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  1. Content type: Research

    Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biom...

    Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2019 26:20

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  2. Content type: Review

    The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and t...

    Authors: Sabah Haq, Jensine Grondin, Suhrid Banskota and Waliul I. Khan

    Citation: Journal of Biomedical Science 2019 26:19

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  3. Content type: Research

    Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated w...

    Authors: Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak and Katarzyna Lamperska

    Citation: Journal of Biomedical Science 2019 26:17

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  4. Content type: Research

    Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative ...

    Authors: Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson and Jorge Goldstein

    Citation: Journal of Biomedical Science 2019 26:16

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  5. Content type: Review

    Among the various types of dementia, Alzheimer’s disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central...

    Authors: Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado and Jaderson Costa Da Costa

    Citation: Journal of Biomedical Science 2019 26:15

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  6. Content type: Research

    Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited...

    Authors: Zhihai Wang, Wenqi Zuo, Quan Zeng, Yi Qian, Yanshi Li, Chuan Liu, Jue Wang, Shixun Zhong, Youquan Bu and Guohua Hu

    Citation: Journal of Biomedical Science 2019 26:14

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  7. Content type: Research

    Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of th...

    Authors: Wenxia Meng, Weina Cui, Lei Zhao, Weiwei Chi, Huan Cao and Baoshan Wang

    Citation: Journal of Biomedical Science 2019 26:13

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  8. Content type: Research

    Osteoclasts (OCs) are motile multinucleated cells derived from differentiation and fusion of hematopoietic progenitors of the monocyte-macrophage lineage that undergo a multistep process called osteoclastogene...

    Authors: Chu-Lung Chan, Jiann-Yeu Chen, Ming-Chih Shih, Chih-Lueh Albert Wang and Ying-Ming Liou

    Citation: Journal of Biomedical Science 2019 26:12

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  9. Content type: Review

    Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age th...

    Authors: Govind R. Chaudhary, Pramod K. Yadav, Anil K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Ashutosh N. Pandey, Ajai K. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2019 26:11

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  10. Content type: Research

    Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlând...

    Authors: Priscila Silva Franco, Paula Suellen Guimarães Gois, Thádia Evelyn de Araújo, Rafaela José da Silva, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Francesca Ietta, Lara Affonso dos Santos, Maria Célia dos Santos, José Roberto Mineo and Eloisa Amália Vieira Ferro

    Citation: Journal of Biomedical Science 2019 26:10

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  11. Content type: Review

    Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast c...

    Authors: Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya

    Citation: Journal of Biomedical Science 2019 26:7

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  12. Content type: Research

    Pulmonary hypertension (PH) is a progressive disease leading to death ultimately. Our recently published data demonstrated that inhibiting dipeptidyl peptidase IV (DPP-4) alleviated pulmonary vascular remodeli...

    Authors: Jingjing Wang, Min Yu, Jian Xu, Yusheng Cheng, Xiang Li, Guihong Wei, Hong Wang, Hui Kong and Weiping Xie

    Citation: Journal of Biomedical Science 2019 26:6

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  13. Content type: Review

    Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservat...

    Authors: Jonatas Rafael de Oliveira, Samira Esteves Afonso Camargo and Luciane Dias de Oliveira

    Citation: Journal of Biomedical Science 2019 26:5

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  14. Content type: Research

    H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadheri...

    Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2019 26:4

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  15. Content type: Review

    Dysbiosis of gut microbiota is closely related to occurrence of many important chronic inflammations-related diseases. So far the traditionally prescribed prebiotics and probiotics do not show significant impa...

    Authors: Yu-Ling Tsai, Tzu-Lung Lin, Chih-Jung Chang, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai

    Citation: Journal of Biomedical Science 2019 26:3

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  16. Content type: Review

    Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only tr...

    Authors: Shuangling Chen, Qin Zhu, Hong Sun, Yuan Zhang, Sean Tighe, Li Xu and Yingting Zhu

    Citation: Journal of Biomedical Science 2019 26:2

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  17. Content type: Review

    Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these micro...

    Authors: Andre Gerald Buret, Jean-Paul Motta, Thibault Allain, Jose Ferraz and John Lawrence Wallace

    Citation: Journal of Biomedical Science 2019 26:1

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  18. Content type: Review

    Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and...

    Authors: Steven Ting-Yu Chuo, Jasper Che-Yung Chien and Charles Pin-Kuang Lai

    Citation: Journal of Biomedical Science 2018 25:91

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  19. Content type: Review

    The nervous system is a crucial component of the body and damages to this system, either by of injury or disease, can result in serious or potentially lethal consequences. Restoring the damaged nervous system ...

    Authors: Rossana Boni, Azam Ali, Amin Shavandi and Andrew N. Clarkson

    Citation: Journal of Biomedical Science 2018 25:90

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  20. Content type: Review

    Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific...

    Authors: Sarah Jayne Fitzgerald, Amol Vijay Janorkar, Allison Barnes and Rodrigo Oscar Maranon

    Citation: Journal of Biomedical Science 2018 25:89

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  21. Content type: Research

    Cytokines play an important role in controlling the homeostasis of the immune system and infection with Human Immunodeficiency virus (HIV) leads to deregulated production of both pro- and anti-inflammatory cyt...

    Authors: Faustina Nkechi Osuji, Charles Chinedu Onyenekwe, Joseph Ebere Ahaneku and Nkiruka Rose Ukibe

    Citation: Journal of Biomedical Science 2018 25:88

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  22. Content type: Review

    Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or exces...

    Authors: Ruiqiao Guan, Wei Zou, Xiaohong Dai, Xueping Yu, Hao Liu, Qiuxin Chen and Wei Teng

    Citation: Journal of Biomedical Science 2018 25:87

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  23. Content type: Review

    Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

    Authors: Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen

    Citation: Journal of Biomedical Science 2018 25:85

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  24. Content type: Research

    Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes causing...

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees

    Citation: Journal of Biomedical Science 2018 25:82

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    The Correction to this article has been published in Journal of Biomedical Science 2019 26:31

  25. Content type: Research

    Metformin is the most commonly used first-line medicine for type II diabetes mellitus. Acting via AMP-activated protein kinase, it has been used for more than 60 years and has an outstanding safety record. Met...

    Authors: Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Ching-Liang Ho and Shih-Ming Huang

    Citation: Journal of Biomedical Science 2018 25:81

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  26. Content type: Research

    TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although TNS2 can bind with Axl, the details of their interactions have not been elucidate...

    Authors: Li-Chun Cheng, Yen-Lin Chen, An-Ning Cheng, Alan Yueh-Luen Lee, Chun-Yu Cho, Jhy-Shrian Huang and Shuang-En Chuang

    Citation: Journal of Biomedical Science 2018 25:80

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  27. Content type: Review

    Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestin...

    Authors: Linda Chia-Hui Yu

    Citation: Journal of Biomedical Science 2018 25:79

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  28. Content type: Review

    Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylor...

    Authors: Magdalena Chmiela, Natalia Walczak and Karolina Rudnicka

    Citation: Journal of Biomedical Science 2018 25:78

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  29. Content type: Review

    Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages...

    Authors: Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang and Robert Anderson

    Citation: Journal of Biomedical Science 2018 25:77

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  30. Content type: Research

    The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang

    Citation: Journal of Biomedical Science 2018 25:76

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  31. Content type: Review

    Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metaboli...

    Authors: Huey-Ling Chen, Shang-Hsin Wu, Shu-Hao Hsu, Bang-Yu Liou, Hui-Ling Chen and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2018 25:75

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  32. Content type: Research

    Alternative polyadenylation (APA) is a widespread phenomenon in the posttranscriptional regulation of gene expression that generates mRNAs with alternative 3′-untranslated regions (3’UTRs). APA contributes to ...

    Authors: Ya-Fei Xu, Ying-Qing Li, Na Liu, Qing-Mei He, Xin-Ran Tang, Xin Wen, Xiao-Jing Yang, Ying Sun, Jun Ma and Ling-Long Tang

    Citation: Journal of Biomedical Science 2018 25:74

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  33. Content type: Review

    Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well...

    Authors: Matteo M Pusceddu and Melanie G Gareau

    Citation: Journal of Biomedical Science 2018 25:73

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  34. Content type: Research

    Neurofibromatosis type 1 (NF1) is a dominantly inherited tumor predisposition syndrome that targets the peripheral nervous system. It is caused by mutations of the NF1 gene which serve as a negative regulator of ...

    Authors: Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh and Yu-Ray Chen

    Citation: Journal of Biomedical Science 2018 25:72

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  35. Content type: Research

    Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelia...

    Authors: Nádia Calvo Martins Okuyama, Fernando Cezar-dos-Santos, Érica Romão Pereira, Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Michelle Mota Sena, Ana Paula Lombardi Pereira, Adriano Martin Felis Aranome, Luis Fernando Lasaro Mangieri, Rodolfo Sanches Ferreira, Maria Angelica Ehara Watanabe and Karen Brajão de Oliveira

    Citation: Journal of Biomedical Science 2018 25:69

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  36. Content type: Review

    Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, whi...

    Authors: Shih-Han Kao, Han-Tsang Wu and Kou-Juey Wu

    Citation: Journal of Biomedical Science 2018 25:67

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  37. Content type: Review

    Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer worldwide and highly prevalent in less developed regions. Management of ESCC is challenging and involves multimodal tre...

    Authors: Nikki P. Lee, Chung Man Chan, Lai Nar Tung, Hector K. Wang and Simon Law

    Citation: Journal of Biomedical Science 2018 25:66

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  38. Content type: Review

    Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with ma...

    Authors: Feng-Woei Tsay and Ping-I Hsu

    Citation: Journal of Biomedical Science 2018 25:65

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  39. Content type: Research

    B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The...

    Authors: Kovit Pattanapanyasat, Ladawan Khowawisetsut, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Premrutai Thitilertdecha, Tipaporn Sae-Ung and Nattawat Onlamoon

    Citation: Journal of Biomedical Science 2018 25:64

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  40. Content type: Research

    Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the central nervous system. Despite advances made in understanding this complex disease, little has been achieved in improving clinical ef...

    Authors: Ira Sharma, Avninder Singh, Fouzia Siraj and Sunita Saxena

    Citation: Journal of Biomedical Science 2018 25:62

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