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  1. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour
    Citation: Journal of Biomedical Science 2009 16:82
  2. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski
    Citation: Journal of Biomedical Science 2009 16:81
  3. To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...

    Authors: Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang and Shih-Yen Lo
    Citation: Journal of Biomedical Science 2009 16:80
  4. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek
    Citation: Journal of Biomedical Science 2009 16:79
  5. Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on ...

    Authors: Ting-Chun Weng, Chien-Chang Shen, Yung-Tsung Chiu, Yun-Lian Lin, Cheng-Deng Kuo and Yi-Tsau Huang
    Citation: Journal of Biomedical Science 2009 16:78
  6. In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin sign...

    Authors: Jiung-Pang Huang, Shiang-Suo Huang, Jen-Ying Deng and Li-Man Hung
    Citation: Journal of Biomedical Science 2009 16:77
  7. Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented s...

    Authors: Hung-Chuan Pan, Dar-Yu Yang, Shu-Peng Ho, Meei-Ling Sheu, Chung-Jung Chen, Shiaw-Min Hwang, Ming-Hong Chang and Fu-Chou Cheng
    Citation: Journal of Biomedical Science 2009 16:75
  8. Mesenchymal stem cells (MSCs)-based regenerative therapy is currently regarded as an alternative approach to salvage the acute myocardial infarcted hearts. However, the efficiency of MSCs transplantation is li...

    Authors: Yongwei Yao, Fumin Zhang, Liansheng Wang, Guohui Zhang, Zhaojun Wang, Jianmei Chen and Xiang Gao
    Citation: Journal of Biomedical Science 2009 16:74
  9. The application of a subset of single nucleotide polymorphisms, the tagSNPs, can be useful in capturing untyped SNPs information in a genomic region. TagSNP transferability from the HapMap dataset to admixed p...

    Authors: Tulio C Lins, Breno S Abreu and Rinaldo W Pereira
    Citation: Journal of Biomedical Science 2009 16:73
  10. The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) we...

    Authors: Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang and Che-Se Tung
    Citation: Journal of Biomedical Science 2009 16:72
  11. Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and au...

    Authors: Feng-Cheng Chou and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2009 16:71
  12. Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isola...

    Authors: Vilmante Borutaite, Ramune Morkuniene, Odeta Arandarcikaite, Aiste Jekabsone, Jurgita Barauskaite and Guy C Brown
    Citation: Journal of Biomedical Science 2009 16:70
  13. Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications ...

    Authors: Chien-Der Lee, Yao-Pei Yan, Shu-Mei Liang and Ting-Fang Wang
    Citation: Journal of Biomedical Science 2009 16:69
  14. Diabetes Mellitus is a chronic disease and many patients of which require frequent subcutaneous insulin injection to maintain proper blood glucose levels. Due to the inconvenience of insulin administration, an...

    Authors: Henry J Tsai and Shan-Yen Chou
    Citation: Journal of Biomedical Science 2009 16:68
  15. Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts...

    Authors: Shyan-Yuan Kao
    Citation: Journal of Biomedical Science 2009 16:67
  16. In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellul...

    Authors: Jiang Liuyun, Li Yubao and Xiong Chengdong
    Citation: Journal of Biomedical Science 2009 16:65
  17. This study aimed to investigate if food components that exert anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA). The cytokine profile and...

    Authors: Yong-Han Hong, Wen-Wan Chao, Miaw-Ling Chen and Bi-Fong Lin
    Citation: Journal of Biomedical Science 2009 16:64
  18. Parkinson's disease (PD) is a neurodegenerative disorder. The diagnosis of Parkinsonism is challenging because currently none of the clinical tests have been proven to help in diagnosis. PD may produce charact...

    Authors: Shiek SSJ Ahmed, Winkins Santosh, Suresh Kumar and Hema T Thanka Christlet
    Citation: Journal of Biomedical Science 2009 16:63
  19. The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and accurate determinati...

    Authors: Ping Qiu, Xiao-Yan Cai, Wei Ding, Qing Zhang, Ellie D Norris and Jonathan R Greene
    Citation: Journal of Biomedical Science 2009 16:62
  20. Oxidative stress induced by the production of reactive oxygen species may play a critical role in the stimulation of HIV replication and the development of immunodeficiency. This study was conducted as there a...

    Authors: DR Suresh, Vamseedhar Annam, K Pratibha and BV Maruti Prasad
    Citation: Journal of Biomedical Science 2009 16:61
  21. Apart from their well-known peripheral cardiovascular effects, emerging evidence indicates that estrogen acts as a modulator in the brain to regulate cardiovascular functions. The underlying mechanisms of estr...

    Authors: Cheng-Dean Shih
    Citation: Journal of Biomedical Science 2009 16:60
  22. During apoptosis several mitochondrial proteins are released. Some of them participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF) and endonuclease G (endoG). Ano...

    Authors: Miroslav Vařecha, Michal Zimmermann, Jana Amrichová, Vladimír Ulman, Pavel Matula and Michal Kozubek
    Citation: Journal of Biomedical Science 2009 16:59
  23. Airborne particulate matter, from cooking oil, smoking, engine exhaust and other sources, is associated with the development of atherosclerosis and myocardial infarction. In order to explore the cellular and m...

    Authors: Li Ping-Chia, Lai I-Ju, Lin Yu-Ching, Chang Li-Ching and Chen Wen-Chung
    Citation: Journal of Biomedical Science 2009 16:58
  24. Lysophosphatidylcholine (LPC), an atherogenic component of oxidized low-density lipoprotein, has been shown to induce the attenuation of endothelium-dependent vascular relaxation. Although benidipine, a dihydr...

    Authors: Makoto Takayama, Kozo Yao and Michihito Wada
    Citation: Journal of Biomedical Science 2009 16:57
  25. RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDIβ plays a previously undefined role in regulat...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, I-Chang Chang, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang
    Citation: Journal of Biomedical Science 2009 16:56
  26. Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge
    Citation: Journal of Biomedical Science 2009 16:55
  27. The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah
    Citation: Journal of Biomedical Science 2009 16:54

    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  28. Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf
    Citation: Journal of Biomedical Science 2009 16:53
  29. High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw
    Citation: Journal of Biomedical Science 2009 16:51
  30. Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we s...

    Authors: Kou-Gi Shyu, Su-Kiat Chua, Bao-Wai Wang and Peiliang Kuan
    Citation: Journal of Biomedical Science 2009 16:50
  31. It is important to develop innovative therapies for advanced stage cancers in addition to the conventional therapies including chemotherapy, radiation and surgery. Antigen-specific immunotherapy has emerged as...

    Authors: Chi-Mu Chuang, Archana Monie, Annie Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2009 16:49
  32. Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector expressing I...

    Authors: Giou-Teng Yiang, Horng-Jyh Harn, Yung-Luen Yu, Sheng-Chuan Hu, Yu-Ting Hung, Chia-Jung Hsieh, Shinn-Zong Lin and Chyou-Wei Wei
    Citation: Journal of Biomedical Science 2009 16:47
  33. Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended t...

    Authors: Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang and Yong-Qing Yang
    Citation: Journal of Biomedical Science 2009 16:46
  34. Segments of the canine internal mammary artery (35 mm in length) were suspended in vitro in an organ chamber containing physiological salt solution (95% O2/5% CO2, pH = 7.4, 37°C). Segments were individually cann...

    Authors: Nilce Mitiko Matsuda, Paul J Pearson, Hartzell V Schaff, Carlos E Piccinato, Alfredo J Rodrigues and Paulo Roberto Barbosa Evora
    Citation: Journal of Biomedical Science 2009 16:45
  35. An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C. Basal levels of the c-Fos expression in ...

    Authors: Chun-Kuei Su, Chiu-Ming Ho, Hsiao-Hui Kuo, Yu-Chuan Wen and Chok-Yung Chai
    Citation: Journal of Biomedical Science 2009 16:44
  36. In the present study, we explore the role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced apoptosis in human lung adenocarcinoma (A549) cells. Denbinobin-induced cell apoptosis was attenua...

    Authors: Chen-Tzu Kuo, Bing-Chang Chen, Chung-Chi Yu, Chih-Ming Weng, Ming-Jen Hsu, Chien-Chih Chen, Mei-Chieh Chen, Che-Ming Teng, Shiow-Lin Pan, Mauo-Ying Bien, Chung-Hung Shih and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2009 16:43
  37. Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to b...

    Authors: Tzer-Min Kuo, Cheng-po Hu, Ya-Ling Chen, Ming-Hsiang Hong, King-Song Jeng, Chun-Chin T Liang, Mong-Liang Chen and Chungming Chang
    Citation: Journal of Biomedical Science 2009 16:41
  38. Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of v...

    Authors: Shang-Hua Yang, Mei-Lan Liu, Chih-Feng Tien, Shih-Jie Chou and Ruey-Yi Chang
    Citation: Journal of Biomedical Science 2009 16:40
  39. It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered ...

    Authors: Shun-Miao Fang, Qing-Hua Zhang and Zhi-Xin Jiang
    Citation: Journal of Biomedical Science 2009 16:39
  40. Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine...

    Authors: G Gireesh, T Peeyush Kumar, Jobin Mathew and CS Paulose
    Citation: Journal of Biomedical Science 2009 16:38
  41. Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen
    Citation: Journal of Biomedical Science 2009 16:35
  42. Statins reduce cholesterol biosynthesis by inhibiting HMG-CoA reductase and thereby lower total cholesterol and LDL cholesterol levels in serum, which in turn lower the incidence of cardiovascular disease (CVD...

    Authors: Chung-Eun Ha, Ji-Sook Ha, Andre G Theriault and Nadhipuram V Bhagavan
    Citation: Journal of Biomedical Science 2009 16:32

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