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146 result(s) for '2023' within Journal of Biomedical Science

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  2. mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e...

    Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:84
    Content type: Review Published on:

  6. Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) vi...

    Authors: Monika Kumari, Shih-Chieh Su, Kang-Hao Liang, Hsiu-Ting Lin, Yu-Feng Lu, Kai-Chi Chen, Wan-Yu Chen and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:46
    Content type: Research Published on:

  7. Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied. In the context of the current global antimicrobial resistan...

    Authors: Claudia C. Paredes-Amaya, María Teresa Ulloa and Víctor Antonio García-Angulo
    Citation: Journal of Biomedical Science 2023 30:67
    Content type: Review Published on:

  8. The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. T...

    Authors: Jaung-Geng Lin, Guan-Jhong Huang and Yi-Chang Su
    Citation: Journal of Biomedical Science 2023 30:30
    Content type: Review Published on:

  9. The COVID-19 pandemic continues to pose a significant worldwide threat to human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic antibodies and the ability to evade vaccination...

    Authors: Hsiao-Ling Chiang, Kang-Hao Liang, Ruei-Min Lu, Ting-Wen Kuo, Yi‑Ling Lin and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:59
    Content type: Research Published on:

  10. The developments of antibodies for cancer therapeutics have made remarkable success in recent years. There are multiple factors contributing to the success of the biological molecule including origin of the an...

    Authors: Mukesh Kumar, Akansha Jalota, Sushil Kumar Sahu and Shabirul Haque
    Citation: Journal of Biomedical Science 2024 31:6
    Content type: Review Published on:

  12. Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of blaNDM dissemination across the world. ST147 has repeatedly reported from our geographical region, but ...

    Authors: Omid Pajand, Hamzeh Rahimi, Farzad Badmasti, Faeze Gholami, Tahereh Alipour, Narges Darabi, Frank M. Aarestrup and Pimlapas Leekitcharoenphon
    Citation: Journal of Biomedical Science 2023 30:73
    Content type: Research Published on:

  13. Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There...

    Authors: Xiaohu Cui, Bing Du, Junxia Feng, Yanling Feng, Zheng Fan, Jinfeng Chen, Jinghua Cui, Lin Gan, Tongtong Fu, Ziyan Tian, Rui Zhang, Chao Yan, Hanqing Zhao, Wenjian Xu, Ziying Xu, Zihui Yu…
    Citation: Journal of Biomedical Science 2023 30:75
    Content type: Research Published on:

  14. Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2023 30:54
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2022 29:109

  15. We investigated the presence of heteroresistance against both tigecycline and colistin in Acinetobacter baumannii and then evaluated the effectiveness of combined antibiotic treatment given the existence of discr...

    Authors: Jeongwoo Jo, Ki Tae Kwon and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:37
    Content type: Research Published on:

  16. Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. T...

    Authors: Chih-Min Liu, Yi-Chun Chen and Yu-Feng Hu
    Citation: Journal of Biomedical Science 2023 30:74
    Content type: Review Published on:

  17. Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/o...

    Authors: Patience Shumba, Thomas Sura, Kirsten Moll, Bhavya Chakrakodi, Lea A. Tölken, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
    Citation: Journal of Biomedical Science 2023 30:52
    Content type: Research Published on:

  18. A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immuno...

    Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye and Ping Lan
    Citation: Journal of Biomedical Science 2023 30:47
    Content type: Research Published on:

  19. Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important consequences for disease diagnosis and treatment. In addition to the many genetic and non-genetic (e.g., epige...

    Authors: Y. Henry Sun, Yueh-Lin Wu and Ben-Yang Liao
    Citation: Journal of Biomedical Science 2023 30:58
    Content type: Review Published on:

  20. Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the cellular events in UVA-treated retinal pigment epithelial (RPE) cells.

    Authors: Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2023 30:91
    Content type: Research Published on:

  21. Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation...

    Authors: Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang and Hai Hu
    Citation: Journal of Biomedical Science 2023 30:44
    Content type: Research Published on:

  22. Parkinson’s disease (PD) is the second most frequent age-related neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both environmental and genetic aspects are involved in the ...

    Authors: Jun Sung Park, Kyonghwan Choe, Hyeon Jin Lee, Tae Ju Park and Myeong Ok Kim
    Citation: Journal of Biomedical Science 2023 30:66
    Content type: Research Published on:

  23. Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SAR...

    Authors: Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang and Yi-Ling Lin
    Citation: Journal of Biomedical Science 2023 30:87
    Content type: Research Published on:

  24. ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC)...

    Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang
    Citation: Journal of Biomedical Science 2023 30:94
    Content type: Research Published on:

  25. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
    Content type: Research Published on:

  26. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub...

    Authors: Mi-Hyun Lee, Hye Lin Kim, Hyejun Seo, Sangkwon Jung and Bum-Joon Kim
    Citation: Journal of Biomedical Science 2023 30:95
    Content type: Research Published on:

  27. Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechani...

    Authors: Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund and Dirk M. Hermann
    Citation: Journal of Biomedical Science 2023 30:76
    Content type: Research Published on:

  28. Excess polymorphonuclear neutrophil (PMN) recruitment or excessive neutrophil extracellular trap (NET) formation can lead to the development of multiple organ dysfunction during sepsis. M2 macrophage-derived e...

    Authors: Yang Jiao, Ti Zhang, Mei Liu, Luyang Zhou, Mengzhi Qi, Xin Xie, Xueyin Shi, Xiaoping Gu and Zhengliang Ma
    Citation: Journal of Biomedical Science 2023 30:62
    Content type: Research Published on:

  29. The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transme...

    Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala and Dinakar M. Salunke
    Citation: Journal of Biomedical Science 2023 30:56
    Content type: Research Published on:

  30. The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a s...

    Authors: Valentina Arrè, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro
    Citation: Journal of Biomedical Science 2023 30:90
    Content type: Review Published on:

  31. Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population.

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
    Content type: Research Published on:

  32. Emerging research has reported that circular RNAs (circRNAs) play important roles in cardiac cell death after myocardial ischemia and reperfusion (I/R). Ferroptosis, a new form of cell death discovered in rece...

    Authors: Jie Ju, Xin-Min Li, Xue-Mei Zhao, Fu-Hai Li, Shao-Cong Wang, Kai Wang, Rui-Feng Li, Lu-Yu Zhou, Lin Liang, Yin Wang, Yu-Hui Zhang and Kun Wang
    Citation: Journal of Biomedical Science 2023 30:45
    Content type: Research Published on:

  34. Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment a...

    Authors: Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson and James R. Connor
    Citation: Journal of Biomedical Science 2023 30:36
    Content type: Research Published on:

  36. The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interacti...

    Authors: Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka and Raymond Kaempfer
    Citation: Journal of Biomedical Science 2023 30:49
    Content type: Research Published on:

  37. G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) genome. Howev...

    Authors: Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard and Tao Jia
    Citation: Journal of Biomedical Science 2024 31:50
    Content type: Research Published on:

  38. The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matrix and cell signalling proteins. Cell signalling activates distinctive subsections of ta...

    Authors: Sandy Winfield Jere, Heidi Abrahamse and Nicolette Nadene Houreld
    Citation: Journal of Biomedical Science 2023 30:81
    Content type: Review Published on:

  39. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a clinically critical pathogen that causes severe infection. Due to improper antibiotic administration, the prevalence of CRKP infection has been increasing co...

    Authors: Yu-Ming Zhang, Mei-Fen Tsao, Ching-Yu Chang, Kuan-Ting Lin, Joseph Jordan Keller and Hsiu-Chen Lin
    Citation: Journal of Biomedical Science 2023 30:25
    Content type: Research Published on:

  40. Supplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation attenuates respiratory viral infection in mice and exhibits anti-inflammatory eff...

    Authors: Chung-Ming Chen, Yu-Chen S. H. Yang, Hsiu-Chu Chou and Shan Lin
    Citation: Journal of Biomedical Science 2023 30:57
    Content type: Research Published on:

  41. Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the stud...

    Authors: Rima Zein-Eddine, Guislaine Refrégier, Jorge Cervantes and Noemí Kaoru Yokobori
    Citation: Journal of Biomedical Science 2023 30:34
    Content type: Review Published on:

  42. Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p....

    Authors: Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo and Min-Xin Guan
    Citation: Journal of Biomedical Science 2023 30:63
    Content type: Research Published on:

  43. Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10) contributes to distant migration of PDAC. The role of KLF1...

    Authors: Yi-Chih Tsai, Kung Hung Cheng, Shih Sheng Jiang, John R. Hawse, Shun En Chuang, Su Liang Chen, Tze-Sing Huang and Hui-Ju Ch’ang
    Citation: Journal of Biomedical Science 2023 30:39
    Content type: Research Published on:

  44. Klebsiella pneumoniae capsular types K1, K2, K5, K20, K54, and K57 are prevalent hypervirulent types associated with community infections, and worrisomely, hypervirulent strains that acquired drug resistance have...

    Authors: Jia-Wen Wu, Jin-Town Wang, Tzu-Lung Lin, Ya-Zhu Liu, Lii-Tzu Wu and Yi-Jiun Pan
    Citation: Journal of Biomedical Science 2023 30:31
    Content type: Research Published on:

  45. Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papillomavirus-negative (HPV-negative) head and neck squamous cell carcinomas (HNSCC). Sustained...

    Authors: Enxian Shi, Zhengquan Wu, Birnur Sinem Karaoglan, Sabina Schwenk-Zieger, Gisela Kranz, Nilofer Abdul Razak, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Reinhard Zeidler and Olivier Gires
    Citation: Journal of Biomedical Science 2023 30:72
    Content type: Research Published on:

  46. Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in chi...

    Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan and Bor-Luen Chiang
    Citation: Journal of Biomedical Science 2023 30:96
    Content type: Research Published on:

  49. Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosine (m6A) modification is a type of RNA modification that regulates metabolism of mRNAs. Pre...

    Authors: Dipayan Bose, Xiang Lin, Le Gao, Zhi Wei, Yonggang Pei and Erle S. Robertson
    Citation: Journal of Biomedical Science 2023 30:18
    Content type: Research Published on:

  50. This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic cataractogenesis. Novel evidence in our model...

    Authors: Ehsan Ranaei Pirmardan, Yuanlin Zhang, Aliaa Barakat, Marzieh Naseri, Christoph Russmann and Ali Hafezi-Moghadam
    Citation: Journal of Biomedical Science 2023 30:6
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127