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353 result(s) for 'screening test' within Journal of Biomedical Science

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  1. The best five-features pharmacophore model, which includes one hydrogen bond donor and four hydrophobic features, was generated from a training set of 62 compounds that yielded a correlation coefficient of R = 0....

    Authors: Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai and Yih Ho
    Citation: Journal of Biomedical Science 2011 18:8
    Content type: Research Published on:

  2. Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge
    Citation: Journal of Biomedical Science 2009 16:55
    Content type: Research Published on:

  3. A total of 969 pregnant women were randomly screened in first and second trimester, of which ... fluid. Preliminary prediction models were developed to test the screening potential for early preeclampsia, late pr...

    Authors: Sharona Vonck, Anneleen S. Staelens, Dorien Lanssens, Kathleen Tomsin, Jolien Oben, Liesbeth Bruckers and Wilfried Gyselaers
    Citation: Journal of Biomedical Science 2019 26:38
    Content type: Research Published on:

  4. Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used ...

    Authors: Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang and Yi-Fang Chang
    Citation: Journal of Biomedical Science 2018 25:60
    Content type: Research Published on:

  5. Familial Hypercholesterolaemia is an autosomal, dominant genetic disorder that leads to elevated blood cholesterol and a dramatically increased risk of atherosclerosis. It is perceived as a rare condition. How...

    Authors: Raymond Henderson, Maurice O’Kane, Victoria McGilligan and Steven Watterson
    Citation: Journal of Biomedical Science 2016 23:39
    Content type: Review Published on:

  6. The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-li...

    Authors: Hsiang-Ping Tsai, Li-Wei Lin, Zhi-Yang Lai, Jui-Yu Wu, Chiao-En Chen, Jaulang Hwang, Chien-Shu Chen and Chun-Mao Lin
    Citation: Journal of Biomedical Science 2010 17:49
    Content type: Research Published on:

  7. Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for patients with CRC are still needed. Recently, fluorescent chemical probes have been developed for cancer imaging ...

    Authors: Pei-Hsuan Chou, Cong-Kai Luo, Niaz Wali, Wen-Yen Lin, Shang-Kok Ng, Chun-Hao Wang, Mingtao Zhao, Sheng-Wei Lin, Pei-Ming Yang, Pin-Jung Liu, Jiun-Jie Shie and Tzu-Tang Wei
    Citation: Journal of Biomedical Science 2022 29:20
    Content type: Research Published on:

  8. The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection. Owing to their high specificity and reliability...

    Authors: Yu-Chyi Hwang, Ruei-Min Lu, Shih-Chieh Su, Pao-Yin Chiang, Shih-Han Ko, Feng-Yi Ke, Kang-Hao Liang, Tzung-Yang Hsieh and Han-Chung Wu
    Citation: Journal of Biomedical Science 2022 29:1
    Content type: Review Published on:

  9. The global burden of invasive fungal infections (IFIs) has shown an upsurge in recent years due to the higher load of immunocompromised patients suffering from various diseases. The role of early and accurate ...

    Authors: Wenjie Fang, Junqi Wu, Mingrong Cheng, Xinlin Zhu, Mingwei Du, Chang Chen, Wanqing Liao, Kangkang Zhi and Weihua Pan
    Citation: Journal of Biomedical Science 2023 30:42
    Content type: Review Published on:

  10. Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical ...

    Authors: Kunal Nepali, Ram Sharma, Sachin Sharma, Amandeep Thakur and Jing-Ping Liou
    Citation: Journal of Biomedical Science 2022 29:65
    Content type: Review Published on:

  11. Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors az...

    Authors: Yi-Shiuan Lin, Arthur Y Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim HM Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:3
    Content type: Research Published on:

  12. Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression patterns render them attractive biomarkers and therapeutic targets. Yet, the functional ...

    Authors: Joshua M. Hazan, Raziel Amador, Tahleel Ali-Nasser, Tamar Lahav, Stav Roni Shotan, Miryam Steinberg, Ziv Cohen, Dvir Aran, David Meiri, Yehuda G. Assaraf, Roderic Guigó and Assaf C. Bester
    Citation: Journal of Biomedical Science 2024 31:27
    Content type: Research Published on:

  14. Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer c...

    Authors: Waad H. Abuwatfa, William G. Pitt and Ghaleb A. Husseini
    Citation: Journal of Biomedical Science 2024 31:7
    Content type: Review Published on:

  15. A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. B...

    Authors: Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang and Jinquan Cai
    Citation: Journal of Biomedical Science 2021 28:30
    Content type: Review Published on:

  16. CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing...

    Authors: Guzide Bender, Rezan Fahrioglu Yamaci and Bahar Taneri
    Citation: Journal of Biomedical Science 2021 28:77
    Content type: Review Published on:

  17. Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogeneis, we took a novel approach based on phenotype chan...

    Authors: Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye and Bing Sun
    Citation: Journal of Biomedical Science 2009 16:92
    Content type: Research Published on:

  18. Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious pu...

    Authors: Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Wen-Fang Tang, Ming-sian Wu, Jiann-Yih Yeh, Yu-Sheng Chao, John TA Hsu, Hsing-Pang Hsieh and Jim-Tong Horng
    Citation: Journal of Biomedical Science 2010 17:13
    Content type: Research Published on:

  19. Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the ...

    Authors: Fan-Ching Shen, Ih-Jen Su, Han-Chieh Wu, Yi-Hsuan Hsieh, Wei-Jen Yao, Kung-Chia Young, Tsung-Chuan Chang, Hui-Chuan Hsieh, Han-Ni Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2009 16:84
    Content type: Research Published on:

  20. GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin
    Citation: Journal of Biomedical Science 2017 24:23
    Content type: Research Published on:

  21. Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe...

    Authors: Jing-You Guo, I-Ju Liu, Hsiu-Ting Lin, Mei-Jung Wang, Yu-Ling Chang, Shin-Chang Lin, Mei-Ying Liao, Wei-Chia Hsu, Yi-Ling Lin, James C. Liao and Han-Chung Wu
    Citation: Journal of Biomedical Science 2021 28:43
    Content type: Research Published on:

  22. Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by ...

    Authors: Thierry Burnouf, Ming-Li Chou, David J. Lundy, Er-Yuan Chuang, Ching-Li Tseng and Hadi Goubran
    Citation: Journal of Biomedical Science 2023 30:79
    Content type: Review Published on:

  23. Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the stud...

    Authors: Rima Zein-Eddine, Guislaine Refrégier, Jorge Cervantes and Noemí Kaoru Yokobori
    Citation: Journal of Biomedical Science 2023 30:34
    Content type: Review Published on:

  24. Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being hi...

    Authors: Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi and Jafar Majidi
    Citation: Journal of Biomedical Science 2016 23:66
    Content type: Review Published on:

  26. Trophoblast differentiation and formation of the placenta are important events linked to post-implantation embryonic development. Models mimicking the biology of trophoblast differentiation in a post-implantation...

    Authors: Kavitha Sivasubramaiyan, Swapnil Totey, Vijay Bhat, Satish M Totey and Kaushik Deb
    Citation: Journal of Biomedical Science 2009 16:88
    Content type: Research Published on:

  27. Congenital myopathy (CM) is a group of clinically and genetically heterogeneous muscle disorders, characterized by muscle weakness and hypotonia from birth. Currently, no definite treatment exists for CM. A de...

    Authors: Po-Jui Hsu, Horng-Dar Wang, Yung-Che Tseng, Shao-Wei Pan, Bonifasius Putera Sampurna, Yuh-Jyh Jong and Chiou-Hwa Yuh
    Citation: Journal of Biomedical Science 2021 28:8
    Content type: Research Published on:

  28. Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf
    Citation: Journal of Biomedical Science 2009 16:53
    Content type: Research Published on:

  29. Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have ...

    Authors: Radha Gopalaswamy, Sivakumar Shanmugam, Rajesh Mondal and Selvakumar Subbian
    Citation: Journal of Biomedical Science 2020 27:74
    Content type: Review Published on:

  30. In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular ...

    Authors: Adelfia Talà, Flora Guerra, Matteo Calcagnile, Roberta Romano, Silvia Caterina Resta, Aurora Paiano, Mario Chiariello, Graziano Pizzolante, Cecilia Bucci and Pietro Alifano
    Citation: Journal of Biomedical Science 2022 29:45
    Content type: Research Published on:

  31. Early diagnosis of dengue virus infection during the febrile stage is essential for adjusting appropriate management. This study is to identify the predictive markers of clinical and laboratory findings in the...

    Authors: Tzong-Shiann Ho, Shih-Min Wang, Yee-Shin Lin and Ching-Chuan Liu
    Citation: Journal of Biomedical Science 2013 20:75
    Content type: Research Published on:

  32. The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transme...

    Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala and Dinakar M. Salunke
    Citation: Journal of Biomedical Science 2023 30:56
    Content type: Research Published on:

  33. This study aimed to investigate if food components that exert anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA). The cytokine profile and...

    Authors: Yong-Han Hong, Wen-Wan Chao, Miaw-Ling Chen and Bi-Fong Lin
    Citation: Journal of Biomedical Science 2009 16:64
    Content type: Research Published on:

  34. Streptococcus pneumoniae is a common cause of post-influenza secondary bacterial infection, which results in excessive morbidity and mortality. Although 13-valent pneumococcal conjugate vaccine (PCV13) vaccinatio...

    Authors: Yi-Yin Chen, Ching-Tai Huang, Shiao-Wen Li, Yi-Jiun Pan, Tzu-Lung Lin, Ya-Yu Huang, Ting-Hsuan Li, Yu-Ching Yang, Yu-Nong Gong and Yu-Chia Hsieh
    Citation: Journal of Biomedical Science 2021 28:60
    Content type: Research Published on:

  35. Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population.

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
    Content type: Research Published on:

  36. Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (...

    Authors: Tsung-Chih Tsai, Yi-Syuan Fang, Yu-Chieh Hung, Ling-Chien Hung and Kuei-Sen Hsu
    Citation: Journal of Biomedical Science 2022 29:50
    Content type: Research Published on:

  37. The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based d...

    Authors: Ching-Ying Huang, Chun-Lin Liu, Chien-Yu Ting, Yueh-Ting Chiu, Yu-Che Cheng, Martin W. Nicholson and Patrick C. H. Hsieh
    Citation: Journal of Biomedical Science 2019 26:87
    Content type: Review Published on:

  38. Cervical cancer is one of the most common female cancers and is caused by human papillomavirus (HPV). Viral infection leads to cell cycle deregulation by inactivating p53 and retinoblastoma protein by viral on...

    Authors: Adrya Lúcia Peres, Keilla Maria Paz e Silva, Rosângela Ferreira Frade de Araújo, José Luiz de Lima Filho, Mário Ribeiro de Melo Júnior, Danyelly Bruneska Gondim Martins and Nicodemos Teles de Pontes Filho
    Citation: Journal of Biomedical Science 2016 23:42
    Content type: Research Published on:

  39. N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in m...

    Authors: Tsung-Chieh Chen, José Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh and Bai-Chuang Shyu
    Citation: Journal of Biomedical Science 2012 19:55
    Content type: Research Published on:

  40. The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell research initiatives and provide a platform for researchers interested in utilizing induced pluripotent...

    Authors: Ching-Ying Huang, Ling-Hui Li, Wan-Tseng Hsu, Yu-Che Cheng, Martin W. Nicholson, Chun-Lin Liu, Chien-Yu Ting, Hui-Wen Ko, Shih-Han Syu, Cheng-Hao Wen, Zhuge Yan, Hsiang-Po Huang, Hong-Lin Su, Po-Min Chiang, Chia-Ning Shen, Hsin-Fu Chen…
    Citation: Journal of Biomedical Science 2020 27:92
    Content type: Research Published on:

  42. Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent...

    Authors: M S AlSalhi, Farjah H AlGahtani, S Devanesan, V Trinka Vijmasi, K Jeyaprakash, Abbas H AlSaeed and V Masilamani
    Citation: Journal of Biomedical Science 2014 21:26
    Content type: Research Published on:

  43. Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer worldwide and highly prevalent in less developed regions. Management of ESCC is challenging and involves multimodal tre...

    Authors: Nikki P. Lee, Chung Man Chan, Lai Nar Tung, Hector K. Wang and Simon Law
    Citation: Journal of Biomedical Science 2018 25:66
    Content type: Review Published on:

  44. Neurofibromatosis type 1 (NF1) is a dominantly inherited tumor predisposition syndrome that targets the peripheral nervous system. It is caused by mutations of the NF1 gene which serve as a negative regulator of ...

    Authors: Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh and Yu-Ray Chen
    Citation: Journal of Biomedical Science 2018 25:72
    Content type: Research Published on:

  45. Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mec...

    Authors: Sajal K. Ghosh, Abhishek Ganta and Remco A. Spanjaard
    Citation: Journal of Biomedical Science 2018 25:12
    Content type: Research Published on:

  46. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi
    Citation: Journal of Biomedical Science 2011 18:60
    Content type: Research Published on:

  47. Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after H. pylori infection. The stu...

    Authors: Yu-Ching Tsai, Wei-Hsin Hsiao, Sheng-Hsiang Lin, Hsiao-Bai Yang, Hsiu-Chi Cheng, Wei-Lun Chang, Cheng-Chan Lu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2015 22:16
    Content type: Research Published on:

  48. Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review intr...

    Authors: Jyong-Huei Lee, Kuan-Lun Ho and Shih-Kang Fan
    Citation: Journal of Biomedical Science 2019 26:88
    Content type: Review Published on:

  49. Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have l...

    Authors: Yothin Teethaisong, Nongluk Autarkool, Kittipot Sirichaiwetchakoon, Pongrit Krubphachaya, Sajeera Kupittayanant and Griangsak Eumkeb
    Citation: Journal of Biomedical Science 2014 21:90
    Content type: Research Published on:

  50. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq
    Citation: Journal of Biomedical Science 2011 18:50
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127