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Review
Despite growing interest and effort, a consensus has yet to be reached in regards to the identification of adult renal stem cells. Organ complexity and low turnover of renal cells has made stem cell identifica...
Journal of Biomedical Science 2017 24:32
Published on: 16 May 2017
Research
In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...
Journal of Biomedical Science 2017 24:31
Published on: 12 May 2017
Research
L-Citrulline is a neutral amino acid and a major precursor of L-arginine in the nitric oxide (NO) cycle. Recently it has been reported that L-citrulline prevents neuronal cell death an...
Journal of Biomedical Science 2017 24:28
Published on: 10 May 2017
Research
Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...
Journal of Biomedical Science 2017 24:29
Published on: 10 May 2017
Research
The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...
Journal of Biomedical Science 2017 24:30
Published on: 10 May 2017
Research
Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...
Journal of Biomedical Science 2017 24:27
Published on: 9 May 2017
Review
Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...
Journal of Biomedical Science 2017 24:26
Published on: 4 April 2017
Research
Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...
Journal of Biomedical Science 2017 24:25
Published on: 28 March 2017
Research
GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...
Journal of Biomedical Science 2017 24:23
Published on: 27 March 2017
Research
Malfunctioning of the serotonergic system in Parkinson’s disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 re...
Journal of Biomedical Science 2017 24:24
Published on: 27 March 2017
Review
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by...
Journal of Biomedical Science 2017 24:22
Published on: 23 March 2017
Review
Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...
Journal of Biomedical Science 2017 24:21
Published on: 21 March 2017
Research
The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...
Journal of Biomedical Science 2017 24:20
Published on: 7 March 2017
Review
The occurrence of more than 200 diseases, including cancer, can be attributed to alcohol drinking. The global cancer deaths attributed to alcohol-consumption rose from 243,000 in 1990 to 337,400 in 2010. In 20...
Journal of Biomedical Science 2017 24:19
Published on: 3 March 2017
Review
Multi voxel magnetic resonance spectroscopic imaging (MRSI) is an important imaging tool that combines imaging and spectroscopic techniques. MRSI of the human brain has been beneficially applied to different c...
Journal of Biomedical Science 2017 24:17
Published on: 28 February 2017
Research
Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-...
Journal of Biomedical Science 2017 24:18
Published on: 28 February 2017
Research
Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulce...
Journal of Biomedical Science 2017 24:16
Published on: 27 February 2017
Review
Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...
Journal of Biomedical Science 2017 24:15
Published on: 20 February 2017
Review
Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...
Journal of Biomedical Science 2017 24:14
Published on: 8 February 2017
Research
Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...
Journal of Biomedical Science 2017 24:12
Published on: 7 February 2017
Review
Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...
Journal of Biomedical Science 2017 24:13
Published on: 7 February 2017
Research
Reduced bone formation is associated with increased bone marrow fat in many bone-loss related diseases including aging, post-menopause, and anorexia nervosa. Several lines of evidence suggested the regulation ...
Journal of Biomedical Science 2017 24:11
Published on: 7 February 2017
Review
Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...
Journal of Biomedical Science 2017 24:10
Published on: 1 February 2017
Review
Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...
Journal of Biomedical Science 2017 24:9
Published on: 31 January 2017
Research
Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynam...
Journal of Biomedical Science 2017 24:8
Published on: 17 January 2017
Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.
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