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  1. The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We ...

    Authors: Chih-Hsu Chang, Shu-Fan Chou and Chiaho Shih
    Citation: Journal of Biomedical Science 2021 28:82
    Content type: Research Published on:

  2. RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKA...

    Authors: Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang and Fu-Jung Lin
    Citation: Journal of Biomedical Science 2021 28:81
    Content type: Research Published on:

  3. Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate. Importantly, several currently circulating SARS-CoV-2 vari...

    Authors: Kang-Hao Liang, Pao-Yin Chiang, Shih-Han Ko, Yu-Chi Chou, Ruei-Min Lu, Hsiu-Ting Lin, Wan-Yu Chen, Yi-Ling Lin, Mi-Hua Tao, Jia-Tsrong Jan and Han-Chung Wu
    Citation: Journal of Biomedical Science 2021 28:80
    Content type: Research Published on:

  4. Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the m...

    Authors: Ping-Chieh Pao and Li-Huei Tsai
    Citation: Journal of Biomedical Science 2021 28:79
    Content type: Review Published on:

  5. The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncR...

    Authors: Ming-Che Kuo, Sam Chi-Hao Liu, Ya-Fang Hsu and Ruey-Meei Wu
    Citation: Journal of Biomedical Science 2021 28:78
    Content type: Review Published on:

  6. CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing...

    Authors: Guzide Bender, Rezan Fahrioglu Yamaci and Bahar Taneri
    Citation: Journal of Biomedical Science 2021 28:77
    Content type: Review Published on:

  7. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to s...

    Authors: María Victoria Castro, Gastón Alexis Barbero, María Belén Villanueva, Luca Grumolato, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada and Pablo Lopez-Bergami
    Citation: Journal of Biomedical Science 2021 28:76
    Content type: Research Published on:

  8. A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon-γ (IFN-γ)/ Janus kin...

    Authors: Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu and Kun-Huei Yeh
    Citation: Journal of Biomedical Science 2021 28:75
    Content type: Research Published on:

  9. Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly id...

    Authors: Guan-Lin Lee, Tsai-Lien Liao, Jing-Yiing Wu, Kenneth K. Wu and Cheng-Chin Kuo
    Citation: Journal of Biomedical Science 2021 28:74
    Content type: Research Published on:

  10. Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney ...

    Authors: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen and Shuei-Liong Lin
    Citation: Journal of Biomedical Science 2021 28:73
    Content type: Research Published on:

  11. During autophagy defense against invading microbes, certain lipid types are indispensable for generating specialized membrane-bound organelles. The lipid composition of autophagosomes remains obscure, as does ...

    Authors: Sasikala Muthusamy, Hau-Ming Jan, Ming-Yen Hsieh, Soumik Mondal, Wen-Chun Liu, Yi-An Ko, Wei-Yuan Yang, Kwok-Kong Tony Mong, Guang-Chao Chen and Chun-Hung Lin
    Citation: Journal of Biomedical Science 2021 28:72
    Content type: Research Published on:

  13. In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively become greater socioeconomic burdens. To date, despite the tremendous effort devoted to ...

    Authors: Ching-Pang Chang, Kuo-Chen Wu, Chien-Yu Lin and Yijuang Chern
    Citation: Journal of Biomedical Science 2021 28:70
    Content type: Review Published on:

  14. Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer the...

    Authors: Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska and Łukasz Opaliński
    Citation: Journal of Biomedical Science 2021 28:69
    Content type: Research Published on:

  15. NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Neverthe...

    Authors: Moloud Aflaki Sooreshjani, Mohini Kamra, Amina Zoubeidi and Kavita Shah
    Citation: Journal of Biomedical Science 2021 28:68
    Content type: Research Published on:

  16. Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however, the underlying mechanism by whic...

    Authors: Guo-Zhen Liu, Xu-Wen Xu, Shu-Hui Tao, Ming-Jian Gao and Zhou-Hua Hou
    Citation: Journal of Biomedical Science 2021 28:67
    Content type: Research Published on:

  17. Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter...

    Authors: Chun-Yang Lin, Meng-Cen Shih, Hung-Chun Chang, Kuan-Jung Lin, Lin-Fang Chen, Sheng-Wen Huang, Mei-Lin Yang, Sheng-Kai Ma, Ai-Li Shiau, Jen-Ren Wang, Kuan-Ru Chen and Pin Ling
    Citation: Journal of Biomedical Science 2021 28:66
    Content type: Research Published on:

  18. Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona...

    Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin
    Citation: Journal of Biomedical Science 2021 28:65
    Content type: Research Published on:

  19. Mainstay haemophilia treatment, namely intravenous factor replacement, poses several clinical challenges including frequent injections due to the short half-life of recombinant factors, intravenous administrat...

    Authors: Dide Okaygoun, Danielle D. Oliveira, Sooriya Soman and Riccardo Williams
    Citation: Journal of Biomedical Science 2021 28:64
    Content type: Review Published on:

  20. Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated can...

    Authors: Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung and T. -C. Wu
    Citation: Journal of Biomedical Science 2021 28:63
    Content type: Research Published on:

  21. One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropria...

    Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek and Thomas E. Prisinzano
    Citation: Journal of Biomedical Science 2021 28:62
    Content type: Research Published on:

  22. The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, cell proliferation and cell...

    Authors: Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom and Catherine E. Costello
    Citation: Journal of Biomedical Science 2021 28:61
    Content type: Research Published on:

  23. Streptococcus pneumoniae is a common cause of post-influenza secondary bacterial infection, which results in excessive morbidity and mortality. Although 13-valent pneumococcal conjugate vaccine (PCV13) vaccinatio...

    Authors: Yi-Yin Chen, Ching-Tai Huang, Shiao-Wen Li, Yi-Jiun Pan, Tzu-Lung Lin, Ya-Yu Huang, Ting-Hsuan Li, Yu-Ching Yang, Yu-Nong Gong and Yu-Chia Hsieh
    Citation: Journal of Biomedical Science 2021 28:60
    Content type: Research Published on:

  24. Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and furt...

    Authors: Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng and Shang-Hsun Yang
    Citation: Journal of Biomedical Science 2021 28:59
    Content type: Review Published on:

  25. Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w...

    Authors: Pu-Sheng Hsu, Shu-Han Yu, Yi-Tzang Tsai, Jen-Yun Chang, Li-Kuang Tsai, Chih-Hung Ye, Ning-Yu Song, Lih-Chiao Yau and Shau-Ping Lin
    Citation: Journal of Biomedical Science 2021 28:58
    Content type: Review Published on:

  27. Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Thro...

    Authors: Tong-tong Li, Jie Mou, Yao-jie Pan, Fu-chun Huo, Wen-qi Du, Jia Liang, Yang Wang, Lan-sheng Zhang and Dong-sheng Pei
    Citation: Journal of Biomedical Science 2021 28:56
    Content type: Research Published on:

  28. Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal t...

    Authors: Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang and Li-Tzong Chen
    Citation: Journal of Biomedical Science 2021 28:55
    Content type: Research Published on:

  29. Current multiparametric MRI (mp-MRI) in routine clinical practice has poor-to-moderate diagnostic performance for transition zone prostate cancer. The aim of this study was to evaluate the potential diagnostic...

    Authors: Neda Gholizadeh, Peter B. Greer, John Simpson, Jonathan Goodwin, Caixia Fu, Peter Lau, Saabir Siddique, Arend Heerschap and Saadallah Ramadan
    Citation: Journal of Biomedical Science 2021 28:54
    Content type: Research Published on:

  30. Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant...

    Authors: Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun and Qi Yu
    Citation: Journal of Biomedical Science 2021 28:53
    Content type: Research Published on:

  31. Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate...

    Authors: Neha Pandey, Meghana Rastogi and Sunit K. Singh
    Citation: Journal of Biomedical Science 2021 28:52
    Content type: Research Published on:

  32. Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation ...

    Authors: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe and Ilo Jou
    Citation: Journal of Biomedical Science 2021 28:51
    Content type: Research Published on:

  33. Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James...

    Authors: Austin W. T. Chiang, Hratch M. Baghdassarian, Benjamin P. Kellman, Bokan Bao, James T. Sorrentino, Chenguang Liang, Chih-Chung Kuo, Helen O. Masson and Nathan E. Lewis
    Citation: Journal of Biomedical Science 2021 28:50
    Content type: Review Published on:

  34. Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the mi...

    Authors: Ali Jangjou, Amir Hossein Meisami, Kazem Jamali, Mohammad Hadi Niakan, Milad Abbasi, Mostafa Shafiee, Majid Salehi, Ahmad Hosseinzadeh, Ali Mohammad Amani and Ahmad Vaez
    Citation: Journal of Biomedical Science 2021 28:49
    Content type: Review Published on:

  35. Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA ...

    Authors: Chia-Ling Hsu, Shin Yen Chong, Chia-Yeh Lin and Cheng-Fu Kao
    Citation: Journal of Biomedical Science 2021 28:48
    Content type: Review Published on:

  36. Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) regulation in primary open-angle glaucoma...

    Authors: Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki and Makoto Aihara
    Citation: Journal of Biomedical Science 2021 28:47
    Content type: Research Published on:

  38. Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high individual and societal burden. While not all patients display overt markers of elevated inflammation, significant evidence...

    Authors: Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari and Rodrigo Machado-Vieira
    Citation: Journal of Biomedical Science 2021 28:45
    Content type: Review Published on:

  39. Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

    Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji
    Citation: Journal of Biomedical Science 2021 28:44
    Content type: Research Published on:

  40. Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe...

    Authors: Jing-You Guo, I-Ju Liu, Hsiu-Ting Lin, Mei-Jung Wang, Yu-Ling Chang, Shin-Chang Lin, Mei-Ying Liao, Wei-Chia Hsu, Yi-Ling Lin, James C. Liao and Han-Chung Wu
    Citation: Journal of Biomedical Science 2021 28:43
    Content type: Research Published on:

  41. The evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging ...

    Authors: Annie Horng, Johannes Stroebel, Tobias Geith, Stefan Milz, Alexandra Pacureanu, Yang Yang, Peter Cloetens, Goran Lovric, Alberto Mittone, Alberto Bravin and Paola Coan
    Citation: Journal of Biomedical Science 2021 28:42
    Content type: Research Published on:

  44. Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily...

    Authors: Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha
    Citation: Journal of Biomedical Science 2021 28:39
    Content type: Review Published on:

  45. Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fi...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2021 28:38
    Content type: Research Published on:

  46. Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is conside...

    Authors: Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett…
    Citation: Journal of Biomedical Science 2021 28:37
    Content type: Research Published on:

  47. Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix proteins, causing loss of physiological architecture and dysfunction of different tissues and organs. In the skin, fib...

    Authors: Angelo Giuseppe Condorelli, May El Hachem, Giovanna Zambruno, Alexander Nystrom, Eleonora Candi and Daniele Castiglia
    Citation: Journal of Biomedical Science 2021 28:36
    Content type: Review Published on:

  49. The spread of SARS-CoV-2, the virus that causes Coronavirus Disease 2019 (COVID-19), has been characterized as a worldwide pandemic. Currently, there are few preclinical animal models that suitably represent i...

    Authors: Ssu-Hsueh Tseng, Brandon Lam, Yu Jui Kung, John Lin, Li Liu, Ya Chea Tsai, Louise Ferrall, Richard B. S. Roden, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2021 28:34
    Content type: Research Published on:

  50. The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts a...

    Authors: Lucia Sophie Kilian, Jakob Voran, Derk Frank and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2021 28:33
    Content type: Review Published on:
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ISSN: 1423-0127