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  1. Research

    Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

    In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon

    Journal of Biomedical Science 2017 24:31

    Published on: 12 May 2017

  2. Research

    Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

    Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian

    Journal of Biomedical Science 2017 24:29

    Published on: 10 May 2017

  3. Research

    Adducin family proteins possess different nuclear export potentials

    The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen

    Journal of Biomedical Science 2017 24:30

    Published on: 10 May 2017

  4. Research

    KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

    Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate

    Journal of Biomedical Science 2017 24:27

    Published on: 9 May 2017

  5. Review

    Cancer immunotherapies targeting the PD-1 signaling pathway

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Journal of Biomedical Science 2017 24:26

    Published on: 4 April 2017

  6. Research

    Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

    Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Journal of Biomedical Science 2017 24:25

    Published on: 28 March 2017

  7. Research

    Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

    GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Journal of Biomedical Science 2017 24:23

    Published on: 27 March 2017

  8. Review

    Evaluation of the use of therapeutic peptides for cancer treatment

    Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Susan Marqus, Elena Pirogova and Terrence J. Piva

    Journal of Biomedical Science 2017 24:21

    Published on: 21 March 2017

  9. Research

    Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

    The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo

    Journal of Biomedical Science 2017 24:20

    Published on: 7 March 2017

  10. Review

    State of the art in anti-cancer mAbs

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Journal of Biomedical Science 2017 24:15

    Published on: 20 February 2017

  11. Review

    Neuroblastoma treatment in the post-genomic era

    Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini

    Journal of Biomedical Science 2017 24:14

    Published on: 8 February 2017

  12. Research

    Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation

    Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf

    Journal of Biomedical Science 2017 24:12

    Published on: 7 February 2017

  13. Review

    Macrophage activation and polarization in post-infarction cardiac remodeling

    Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov

    Journal of Biomedical Science 2017 24:13

    Published on: 7 February 2017

  14. Review

    Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Journal of Biomedical Science 2017 24:10

    Published on: 1 February 2017

  15. Review

    Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications

    Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee

    Journal of Biomedical Science 2017 24:9

    Published on: 31 January 2017

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.

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