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  1. Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such ...

    Authors: Ming-Jer Young, Kai-Cheng Hsu, Tony Eight Lin, Wen-Chang Chang and Jan-Jong Hung

    Citation: Journal of Biomedical Science 2019 26:42

    Content type: Review

    Published on:

  2. Endoplasmic reticulum stress has a profound effect on cancer cell proliferation and survival, and also has the capacity to activate cells of the adaptive immune system. Multimodal treatment methods that utiliz...

    Authors: Sung Yong Lee, Jee Youn Oh, Tae Heung Kang, Hyun Seock Shin, Max A. Cheng, Emily Farmer, T.-C. Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2019 26:41

    Content type: Research

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  3. Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell dama...

    Authors: Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu and Wan-Wan Lin

    Citation: Journal of Biomedical Science 2019 26:40

    Content type: Research

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    The Correction to this article has been published in Journal of Biomedical Science 2019 26:66

  4. Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a co...

    Authors: Junaida Osman, Shing Cheng Tan, Pey Yee Lee, Teck Yew Low and Rahman Jamal

    Citation: Journal of Biomedical Science 2019 26:39

    Content type: Review

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  6. The blood–spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. ...

    Authors: Ting-Hein Lee, Sung-Tsang Hsieh and Hou-Yu Chiang

    Citation: Journal of Biomedical Science 2019 26:37

    Content type: Research

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  7. Vascular dementia is the second dementing illness after Alzheimer’s disease and caused by reduced blood flow to the brain, and affects cognitive abilities. Our previous study found that auricular electrical st...

    Authors: Tai-Hsiang Huang, Yi-Wen Lin, Chun-Ping Huang, Jing-Ming Chen and Ching-Liang Hsieh

    Citation: Journal of Biomedical Science 2019 26:36

    Content type: Research

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  8. Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering th...

    Authors: Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo and Tang-Long Shen

    Citation: Journal of Biomedical Science 2019 26:35

    Content type: Review

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  9. Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it is a requ...

    Authors: Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe and Takashi Nakagawa

    Citation: Journal of Biomedical Science 2019 26:34

    Content type: Review

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  10. Alzheimer’s disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills ...

    Authors: Marcos Vinícius Ferreira Silva, Cristina de Mello Gomide Loures, Luan Carlos Vieira Alves, Leonardo Cruz de Souza, Karina Braga Gomes Borges and Maria das Graças Carvalho

    Citation: Journal of Biomedical Science 2019 26:33

    Content type: Review

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  11. Our previous studies have demonstrated that Ca2+ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effect...

    Authors: Junjun Quan, Zhongli Jia, Tiewei Lv, Lei Zhang, Lingjuan Liu, Bo Pan, Jing Zhu, Ira J. Gelb, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2019 26:32

    Content type: Research

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  12. In the original publication of this article [1], there are two errors in the article which the cDNA position of the pathogenic variant WNT1 p.Gly324Cys should be c.970G>T instead of c.1168G>T.

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees

    Citation: Journal of Biomedical Science 2019 26:31

    Content type: Correction

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    The original article was published in Journal of Biomedical Science 2018 25:82

  13. Promyelocytic leukemia zinc finger (Plzf), a transcriptional regulator involved in a lot of important biological processes during development, has been implied to maintain neural stem cells and inhibit their d...

    Authors: Hsin-Chuan Lin, Yung-Hao Ching, Chi-Chen Huang, Ping-Chieh Pao, Yi-Hua Lee, Wen-Chang Chang, Tzu-Jen Kao and Yi-Chao Lee

    Citation: Journal of Biomedical Science 2019 26:30

    Content type: Research

    Published on:

  15. Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of mortality in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is a necessary cause...

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik

    Citation: Journal of Biomedical Science 2019 26:28

    Content type: Review

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    The Retraction Note to this article has been published in Journal of Biomedical Science 2019 26:50

  16. Promoting post-stroke neurogenesis has long been proposed to be a therapeutic strategy for the enhancement of functional recovery after cerebral ischemic stroke. Despite numerous approaches have been widely re...

    Authors: Joen-Rong Sheu, Cheng-Ying Hsieh, Thanasekaran Jayakumar, Guan-Yi Lin, Hsing-Ni Lee, Shin-Wei Huang and Chih-Hao Yang

    Citation: Journal of Biomedical Science 2019 26:27

    Content type: Research

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  17. Traumatic experience may lead to various psychological sequelae including the unforgettable trauma-associated memory as seen in posttraumatic stress disorder (PTSD), with a mechanism of impaired fear extinctio...

    Authors: Sheng-Chiang Wang, Chen-Cheng Lin, Nian-Sheng Tzeng, Che-Se Tung and Yia-Ping Liu

    Citation: Journal of Biomedical Science 2019 26:26

    Content type: Research

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  18. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute k...

    Authors: Vladislav Volarevic, Bojana Djokovic, Marina Gazdic Jankovic, C. Randall Harrell, Crissy Fellabaum, Valentin Djonov and Nebojsa Arsenijevic

    Citation: Journal of Biomedical Science 2019 26:25

    Content type: Review

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  19. The liver is controlled by several metabolic hormones, including thyroid hormone, and characteristically displays high lysosomal activity as well as metabolic stress-triggered autophagy, which is stringently r...

    Authors: Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin

    Citation: Journal of Biomedical Science 2019 26:24

    Content type: Review

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  20. Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC)...

    Authors: Weronika Gonciarz, Maria Walencka, Anthony P. Moran, Krzysztof Hinc, Michał Obuchowski and Magdalena Chmiela

    Citation: Journal of Biomedical Science 2019 26:23

    Content type: Research

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  21. Psychological investigations and functional imaging technology have been used to describe neural correlations of different types of memory with various stimuli. Memory with limited storage capacity and a short...

    Authors: Jingxin Nie, Zengqiang Zhang, Bin Wang, Hong Li, Jianghua Xu, Sheng Wu, Chunhua Zhu, Xin Yang, Bin Liu, Yongming Wu, Sheng Tan, Zhibo Wen, Jinlong Zheng, Siyun Shu and Lin Ma

    Citation: Journal of Biomedical Science 2019 26:22

    Content type: Research

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  22. The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence i...

    Authors: Faezeh Basiri, Abolfazl Rad, Davood Mahdian, Mehdi Molavi and Bahareh Amin

    Citation: Journal of Biomedical Science 2019 26:21

    Content type: Research

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  23. Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biom...

    Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2019 26:20

    Content type: Research

    Published on:

  24. The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and t...

    Authors: Sabah Haq, Jensine Grondin, Suhrid Banskota and Waliul I. Khan

    Citation: Journal of Biomedical Science 2019 26:19

    Content type: Review

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  26. Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated w...

    Authors: Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak and Katarzyna Lamperska

    Citation: Journal of Biomedical Science 2019 26:17

    Content type: Research

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  27. Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative ...

    Authors: Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson and Jorge Goldstein

    Citation: Journal of Biomedical Science 2019 26:16

    Content type: Research

    Published on:

  28. Among the various types of dementia, Alzheimer’s disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central...

    Authors: Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado and Jaderson Costa Da Costa

    Citation: Journal of Biomedical Science 2019 26:15

    Content type: Review

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  29. Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited...

    Authors: Zhihai Wang, Wenqi Zuo, Quan Zeng, Yi Qian, Yanshi Li, Chuan Liu, Jue Wang, Shixun Zhong, Youquan Bu and Guohua Hu

    Citation: Journal of Biomedical Science 2019 26:14

    Content type: Research

    Published on:

  30. Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of th...

    Authors: Wenxia Meng, Weina Cui, Lei Zhao, Weiwei Chi, Huan Cao and Baoshan Wang

    Citation: Journal of Biomedical Science 2019 26:13

    Content type: Research

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  31. Osteoclasts (OCs) are motile multinucleated cells derived from differentiation and fusion of hematopoietic progenitors of the monocyte-macrophage lineage that undergo a multistep process called osteoclastogene...

    Authors: Chu-Lung Chan, Jiann-Yeu Chen, Ming-Chih Shih, Chih-Lueh Albert Wang and Ying-Ming Liou

    Citation: Journal of Biomedical Science 2019 26:12

    Content type: Research

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  32. Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age th...

    Authors: Govind R. Chaudhary, Pramod K. Yadav, Anil K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Ashutosh N. Pandey, Ajai K. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2019 26:11

    Content type: Review

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  33. Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlând...

    Authors: Priscila Silva Franco, Paula Suellen Guimarães Gois, Thádia Evelyn de Araújo, Rafaela José da Silva, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Francesca Ietta, Lara Affonso dos Santos, Maria Célia dos Santos, José Roberto Mineo and Eloisa Amália Vieira Ferro

    Citation: Journal of Biomedical Science 2019 26:10

    Content type: Research

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  36. Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast c...

    Authors: Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya

    Citation: Journal of Biomedical Science 2019 26:7

    Content type: Review

    Published on:

  37. Pulmonary hypertension (PH) is a progressive disease leading to death ultimately. Our recently published data demonstrated that inhibiting dipeptidyl peptidase IV (DPP-4) alleviated pulmonary vascular remodeli...

    Authors: Jingjing Wang, Min Yu, Jian Xu, Yusheng Cheng, Xiang Li, Guihong Wei, Hong Wang, Hui Kong and Weiping Xie

    Citation: Journal of Biomedical Science 2019 26:6

    Content type: Research

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  38. Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservat...

    Authors: Jonatas Rafael de Oliveira, Samira Esteves Afonso Camargo and Luciane Dias de Oliveira

    Citation: Journal of Biomedical Science 2019 26:5

    Content type: Review

    Published on:

  39. H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadheri...

    Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2019 26:4

    Content type: Research

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  40. Dysbiosis of gut microbiota is closely related to occurrence of many important chronic inflammations-related diseases. So far the traditionally prescribed prebiotics and probiotics do not show significant impa...

    Authors: Yu-Ling Tsai, Tzu-Lung Lin, Chih-Jung Chang, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai

    Citation: Journal of Biomedical Science 2019 26:3

    Content type: Review

    Published on:

  41. Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only tr...

    Authors: Shuangling Chen, Qin Zhu, Hong Sun, Yuan Zhang, Sean Tighe, Li Xu and Yingting Zhu

    Citation: Journal of Biomedical Science 2019 26:2

    Content type: Review

    Published on:

  42. Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these micro...

    Authors: Andre Gerald Buret, Jean-Paul Motta, Thibault Allain, Jose Ferraz and John Lawrence Wallace

    Citation: Journal of Biomedical Science 2019 26:1

    Content type: Review

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  43. Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and...

    Authors: Steven Ting-Yu Chuo, Jasper Che-Yung Chien and Charles Pin-Kuang Lai

    Citation: Journal of Biomedical Science 2018 25:91

    Content type: Review

    Published on:

  44. The nervous system is a crucial component of the body and damages to this system, either by of injury or disease, can result in serious or potentially lethal consequences. Restoring the damaged nervous system ...

    Authors: Rossana Boni, Azam Ali, Amin Shavandi and Andrew N. Clarkson

    Citation: Journal of Biomedical Science 2018 25:90

    Content type: Review

    Published on:

  45. Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific...

    Authors: Sarah Jayne Fitzgerald, Amol Vijay Janorkar, Allison Barnes and Rodrigo Oscar Maranon

    Citation: Journal of Biomedical Science 2018 25:89

    Content type: Review

    Published on:

  46. Cytokines play an important role in controlling the homeostasis of the immune system and infection with Human Immunodeficiency virus (HIV) leads to deregulated production of both pro- and anti-inflammatory cyt...

    Authors: Faustina Nkechi Osuji, Charles Chinedu Onyenekwe, Joseph Ebere Ahaneku and Nkiruka Rose Ukibe

    Citation: Journal of Biomedical Science 2018 25:88

    Content type: Research

    Published on:

  47. Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or exces...

    Authors: Ruiqiao Guan, Wei Zou, Xiaohong Dai, Xueping Yu, Hao Liu, Qiuxin Chen and Wei Teng

    Citation: Journal of Biomedical Science 2018 25:87

    Content type: Review

    Published on:

  49. Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

    Authors: Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen

    Citation: Journal of Biomedical Science 2018 25:85

    Content type: Review

    Published on:

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Journal of Biomedical Science

ISSN: 1423-0127