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  1. Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieve...

    Authors: Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin and Liudmila M. Tsybalova

    Citation: Journal of Biomedical Science 2018 25:33

    Content type: Research

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  2. During metastasis, cancer cells require anokis resistant mechanism to survive until reach the distant secondary tissues. As anoikis sensitization may benefit for cancer therapy, this study demonstrated the pot...

    Authors: Arisara Prateep, Somruethai Sumkhemthong, Wiranpat Karnsomwan, Wanchai De-Eknamkul, Supakarn Chamni, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Journal of Biomedical Science 2018 25:32

    Content type: Research

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  3. Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen

    Citation: Journal of Biomedical Science 2018 25:30

    Content type: Review

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  4. Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad

    Citation: Journal of Biomedical Science 2018 25:29

    Content type: Review

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  5. Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanis...

    Authors: I-Ting Tsai, Ching-Chuan Kuo, Jing-Ping Liou and Jang-Yang Chang

    Citation: Journal of Biomedical Science 2018 25:28

    Content type: Research

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  6. β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee

    Citation: Journal of Biomedical Science 2018 25:27

    Content type: Research

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  7. Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision makin...

    Authors: Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini and Silmar Teixeira

    Citation: Journal of Biomedical Science 2018 25:26

    Content type: Review

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  8. Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses...

    Authors: Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu and Shih-Torng Ding

    Citation: Journal of Biomedical Science 2018 25:24

    Content type: Research

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  9. Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression ...

    Authors: Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang and Yunfu Cui

    Citation: Journal of Biomedical Science 2018 25:23

    Content type: Review

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  10. Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major...

    Authors: Ricardo Leão, Joana Dias Apolónio, Donghyun Lee, Arnaldo Figueiredo, Uri Tabori and Pedro Castelo-Branco

    Citation: Journal of Biomedical Science 2018 25:22

    Content type: Review

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  11. Pericytes are multipotent cells present in every vascularized tissue in the body. Despite the fact that they are well-known for more than a century, pericytes are still representing cells with intriguing prope...

    Authors: C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov and Vladislav Volarevic

    Citation: Journal of Biomedical Science 2018 25:21

    Content type: Review

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  12. Cancer stem cells (CSCs) are subpopulations of cancer cells sharing similar characteristics as normal stem or progenitor cells such as self-renewal ability and multi-lineage differentiation to drive tumour gro...

    Authors: Ain Zubaidah Ayob and Thamil Selvee Ramasamy

    Citation: Journal of Biomedical Science 2018 25:20

    Content type: Review

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  13. In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of...

    Authors: Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang and Bing-Chang Chen

    Citation: Journal of Biomedical Science 2018 25:19

    Content type: Research

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  14. LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined.

    Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong and Jian Zhang

    Citation: Journal of Biomedical Science 2018 25:18

    Content type: Research

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  15. Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed 99mT...

    Authors: Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr

    Citation: Journal of Biomedical Science 2018 25:17

    Content type: Research

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  16. Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed ...

    Authors: Lan Zhao, Alvin H. W. Fong, Na Liu and William C. S. Cho

    Citation: Journal of Biomedical Science 2018 25:16

    Content type: Research

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  17. Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has dev...

    Authors: Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam and Shamala Devi Sekaran

    Citation: Journal of Biomedical Science 2018 25:15

    Content type: Research

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  18. Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastic...

    Authors: Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu and Meei Jyh Jiang

    Citation: Journal of Biomedical Science 2018 25:14

    Content type: Research

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  19. Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated. In the present study, t...

    Authors: Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen and Shenghai Huang

    Citation: Journal of Biomedical Science 2018 25:13

    Content type: Research

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  20. Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mec...

    Authors: Sajal K. Ghosh, Abhishek Ganta and Remco A. Spanjaard

    Citation: Journal of Biomedical Science 2018 25:12

    Content type: Research

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  21. Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms of lncRNA H19 in vascular sm...

    Authors: Lei Zhang, Hailing Cheng, Yuxia Yue, Shuangzhan Li, Daping Zhang and Ruili He

    Citation: Journal of Biomedical Science 2018 25:11

    Content type: Research

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  22. Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tole...

    Authors: Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Zu-Min Xing, Han-Wen Chen and Yi-Wen Zhang

    Citation: Journal of Biomedical Science 2018 25:10

    Content type: Research

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  23. Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) i...

    Authors: Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan and Jim-Tong Horng

    Citation: Journal of Biomedical Science 2018 25:9

    Content type: Research

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  24. Intake of ethanol (alcohol) has been shown to influence cardiovascular function; the underlying brain mechanism remains unclear. Noting that nitric oxide (NO) system in the CNS is involved in the regulation of...

    Authors: Jiro Hasegawa Situmorang, Hsun-Hsun Lin, Hsuan Lo and Chih-Chia Lai

    Citation: Journal of Biomedical Science 2018 25:8

    Content type: Research

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  25. Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrade...

    Authors: Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen and Marianne M. Stanford

    Citation: Journal of Biomedical Science 2018 25:7

    Content type: Research

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  26. Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essenti...

    Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and Lee-Young Chau

    Citation: Journal of Biomedical Science 2018 25:6

    Content type: Research

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  27. Mesenchymal stem cells (MSC) are used for several therapeutic applications to improve the functions of bone, cardiac, nervous tissue as well as to facilitate the repopulation of hematopoietic stem cells. MSC g...

    Authors: Chinnapaka Somaiah, Atul Kumar, Renu Sharma, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, Sewali Deka Talukdar and Bithiah Grace Jaganathan

    Citation: Journal of Biomedical Science 2018 25:5

    Content type: Research

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  28. Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic ...

    Authors: Zhenyu Tang, Zongming Gong and Xiaoliang Sun

    Citation: Journal of Biomedical Science 2018 25:4

    Content type: Research

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  29. The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling me...

    Authors: Yu-Tzu Shih and Yi-Ping Hsueh

    Citation: Journal of Biomedical Science 2018 25:2

    Content type: Review

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  30. Atherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their co...

    Authors: Tung-Lin Yang, Pei-Ling Lee, Ding-Yu Lee, Wei-Li Wang, Shu-Yi Wei, Chih-I Lee and Jeng-Jiann Chiu

    Citation: Journal of Biomedical Science 2018 25:1

    Content type: Research

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  31. Numerous studies have shown that Id-1 (Inhibitor of differentiation 1) is upregulated in several cancers and associated with tumor malignant characters. However, the clinical significance and biological role o...

    Authors: Jie Li, Yingjie Li, Bin Wang, Yongfu Ma and Ping Chen

    Citation: Journal of Biomedical Science 2017 24:95

    Content type: Research

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  32. Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and cerebrospinal fluid of infected patients with brainst...

    Authors: Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang and Shun-Hua Chen

    Citation: Journal of Biomedical Science 2017 24:94

    Content type: Research

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  33. Beta-thalassemia is common in the Mediterranean area as well as the Middle East and India. Official report in Iran revealed the average prevalence rate of carriers about 4%. More than 20 restriction fragment l...

    Authors: Mohammad Bagher Hashemi-Soteh, Seyed Saeed Mousavi and Alireza Tafazoli

    Citation: Journal of Biomedical Science 2017 24:92

    Content type: Research

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  34. A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical man...

    Authors: Hiroya Matsumura, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Shunsuke Tomomori, Chikaaki Motoda, Michitaka Amioka, Naoya Hironobe, Masaaki Toshishige, Shinya Takahashi, Katsuhiko Imai, Taijiro Sueda, Kazuaki Chayama and Yasuki Kihara

    Citation: Journal of Biomedical Science 2017 24:91

    Content type: Research

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  35. Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytoki...

    Authors: Isela Martínez-Reza, Lorenza Díaz and Rocío García-Becerra

    Citation: Journal of Biomedical Science 2017 24:90

    Content type: Review

    Published on:

  36. MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for...

    Authors: Che-Chung Yeh, Yanying Fan, Yi-Lin Yang and Michael J. Mann

    Citation: Journal of Biomedical Science 2017 24:89

    Content type: Research

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  37. The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enh...

    Authors: Lorrany dos Santos Franco, Paloma Oliveira Vidal and Jaime Henrique Amorim

    Citation: Journal of Biomedical Science 2017 24:88

    Content type: Research

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  38. Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellula...

    Authors: Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal and Stephen Myers

    Citation: Journal of Biomedical Science 2017 24:87

    Content type: Review

    Published on:

  39. This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascula...

    Authors: Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen and Li-Chin Sung

    Citation: Journal of Biomedical Science 2017 24:85

    Content type: Research

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  40. Blood pressure control with renin-angiotensin system (RAS) blockade has remained the gold standard for treating patients with proteinuric chronic kidney disease (CKD) up to date. Nevertheless, RAS blockade slo...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin and Tun-Jun Tsai

    Citation: Journal of Biomedical Science 2017 24:84

    Content type: Review

    Published on:

  41. Cells adapt to hypoxia by transcriptional induction of genes that participate in regulation of angiogenesis, glucose metabolism and cell proliferation. The primary factors mediating cell response to low oxygen...

    Authors: Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Anna Lipińska, Lech Pomorski, Marek Wieczorek, Magdalena Bryś, Ewa Forma and Anna Krześlak

    Citation: Journal of Biomedical Science 2017 24:83

    Content type: Research

    Published on:

  42. Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric infl...

    Authors: Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2017 24:82

    Content type: Research

    Published on:

  43. Luteinizing hormone-releasing hormone (LH-RH) agonists are the standard for androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. Current guidelines recommend serum testosterone measurement to ...

    Authors: Juan Morote, Imma Comas, Roser Ferrer, Jacques Planas, Anna Celma and Lucas Regis

    Citation: Journal of Biomedical Science 2017 24:81

    Content type: Research

    Published on:

  44. Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+

    Authors: Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya

    Citation: Journal of Biomedical Science 2017 24:79

    Content type: Research

    Published on:

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