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  2. Heroin use among young women of reproductive age has drawn much attention around the world. Although methadone is widely used in maintenance therapy for heroin/morphine addiction, the long-term effects of pren...

    Authors: Yao-Chang Chiang, Li-Ci Ye, Kuei-Ying Hsu, Chien-Wei Liao, Tsai-Wei Hung, Wan-Jou Lo, Ing-Kang Ho and Pao-Luh Tao
    Citation: Journal of Biomedical Science 2015 22:19
    Content type: Research Published on:

  3. Coronary heart disease is a leading cause of death in the world and therapy to reduce injury is still needed. The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial i...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, His-Lin Chiu and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:18
    Content type: Research Published on:

  5. Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after H. pylori infection. The stu...

    Authors: Yu-Ching Tsai, Wei-Hsin Hsiao, Sheng-Hsiang Lin, Hsiao-Bai Yang, Hsiu-Chi Cheng, Wei-Lun Chang, Cheng-Chan Lu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2015 22:16
    Content type: Research Published on:

  6. Novel pentacycloundecane (PCU)-lactone-CO-EAIS peptide inhibitors were designed, synthesized, and evaluated against wild-type C-South African (C-SA) HIV-1 protease. Three compounds are reported herein, two of ...

    Authors: Bahareh Honarparvar, Sachin A Pawar, Cláudio Nahum Alves, Jerônimo Lameira, Glenn EM Maguire, José Rogério A Silva, Thavendran Govender and Hendrik G Kruger
    Citation: Journal of Biomedical Science 2015 22:15
    Content type: Research Published on:

  7. One of the most important manifestations of perinatal asphyxia is the occurrence of seizures, which are treated with antiepileptic drugs, such as carbamazepine. These early seizures, combined with pharmacologi...

    Authors: Silvia J López-Pérez, Alberto Morales-Villagrán and Laura Medina-Ceja
    Citation: Journal of Biomedical Science 2015 22:14
    Content type: Research Published on:

  8. Candida tropicalis is an increasingly important human pathogen associated with high mortality rates; however, little is known regarding the virulence properties of C. tropicalis, particularly t...

    Authors: Marcia Cristina Furlaneto, Daniel Favero, Emanuele Julio Galvão França and Luciana Furlaneto-Maia
    Citation: Journal of Biomedical Science 2015 22:13
    Content type: Research Published on:

  9. Polyunsaturated fatty acids (PUFAs) are nutrients necessary for life. The liver is the essential metabolic center, which aids in maintaining health via diverse biological actions. In the present work, a proteo...

    Authors: Chun-Ying Huang, Wei-Ming Chen, Yeou-Guang Tsay, Shu-Chen Hsieh, Yun Lin, Wen-Jane Lee, Wayne Huey-Herng Sheu and An-Na Chiang
    Citation: Journal of Biomedical Science 2015 22:12
    Content type: Research Published on:

  10. Telomerase deficiency has been associated with inadequate differentiation of mesenchymal stem cells. However, the effect of telomerase deficiency on differential regulation of osteoblast specific genes, based ...

    Authors: Hamid Saeed and Mehwish Iqtedar
    Citation: Journal of Biomedical Science 2015 22:11
    Content type: Research Published on:

  11. Argininosuccinate synthetase (ASS) participates in urea and nitric oxide production and is a rate-limiting enzyme in arginine biosynthesis. Regulation of ASS expression appears complex and dynamic. In addition to...

    Authors: Shih-Chang Shiue, Miao-Zeng Huang, Ting-Fen Tsai, Alice Chien Chang, Kong Bung Choo, Chiu-Jung Huang and Tsung-Sheng Su
    Citation: Journal of Biomedical Science 2015 22:10
    Content type: Research Published on:

  12. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been found highly conserved among species. MiRNAs are able to negatively regulate gene expression through base pairing of 3’ UTRs of...

    Authors: Shih-Hsuan Chan and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2015 22:9
    Content type: Review Published on:

  13. Intermittent hypobaric hypoxia (IHH) induces changes in the redox status and structure in rat testis. These effects may be present in people at high altitudes, such as athletes and miners. Polyunsaturated fatt...

    Authors: Rodrigo L Castillo, Andrea B Zepeda, Stefania E Short, Elías Figueroa, Eduardo Bustos-Obregon and Jorge G Farías
    Citation: Journal of Biomedical Science 2015 22:8
    Content type: Research Published on:

  14. Bortezomib, a proteasome inhibitor and suberoylanilide hydroxamic acid (SAHA, also known as Vorinostat), a histone deacetylase inhibitor, have been recognized as potent chemotherapeutic drugs. Bortezomib and S...

    Authors: Zhuomin Huang, Shiwen Peng, Jayne Knoff, Sung Yong Lee, Benjamin Yang, Tzyy-Choou Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2015 22:7
    Content type: Research Published on:

  16. Leptin, produced mainly by white adipose tissue, is a hormone that promotes vascular smooth muscle cell (VSMC) migration and proliferation, a process involved in the pathophysiology of atherosclerosis. Leptin ...

    Authors: Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2015 22:5
    Content type: Research Published on:

  17. Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual a...

    Authors: Nithya Subramanian, Jagat R Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rupinder K Kanwar, Sailaja Eluchuri and Subramanian Krishnakumar
    Citation: Journal of Biomedical Science 2015 22:4
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:100

  18. Hormone-refractory prostate cancer (HRPC), which is resistant to hormone therapy, is a major obstacle in clinical treatment. An approach to inhibit HRPC growth and ultimately to kill cancers is highly demanded.

    Authors: Chia-Chun Yu, Shih-Ping Liu, Jui-Ling Hsu, John TA Hsu, Konstantin V Kudryavtsev and Jih-Hwa Guh
    Citation: Journal of Biomedical Science 2015 22:2
    Content type: Research Published on:

  19. We profiled the expression of circulating microRNAs (miRNAs) in mice using Illumina small RNA deep sequencing in order to identify the miRNAs that may potentially be used as biomarkers to distinguish between g...

    Authors: Cheng-Shyuan Rau, Shao-Chun Wu, Johnson Chia-Shen Yang, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2015 22:1
    Content type: Research Published on:

  20. Lymphangiogenesis is one of the major causes of corneal graft rejection. Among the lymphangiogenic factors, vascular endothelial growth factor (VEGF)-C and -D are considered to be the most potent. Both bind to...

    Authors: Minkoo Seo, Jun-Sub Choi, Chang Rae Rho, Choun-Ki Joo and Suk Kyeong Lee
    Citation: Journal of Biomedical Science 2015 22:3
    Content type: Research Published on:

  21. Although cigarette smoke is known to be a complex mixture of over 4000 substances that can lead to damage through active or passive smoking, its mechanisms and biochemical consequences in pregnancy and neonate...

    Authors: Ednildes de Almeida Olympio Rua, Marcella Leite Porto, Jean Pierre Louzada Ramos, Breno Valentim Nogueira, Silvana dos Santos Meyrelles, Elisardo Corral Vasquez and Thiago de Melo Costa Pereira
    Citation: Journal of Biomedical Science 2014 21:105
    Content type: Research Published on:

  22. Surgery has wide ranging immunomodulatory properties of which the mechanism is poorly understood. In order to investigate how different types of surgery influence inflammation, we designed a longitudinal obser...

    Authors: Jaap Willem Hol, Robert J Stolker, Markus Klimek, Dirk L Stronks and Durk Fekkes
    Citation: Journal of Biomedical Science 2014 21:102
    Content type: Research Published on:

  24. Use of the chemotherapeutic drug doxorubicin (DOX) is associated with serious cardiotoxicity, as it increases levels of reactive oxygen species (ROS). N-3 polyunsaturated fatty acid dietary supplements can be ...

    Authors: Hsiu-Ching Hsu, Ching-Yi Chen and Ming-Fong Chen
    Citation: Journal of Biomedical Science 2014 21:101
    Content type: Research Published on:

  25. Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these patho...

    Authors: Sue-Jane Lin, Ming Lo, Rei-Lin Kuo, Shin-Ru Shih, David M Ojcius, Jean Lu, Chien-Kuo Lee, Hui-Chen Chen, Meei Yun Lin, Chuen-Miin Leu, Chia-Ni Lin and Ching-Hwa Tsai
    Citation: Journal of Biomedical Science 2014 21:99
    Content type: Research Published on:

  26. Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as wi...

    Authors: Francesca Bonafè, Marco Govoni, Emanuele Giordano, Claudio Marcello Caldarera, Carlo Guarnieri and Claudio Muscari
    Citation: Journal of Biomedical Science 2014 21:100
    Content type: Review Published on:

  27. Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regene...

    Authors: Ih-Jen Su, Lily Hui-Ching Wang, Wen-Chuan Hsieh, Han-Chieh Wu, Chiao-Fang Teng, Hung-Wen Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2014 21:98
    Content type: Review Published on:

  28. Hyperglycemia increases the risk of gastric cancer in H. pylori-infected patients. High glucose could increase endothelial permeability and cancer-associated signaling. These suggest high glucose may affect H. py...

    Authors: Shew-Meei Sheu, Hsin Cheng, Cheng-Ye Kao, Yao-Jong Yang, Jiunn-Jong Wu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2014 21:96
    Content type: Research Published on:

  29. Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be ...

    Authors: Wenbin Zhou, Hong Pan, Tiansong Xia, Jinqiu Xue, Lin Cheng, Ping Fan, Yifen Zhang, Weidong Zhu, Yi Xue, Xiaoan Liu, Qiang Ding, Yun Liu and Shui Wang
    Citation: Journal of Biomedical Science 2014 21:97
    Content type: Research Published on:

  30. Progressive micro-vascular vaso-degeneration is the major factor in progression of diabetic complications. Adrenomedullin (AM) and basic-Fibroblast growth factor (b-FGF) are strongly correlated with angiogenes...

    Authors: Fawziah A Alrouq, Abeer A Al-Masri, Laila M AL-Dokhi, Khalid A Alregaiey, Nervana M Bayoumy and Faten A Zakareia
    Citation: Journal of Biomedical Science 2014 21:94
    Content type: Research Published on:

  31. Two mature miRNA species may be generated from the 5’ and 3’ arms of a pre-miRNA precursor. In most cases, only one species remains while the complementary species is degraded. However, co-existence of miRNA-5...

    Authors: Kong Bung Choo, Yuen Loon Soon, Phan Nguyen Nhi Nguyen, Michele Sook Yuin Hiew and Chiu-Jung Huang
    Citation: Journal of Biomedical Science 2014 21:95
    Content type: Research Published on:

  32. The reported efficiency of differentiation of human bone marrow derived Mesenchymal Stem Cells (hBM MSC) into dopaminergic neurons with different inducers is found to vary. Thus, in the current study we have i...

    Authors: Sushmita Bose Nandy, Sujata Mohanty, Manisha Singh, Madhuri Behari and Balram Airan
    Citation: Journal of Biomedical Science 2014 21:83
    Content type: Research Published on:

  33. The evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer's disease, while confirming the adverse events consisting mainly in the elevated ...

    Authors: Kai Y Wong, Andrew G Mercader, Laura M Saavedra, Bahareh Honarparvar, Gustavo P Romanelli and Pablo R Duchowicz
    Citation: Journal of Biomedical Science 2014 21:84
    Content type: Research Published on:

  34. The functions of free radicals on the effects of insulin that result in protection against cerebral ischemic insult in diabetes remain undefined. This present study aims to explain the contradiction among nitr...

    Authors: Li-Man Hung, Jiung-Pang Huang, Jiuan-Miaw Liao, Meng-Hsuan Yang, Dai-Er Li, Yuan-Ji Day and Shiang-Suo Huang
    Citation: Journal of Biomedical Science 2014 21:92
    Content type: Research Published on:

  35. Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have l...

    Authors: Yothin Teethaisong, Nongluk Autarkool, Kittipot Sirichaiwetchakoon, Pongrit Krubphachaya, Sajeera Kupittayanant and Griangsak Eumkeb
    Citation: Journal of Biomedical Science 2014 21:90
    Content type: Research Published on:

  36. Arecoline, a major alkaloid in Areca nut has the ability to induce oxidative stress. The effect of Areca nut, arecoline on reducing sperm quality and quantity were documented previously using several animal mo...

    Authors: Tzer-Min Kuo, Shun-Yuan Luo, Shang-Lun Chiang, Chi-Pin Lee, Yu-Fan Liu, Jan-Gowth Chang, Ming-Hsui Tsai and Ying-Chin Ko
    Citation: Journal of Biomedical Science 2014 21:93
    Content type: Research Published on:

  37. Mutation in the Wiskott-Aldrich syndrome Protein (WASP) causes Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN). The majority of missense mutations caus...

    Authors: Neeraj Jain, Jun Hou Tan, Shijin Feng, Bhawana George and Thirumaran Thanabalu
    Citation: Journal of Biomedical Science 2014 21:91
    Content type: Research Published on:

  38. The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product re...

    Authors: Marcella Martinelli, Luca Scapoli, Francesca Cura, Maria Teresa Rodia, Giampaolo Ugolini, Isacco Montroni and Rossella Solmi
    Citation: Journal of Biomedical Science 2014 21:89
    Content type: Research Published on:

  39. Lipid accumulation is the primary evidence of non-alcoholic fatty liver disease (NAFLD). Ginkgo biloba extract (GBE) and its flavonoid ingredients (quercetin, kaempferol, and isorhamnetin) could lessen the lipid ...

    Authors: Ting Wei, Fei-fei Xiong, Shi-dong Wang, Ke Wang, Yong-yu Zhang and Qing-hua Zhang
    Citation: Journal of Biomedical Science 2014 21:87
    Content type: Research Published on:

  40. Genome-wide association studies have been successful in identifying common genetic variants for human diseases. However, much of the heritable variation associated with diseases such as Parkinson's disease rem...

    Authors: Ying-Chao Lin, Ai-Ru Hsieh, Ching-Lin Hsiao, Shang-Jung Wu, Hui-Min Wang, Ie-Bin Lian and Cathy SJ Fann
    Citation: Journal of Biomedical Science 2014 21:88
    Content type: Research Published on:

  41. Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaO...

    Authors: Ponnusamy Sasikumar, Sivasamy Gomathi, Kolandaswamy Anbazhagan, Albert Abhishek, Eldho Paul, Varadaraj Vasudevan, Sundaresan Sasikumar and Govindan Sadasivam Selvam
    Citation: Journal of Biomedical Science 2014 21:86
    Content type: Research Published on:

  42. The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cau...

    Authors: Federica Incani, Maria Luisa Serra, Alessandra Meloni, Carla Cossu, Luisella Saba, Tiziana Cabras, Irene Messana and Maria Cristina Rosatelli
    Citation: Journal of Biomedical Science 2014 21:85
    Content type: Research Published on:

  43. The membrane-proximal external region (MPER) of HIV-1 gp41 is particularly conserved and target for the potent broadly neutralizing monoclonal antibodies (bnMAbs) 2F5, 4E10 and 10E8. Epitope focusing and stabi...

    Authors: Thomas D Benen, Paul Tonks, Alexander Kliche, Ruth Kapzan, Jonathan L Heeney and Ralf Wagner
    Citation: Journal of Biomedical Science 2014 21:79
    Content type: Research Published on:

  44. Pin1 promotes oncogenesis by regulating multiple oncogenic signaling. In this study, we investigated the involvement of Pin1 in tumor progression and in the prognosis of human esophageal squamous cell carcinom...

    Authors: Forn-Chia Lin, Yu-Cheng Lee, Yih-Gang Goan, Chen-Hsun Tsai, Yun-Chin Yao, Hui-Chuan Cheng, Wu-Wei Lai, Yi-Ching Wang, Bor-Shyang Sheu and Pei-Jung Lu
    Citation: Journal of Biomedical Science 2014 21:75
    Content type: Research Published on:

  45. We previously reported that Enterovirus 71 (EV71) infection activates autophagy, which promotes viral replication both in vitro and in vivo. In the present study we further investigated whether EV71 infection of ...

    Authors: Ying-Ray Lee, Po-Shun Wang, Jen-Ren Wang and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2014 21:80
    Content type: Research Published on:

  46. Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into saliva and milk. Although CA VI was first described as ...

    Authors: Maarit Patrikainen, Peiwen Pan, Natalia Kulesskaya, Vootele Voikar and Seppo Parkkila
    Citation: Journal of Biomedical Science 2014 21:82
    Content type: Research Published on:

  47. Mesenchymal stem cells (MSCs) at maternal-fetal interface are considered to play an important role in the pathogenesis of pre-eclampsia (PE). microRNAs (miRNAs) also have an important influence on differentiat...

    Authors: Guangfeng Zhao, Xue Zhou, Shiwen Chen, Huishuang Miao, Hongye Fan, Zhiqun Wang, Yali Hu and Yayi Hou
    Citation: Journal of Biomedical Science 2014 21:81
    Content type: Research Published on:

  48. The green fluorescence protein (GFP)-associated fluorescence method and the luciferase-associated bioluminescence method are the two major methods for IVIS imaging system to investigate the bacterial infection...

    Authors: Yao-Kuang Huang, Chishih Chu, Chih-Hsiung Wu, Chyi-Liang Chen and Cheng-Hsun Chiu
    Citation: Journal of Biomedical Science 2014 21:78
    Content type: Research Published on:

  49. Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. Few studies are available that describe this association with bladder cancer either related or unrelated to ...

    Authors: Fathia El-Sharkawi, Mahmoud El Sabah, Zeinab Hassan and Hussein Khaled
    Citation: Journal of Biomedical Science 2014 21:72
    Content type: Research Published on:

  50. Our previous study showed NF-κB repressing factor (NKRF) downregulates IP-10 and IL-8 synthesis in the peripheral blood mononuclear cells and alveolar macrophages of TB patients with high bacterial loads. Howe...

    Authors: Kuo-Hsiung Huang, Chun-Hua Wang, Chien-Huang Lin and Han-Pin Kuo
    Citation: Journal of Biomedical Science 2014 21:71
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127