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  1. SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that has impacted many aspects of human society. Several issues concerning the origin, time of introduction to humans, evolutionary p...

    Authors: Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen and Hurng-Yi Wang
    Citation: Journal of Biomedical Science 2020 27:73
    Content type: Research Published on:

  2. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2020 27:72
    Content type: Review Published on:

  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo and John H. Zhang
    Citation: Journal of Biomedical Science 2020 27:71
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2020 27:61

  4. Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic v...

    Authors: Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding-Shinn Chen and Pei-Jer Chen
    Citation: Journal of Biomedical Science 2020 27:70
    Content type: Research Published on:

  5. Due to differences in genetic background, it is unclear whether the genetic loci identified by the previous genome-wide association studies (GWAS) of pancreatic cancer also play significant roles in the develo...

    Authors: Yan-Shen Shan, Li-Tzong Chen, Jin-Shang Wu, Yin-Fan Chang, Chih-Ting Lee, Chih-Hsing Wu, Nai-Jung Chiang, Hsin-En Huang, Chia-Jui Yen, Ying-Jui Chao, Hui-Jen Tsai, Chiung-Yu Chen, Jui-Wen Kang, Chin-Fu Kuo, Chia-Rung Tsai, Ya-Ling Weng…
    Citation: Journal of Biomedical Science 2020 27:69
    Content type: Research Published on:

  6. Tissue oxidative stress, sympathetic activation and nutrient sensing signals are closely related to adult hypertension of fetal origin, although their interactions in hypertension programming remain unclear. B...

    Authors: Yung-Mei Chao, Kay L. H. Wu, Pei-Chia Tsai, You-Lin Tain, Steve Leu, Wei-Chia Lee and Julie Y. H. Chan
    Citation: Journal of Biomedical Science 2020 27:68
    Content type: Research Published on:

  7. Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and organs. As a resul...

    Authors: Alejandra Vargas-Valderrama, Antonietta Messina, Maria Teresa Mitjavila-Garcia and Hind Guenou
    Citation: Journal of Biomedical Science 2020 27:67
    Content type: Review Published on:

  8. Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes a...

    Authors: Fajar Budi Lestari, Sompong Vongpunsawad, Nasamon Wanlapakorn and Yong Poovorawan
    Citation: Journal of Biomedical Science 2020 27:66
    Content type: Review Published on:

  9. Hepatitis D virus (HDV) infection may induce fulminant hepatitis in chronic hepatitis B patients (CHB) or rapid progression of CHB to cirrhosis or hepatocellular carcinoma. There is no effective treatment for ...

    Authors: Yuh-Jin Liang, Cheng-Pu Sun, Yu-Chen Hsu, Yi-Wen Chen, I-An Wang, Chien-Wei Su, Mi-Hua Tao and Jaw-Ching Wu
    Citation: Journal of Biomedical Science 2020 27:65
    Content type: Research Published on:

  10. The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, belong to a family of neurological disorders that cause blindness, seizures, loss of motor function and cognitive ability, and prema...

    Authors: Robert J. Huber
    Citation: Journal of Biomedical Science 2020 27:64
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:94

  11. Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nuc...

    Authors: Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang and Shaw-Jenq Tsai
    Citation: Journal of Biomedical Science 2020 27:63
    Content type: Review Published on:

  12. Cerebral arteriovenous malformation (AVM) is a serious life-threatening congenital cerebrovascular disease. Specific anatomical features, such as nidus size, location, and venous drainage, have been validated ...

    Authors: Lin-jian Wang, Yimeng Xue, Ran Huo, Zihan Yan, Hongyuan Xu, Hao Li, Jia Wang, Qian Zhang, Yong Cao and Ji-zong Zhao
    Citation: Journal of Biomedical Science 2020 27:62
    Content type: Research Published on:

  13. The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders.

    Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo and John H. Zhang
    Citation: Journal of Biomedical Science 2020 27:61
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:71

  14. Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic ...

    Authors: Shaw-Min Hou, Chih-Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Marappan Velusamy and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2020 27:60
    Content type: Research Published on:

  15. Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological ...

    Authors: Tse-Chun Kuo, Hsing-Jien Kung and Jing-Wen Shih
    Citation: Journal of Biomedical Science 2020 27:59
    Content type: Review Published on:

  16. Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression, it can be hypothesized that STF can improve the efficacy of ...

    Authors: Jing Zhang, Yanlin Deng and Bee Luan Khoo
    Citation: Journal of Biomedical Science 2020 27:58
    Content type: Review Published on:

  17. O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of nuclear or cytoplasmic proteins by O-GlcN...

    Authors: Yi-Hsuan Chang, Chia-Lin Weng and Kuo-I Lin
    Citation: Journal of Biomedical Science 2020 27:57
    Content type: Review Published on:

  18. Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major chal...

    Authors: Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim and Seungkwon You
    Citation: Journal of Biomedical Science 2020 27:56
    Content type: Research Published on:

  19. Very few studies have identified receptor molecules for dengue virus (DENV) on neural cells. This study was designed to identify putative receptor/(s) involved in entry of DENV-3 in human neural cells of vario...

    Authors: Amita Sharma, Ravi Vasanthapuram, Manjunatha M Venkataswamy and Anita Desai
    Citation: Journal of Biomedical Science 2020 27:55
    Content type: Research Published on:

  20. Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immuni...

    Authors: Patricia Ruiz-Limon, Maria Lourdes Ladehesa-Pineda, Maria del Carmen Castro-Villegas, Maria del Carmen Abalos-Aguilera, Clementina Lopez-Medina, Chary Lopez-Pedrera, Nuria Barbarroja, Daniel Espejo-Peralbo, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Carlos Perez-Sanchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Pilar Font-Ugalde and Yolanda Jimenez-Gomez
    Citation: Journal of Biomedical Science 2020 27:54
    Content type: Research Published on:

  21. Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss...

    Authors: Shao-Hsuan Hsia, Jainn-Jim Lin, Oi-Wa Chan and Tzou-Yien Lin
    Citation: Journal of Biomedical Science 2020 27:53
    Content type: Review Published on:

  22. Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause ab...

    Authors: Yen-Ting Lai, Hsu-Wen Chao, Alan Chuan-Ying Lai, Shu-Hui Lin, Ya-Jen Chang and Yi-Shuian Huang
    Citation: Journal of Biomedical Science 2020 27:52
    Content type: Research Published on:

  23. The emergence of Zika virus (ZV) in tropical and subtropical areas of the world has created an urgent need for vaccines against ZV. However, approved vaccines that prevent ZV infection are not available. To de...

    Authors: Mei-Yu Chen, Kit Man Chai, Chen-Yi Chiang, Chiao-Chieh Wu, Guann-Yi Yu, Shih-Jen Liu and Hsin-Wei Chen
    Citation: Journal of Biomedical Science 2020 27:51
    Content type: Research Published on:

  24. The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied.

    Authors: Ayesha Wijesinghe, Jayani Gamage, Hemantha Goonewardena, Laksiri Gomes, Deshni Jayathilaka, Dulharie T. Wijeratne, Ruklanthi de Alwis, Chandima Jeewandara, Ananda Wijewickrama, Graham S. Ogg and Gathsaurie Neelika Malavige
    Citation: Journal of Biomedical Science 2020 27:50
    Content type: Research Published on:

  26. With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcrib...

    Authors: Chih-Fan Yeh, Yu-Chen Eugene Chang, Cheng-Yuan Lu, Chin-Feng Hsuan, Wei-Tien Chang and Kai-Chien Yang
    Citation: Journal of Biomedical Science 2020 27:48
    Content type: Review Published on:

  27. Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an...

    Authors: Tsai-Teng Tzeng, Po-Ling Chen, Tsai-Chuan Weng, Shin-Yi Tsai, Chia-Chun Lai, Hsin-I Chou, Pin-Wen Chen, Chia-Chun Lu, Ming-Tsan Liu, Wang-Chou Sung, Min-Shi Lee and Alan Yung-Chih Hu
    Citation: Journal of Biomedical Science 2020 27:47
    Content type: Research Published on:

  28. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2020 27:46
    Content type: Research Published on:

  29. Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents....

    Authors: Yu-Wen Wu, Cheng-Chain Huang, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran and Thierry Burnouf
    Citation: Journal of Biomedical Science 2020 27:45
    Content type: Research Published on:

  31. Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem c...

    Authors: Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai and Sung-Jan Lin
    Citation: Journal of Biomedical Science 2020 27:43
    Content type: Review Published on:

  32. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang
    Citation: Journal of Biomedical Science 2020 27:42
    Content type: Research Published on:

  33. Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Cas...

    Authors: Mel Campbell and Yoshihiro Izumiya
    Citation: Journal of Biomedical Science 2020 27:41
    Content type: Review Published on:

  34. The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to explore the mechanism by which MALAT1 regulates aquap...

    Authors: Hongwei Wang, Xiaoxiao Zheng, Jing Jin, Li Zheng, Ting Guan, Yangfan Huo, Shufen Xie, Ying Wu and Wei Chen
    Citation: Journal of Biomedical Science 2020 27:40
    Content type: Research Published on:

  37. Aerobically-grown bacteria can be challenged by hydrogen peroxide stress from endogenous aerobic metabolism and exogenously generated reactive oxygen species. Catalase (Kat), alkyl hydroperoxidase (Ahp), and g...

    Authors: Li-Hua Li, Yung-Luen Shih, Jing-Yun Huang, Chao-Jung Wu, Yi-Wei Huang, Hsin-Hui Huang, Yu-Chieh Tsai and Tsuey-Ching Yang
    Citation: Journal of Biomedical Science 2020 27:37
    Content type: Research Published on:

  38. Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Fo...

    Authors: Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou and Wen-Tai Chiu
    Citation: Journal of Biomedical Science 2020 27:36
    Content type: Research Published on:

  39. Spinal cord injury (SCI) is a highly debilitating pathology without curative treatment. One of the most promising disease modifying strategies consists in the implantation of stem cells to reduce inflammation ...

    Authors: Lorenzo Romero-Ramírez, Siyu Wu, Johannes de Munter, Erik Ch. Wolters, Boris W. Kramer and Jörg Mey
    Citation: Journal of Biomedical Science 2020 27:35
    Content type: Research Published on:

  40. In the past years evidence has been growing about the interconnection of chronic kidney disease and acute kidney injury. The underlying pathophysiological mechanisms remain unclear. We hypothesized, that a thr...

    Authors: Alexander Holderied, Franziska Kraft, Julian Aurelio Marschner, Marc Weidenbusch and Hans-Joachim Anders
    Citation: Journal of Biomedical Science 2020 27:34
    Content type: Research Published on:

  41. Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with exten...

    Authors: Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng and Che Ma
    Citation: Journal of Biomedical Science 2020 27:33
    Content type: Review Published on:

  42. Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously,...

    Authors: Yu-Hsun Chang, Tang-Yuan Chu and Dah-Ching Ding
    Citation: Journal of Biomedical Science 2020 27:32
    Content type: Research Published on:

  43. X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of th...

    Authors: Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng and Euphemia Leung
    Citation: Journal of Biomedical Science 2020 27:31
    Content type: Review Published on:

  44. The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence is a leading clinical bottleneck in NPC. Revealing the mechanism of NPC radioresistance wi...

    Authors: Panpan Zhang, Xiaomin Li, Qiuping He, Lulu Zhang, Keqing Song, Xiaojing Yang, Qingmei He, Yaqin Wang, Xiaohong Hong, Jun Ma and Na Liu
    Citation: Journal of Biomedical Science 2020 27:30
    Content type: Research Published on:

  47. Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpec...

    Authors: Muhammad Izzuddin Mohd Ropidi, Ahmad Suhail Khazali, Nurshamimi Nor Rashid and Rohana Yusof
    Citation: Journal of Biomedical Science 2020 27:27
    Content type: Review Published on:

  48. Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protei...

    Authors: Dan Nie, Yue Hu, Zhou Chen, Mingkai Li, Zheng Hou, Xiaoxing Luo, Xinggang Mao and Xiaoyan Xue
    Citation: Journal of Biomedical Science 2020 27:26
    Content type: Review Published on:

  49. Dengue presents a wide clinical spectrum. Most patients recover following a self-limiting non-severe clinical course. A small proportion of patients progress to severe disease, mostly characterized by plasma l...

    Authors: Harsha Hapugaswatta, Pubudu Amarasena, Ranjan Premaratna, Kapila N. Seneviratne and Nimanthi Jayathilaka
    Citation: Journal of Biomedical Science 2020 27:25
    Content type: Research Published on:
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ISSN: 1423-0127