Review Published on:

  36. Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Authors: Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki, Yu Sogo, Atsuo Ito and Akira Matsumura
    Citation: Journal of Biomedical Science 2011 18:62
    Content type: Research Published on:

  37. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang
    Citation: Journal of Biomedical Science 2011 18:61
    Content type: Research Published on:

  38. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi
    Citation: Journal of Biomedical Science 2011 18:60
    Content type: Research Published on:

  39. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li
    Citation: Journal of Biomedical Science 2011 18:59
    Content type: Research Published on:

  40. Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. R...

    Authors: Shan-shan Liu, Xiang-mei Chen, Hong-xia Zheng, Shu-liang Shi and Yu Li
    Citation: Journal of Biomedical Science 2011 18:58
    Content type: Research Published on:

  41. High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...

    Authors: Ke Chen, ping jin, Hong-hui He, Yan-hong Xie, Xiao-yun Xie and Zhao-hui Mo
    Citation: Journal of Biomedical Science 2011 18:57
    Content type: Research Published on:

  42. Notch and TLR pathways were found to act cooperatively to activate Notch target genes and to increase the production of TLR-induced cytokines in macrophages. However, the mechanism of LPS-induced Notch activat...

    Authors: Po-Nien Tsao, Shu-Chen Wei, Miao-Tzu Huang, Ming-Cheng Lee, Hung-Chieh Chou, Chien-Yi Chen and Wu-Shiun Hsieh
    Citation: Journal of Biomedical Science 2011 18:56
    Content type: Research Published on:

  43. Sphingosylphosphorylcholine (SPC) acts as a potent lipid mediator and signaling molecule in various cell types. In the present study, we investigated the effects of SPC on melanogenesis and SPC-modulated signa...

    Authors: Hyo-Soon Jeong, Seung Hoon Lee, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung-Chan Park and Dong-Seok Kim
    Citation: Journal of Biomedical Science 2011 18:55
    Content type: Research Published on:

  44. Spinocerebellar ataxia (SCA) refers to a disease entity in which polyglutamine aggregates are over-produced in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and...

    Authors: You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bing-Wen Soong, Jennifer H Ho and Oscar K Lee
    Citation: Journal of Biomedical Science 2011 18:54
    Content type: Research Published on:

  45. Postconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of precondit...

    Authors: Yikui Tian, Wenjuan Zhang, Dachuan Xia, Paul Modi, Degang Liang and Minxin Wei
    Citation: Journal of Biomedical Science 2011 18:53
    Content type: Research Published on:

  46. Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers...

    Authors: Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen and Jungshan Chang
    Citation: Journal of Biomedical Science 2011 18:52
    Content type: Research Published on:

  47. Arsenic exposure is an important public health issue worldwide. Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed. Inorganic arsenic is methylat...

    Authors: Ling-I Hsu, Wu-Ping Chen, Tse-Yen Yang, Yu-Hsin Chen, Wann-Cheng Lo, Yuan-Hung Wang, Ya-Tang Liao, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2011 18:51
    Content type: Research Published on:

  48. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq
    Citation: Journal of Biomedical Science 2011 18:50
    Content type: Research Published on:

  49. In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (B...

    Authors: Pei-Min Chen, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu and B-Linju Yen
    Citation: Journal of Biomedical Science 2011 18:49
    Content type: Review Published on:

  50. At the beginning of neurogenesis, massive brain cell death occurs and more than 50% of cells are eliminated by apoptosis along with neuronal differentiation. However, few studies were conducted so far regardin...

    Authors: Hyo Sang Go, Jung Eun Seo, Ki Chan Kim, So Min Han, Pitna Kim, Young Sun Kang, Seol Heui Han, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2011 18:48
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2023 Citation Impact
    9.0 - 2-year Impact Factor
    10.7 - 5-year Impact Factor
    2.014 - SNIP (Source Normalized Impact per Paper)
    2.606 - SJR (SCImago Journal Rank)

    2023 Speed
    14 days submission to first editorial decision for all manuscripts (Median)
    107 days submission to accept (Median)

    2023 Usage 
    1,698,723 downloads
    3,813 Altmetric mentions 

Journal of Biomedical Science

ISSN: 1423-0127