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  1. Content type: Research

    The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied wit...

    Authors: Wanisa Salaemae, Muhammad Junaid, Chanan Angsuthanasombat and Gerd Katzenmeier

    Citation: Journal of Biomedical Science 2010 17:68

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  2. Content type: Review

    The prevalence of metabolic syndrome (MS) in children and adolescents has been increasing at an alarming rate. MS risks during childhood and adolescence adversely affect health conditions in later life. Thus, ...

    Authors: Megumi Ishikawa, Shiho Arai, Mio Takano, Atsumi Hamada, Kazuhiro Kunimasa and Mari Mori

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S47

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    This article is part of a Supplement: Volume 17 Supplement 1

  3. Content type: Review

    Pigmentation in human skin is an important defense mechanism against sunlight or oxidative stress. Despite the protective role of melanin, abnormal hyperpigmentation such as freckles and chloasma sometimes can...

    Authors: Ji Sun Yu and An Keun Kim

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S45

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    This article is part of a Supplement: Volume 17 Supplement 1

  4. Content type: Review

    Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of...

    Authors: Mari Mori, Hideki Mori, Atsumi Hamada and Yukio Yamori

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S43

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    This article is part of a Supplement: Volume 17 Supplement 1

  5. Content type: Research

    Constipation is a common gastrointestinal symptom in Korea as well as in Western countries. This study was performed to investigate the dietary taurine intake, nutrient status, and life stress of functional co...

    Authors: Jeong-Soon You, Ji-Yeon Park and Kyung-Ja Chang

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S41

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    This article is part of a Supplement: Volume 17 Supplement 1

  6. Content type: Research

    Nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxi...

    Authors: Huan Du, Xu Zhao, Jeong-Soon You, Ji-Yeon Park, Sung-Hoon Kim and Kyung-Ja Chang

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S39

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    This article is part of a Supplement: Volume 17 Supplement 1

  7. Content type: Review

    Low birth weight is associated with an increased risk of developing impaired glucose tolerance, and eventually type 2 diabetes in adult life. Gestational protein restriction in rodents gives rise to a low birt...

    Authors: Ole Hartvig Mortensen, Hanne Lodberg Olsen, Lis Frandsen, Peter Eigil Nielsen, Finn Cilius Nielsen, Niels Grunnet and Bjørn Quistorff

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S38

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    This article is part of a Supplement: Volume 17 Supplement 1

  8. Content type: Review

    In the present study, we investigated the changes of uptake and efflux transport of taurine under various stress conditions using rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT cells), as in...

    Authors: Na-Young Lee and Young-Sook Kang

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S37

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    This article is part of a Supplement: Volume 17 Supplement 1

  9. Content type: Review

    When used in overdoses, acetaminophen (APAP) is a common cause of morbidity and mortality in humans. At present, N-acetylcysteine (NAC) is the antidote of choice for acetaminophen overdoses. Prompt administrat...

    Authors: Miteshkumar Acharya and Cesar A Lau-Cam

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S35

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    This article is part of a Supplement: Volume 17 Supplement 1

  10. Content type: Review

    Taurine plays an important role in reducing physiological stress. Recent studies indicated that taurine may serve as an anti-obesity agent at the cellular level. This study characterizes taurine’s potential an...

    Authors: Hye Min Kim, Chang-Hee Do and Dong Hee Lee

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S33

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    This article is part of a Supplement: Volume 17 Supplement 1

  11. Content type: Review

    Taurine possesses membrane stabilization, osmoregulatory and antioxidant properties, aspects of relevance to ischemic injury. We tested the hypothesis that body taurine status is a determinant of renal ischemi...

    Authors: Mahmood S Mozaffari, Rafik Abdelsayed, Champa Patel, Hereward Wimborne, Jun Yao Liu and Stephen W Schaffer

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S32

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    This article is part of a Supplement: Volume 17 Supplement 1

  12. Content type: Review

    Perinatal taurine exposure influences renal function in adult female offspring. This study tests the hypothesis that prenatal rather than postnatal taurine exposure alters renal function in adult conscious mal...

    Authors: Sanya Roysommuti, Pisamai Malila, Dusit Jirakulsomchok and J Michael Wyss

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S31

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  13. Content type: Review

    Perinatal taurine depletion leads to several physiological impairments in adult life, in part, due to taurine’s effects on the renin-angiotensin system, a crucial regulator of growth and differentiation during...

    Authors: Atcharaporn Thaeomor, J Michael Wyss, Dusit Jirakulsomchok and Sanya Roysommuti

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S30

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  14. Content type: Review

    Perinatal taurine exposure has long-term effects on the arterial pressure and renal function. This study tests its influence on renal potassium excretion in young adult, conscious rats. Female Sprague-Dawley r...

    Authors: Sanya Roysommuti, Pisamai Malila, Wichaporn Lerdweeraphon, Dusit Jirakulsomchok and J Michael Wyss

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S29

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  15. Content type: Review

    Adiponectin greatly stimulated the expression of matrix metalloproteinases (MMPs) in fibroblast-like synoviocytes (FLSs) as did IL-1β. We wondered whether taurine chloramine (TauCl) inhibits the production of ...

    Authors: Kyoung Soo Kim, Hyun-Mi Choi, Da Hee Oh, Chaekyun Kim, Jin Seok Jeong, Myung Chul Yoo and Hyung-In Yang

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S27

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  16. Content type: Review

    ER stress is a strong indicator of whether or not a cell is undergoing physiological stress. C. elegans is a practical system of characterizing the effect of ER stress at the in vivo or organismal level.

    Authors: Hye Min Kim, Chang-Hee Do and Dong Hee Lee

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S26

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  17. Content type: Review

    The β-amino acid, taurine, is a nutritional requirement in some species. In these species, the depletion of intracellular stores of taurine leads to the development of severe organ dysfunction. The basis under...

    Authors: Chian Ju Jong, Takashi Ito, Mahmood Mozaffari, Junichi Azuma and Stephen Schaffer

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S25

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  18. Content type: Review

    Taurine is present in lymphocytes and seems to modulate certain immune cell functions. Among the effects of taurine on these cells are protection against antioxidants and regulation of inflammatory aspects of ...

    Authors: Fili Fazzino, Francisco Obregón and Lucimey Lima

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S24

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    This article is part of a Supplement: Volume 17 Supplement 1

  19. Content type: Review

    Perinatal taurine depletion and high sugar diets blunted baroreflex function and heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders and taurine treat...

    Authors: Supaporn Kulthinee, J Michael Wyss, Dusit Jirakulsomchok and Sanya Roysommuti

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S22

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    This article is part of a Supplement: Volume 17 Supplement 1

  20. Content type: Review

    Taurine, a sulfur-containing β-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardia...

    Authors: Takashi Ito, Shohei Oishi, Mika Takai, Yasushi Kimura, Yoriko Uozumi, Yasushi Fujio, Stephen W Schaffer and Junichi Azuma

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S20

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  21. Content type: Review

    To assess the effect of taurine on lipopolysaccharide (LPS)-induced lung inflammation, oxidative stress and apoptosis, female Golden Syrian hamsters were intratracheally instilled with bacterial LPS (0.02 mg i...

    Authors: Tapan M Bhavsar, Sanket N Patel and Cesar A Lau-Cam

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S19

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  22. Content type: Review

    Both taurine, an inhibitory neurotransmitter and granulocyte colony-stimulating factor (G-CSF), a growth factor, possess neuroprotective and neurotrophic properties in vitro. However, the mechanisms of their u...

    Authors: Chunliu Pan, Amit Gupta, Howard Prentice and Jang-Yen Wu

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S18

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  23. Content type: Review

    Poly(ADP-ribose) is a NAD+-requiring, DNA-repairing, enzyme playing a central role in pancreatic β-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation ...

    Authors: Kashyap G Pandya, Maulik R Patel and Cesar A Lau-Cam

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S16

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  24. Content type: Review

    Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Chronic supplementation of taurine in drinking water to mice increases brain excitability ...

    Authors: William J L’Amoreaux, Alexandra Marsillo and Abdeslem El Idrissi

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S14

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  25. Content type: Review

    Acute ethanol administration leads to massive apoptotic neurodegeneration in the developing central nervous system. We studied whether taurine is neuroprotective in ethanol-induced apoptosis in the mouse cereb...

    Authors: Andrey G Taranukhin, Elena Y Taranukhina, Pirjo Saransaari, Irina M Podkletnova, Markku Pelto-Huikko and Simo S Oja

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S12

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  26. Content type: Review

    Hippocampal slices swell and release taurine during oxidative stress. The influence of cellular signalling pathways on this process is unclear. Glutamate signalling can facilitate volume regulation in other CN...

    Authors: Brian Tucker and James E Olson

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S10

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  27. Content type: Review

    The fragile X mouse model shows an increase in seizure susceptibility, indicating an involvement of the GABAergic system via an alteration in cellular excitability. In the brain, we have previously described a...

    Authors: Abdeslem El Idrissi, Xin Yan, Francoise Sidime and William L’Amoreaux

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S8

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  28. Content type: Research

    Taurine (T) was first noted as beneficial for stroke and cardiovascular diseases (CVD) prevention in genetic rat models, stroke-prone spontaneously hypertensive rats (SHRSP). The preventive mechanisms of T wer...

    Authors: Yukio Yamori, Takashi Taguchi, Atsumi Hamada, Kazuhiro Kunimasa, Hideki Mori and Mari Mori

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S6

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  29. Content type: Research

    Although taurine and glutamate are the most abundant amino acids conducting neural signals in the central nervous system, the communication between these two neurotransmitters is largely unknown. This study ex...

    Authors: Simon Bulley and Wen Shen

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S5

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    This article is part of a Supplement: Volume 17 Supplement 1

  30. Content type: Research

    Taurine participates in a number of different physiologic and biologic processes in the kidney, often reflected by urinary excretion patterns. The kidney is key to aspects of taurine body pool size and homeost...

    Authors: Russell W Chesney, Xiaobin Han and Andrea B Patters

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S4

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    This article is part of a Supplement: Volume 17 Supplement 1

  31. Content type: Research

    Taurine (aminoethane sulfonic acid) is an ubiquitous compound, found in very high concentrations in heart and muscle. Although taurine is classified as an amino acid, it does not participate in peptide bond fo...

    Authors: Stephen W Schaffer, Chian Ju Jong, Ramila KC and Junichi Azuma

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S2

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  32. Content type: Research

    Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating c...

    Authors: Jang-Yen Wu and Howard Prentice

    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S1

    Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  33. Content type: Research

    Parkinson's disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. Genetic association studies have linked 13 h...

    Authors: Shahrooz Vahedi, Mehrnoosh Rajabian, Arman Misaghian, Daniel Grbec, Horst H Simon and Kambiz N Alavian

    Citation: Journal of Biomedical Science 2010 17:66

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  34. Content type: Research

    Enterovirus type 71 (EV71) 2A protease exhibited strong transcriptional activity in yeast cells. The transcriptional activity of 2A protease was independent of its protease activity. EV71 2A protease retained ...

    Authors: Chee-Hing Yang, Hui-Chun Li, Jeng-Geng Jiang, Che-Fang Hsu, Yi-Jen Wang, Meng-Jiun Lai, Yue-Li Juang and Shih-Yen Lo

    Citation: Journal of Biomedical Science 2010 17:65

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  35. Content type: Research

    To overcome loss of stem-like properties and spontaneous differentiation those hinder the expansion and application of human mesenchymal stem cells (hMSCs), we have clonally isolated permanent and stable human...

    Authors: Chih-Chien Tsai, Chun-Li Chen, Hwa-Chung Liu, Yi-Ting Lee, Hsei-Wei Wang, Lein-Tuan Hou and Shih-Chieh Hung

    Citation: Journal of Biomedical Science 2010 17:64

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  36. Content type: Research

    Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present...

    Authors: Paola Cuccarolo, Francesca Barbieri, Monica Sancandi, Silvia Viaggi and Paolo Degan

    Citation: Journal of Biomedical Science 2010 17:63

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  37. Content type: Research

    Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of ...

    Authors: Youssef Sari, Anne L Prieto, Scott J Barton, Benjamin R Miller and George V Rebec

    Citation: Journal of Biomedical Science 2010 17:62

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  38. Content type: Research

    Ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. Advanced ovarian cancers are difficult to cure with the current available chemotherapy, which has ma...

    Authors: Daejin Kim, Talia Hoory, Archana Monie, Annie Wu, Wei-Ting Hsueh, Sara I Pai and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2010 17:61

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  39. Content type: Research

    Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttle...

    Authors: Hongxing Gui, Chi-Wei Lu, Sandra Adams, Victor Stollar and Mei-Ling Li

    Citation: Journal of Biomedical Science 2010 17:59

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  40. Content type: Research

    The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical is...

    Authors: Ai-Sheng Ho, Chun-Chia Cheng, Shui-Cheng Lee, Meng-Lun Liu, Jing-Ying Lee, Wen-Ming Wang and Chia-Chi Wang

    Citation: Journal of Biomedical Science 2010 17:58

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  41. Content type: Research

    The treatment of AIDS remains a serious challenge owing to high genetic variation of Human Immunodeficiency Virus type 1 (HIV-1). The use of different antiretroviral drugs (ARV) is significantly limited by sev...

    Authors: Lakshmi N Ramana, Swaminathan Sethuraman, Udaykumar Ranga and Uma M Krishnan

    Citation: Journal of Biomedical Science 2010 17:57

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  42. Content type: Research

    Islet transplantation provides a promising cure for Type 1 diabetes; however it is limited by a shortage of pancreas donors. Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells ...

    Authors: Hsiao-Yun Lin, Chih-Chien Tsai, Ling-Lan Chen, Shih-Hwa Chiou, Yng-Jiin Wang and Shih-Chieh Hung

    Citation: Journal of Biomedical Science 2010 17:56

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  43. Content type: Research

    Paraplegia remains a potential complication of spinal cord ischemic reperfusion injury (IRI) in which oxidative stress induced cyclooxygenase activities may contribute to ischemic neuronal damage. Prolonged ad...

    Authors: Mohamed D Morsy, Ossama A Mostafa and Waleed N Hassan

    Citation: Journal of Biomedical Science 2010 17:55

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  44. Content type: Research

    MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however...

    Authors: Genesio M Karere, Jeremy P Glenn, John L VandeBerg and Laura A Cox

    Citation: Journal of Biomedical Science 2010 17:54

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  45. Content type: Review

    Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells...

    Authors: Rasmus O Bak and Jacob G Mikkelsen

    Citation: Journal of Biomedical Science 2010 17:53

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  46. Content type: Research

    Open reading frame l0045 in the pathogenic island of enterohemorrhagic Escherichia coli O157:H7 has been predicted to encode a lytic transglycosylase that is homologous to two different gene products encoded by t...

    Authors: Yen-Chi Yu, Ching-Nan Lin, Shao-Hung Wang, Swee-Chuan Ng, Wensi S Hu and Wan-Jr Syu

    Citation: Journal of Biomedical Science 2010 17:52

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  47. Content type: Research

    RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like par...

    Authors: Meng-Ing Chou, Yu-Fan Hsieh, Meilin Wang, Jinghua Tsai Chang, Deching Chang, Moncef Zouali and Gregory J Tsay

    Citation: Journal of Biomedical Science 2010 17:51

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  48. Content type: Research

    The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-li...

    Authors: Hsiang-Ping Tsai, Li-Wei Lin, Zhi-Yang Lai, Jui-Yu Wu, Chiao-En Chen, Jaulang Hwang, Chien-Shu Chen and Chun-Mao Lin

    Citation: Journal of Biomedical Science 2010 17:49

    Published on:

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