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  1. Review

    The complexity of TRIM28 contribution to cancer

    Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular biology has been extensively studied resulting in identification of a complex nature of TRIM28 protein. In this revie...

    Patrycja Czerwińska, Sylwia Mazurek and Maciej Wiznerowicz

    Journal of Biomedical Science 2017 24:63

    Published on: 29 August 2017

  2. Research

    The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis

    Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

    Hong-Yi Chang, Hsin-Mei Chang, Tsung-Jung Wu, Chang-Yao Chaing, Tzong-Shin Tzai, Hong-Lin Cheng, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu

    Journal of Biomedical Science 2017 24:61

    Published on: 26 August 2017

  3. Review

    3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders

    Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...

    Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen

    Journal of Biomedical Science 2017 24:59

    Published on: 20 August 2017

  4. Research

    Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

    Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU m...

    Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth…

    Journal of Biomedical Science 2017 24:57

    Published on: 17 August 2017

  5. Review

    Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies

    Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri

    Journal of Biomedical Science 2017 24:56

    Published on: 15 August 2017

  6. Research

    Lrp, a global regulator, regulates the virulence of Vibrio vulnificus

    An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cy...

    Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto and Lien-I Hor

    Journal of Biomedical Science 2017 24:54

    Published on: 11 August 2017

  7. Research

    Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

    Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary ar...

    Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao and Liangxing Wang

    Journal of Biomedical Science 2017 24:52

    Published on: 3 August 2017

  8. Review

    Role of free fatty acids in endothelial dysfunction

    Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence show...

    Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu and Christopher W. K. Lai

    Journal of Biomedical Science 2017 24:50

    Published on: 27 July 2017

  9. Research

    Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells

    Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...

    Yu-Tang Chin, Le-Ming Wang, Meng-Ti Hsieh, Ya-Jung Shih, André Wendindondé Nana, Chun A. Changou, Yu-Chen S. H. Yang, Hsien-Chung Chiu, Earl Fu, Paul J. Davis, Heng-Yuan Tang and Hung-Yun Lin

    Journal of Biomedical Science 2017 24:51

    Published on: 27 July 2017

  10. Review

    Drug candidates in clinical trials for Alzheimer’s disease

    Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with cognitive impairment. AD is the most common neurodegenerative disease worldwide,...

    Shih-Ya Hung and Wen-Mei Fu

    Journal of Biomedical Science 2017 24:47

    Published on: 19 July 2017

  11. Research

    Klf8 regulates left-right asymmetric patterning through modulation of Kupffer’s vesicle morphogenesis and spaw expression

    Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human...

    Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang and Sheng-Ping L. Hwang

    Journal of Biomedical Science 2017 24:45

    Published on: 17 July 2017

  12. Research

    PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

    The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate ...

    Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger and Marcel A. G. van der Heyden

    Journal of Biomedical Science 2017 24:44

    Published on: 15 July 2017

  13. Research

    V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients

    Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythr...

    Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu and Wei-Chiao Chang

    Journal of Biomedical Science 2017 24:43

    Published on: 11 July 2017

  14. Review

    Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease

    Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects periphe...

    Peggy Sfyri and Antonios Matsakas

    Journal of Biomedical Science 2017 24:42

    Published on: 8 July 2017

  15. Research

    Nuclear factor-kappa B influences early phase of compensatory lung growth after pneumonectomy in mice

    Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF...

    Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara and Masafumi Kawamura

    Journal of Biomedical Science 2017 24:41

    Published on: 5 July 2017

  16. Research

    Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study

    Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. ...

    Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin and Hui-Yee Chee

    Journal of Biomedical Science 2017 24:40

    Published on: 28 June 2017

  17. Research

    Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis

    Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu

    Journal of Biomedical Science 2017 24:38

    Published on: 15 June 2017

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.