Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
Articles
Page 24 of 33
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Citation: Journal of Biomedical Science 2013 20:7
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Role of SALL4 in the progression and metastasis of colorectal cancer
Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. A complex network of transcription factors and signaling molecules are required ...
Citation: Journal of Biomedical Science 2013 20:6 -
Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...
Citation: Journal of Biomedical Science 2013 20:5 -
Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets
Brazilin, isolated from the heartwood of Caesalpinia sappan L., has been shown to possess multiple pharmacological properties.
Citation: Journal of Biomedical Science 2013 20:4 -
Beyond NF-κB activation: nuclear functions of IκB kinase α
IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and i...
Citation: Journal of Biomedical Science 2013 20:3 -
Circulating microRNA signatures in mice exposed to lipoteichoic acid
Previously, we had identified a specific whole blood–derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was des...
Citation: Journal of Biomedical Science 2013 20:2 -
Concurrent exposure to a dectin-1 agonist suppresses the Th2 response to epicutaneously introduced antigen in mice
Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell different...
Citation: Journal of Biomedical Science 2013 20:1 -
Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates
Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicit...
Citation: Journal of Biomedical Science 2012 19:104 -
The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat
Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially...
Citation: Journal of Biomedical Science 2012 19:103 -
Hypoxia-regulated target genes implicated in tumor metastasis
Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-...
Citation: Journal of Biomedical Science 2012 19:102 -
Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration
The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural developme...
Citation: Journal of Biomedical Science 2012 19:101 -
Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population
Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we ...
Citation: Journal of Biomedical Science 2012 19:100 -
SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects
The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on ...
Citation: Journal of Biomedical Science 2012 19:99 -
Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats
Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induce...
Citation: Journal of Biomedical Science 2012 19:98 -
Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population
Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpos...
Citation: Journal of Biomedical Science 2012 19:97 -
Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death
Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitoge...
Citation: Journal of Biomedical Science 2012 19:96 -
Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine
Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and abdominal wall defects. Secondary features that are fr...
Citation: Journal of Biomedical Science 2012 19:95 -
Functional role of post-translational modifications of Sp1 in tumorigenesis
Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies found that an ...
Citation: Journal of Biomedical Science 2012 19:94 -
Repairing chronic myocardial infarction with autologous mesenchymal stem cells engineered tissue in rat promotes angiogenesis and limits ventricular remodeling
Tissue engineering scaffold constitutes a new strategy of myocardial repair. Here, we studied the contribution of a patch using autologous mesenchymal stem cells (MSCs) seeded on collagen-1 scaffold on the car...
Citation: Journal of Biomedical Science 2012 19:93 -
Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses
Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...
Citation: Journal of Biomedical Science 2012 19:92 -
CXC chemokine ligand 12/Stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1
The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC. In...
Citation: Journal of Biomedical Science 2012 19:91 -
Dysregulation of MicroRNAs in cancer
MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the func...
Citation: Journal of Biomedical Science 2012 19:90 -
Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils
Several low-molecular-weight phenolic acids are present in the blood of septic patients at high levels. The microbial origin of the most of phenolic acids in the human body was shown previously, but pathophysi...
Citation: Journal of Biomedical Science 2012 19:89 -
HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing
Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the tr...
Citation: Journal of Biomedical Science 2012 19:88 -
Erratum to: A smallest 6 kda metalloprotease, mini-matrilysin, in living world: a revolutionary conserved zinc-dependent proteolytic domain- helix-loop-helix catalytic zinc binding domain (ZBD)
Citation: Journal of Biomedical Science 2012 19:87 -
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumb...
Citation: Journal of Biomedical Science 2012 19:86 -
BCL10GFP fusion protein as a substrate for analysis of determinants required for Mucosa-Associated Lymphoid Tissue 1 (MALT1)-mediated cleavage
MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged Arginine r...
Citation: Journal of Biomedical Science 2012 19:85 -
Erratum to: Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans
Citation: Journal of Biomedical Science 2012 19:84 -
Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter
Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been i...
Citation: Journal of Biomedical Science 2012 19:83 -
Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways
The root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and anti-inf...
Citation: Journal of Biomedical Science 2012 19:82 -
The role of PML ubiquitination in human malignancies
Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and int...
Citation: Journal of Biomedical Science 2012 19:81 -
Daidzein induces neuritogenesis in DRG neuronal cultures
Daidzein, a phytoestrogen found in isoflavone, is known to exert neurotrophic and neuroprotective effects on the nervous system. Using primary rat dorsal root ganglion (DRG) neuronal cultures, we have examined...
Citation: Journal of Biomedical Science 2012 19:80 -
Roles of microRNAs in atherosclerosis and restenosis
Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly...
Citation: Journal of Biomedical Science 2012 19:79 -
Rapid compensatory changes in the expression of EAAT-3 and GAT-1 transporters during seizures in cells of the CA1 and dentate gyrus
Epilepsy is a neurological disorder produced by an imbalance between excitatory and inhibitory neurotransmission, in which transporters of both glutamate and GABA have been implicated. Hence, at different time...
Citation: Journal of Biomedical Science 2012 19:78 -
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The purpose of this study was to clarify the role of...
Citation: Journal of Biomedical Science 2012 19:77 -
Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats
Estrogen acts on the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ER)β-dependent mechanism. We investigated in...
Citation: Journal of Biomedical Science 2012 19:76 -
Characterization of Mg2+-regulated TRPM7-like current in human atrial myocytes
TRPM7 (T ransient R eceptor P otential of the M elastatin subfamily) proteins are highly expressed in the heart, however, electrophysiological studies, demonstrating and characterizing these channels in human car...
Citation: Journal of Biomedical Science 2012 19:75 -
Protective effects of indomethacin and dexamethasone in a goat model with intrauterine balloon aortic valvuloplasty
Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a...
Citation: Journal of Biomedical Science 2012 19:74 -
The highly conserved 5' untranslated region as an effective target towards the inhibition of Enterovirus 71 replication by unmodified and appropriate 2'-modified siRNAs
Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalitie...
Citation: Journal of Biomedical Science 2012 19:73 -
Regulation of PUMA induced by mechanical stress in rat cardiomyocytes
PUMA (p53-up-regulated modulator of apoptosis), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of PUMA in cardiomyocytes under mechanical stress is little k...
Citation: Journal of Biomedical Science 2012 19:72 -
Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment
Endoplasmic reticulum (ER) and mitochondria have been implicated in the pathology of renal ischemia/reperfusion (I/R). In the present study, we investigated whether the use of ischemic postconditioning (IPostC...
Citation: Journal of Biomedical Science 2012 19:71 -
Cardiovascular protection of magnolol: cell-type specificity and dose-related effects
Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mec...
Citation: Journal of Biomedical Science 2012 19:70 -
Whole blood-derived microRNA signatures in mice exposed to lipopolysaccharides
Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This stud...
Citation: Journal of Biomedical Science 2012 19:69 -
Mechanisms of the antinociceptive action of (−) Epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents
The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.
Citation: Journal of Biomedical Science 2012 19:68 -
The ubiquitin–proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer
Epithelial to Mesenchymal transition (EMT) in cancer, a process permitting cancer cells to become mobile and metastatic, has a signaling hardwire forged from development. Multiple signaling pathways that regul...
Citation: Journal of Biomedical Science 2012 19:67 -
Levels and values of circulating endothelial progenitor cells, soluble angiogenic factors, and mononuclear cell apoptosis in liver cirrhosis patients
The roles of circulating endothelial progenitor cell (EPC) and mononuclear cell apoptosis (MCA) in liver cirrhosis (LC) patients are unknown. Moreover, vascular endothelial growth factor (VEGF) and stromal cel...
Citation: Journal of Biomedical Science 2012 19:66 -
A bioactive peptide analogue for myxoma virus protein with a targeted cytotoxicity for human skin cancer in vitro
Cancer is an international health problem, and the search for effective treatments is still in progress. Peptide therapy is focused on the development of short peptides with strong tumoricidal activity and low...
Citation: Journal of Biomedical Science 2012 19:65 -
Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells
Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen spe...
Citation: Journal of Biomedical Science 2012 19:64 -
The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos
Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome.
Citation: Journal of Biomedical Science 2012 19:63 -
Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation
The threat of emerging pathogens and microbial drug resistance has spurred tremendous efforts to develop new and more effective antimicrobial strategies. Recently, a novel ultrashort pulsed (USP) laser technol...
Citation: Journal of Biomedical Science 2012 19:62
Annual Journal Metrics
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Citation Impact 2023
Journal Impact Factor: 9.0
5-year Journal Impact Factor: 10.7
Source Normalized Impact per Paper (SNIP): 2.014
SCImago Journal Rank (SJR): 2.606Speed 2023
Submission to first editorial decision (median days): 14
Submission to acceptance (median days): 107Usage 2023
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