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  1. Research

    Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells

    This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascula...

    Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen and Li-Chin Sung

    Journal of Biomedical Science 2017 24:85

    Published on: 15 November 2017

  2. Research

    Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions

    Cells adapt to hypoxia by transcriptional induction of genes that participate in regulation of angiogenesis, glucose metabolism and cell proliferation. The primary factors mediating cell response to low oxygen...

    Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Anna Lipińska, Lech Pomorski, Marek Wieczorek, Magdalena Bryś, Ewa Forma and Anna Krześlak

    Journal of Biomedical Science 2017 24:83

    Published on: 30 October 2017

  3. Research

    Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection

    Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric infl...

    Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu and Bor-Shyang Sheu

    Journal of Biomedical Science 2017 24:82

    Published on: 30 October 2017

  4. Research

    Accuracy of serum luteinizing hormone and serum testosterone measurements to assess the efficacy of medical castration in prostate cancer patients

    Luteinizing hormone-releasing hormone (LH-RH) agonists are the standard for androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. Current guidelines recommend serum testosterone measurement to ...

    Juan Morote, Imma Comas, Roser Ferrer, Jacques Planas, Anna Celma and Lucas Regis

    Journal of Biomedical Science 2017 24:81

    Published on: 22 October 2017

  5. Research

    The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice

    Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+

    Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya

    Journal of Biomedical Science 2017 24:79

    Published on: 17 October 2017

  6. Research

    Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner

    Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely...

    Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G. Weiss, Daniela Panáková and Stéphanie Lucas

    Journal of Biomedical Science 2017 24:78

    Published on: 16 October 2017

  7. Research

    Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries

    Several tumour necrosis factor (TNF) based therapeutics have already been approved for human use and several others are emerging. Therefore, we determined the mRNA expression levels of the TNF superfamily liga...

    Satish Kumar Devarapu, Julia Felicitas Grill, Junhui Xie, Marc Weidenbusch, Mohsen Honarpisheh, Volker Vielhauer, Hans-Joachim Anders and Shrikant R. Mulay

    Journal of Biomedical Science 2017 24:77

    Published on: 19 September 2017

  8. Research

    Rosmarinic acid induces rabbit articular chondrocyte differentiation by decreases matrix metalloproteinase-13 and inflammation by upregulating cyclooxygenase-2 expression

    Matrix metalloproteinases (MMPs) are known to play an important role in the degradation of the extracellular matrix and the pathological progression of osteoarthritis (OA). The natural polyphenolic compound ro...

    Seong-Hui Eo and Song Ja Kim

    Journal of Biomedical Science 2017 24:75

    Published on: 18 September 2017

  9. Review

    Psoriasis-associated vascular disease: the role of HDL

    Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2–3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiova...

    Maria Joao Paiva-Lopes and José Delgado Alves

    Journal of Biomedical Science 2017 24:73

    Published on: 14 September 2017

  10. Research

    Age-dependent redox status in the brain stem of NO-deficient hypertensive rats

    The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide. Its biological activity is also largely det...

    Miroslava Majzúnová, Zuzana Pakanová, Peter Kvasnička, Peter Bališ, Soňa Čačányiová and Ima Dovinová

    Journal of Biomedical Science 2017 24:72

    Published on: 11 September 2017

  11. Review

    Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine

    Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in ...

    Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang and Nigel H. Greig

    Journal of Biomedical Science 2017 24:71

    Published on: 9 September 2017

  12. Research

    The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

    The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...

    Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen and Yijuang Chern

    Journal of Biomedical Science 2017 24:68

    Published on: 4 September 2017

  13. Research

    Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

    The aim of this study was to determine the biofilm formation, the extracellular enzymatic activities of 182 clinical isolates of the Candida parapsilosis complex.

    Sourour Neji, Ines Hadrich, Houaida Trabelsi, Salma Abbes, Fatma Cheikhrouhou, Hayet Sellami, Fattouma Makni and Ali Ayadi

    Journal of Biomedical Science 2017 24:67

    Published on: 4 September 2017

  14. Research

    Beneficial effects of curcumin nano-emulsion on spermatogenesis and reproductive performance in male rats under protein deficient diet model: enhancement of sperm motility, conservancy of testicular tissue integrity, cell energy and seminal plasma amino acids content

    Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence repr...

    Omar A.H. Ahmed-Farid, Maha Nasr, Rania F. Ahmed and Rofanda M. Bakeer

    Journal of Biomedical Science 2017 24:66

    Published on: 2 September 2017

  15. Review

    FTO associations with obesity and telomere length

    This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO...

    Yuling Zhou, Brett D. Hambly and Craig S. McLachlan

    Journal of Biomedical Science 2017 24:65

    Published on: 1 September 2017

  16. Review

    Distribution of glucose transporters in renal diseases

    Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excr...

    Leszek Szablewski

    Journal of Biomedical Science 2017 24:64

    Published on: 31 August 2017

  17. Research

    Prognostic roles of pathology markers immunoexpression and clinical parameters in Hepatoblastoma

    Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-cateni...

    Jia-Feng Wu, Hsiu-Hao Chang, Meng-Yao Lu, Shiann-Tarng Jou, Kai-Chi Chang, Yen-Hsuan Ni and Mei-Hwei Chang

    Journal of Biomedical Science 2017 24:62

    Published on: 29 August 2017

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.