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  1. Content type: Review

    Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effect...

    Authors: Hwei-Fang Tsai and Ping-Ning Hsu

    Citation: Journal of Biomedical Science 2017 24:35

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  2. Content type: Research

    The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen

    Citation: Journal of Biomedical Science 2017 24:33

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  3. Content type: Research

    In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Authors: Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon

    Citation: Journal of Biomedical Science 2017 24:31

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  4. Content type: Research

    Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Authors: Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2017 24:29

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  5. Content type: Research

    The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen

    Citation: Journal of Biomedical Science 2017 24:30

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  6. Content type: Research

    Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate

    Citation: Journal of Biomedical Science 2017 24:27

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  7. Content type: Review

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Authors: Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Citation: Journal of Biomedical Science 2017 24:26

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  8. Content type: Research

    Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Authors: Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Citation: Journal of Biomedical Science 2017 24:25

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  9. Content type: Research

    GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Citation: Journal of Biomedical Science 2017 24:23

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  10. Content type: Research

    Malfunctioning of the serotonergic system in Parkinson’s disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 re...

    Authors: Kryspin Andrzejewski, Katarzyna Kaczyńska and Małgorzata Zaremba

    Citation: Journal of Biomedical Science 2017 24:24

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  11. Content type: Review

    Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Authors: Susan Marqus, Elena Pirogova and Terrence J. Piva

    Citation: Journal of Biomedical Science 2017 24:21

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  12. Content type: Research

    The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Authors: Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo

    Citation: Journal of Biomedical Science 2017 24:20

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  13. Content type: Review

    Multi voxel magnetic resonance spectroscopic imaging (MRSI) is an important imaging tool that combines imaging and spectroscopic techniques. MRSI of the human brain has been beneficially applied to different c...

    Authors: Oun Al-iedani, Jeannette Lechner-Scott, Karen Ribbons and Saadallah Ramadan

    Citation: Journal of Biomedical Science 2017 24:17

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  14. Content type: Research

    Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-...

    Authors: Mei-Yi Lee, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng, Ming-Huan Chan and Hwei-Hsien Chen

    Citation: Journal of Biomedical Science 2017 24:18

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  15. Content type: Research

    Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulce...

    Authors: Manish Suthar, Saniya Gupta, Suhail Bukhari and Venkatesh Ponemone

    Citation: Journal of Biomedical Science 2017 24:16

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  16. Content type: Review

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    Authors: S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Citation: Journal of Biomedical Science 2017 24:15

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  17. Content type: Review

    Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Authors: Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini

    Citation: Journal of Biomedical Science 2017 24:14

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  18. Content type: Research

    Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Authors: Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf

    Citation: Journal of Biomedical Science 2017 24:12

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  19. Content type: Review

    Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Authors: Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov

    Citation: Journal of Biomedical Science 2017 24:13

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  20. Content type: Review

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Authors: Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Citation: Journal of Biomedical Science 2017 24:10

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  21. Content type: Review

    Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Authors: Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee

    Citation: Journal of Biomedical Science 2017 24:9

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  22. Content type: Research

    Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynam...

    Authors: Sean P. Nassoiy, Kenneth L. Byron and Matthias Majetschak

    Citation: Journal of Biomedical Science 2017 24:8

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  23. Content type: Review

    Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils ar...

    Authors: Bill Cheng, H. C. Chen, I. W. Chou, Tony W. H. Tang and Patrick C. H. Hsieh

    Citation: Journal of Biomedical Science 2017 24:7

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  24. Content type: Research

    The DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squam...

    Authors: Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang and Gang Kuang

    Citation: Journal of Biomedical Science 2017 24:6

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  25. Content type: Review

    Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, wh...

    Authors: Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2017 24:5

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  26. Content type: Research

    Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxi...

    Authors: Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz and Daria Mochly-Rosen

    Citation: Journal of Biomedical Science 2017 24:3

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  27. Content type: Research

    Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of vi...

    Authors: Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai and Jen-Yang Chen

    Citation: Journal of Biomedical Science 2017 24:2

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  28. Content type: Research

    Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on...

    Authors: Xiaochen Yan, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2017 24:1

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  29. Content type: Review

    Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resul...

    Authors: Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj

    Citation: Journal of Biomedical Science 2016 23:88

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  30. Content type: Research

    Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Authors: Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara

    Citation: Journal of Biomedical Science 2016 23:89

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  31. Content type: Review

    The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for adv...

    Authors: Bin-Chi Liao, Chia-Chi Lin, Jih-Hsiang Lee and James Chih-Hsin Yang

    Citation: Journal of Biomedical Science 2016 23:86

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  32. Content type: Research

    The dengue non-structural 3 (NS3) is a multifunctional protein, containing a serine-protease domain, located at the N-terminal portion, and helicase, NTPase and RTPase domains present in the C-terminal region....

    Authors: M. L. Hurtado-Melgoza, A. Ramos-Ligonio, L. M. Álvarez-Rodríguez, T. Meza-Menchaca and A. López-Monteon

    Citation: Journal of Biomedical Science 2016 23:85

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  33. Content type: Research

    As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a...

    Authors: Dong Zhang, Qing Zhao, Hao Sun, Lijuan Yin, Jiajun Wu, Jun Xu, Tianxiang He, Chunlei Yang and Chengwei Liang

    Citation: Journal of Biomedical Science 2016 23:82

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  34. Content type: Research

    Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM pat...

    Authors: Che-Chia Hsu, Wen-Chang Chang, Tsung-I Hsu, Jr-Jiun Liu, Shiu-Hwa Yeh, Jia-Yi Wang, Jing-Ping Liou, Chiung-Yuan Ko, Kwang-Yu Chang and Jian-Ying Chuang

    Citation: Journal of Biomedical Science 2016 23:81

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  35. Content type: Review

    The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Authors: Stacy L. McAllister, Katherine Sun and Eric R. Gross

    Citation: Journal of Biomedical Science 2016 23:80

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  36. Content type: Research

    In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP). Nevertheless, little is known about the ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, Euclides Avila, Fernando Larrea and Lorenza Díaz

    Citation: Journal of Biomedical Science 2016 23:78

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  37. Content type: Research

    miR-199a-3p was significantly downregulated in the majority of human hepatocellular carcinoma (HCC) tissues and HCC cell lines. Yes associated protein 1 (YAP1) was overexpressed in human HCC, which promoted HC...

    Authors: Kewei Ren, Tengfei Li, Wenzhe Zhang, Jianzhuang Ren, Zhen Li and Gang Wu

    Citation: Journal of Biomedical Science 2016 23:79

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  38. Content type: Review

    A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental...

    Authors: G. S. Sailaja, P. Ramesh, Sajith Vellappally, Sukumaran Anil and H. K. Varma

    Citation: Journal of Biomedical Science 2016 23:77

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  39. Content type: Review

    Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomod...

    Authors: Li-Tzu Wang, Chiao-Hsuan Ting, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, Kenneth K. Wu and B. Linju Yen

    Citation: Journal of Biomedical Science 2016 23:76

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  40. Content type: Review

    Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and...

    Authors: Andrew Yang, Emily Farmer, T. C. Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2016 23:75

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