Articles

Retraction Note to: Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis

Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively become greater socioeconomic burdens. To date, despite the tremendous effort devoted to ...

Authors: Ching-Pang Chang, Kuo-Chen Wu, Chien-Yu Lin and Yijuang Chern

Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors

Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer the...

Authors: Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska and Łukasz Opaliński

Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models

NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Neverthe...

Authors: Moloud Aflaki Sooreshjani, Mohini Kamra, Amina Zoubeidi and Kavita Shah

HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression

Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however, the underlying mechanism by whic...

Authors: Guo-Zhen Liu, Xu-Wen Xu, Shu-Hui Tao, Ming-Jian Gao and Zhou-Hua Hou

Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity

Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter...

Authors: Chun-Yang Lin, Meng-Cen Shih, Hung-Chun Chang, Kuan-Jung Lin, Lin-Fang Chen, Sheng-Wen Huang, Mei-Lin Yang, Sheng-Kai Ma, Ai-Li Shiau, Jen-Ren Wang, Kuan-Ru Chen and Pin Ling

Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48)

Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona...

Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin

Advances in the management of haemophilia: emerging treatments and their mechanisms

Mainstay haemophilia treatment, namely intravenous factor replacement, poses several clinical challenges including frequent injections due to the short half-life of recombinant factors, intravenous administrat...

Authors: Dide Okaygoun, Danielle D. Oliveira, Sooriya Soman and Riccardo Williams

Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine

Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated can...

Authors: Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung and T. -C. Wu

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropria...

Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek and Thomas E. Prisinzano

The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration

The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, cell proliferation and cell...

Authors: Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom and Catherine E. Costello

Bacterial factors required for Streptococcus pneumoniae coinfection with influenza A virus

Streptococcus pneumoniae is a common cause of post-influenza secondary bacterial infection, which results in excessive morbidity and mortality. Although 13-valent pneumococcal conjugate vaccine (PCV13) vaccinatio...

Authors: Yi-Yin Chen, Ching-Tai Huang, Shiao-Wen Li, Yi-Jiun Pan, Tzu-Lung Lin, Ya-Yu Huang, Ting-Hsuan Li, Yu-Ching Yang, Yu-Nong Gong and Yu-Chia Hsieh

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease

Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and furt...

Authors: Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng and Shang-Hsun Yang

More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation

Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w...

Authors: Pu-Sheng Hsu, Shu-Han Yu, Yi-Tzang Tsai, Jen-Yun Chang, Li-Kuang Tsai, Chih-Hung Ye, Ning-Yu Song, Lih-Chiao Yau and Shau-Ping Lin

PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression

Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer therapeutic strategies. Despite its severe adverse effects, seli...

Authors: Yaw-Dong Lang and Yuh-Shan Jou

MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway

Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Thro...

Authors: Tong-tong Li, Jie Mou, Yao-jie Pan, Fu-chun Huo, Wen-qi Du, Jia Liang, Yang Wang, Lan-sheng Zhang and Dong-sheng Pei

AUY922 induces retinal toxicity through attenuating TRPM1

Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal t...

Authors: Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang and Li-Tzong Chen

Diagnosis of transition zone prostate cancer by multiparametric MRI: added value of MR spectroscopic imaging with sLASER volume selection

Current multiparametric MRI (mp-MRI) in routine clinical practice has poor-to-moderate diagnostic performance for transition zone prostate cancer. The aim of this study was to evaluate the potential diagnostic...

Authors: Neda Gholizadeh, Peter B. Greer, John Simpson, Jonathan Goodwin, Caixia Fu, Peter Lau, Saabir Siddique, Arend Heerschap and Saadallah Ramadan

Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant...

Authors: Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun and Qi Yu

Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-κB in human microglial cells

Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate...

Authors: Neha Pandey, Meghana Rastogi and Sunit K. Singh

Small heterodimer partner (SHP) aggravates ER stress in Parkinson’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation

Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation ...

Authors: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe and Ilo Jou

Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James...

Authors: Austin W. T. Chiang, Hratch M. Baghdassarian, Benjamin P. Kellman, Bokan Bao, James T. Sorrentino, Chenguang Liang, Chih-Chung Kuo, Helen O. Masson and Nathan E. Lewis

The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the mi...

Authors: Ali Jangjou, Amir Hossein Meisami, Kazem Jamali, Mohammad Hadi Niakan, Milad Abbasi, Mostafa Shafiee, Majid Salehi, Ahmad Hosseinzadeh, Ali Mohammad Amani and Ahmad Vaez

Histone dynamics during DNA replication stress

Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA ...

Authors: Chia-Ling Hsu, Shin Yen Chong, Chia-Yeh Lin and Cheng-Fu Kao

Crosstalk between transforming growth factor β-2 and Autotaxin in trabecular meshwork and different subtypes of glaucoma

Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) regulation in primary open-angle glaucoma...

Authors: Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki and Makoto Aihara

C-type lectins and extracellular vesicles in virus-induced NETosis

Dysregulated formation of neutrophil extracellular traps (NETs) is observed in acute viral infections. Moreover, NETs contribute to the pathogenesis of acute viral infections, including those caused by the den...

Authors: Pei-Shan Sung and Shie-Liang Hsieh

Inflammatory signaling mechanisms in bipolar disorder

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high individual and societal burden. While not all patients display overt markers of elevated inflammation, significant evidence...

Authors: Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari and Rodrigo Machado-Vieira

USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3

Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji

Identification of COVID-19 B-cell epitopes with phage-displayed peptide library

Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe...

Authors: Jing-You Guo, I-Ju Liu, Hsiu-Ting Lin, Mei-Jung Wang, Yu-Ling Chang, Shin-Chang Lin, Mei-Ying Liao, Wei-Chia Hsu, Yi-Ling Lin, James C. Liao and Han-Chung Wu

Multiscale X-ray phase contrast imaging of human cartilage for investigating osteoarthritis formation

The evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging ...

Authors: Annie Horng, Johannes Stroebel, Tobias Geith, Stefan Milz, Alexandra Pacureanu, Yang Yang, Peter Cloetens, Goran Lovric, Alberto Mittone, Alberto Bravin and Paola Coan

Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or ...

Authors: Dongha Kim, Keun Il Kim and Sung Hee Baek

The m⁶A epitranscriptome on neural development and degeneration

N⁶-methyladenosine (m⁶A) is the most prevalent, conserved, and abundant RNA modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic DNA modifications, m⁶A has been proposed to funct...

Authors: Ya-Ping Yen and Jun-An Chen

New therapeutic approaches of mesenchymal stem cells-derived exosomes

Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily...

Authors: Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha

Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation

Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fi...

Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen and Chien-Huang Lin

Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

Low cardiorespiratory fitness (V̇O_2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O_2peak, there is conside...

Authors: Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett…

Notch-ing up knowledge on molecular mechanisms of skin fibrosis: focus on the multifaceted Notch signalling pathway

Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix proteins, causing loss of physiological architecture and dysfunction of different tissues and organs. In the skin, fib...

Authors: Angelo Giuseppe Condorelli, May El Hachem, Giovanna Zambruno, Alexander Nystrom, Eleonora Candi and Daniele Castiglia

NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway

The cell adhesion molecule IGPR-1 regulates various critical cellular processes including, cell–cell adhesion, mechanosensing and autophagy and plays important roles in angiogenesis and tumor growth; however, ...

Authors: Linzi Sun, Razie Amraei and Nader Rahimi

A novel pseudovirus‐based mouse model of SARS-CoV-2 infection to test COVID-19 interventions

The spread of SARS-CoV-2, the virus that causes Coronavirus Disease 2019 (COVID-19), has been characterized as a worldwide pandemic. Currently, there are few preclinical animal models that suitably represent i...

Authors: Ssu-Hsueh Tseng, Brandon Lam, Yu Jui Kung, John Lin, Li Liu, Ya Chea Tsai, Louise Ferrall, Richard B. S. Roden, T. C. Wu and Chien-Fu Hung

RhoA: a dubious molecule in cardiac pathophysiology

The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts a...

Authors: Lucia Sophie Kilian, Jakob Voran, Derk Frank and Ashraf Yusuf Rangrez

NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma

Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis.

Authors: Po-Hsuan Su, Rui-Lan Huang, Hung-Cheng Lai, Lin-Yu Chen, Yu-Chun Weng, Chih-Chien Wang and Chia-Chun Wu

Correction to: CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling

An amendment to this paper has been published and can be accessed via the original article.

Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu

Applications of brain organoids in neurodevelopment and neurological diseases

A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. B...

Authors: Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang and Jinquan Cai

Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma

Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade. In this study, we established a screening model to discover nov...

Authors: Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh and Michael Hsiao

Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and iso...

Authors: Wei-Zhan Zhuang, Yi-Heng Lin, Long-Jyun Su, Meng-Shiue Wu, Han-Yin Jeng, Huan-Cheng Chang, Yen-Hua Huang and Thai-Yen Ling

Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends

Epigenetic drug discovery field has evidenced significant advancement in the recent times. A plethora of small molecule inhibitors have progressed to clinical stage investigations and are being explored exhaus...

Authors: Kunal Nepali and Jing-Ping Liou

NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer

Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing...

Authors: Sara Socorro Faria, Susan Costantini, Vladmir Cláudio Cordeiro de Lima, Victor Pianna de Andrade, Mickaël Rialland, Rebe Cedric, Alfredo Budillon and Kelly Grace Magalhães

Targeting necroptosis as therapeutic potential in chronic myocardial infarction

Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening...

Authors: Chanon Piamsiri, Chayodom Maneechote, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn and Nipon Chattipakorn

Role of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers

Thyroid hormone analogues—particularly, l-thyroxine (T₄) has been shown to be relevant to the functions of a variety of cancers. Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction...

Authors: Yu-Chen S. H. Yang, Po-Jui Ko, Yi-Shin Pan, Hung-Yun Lin, Jacqueline Whang-Peng, Paul J. Davis and Kuan Wang

HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients.

Authors: Óscar Brochado, Isidoro Martínez, Juan Berenguer, Luz Medrano, Juan González-García, María Ángeles Jiménez-Sousa, Ana Carrero, Víctor Hontañón, Jordi Navarro, Josep M. Guardiola, Amanda Fernández-Rodríguez and Salvador Resino

PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity

Obesity-related cardiovascular risk, end points, and mortality are strongly related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not focused on direct targeting within the...

Authors: Ju-Yi Chen, Yi-Pin Wu, Chih-Yi Li, Huei-Fen Jheng, Ling-Zhen Kao, Ching-Chun Yang, Sy-Ying Leu, I-Chia Lien, Wen-Tsan Weng, Haw-Chih Tai, Yu-Wei Chiou, Ming-Jer Tang, Pei-Jane Tsai and Yau-Sheng Tsai