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  1. Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therap...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai

    Citation: Journal of Biomedical Science 2011 18:65

    Content type: Research

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  2. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang

    Citation: Journal of Biomedical Science 2011 18:64

    Content type: Research

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  3. Prostate cancer is the most frequently diagnosed non-cutaneous tumor of men in Western countries. While surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary ...

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su

    Citation: Journal of Biomedical Science 2011 18:63

    Content type: Review

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  4. Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Authors: Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki, Yu Sogo, Atsuo Ito and Akira Matsumura

    Citation: Journal of Biomedical Science 2011 18:62

    Content type: Research

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  5. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang

    Citation: Journal of Biomedical Science 2011 18:61

    Content type: Research

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  6. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi

    Citation: Journal of Biomedical Science 2011 18:60

    Content type: Research

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  7. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li

    Citation: Journal of Biomedical Science 2011 18:59

    Content type: Research

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  8. Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. R...

    Authors: Shan-shan Liu, Xiang-mei Chen, Hong-xia Zheng, Shu-liang Shi and Yu Li

    Citation: Journal of Biomedical Science 2011 18:58

    Content type: Research

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  9. High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...

    Authors: Ke Chen, ping jin, Hong-hui He, Yan-hong Xie, Xiao-yun Xie and Zhao-hui Mo

    Citation: Journal of Biomedical Science 2011 18:57

    Content type: Research

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  10. Notch and TLR pathways were found to act cooperatively to activate Notch target genes and to increase the production of TLR-induced cytokines in macrophages. However, the mechanism of LPS-induced Notch activat...

    Authors: Po-Nien Tsao, Shu-Chen Wei, Miao-Tzu Huang, Ming-Cheng Lee, Hung-Chieh Chou, Chien-Yi Chen and Wu-Shiun Hsieh

    Citation: Journal of Biomedical Science 2011 18:56

    Content type: Research

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  11. Sphingosylphosphorylcholine (SPC) acts as a potent lipid mediator and signaling molecule in various cell types. In the present study, we investigated the effects of SPC on melanogenesis and SPC-modulated signa...

    Authors: Hyo-Soon Jeong, Seung Hoon Lee, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung-Chan Park and Dong-Seok Kim

    Citation: Journal of Biomedical Science 2011 18:55

    Content type: Research

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  12. Spinocerebellar ataxia (SCA) refers to a disease entity in which polyglutamine aggregates are over-produced in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and...

    Authors: You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bing-Wen Soong, Jennifer H Ho and Oscar K Lee

    Citation: Journal of Biomedical Science 2011 18:54

    Content type: Research

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  13. Postconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of precondit...

    Authors: Yikui Tian, Wenjuan Zhang, Dachuan Xia, Paul Modi, Degang Liang and Minxin Wei

    Citation: Journal of Biomedical Science 2011 18:53

    Content type: Research

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  14. Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers...

    Authors: Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen and Jungshan Chang

    Citation: Journal of Biomedical Science 2011 18:52

    Content type: Research

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  15. Arsenic exposure is an important public health issue worldwide. Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed. Inorganic arsenic is methylat...

    Authors: Ling-I Hsu, Wu-Ping Chen, Tse-Yen Yang, Yu-Hsin Chen, Wann-Cheng Lo, Yuan-Hung Wang, Ya-Tang Liao, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu and Chien-Jen Chen

    Citation: Journal of Biomedical Science 2011 18:51

    Content type: Research

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  16. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq

    Citation: Journal of Biomedical Science 2011 18:50

    Content type: Research

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  17. In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (B...

    Authors: Pei-Min Chen, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu and B-Linju Yen

    Citation: Journal of Biomedical Science 2011 18:49

    Content type: Review

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  18. At the beginning of neurogenesis, massive brain cell death occurs and more than 50% of cells are eliminated by apoptosis along with neuronal differentiation. However, few studies were conducted so far regardin...

    Authors: Hyo Sang Go, Jung Eun Seo, Ki Chan Kim, So Min Han, Pitna Kim, Young Sun Kang, Seol Heui Han, Chan Young Shin and Kwang Ho Ko

    Citation: Journal of Biomedical Science 2011 18:48

    Content type: Research

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  19. Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to possess an insulin-like property in diabetes. In...

    Authors: Chih-Chun Chang, Chieh-Yu Chang, Yang-Tzu Wu, Jiung-Pang Huang, Tzung-Hai Yen and Li-Man Hung

    Citation: Journal of Biomedical Science 2011 18:47

    Content type: Research

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  20. Methionine Sulfoxide Reductase A (MsrA), an enzyme in the Msr gene family, is important in the cellular anti-oxidative stress defense mechanism. It acts by reducing the oxidized methionine sulfoxide in protein...

    Authors: Pingping Jia, Chi Zhang, Yuanyuan Jia, Keith A Webster, Xupei Huang, Andrei A Kochegarov, Sharon L Lemanski and Larry F Lemanski

    Citation: Journal of Biomedical Science 2011 18:46

    Content type: Research

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  21. Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling path...

    Authors: Karen F Chambers, Joanna F Pearson, Davide Pellacani, Naveed Aziz, Miodrag Gužvić, Christoph A Klein and Shona H Lang

    Citation: Journal of Biomedical Science 2011 18:45

    Content type: Research

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  22. Damage-associated molecular patterns (DAMPs) are associated with immunogenic cell death and have the ability to enhance maturation and antigen presentation of dendritic cells (DCs). Specific microtubule-depoly...

    Authors: Chih-Chun Wen, Hui-Ming Chen, Swey-Shen Chen, Li-Ting Huang, Wei-Ting Chang, Wen-Chi Wei, Li-Chen Chou, Palanisamy Arulselvan, Jin-Bin Wu, Sheng-Chu Kuo and Ning-Sun Yang

    Citation: Journal of Biomedical Science 2011 18:44

    Content type: Research

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  23. Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteina...

    Authors: Ta-Liang Chen, Yung-Feng Lin, Chao-Wen Cheng, Shi-Yun Chen, Ming-Thau Sheu, Ting-Kai Leung, Cheng-Hong Qin and Chien-Ho Chen

    Citation: Journal of Biomedical Science 2011 18:43

    Content type: Research

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  24. The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally ...

    Authors: Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh and Li-Mei Pai

    Citation: Journal of Biomedical Science 2011 18:42

    Content type: Research

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  25. The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden. Two seasons existed, one of increased deprivation...

    Authors: Pa T Ngom, Juan Solon, Sophie E Moore, Gareth Morgan, Andrew M Prentice and Richard Aspinall

    Citation: Journal of Biomedical Science 2011 18:41

    Content type: Research

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  26. Carbon monoxide (CO) is a toxic gas, which also acts in the organism as a neurotransmitter. It is generated as a by-product of heme breakdown catalyzed by heme oxygenase. We have investigated changes in electr...

    Authors: Denis V Abramochkin, Nail N Haertdinov, Maria V Porokhnya, Andrew L Zefirov and Gusel F Sitdikova

    Citation: Journal of Biomedical Science 2011 18:40

    Content type: Research

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  27. Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact ro...

    Authors: Ling-fang He, Ting-ting Wang, Qian-ying Gao, Guang-feng Zhao, Ya-hong Huang, Li-ke Yu and Ya-yi Hou

    Citation: Journal of Biomedical Science 2011 18:39

    Content type: Research

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  28. Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one ...

    Authors: Lorenzo A Calò, Luciana Bordin, Paul A Davis, Elisa Pagnin, Lucia Dal Maso, Gian Paolo Rossi, Achille C Pessina and Giulio Clari

    Citation: Journal of Biomedical Science 2011 18:38

    Content type: Research

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  29. It is of growing interest to develop novel approaches to initiate differentiation of mesenchymal stem cells (MSCs) into cardiomyocytes. The purpose of this investigation was to determine if Sphingosine-1-phosp...

    Authors: Zhenqiang Zhao, Zhibin Chen, Xiubo Zhao, Fang Pan, Meihua Cai, Tan Wang, Henggui Zhang, Jian R Lu and Ming Lei

    Citation: Journal of Biomedical Science 2011 18:37

    Content type: Research

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  30. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as repr...

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen

    Citation: Journal of Biomedical Science 2011 18:36

    Content type: Research

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  31. Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to prote...

    Authors: Jian Xiao, Xiaoyan Zhu, Bin He, Yufeng Zhang, Bo Kang, Zhinong Wang and Xin Ni

    Citation: Journal of Biomedical Science 2011 18:35

    Content type: Research

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  32. Mu opioid receptor (MOR), which plays key roles in analgesia and also has effects on learning and memory, was reported to distribute abundantly in the patches of the neostriatum. The marginal division (MrD) of...

    Authors: Chuanxing Wang, Si Yun Shu, Zhouyi Guo, Ye Feng Cai, Xinmin Bao, Changchun Zeng, Bingyi Wu, Ziyou Hu and Xuemei Liu

    Citation: Journal of Biomedical Science 2011 18:34

    Content type: Research

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  33. Adrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS). We previously demonstrated...

    Authors: David HT Yen, Lih-Chi Chen, Yuh-Chiang Shen, Ying-Chen Chiu, I-Chun Ho, Ya-Jou Lou, I-Chin Chen and Jiin-Cherng Yen

    Citation: Journal of Biomedical Science 2011 18:32

    Content type: Research

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  34. Hypoxia during the first week of life can induce neuronal death in vulnerable brain regions usually associated with an impairment of cognitive function that can be detected later in life. The neurobiological c...

    Authors: Thoppil R Anju, Sadanandan Jayanarayanan and Cheramadatikudiyil S Paulose

    Citation: Journal of Biomedical Science 2011 18:31

    Content type: Research

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  35. NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex...

    Authors: Hsin-Yu Liu, Pin-Chao Liao, Kai-Tun Chuang and Mou-Chieh Kao

    Citation: Journal of Biomedical Science 2011 18:29

    Content type: Research

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  36. Natural products have played a significant role in drug discovery and development. Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been suggested to conn...

    Authors: I-Ni Hsieh, Anita Shin-Yuan Chang, Che-Ming Teng, Chien-Chih Chen and Chia-Ron Yang

    Citation: Journal of Biomedical Science 2011 18:28

    Content type: Research

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  37. Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effect...

    Authors: Bao-Wei Wang, Chiu-Mei Lin, Gong-Jhe Wu and Kou-Gi Shyu

    Citation: Journal of Biomedical Science 2011 18:27

    Content type: Research

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  38. Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients ...

    Authors: Wei S Lian, Heng Lin, Winston TK Cheng, Tateki Kikuchi and Ching F Cheng

    Citation: Journal of Biomedical Science 2011 18:26

    Content type: Research

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  39. Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand t...

    Authors: Fe-Lin Lin Wu, Yu-Fen Liang, Yuan-Chen Chang, Hao-Hsin Yo, Ming-Feng Wei and Li-Jiuan Shen

    Citation: Journal of Biomedical Science 2011 18:25

    Content type: Research

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  40. Artemin (ARTN) is a neurotrophic factor belonging to the glial cell-derived neurotrophic factor family of ligands. To develop potential therapy targeting ARTN, we studied the roles of miR-223 in the migration ...

    Authors: Shujun Li, Zhigang Li, Fengjie Guo, Xuebo Qin, Bin Liu, Zhe Lei, Zuoqing Song, Liya Sun, Hong-Tao Zhang, Jiacong You and Qinghua Zhou

    Citation: Journal of Biomedical Science 2011 18:24

    Content type: Research

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  41. Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken ...

    Authors: Bin He, Jian Xiao, An-Jing Ren, Yu-Feng Zhang, Hao Zhang, Min Chen, Bing Xie, Xiao-Gang Gao and Ying-Wei Wang

    Citation: Journal of Biomedical Science 2011 18:22

    Content type: Research

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  42. Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dim...

    Authors: Shiwen Peng, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu

    Citation: Journal of Biomedical Science 2011 18:21

    Content type: Research

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  43. Japanese encephalitis (JE) virus is the most common cause of epidemic viral encephalitis in the world. The virus mainly infects neuronal cells and causes an inflammatory response after invasion of the parenchy...

    Authors: Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang and Wei-June Chen

    Citation: Journal of Biomedical Science 2011 18:20

    Content type: Research

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  44. In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA rec...

    Authors: Hwei-Hsien Chen, Pei-Fei Liao and Ming-Huan Chan

    Citation: Journal of Biomedical Science 2011 18:19

    Content type: Research

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  45. Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptor...

    Authors: Hong-zhu Li, Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang…

    Citation: Journal of Biomedical Science 2011 18:18

    Content type: Research

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  46. Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental ...

    Authors: Se Jin Jeon, Jung Eun Seo, Sung-Il Yang, Ji Woong Choi, David Wells, Chan Young Shin and Kwang Ho Ko

    Citation: Journal of Biomedical Science 2011 18:17

    Content type: Research

    Published on:

  47. The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery (PA) is unknown.

    Authors: Guang-wei Li, Qiu-shi Wang, Jing-hui Hao, Wen-jing Xing, Jin Guo, Hong-zhu Li, Shu-zhi Bai, Hong-xia Li, Wei-hua Zhang, Bao-feng Yang, Guang-dong Yang, Ling-yun Wu, Rui Wang and Chang-qing Xu

    Citation: Journal of Biomedical Science 2011 18:16

    Content type: Research

    Published on:

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