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  1. Rabies is known to be lethal in human. Treatment with passive immunity for the rabies is effective only when the patients have not shown the central nerve system (CNS) signs. The blood–brain barrier (BBB) is a...

    Authors: Pi-Hung Liao, Hui-Hua Yang, Ping-Tse Chou, Ming-Hseng Wang, Po-Chun Chu, Hao-Li Liu and Li-Kuang Chen
    Citation: Journal of Biomedical Science 2012 19:61
  2. The phosphoinositide 3-kinases (PI3K/Akt) dependent signaling pathway plays an important role in cardiac function, specifically cardiac contractility. We have reported that sepsis decreases myocardial Akt acti...

    Authors: Bridget M Graves, Thomas Simerly, Chuanfu Li, David L Williams and Robert Wondergem
    Citation: Journal of Biomedical Science 2012 19:59
  3. Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections. This research evaluates how probiotic lac...

    Authors: R Doug Wagner and Shemedia J Johnson
    Citation: Journal of Biomedical Science 2012 19:58

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:84

  4. Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis ...

    Authors: Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung and Hsuan Liu
    Citation: Journal of Biomedical Science 2012 19:57
  5. Maternal epileptic seizures during pregnancy can affect the hippocampal neurons in the offspring. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is expressed in the developing central nervo...

    Authors: Aliakbar Rajabzadeh, Alireza Ebrahimzadeh Bideskan, Alireza Fazel, Mojtaba Sankian, Houshang Rafatpanah and Hossein Haghir
    Citation: Journal of Biomedical Science 2012 19:56
  6. N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in m...

    Authors: Tsung-Chieh Chen, José Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh and Bai-Chuang Shyu
    Citation: Journal of Biomedical Science 2012 19:55
  7. The Aim of this study is to study the minimum zinc dependent metalloprotease catalytic folding motif, helix B Met loop-helix C, with proteolytic catalytic activities in metzincin super family. The metzincin su...

    Authors: Wei-Hsuan Yu, Po-Tsang Huang, Kuo-Long Lou, Shuan-Su C Yu and Chen Lin
    Citation: Journal of Biomedical Science 2012 19:54

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:87

  8. We aimed to examine the expression level of Nucleophosmin (NPM1) protein in colon cancer tissues and to investigate the potential role of NPM1 in the regulation of cell migration and invasiveness.

    Authors: Yan Liu, Fei Zhang, Xiao-fang Zhang, Li-sha Qi, Lei Yang, Hua Guo and Ning Zhang
    Citation: Journal of Biomedical Science 2012 19:53
  9. Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulatio...

    Authors: Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen and Horng-Dar Wang
    Citation: Journal of Biomedical Science 2012 19:52
  10. Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has demonstrated various pharmacological activities, including antimicrobial, antihyperlipidemic, antithrombotic, and anticancer eff...

    Authors: Yung Hyun Choi and Hyun Soo Park
    Citation: Journal of Biomedical Science 2012 19:50
  11. In the present study we identified a novel gene, Homo Sapiens Chromosome 1 ORF109 (c1orf109, GenBank ID: NM_017850.1), which encodes a substrate of CK2. We analyzed the regulation mode of the gene, the expression...

    Authors: Shan-shan Liu, Hong-xia Zheng, Hua-dong Jiang, Jie He, Yang Yu, You-peng Qu, Lei Yue, Yao Zhang and Yu Li
    Citation: Journal of Biomedical Science 2012 19:49
  12. Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome syste...

    Authors: Carol HY Wu, Julie YH Chan, Jimmy Li-Jer Chou, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:48
  13. Although diabetes mellitus (DM) can be treated with islet transplantation, a scarcity of donors limits the utility of this technique. This study investigated whether human mesenchymal stem cells (MSCs) from um...

    Authors: Pei-Jiun Tsai, Hwai-Shi Wang, Yi-Ming Shyr, Zen-Chung Weng, Ling-Chen Tai, Jia-Fwu Shyu and Tien-Hua Chen
    Citation: Journal of Biomedical Science 2012 19:47
  14. Microglial cells are the predominant immune cells in malignant brain tumors, but tumors may release some factors to reduce their defensive functions. Restoration of the anti-cancer function of microglia has be...

    Authors: Tsung-Lang Chiu, Mei-Jan Wang and Chin-Cheng Su
    Citation: Journal of Biomedical Science 2012 19:45
  15. Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of vir...

    Authors: Szu-Cheng Kuo, Ying-Ju Chen, Yu-Ming Wang, Pei-Yi Tsui, Ming-Der Kuo, Tzong-Yuan Wu and Szecheng J Lo
    Citation: Journal of Biomedical Science 2012 19:44
  16. The aim of the study was to investigate the effect of dietary supplementation with zinc and polyphenol compounds, i.e. resveratrol and genistein, on the effectiveness of chemically induced mammary cancer and t...

    Authors: Barbara Bobrowska-Korczak, Dorota Skrajnowska and Andrzej Tokarz
    Citation: Journal of Biomedical Science 2012 19:43
  17. Shikonin, a phytochemical purified from Lithospermum erythrorhizon, has been shown to confer diverse pharmacological activities, including accelerating granuloma formation, wound healing, anti-inflammation and ot...

    Authors: Hui-Ming Chen, Pi-Hsueh Wang, Kandan Aravindaram, Yun-Hsiang Chen, Hsiu-Hui Yu, Wen-Chin Yang and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2012 19:42
  18. The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic sign...

    Authors: Gordana Đorđević, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac and Nives Jonjić
    Citation: Journal of Biomedical Science 2012 19:40
  19. Metastatic renal cell carcinoma (RCC) is highly resistant to systemic chemotherapy. Unfortunately, nearly all patients die of the metastatic and chemoresistant RCC. Recent studies have shown the atypical PKCζ ...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Jyue-Yu Chen, Wang-Yi Kang, Ying-Chu Lin, Yu-Shiang Shiu, Shu-Ju Chuang, Hong-Jeng Yu, Ming-Kuen Lai, Yu-Chieh Tsai, Wen-Jeng Wu and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2012 19:39
  20. Human olfactomedin 4 (OLFM4) gene is a secreted glycoprotein more commonly known as the anti-apoptotic molecule GW112. OLFM4 is found to be frequently up-regulated in many types of human tumors including gastr...

    Authors: Rui-hua Liu, Mei-hua Yang, Hua Xiang, Li-ming Bao, Hua-an Yang, Li-wen Yue, Xue Jiang, Na Ang, Li-ya Wu and Yi Huang
    Citation: Journal of Biomedical Science 2012 19:38
  21. Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging induces bone loss due to decreased osteoblastic bone formation and increased osteocl...

    Authors: Masayoshi Yamaguchi
    Citation: Journal of Biomedical Science 2012 19:36
  22. In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr-Abl and clinically used for chronic myelogenous leukemia) and TNF-related apoptosis-...

    Authors: Duen-Yi Huang, Yee Chao, Ming-Hui Tai, Yang-Hao Yu and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2012 19:35
  23. Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity....

    Authors: Yi-Heng Li, Cheng-Hsiang Kuo, Guey-Yueh Shi and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2012 19:34
  24. Both Neurofibromatosis type I (NF1) and inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) are autosomal dominant genetic disorders. These two diseases are fully penetran...

    Authors: Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2012 19:33
  25. Excessive oxidative stress and lipid peroxidation have been demonstrated to play important roles in the production of liver damage. L-carnitine is a natural substance and acts as a carrier for fatty acids acro...

    Authors: Jin-Lian Li, Qiao-Yun Wang, Hai-Yun Luan, Ze-Chun Kang and Chun-Bo Wang
    Citation: Journal of Biomedical Science 2012 19:32
  26. In this study, instead of current biochemical methods, the effects of deleterious amino acid substitutions in F8 and F9 gene upon protein structure and function were assayed by means of computational methods and ...

    Authors: George Priya Doss C
    Citation: Journal of Biomedical Science 2012 19:30
  27. Episodic cessation of airflow during sleep in patients with sleep apnea syndrome results in intermittent hypoxia (IH). Our aim was to investigate the effects of IH on cerebellar granule cells and to identify t...

    Authors: Sheng-Chun Chiu, Sung-Ying Huang, Yu-Chieh Tsai, Shee-Ping Chen, Cheng-Yoong Pang, Chih-Feng Lien, Yu-Jou Lin and Kun-Ta Yang
    Citation: Journal of Biomedical Science 2012 19:29
  28. Pro-inflammatory cytokines possess osteoclastogenic or anti-osteoclastogenic activities. They influence osteoclasts directly or via the receptor activator of nuclear factor κB (RANK), RANK ligand (RANKL) and o...

    Authors: Janja Zupan, Radko Komadina and Janja Marc
    Citation: Journal of Biomedical Science 2012 19:28
  29. Phorbol myristate acetate (PMA) is a strong neutrophil activator and has been used to induce acute lung injury (ALI). Niacinamide (NAC) is a compound of B complex. It exerts protective effects on the ALI cause...

    Authors: Chia-Chih Lin, Nan-Kuang Hsieh, Huey Ling Liou and Hsing I Chen
    Citation: Journal of Biomedical Science 2012 19:27
  30. Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis (accumulation of triacylglycerols within hepatocytes) along with inflammation...

    Authors: Alireza Rezazadeh, Razieh Yazdanparast and Mahsa Molaei
    Citation: Journal of Biomedical Science 2012 19:26
  31. Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seiz...

    Authors: Jobin Mathew, Savitha Balakrishnan, Sherin Antony, Pretty Mary Abraham and CS Paulose
    Citation: Journal of Biomedical Science 2012 19:25
  32. In experimentally induced puromycine aminonucleoside nephrosis (PAN) animal models, nephrotic syndrome with minimal change disease and focal and segmental sclerosis-like nephritis similar to that in human is d...

    Authors: Ismail Seckin, Mumin Uzunalan, Meltem Pekpak, Sibel Kokturk, Huseyin Sonmez, Zeynep Öztürk, Sibel Demirci and Elif Yaprak
    Citation: Journal of Biomedical Science 2012 19:24
  33. At least one-third of epithelial ovarian cancers are associated with the development of ascites containing heterogeneous cell populations, including tumor cells, inflammatory cells, and stromal elements. The c...

    Authors: Chih-Ming Ho, Shwu-Fen Chang, Chih-Chiang Hsiao, Tsai-Yen Chien and Daniel Tzu-Bi Shih
    Citation: Journal of Biomedical Science 2012 19:23
  34. Cardiovascular death is frequently associated with atherosclerosis, a chronic multifactorial disease and a leading cause of death worldwide. Genetically engineered mouse models have proven useful for the study...

    Authors: Elisardo C Vasquez, Veronica A Peotta, Agata L Gava, Thiago MC Pereira and Silvana S Meyrelles
    Citation: Journal of Biomedical Science 2012 19:22
  35. Most filarial nematodes contain Wolbachia symbionts. The purpose of this study was to examine the effects of doxycycline on gene expression in Wolbachia and adult female Brugia malayi.

    Authors: Ramakrishna U Rao, Yuefang Huang, Sahar Abubucker, Michael Heinz, Seth D Crosby, Makedonka Mitreva and Gary J Weil
    Citation: Journal of Biomedical Science 2012 19:21
  36. Gene therapy and viral therapy are used for cancer therapy for many years, but the results are less than satisfactory. Our aim was to construct a new recombinant adenovirus which is more efficient to kill hepa...

    Authors: Kang-Jian Zhang, Jing Qian, Shi-Bing Wang and Yi Yang
    Citation: Journal of Biomedical Science 2012 19:20
  37. Cryptococcus neoformans has a predilection for central nervous system infection. C. neoformans traversal of the blood brain barrier, composed of human brain microvascular endothelial cells (HBMEC), is the crucial...

    Authors: Min Long, Sheng-He Huang, Chun-Hua Wu, Gregory M Shackleford and Ambrose Jong
    Citation: Journal of Biomedical Science 2012 19:19
  38. Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor (PDGFR) are thought to contribute to vascular di...

    Authors: Huey-Ming Lo, Yih-Jeng Tsai, Wen-Yuan Du, Chih-Jen Tsou and Wen-Bin Wu
    Citation: Journal of Biomedical Science 2012 19:18
  39. Naturally occurring pre-S deletion mutants have been identified in hepatitis B carriers and shown to be associated with the development of hepatocellular carcinoma. The phenotypes of these pre-S deletion genom...

    Authors: Chih-Ming Lin, Gen-Ming Wang, Guey-Mei Jow and Bing-Fang Chen
    Citation: Journal of Biomedical Science 2012 19:17
  40. Intoxication from the psychostimulant methamphetamine (METH) because of cardiovascular collapse is a common cause of death within the abuse population. For obvious reasons, the heart has been taken as the prim...

    Authors: Faith CH Li, JC Yen, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:16
  41. Studies have shown the existence of p21 induction in a p53-dependent and -independent pathway. Our previous study indicates that DOX-induced p65 is able to bind the p21 promoter to activate its transactivation...

    Authors: YingQi Zhou, Gang Li, Yuan Ji, Chen Liu, JingPing Zhu and YanJun Lu
    Citation: Journal of Biomedical Science 2012 19:15
  42. Nanomaterials, as a new kind of materials, have been greatly applied in different fields due to their special properties. With the industrialization of nanostructured materials and increasing public exposure, ...

    Authors: Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren and Zhuo Yang
    Citation: Journal of Biomedical Science 2012 19:14
  43. Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to...

    Authors: Hyang-Min Byun, Kyu Heo, Kasey J Mitchell and Allen S Yang
    Citation: Journal of Biomedical Science 2012 19:13
  44. The replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV) is a molecular switch that initiates a productive replication of latent KSHV genomes. KSHV RTA (K-RTA) is com...

    Authors: Ying-Chieh Ko, Wan-Hua Tsai, Pei-Wen Wang, I-Lin Wu, Shu-Yu Lin, Yu-Lian Chen, Jen-Yang Chen and Su-Fang Lin
    Citation: Journal of Biomedical Science 2012 19:12
  45. Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethan...

    Authors: Nien-Tzu Keng, Hsun-Hsun Lin, Huei-Ru Lin, Wei-Kung Hsieh and Chih-Chia Lai
    Citation: Journal of Biomedical Science 2012 19:11

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