Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
Articles
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Citation: Journal of Biomedical Science 2023 30:11
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Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to investigate M splicing in various human influenza A viruses and characterize...
Citation: Journal of Biomedical Science 2023 30:10 -
Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population
Pseudomonas aeruginosa intestinal carriage rates are significantly higher in immunosuppressed individuals and hospitalized patients who therefore have increased risk of infections and antibiotic-associated diarrh...
Citation: Journal of Biomedical Science 2023 30:9 -
Chronic stress in solid tumor development: from mechanisms to interventions
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which ag...
Citation: Journal of Biomedical Science 2023 30:8 -
Correction: Akt: a key transducer in cancer
Citation: Journal of Biomedical Science 2023 30:7 -
Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic cataractogenesis. Novel evidence in our model...
Citation: Journal of Biomedical Science 2023 30:6 -
The role of autophagy in viral infections
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasion. However, co-evolution and co-adaptation between viruses and autophagy have armed vir...
Citation: Journal of Biomedical Science 2023 30:5 -
Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory. The understanding of potential molecular targets is necessary for clinic...
Citation: Journal of Biomedical Science 2023 30:4 -
Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional charac...
Citation: Journal of Biomedical Science 2023 30:3 -
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well eluci...
Citation: Journal of Biomedical Science 2023 30:2 -
Intimate communications within the tumor microenvironment: stromal factors function as an orchestra
Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially termed the "seed and soil" theo...
Citation: Journal of Biomedical Science 2023 30:1 -
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling
Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted therapy. Although the study of interplay between cancer cells with their microenvironme...
Citation: Journal of Biomedical Science 2022 29:109 -
Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants
The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics. Therefore, it would be of gr...
Citation: Journal of Biomedical Science 2022 29:108 -
Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcr...
Citation: Journal of Biomedical Science 2022 29:107 -
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcri...
Citation: Journal of Biomedical Science 2022 29:106 -
Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis
In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein call...
Citation: Journal of Biomedical Science 2022 29:105 -
Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer
Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...
Citation: Journal of Biomedical Science 2022 29:104 -
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1
Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...
Citation: Journal of Biomedical Science 2022 29:103 -
Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium
yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria–host interactions...
Citation: Journal of Biomedical Science 2022 29:102 -
Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis
Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear. Decidualization is critical for the establishment and maintenance of norma...
Citation: Journal of Biomedical Science 2022 29:101 -
Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis
Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endo...
Citation: Journal of Biomedical Science 2022 29:100 -
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling
Sorafenib (SOR) is the first line treatment for advanced hepatocellular carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages (TAMs) have been reported to affect the progression of ...
Citation: Journal of Biomedical Science 2022 29:99 -
Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal ...
Citation: Journal of Biomedical Science 2022 29:98 -
Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis
The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during ch...
Citation: Journal of Biomedical Science 2022 29:97 -
Spatial multi-omics analyses of the tumor immune microenvironment
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of th...
Citation: Journal of Biomedical Science 2022 29:96 -
Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells
Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial...
Citation: Journal of Biomedical Science 2022 29:95 -
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries
Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are ...
Citation: Journal of Biomedical Science 2022 29:94 -
Cancer-derived extracellular succinate: a driver of cancer metastasis
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in heredit...
Citation: Journal of Biomedical Science 2022 29:93 -
PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation
Phosphatase and tensin homolog (PTEN) is a tumor suppressor. Low PTEN expression has been observed in pancreatic neuroendocrine tumors (pNETs) and is associated with increased liver metastasis and poor surviva...
Citation: Journal of Biomedical Science 2022 29:92 -
Correction: Radioprotective potential of melatonin against 60Co γ-ray-induced testicular injury in male C57BL/6 mice
Citation: Journal of Biomedical Science 2022 29:91 -
Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall 5-year survival rate of less than 20%. The standard first-line therapy for advanc...
Citation: Journal of Biomedical Science 2022 29:90 -
Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa
Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, we integrated correlative metabolomics and transcriptomics of Pseudomonas aeruginosa to elucid...
Citation: Journal of Biomedical Science 2022 29:89 -
Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas
Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been reported to be enriched in colorectal cancer (CRC) in multiple studies. ...
Citation: Journal of Biomedical Science 2022 29:88 -
The pathogenesis of coronavirus-19 disease
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably severe pulmonary symptoms, cardi...
Citation: Journal of Biomedical Science 2022 29:87 -
Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. P...
Citation: Journal of Biomedical Science 2022 29:86 -
Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observe...
Citation: Journal of Biomedical Science 2022 29:85 -
Reprogramming of sentinel lymph node microenvironment during tumor metastasis
Metastasis is a major cause of death in patients with cancer. The two main routes for cancer cell dissemination are the blood and lymphatic systems. The underlying mechanism of hematogenous metastasis has been...
Citation: Journal of Biomedical Science 2022 29:84 -
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic ...
Citation: Journal of Biomedical Science 2022 29:83 -
COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection
Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid development and deployment of effective COVID-19 vaccines have suc...
Citation: Journal of Biomedical Science 2022 29:82 -
Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma
Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. ...
Citation: Journal of Biomedical Science 2022 29:81 -
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice
Human Papillomavirus type 18 (HPV18) is a high-risk HPV that is commonly associated with cervical cancer. HPV18 oncogenes E6 and E7 are associated with the malignant transformation of cells, thus the identific...
Citation: Journal of Biomedical Science 2022 29:80 -
Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 years
Viruses are naturally endowed with the capacity to transfer genetic material between cells. Following early skepticism, engineered viruses have been used to transfer genetic information into thousands of patie...
Citation: Journal of Biomedical Science 2022 29:79 -
Possible step-up in prevalence for Escherichia coli ST131 from fecal to clinical isolates: inferred virulence potential comparative studies within phylogenetic group B2
Escherichia coli sequence type (ST)131 is an important urinary tract pathogen, and is responsible for considerable healthcare-associated problems and costs worldwide. A better understanding of the factors that co...
Citation: Journal of Biomedical Science 2022 29:78 -
Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review
Living organisms are continuously exposed to multiple internal and external stimuli which may influence their emotional, psychological, and physical behaviors. Stress can modify brain structures, reduces funct...
Citation: Journal of Biomedical Science 2022 29:77 -
Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinas...
Citation: Journal of Biomedical Science 2022 29:76 -
Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages
The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic a...
Citation: Journal of Biomedical Science 2022 29:75 -
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidati...
Citation: Journal of Biomedical Science 2022 29:74 -
LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory effects. Long noncoding RNAs (lncRNAs) have important functions in the immun...
Citation: Journal of Biomedical Science 2022 29:73 -
Pathophysiology of reversible cerebral vasoconstriction syndrome
Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder being recognized during the past two decades. It is characterized by multiple abrupt severe headaches and widespread cer...
Citation: Journal of Biomedical Science 2022 29:72 -
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes...
Citation: Journal of Biomedical Science 2022 29:71
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2023 Citation Impact
9.0 - 2-year Impact Factor
10.7 - 5-year Impact Factor
2.014 - SNIP (Source Normalized Impact per Paper)
2.606 - SJR (SCImago Journal Rank)2023 Speed
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