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  1. Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms a...

    Authors: Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori, Mehrnaz Mehrabani and Saeedeh Salimi

    Citation: Journal of Biomedical Science 2019 26:92

    Content type: Research

    Published on:

  2. Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, wit...

    Authors: Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang and Fuu-Jen Tsai

    Citation: Journal of Biomedical Science 2019 26:91

    Content type: Research

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  3. Toll-like receptors (TLRs) are well known as critical pattern recognition receptors that trigger innate immune responses. In addition, TLRs are expressed in neurons and may act as the gears in the neuronal det...

    Authors: Chiung-Ya Chen, Yi-Chun Shih, Yun-Fen Hung and Yi-Ping Hsueh

    Citation: Journal of Biomedical Science 2019 26:90

    Content type: Review

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  4. Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying stra...

    Authors: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum and Thierry Burnouf

    Citation: Journal of Biomedical Science 2019 26:89

    Content type: Research

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  5. Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review intr...

    Authors: Jyong-Huei Lee, Kuan-Lun Ho and Shih-Kang Fan

    Citation: Journal of Biomedical Science 2019 26:88

    Content type: Review

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  6. The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based d...

    Authors: Ching-Ying Huang, Chun-Lin Liu, Chien-Yu Ting, Yueh-Ting Chiu, Yu-Che Cheng, Martin W. Nicholson and Patrick C. H. Hsieh

    Citation: Journal of Biomedical Science 2019 26:87

    Content type: Review

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  10. Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and ...

    Authors: María Ángeles JIMÉNEZ-SOUSA, José Luis JIMÉNEZ, Amanda FERNÁNDEZ-RODRÍGUEZ, José María BELLÓN, Carmen RODRÍGUEZ, Melchor RIERA, Joaquín PORTILLA, Ángeles CASTRO, María Ángeles MUÑOZ-FERNÁNDEZ and Salvador RESINO

    Citation: Journal of Biomedical Science 2019 26:83

    Content type: Research

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  11. MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and identified as an upstream activator of the MAPK J...

    Authors: Huai-Chia Chuang and Tse-Hua Tan

    Citation: Journal of Biomedical Science 2019 26:82

    Content type: Review

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  13. Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degr...

    Authors: Ruey-Hwa Chen, Yu-Hsuan Chen and Tzu-Yu Huang

    Citation: Journal of Biomedical Science 2019 26:80

    Content type: Review

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  15. In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor...

    Authors: Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang and Zhengzhi Zou

    Citation: Journal of Biomedical Science 2019 26:78

    Content type: Review

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  16. Intratumor subsets with tumor-initiating features in glioblastoma are likely to survive treatment. Our goal is to identify the key factor in the process by which cells develop temozolomide (TMZ) resistance.

    Authors: Chia-Hung Chien, Jian-Ying Chuang, Shun-Tai Yang, Wen-Bin Yang, Pin-Yuan Chen, Tsung-I Hsu, Chih-Yuan Huang, Wei-Lun Lo, Ka-Yen Yang, Ming-Sheng Liu, Jui-Mei Chu, Pei-Hsuan Chung, Jr-Jiun Liu, Shao-Wen Chou, Shang-Hung Chen and Kwang-Yu Chang

    Citation: Journal of Biomedical Science 2019 26:77

    Content type: Research

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  17. The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses ...

    Authors: Daria Mezhenskaya, Irina Isakova-Sivak and Larisa Rudenko

    Citation: Journal of Biomedical Science 2019 26:76

    Content type: Review

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  18. Enterovirus A71 (EV-A71) is one of the common causative pathogens for hand foot and mouth disease (HFMD) affecting young children. HFMD outbreak can result in a substantial pediatric hospitalization and burden...

    Authors: Jiratchaya Puenpa, Nasamon Wanlapakorn, Sompong Vongpunsawad and Yong Poovorawan

    Citation: Journal of Biomedical Science 2019 26:75

    Content type: Review

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  19. Complex regional pain syndrome (CRPS) is related to microcirculation impairment caused by tissue hypoxia and peripheral cytokine overproduction in the affected human limb and chronic post-ischemic pain (CPIP) ...

    Authors: Hung-Tsung Hsiao, Yuan-Yuarn Liu, Jeffrey Chi-Fei Wang, Ya-Chi Lin and Yen-Chin Liu

    Citation: Journal of Biomedical Science 2019 26:74

    Content type: Research

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  20. Soft materials have been developed very rapidly in the biomedical field over the past 10 years because of advances in medical devices, cell therapy, and 3D printing for precision medicine. Smart polymers are o...

    Authors: Hung-Jin Huang, Yu-Liang Tsai, Shih-Ho Lin and Shan-hui Hsu

    Citation: Journal of Biomedical Science 2019 26:73

    Content type: Review

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  21. Transforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis. Currently, there are no effective agents targeting TGF-β s...

    Authors: Ying-Jen Chen, Shih-Ming Huang, Ming-Cheng Tai, Jiann-Torng Chen and Chang-Min Liang

    Citation: Journal of Biomedical Science 2019 26:72

    Content type: Research

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  22. Atrial fibrillation (AF) frequently coexists with congestive heart failure (HF) and arginine vasopressin (AVP) V1 receptor antagonists are used to treat hyponatremia in HF. However, the role of AVP in HF-induc...

    Authors: Jen-Hung Huang, Yao-Chang Chen, Yen-Yu Lu, Yung-Kuo Lin, Shih-Ann Chen and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2019 26:71

    Content type: Research

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  23. Currently available anti-influenza drugs are often associated with limitations such as toxicity and the appearance of drug-resistant strains. Therefore, there is a pressing need for the development of novel, s...

    Authors: Hadi Ghaffari, Ahmad Tavakoli, Abdolvahab Moradi, Alijan Tabarraei, Farah Bokharaei-Salim, Masoumeh Zahmatkeshan, Mohammad Farahmand, Davod Javanmard, Seyed Jalal Kiani, Maryam Esghaei, Vahid Pirhajati-Mahabadi, Seyed Hamidreza Monavari and Angila Ataei-Pirkooh

    Citation: Journal of Biomedical Science 2019 26:70

    Content type: Research

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  24. This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhib...

    Authors: Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata and Ebthag M. Awad

    Citation: Journal of Biomedical Science 2019 26:69

    Content type: Research

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  25. Increasing evidence suggests that high glucose (HG) causes abnormalities in endothelial and vascular smooth muscle cell function (VSMC) and contributes to atherosclerosis. Receptor for advanced glycation end-p...

    Authors: Sheng-Chiang Su, Yi-Jen Hung, Chia-Luen Huang, Yi-Shing Shieh, Chu-Yen Chien, Chi-Fu Chiang, Jhih-Syuan Liu, Chieh-Hua Lu, Chang-Hsun Hsieh, Chien-Ming Lin and Chien-Hsing Lee

    Citation: Journal of Biomedical Science 2019 26:68

    Content type: Research

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  26. Different neurological disorders frequently display antibodies against several self-glycans. Increasing evidence supports their pathogenic role; however, far less is known about their origin. Meanwhile, antibo...

    Authors: Ricardo Dante Lardone, Fernando José Irazoqui and Gustavo Alejandro Nores

    Citation: Journal of Biomedical Science 2019 26:67

    Content type: Research

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  27. After the publication of this article [1], the authors would like to clarify that some immunoblotting data in Figs. 2f, 3a and 4b were obtained from the same samples but individual SDS-PAGE gels.

    Authors: Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu and Wan-Wan Lin

    Citation: Journal of Biomedical Science 2019 26:66

    Content type: Correction

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    The original article was published in Journal of Biomedical Science 2019 26:40

  28. Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or sev...

    Authors: Jing-Yi Lin, Yu-An Kung and Shin-Ru Shih

    Citation: Journal of Biomedical Science 2019 26:65

    Content type: Review

    Published on:

  29. Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activat...

    Authors: Dong-Yan Tsai, Kuo-Hsuan Hung, Chia-Wei Chang and Kuo-I Lin

    Citation: Journal of Biomedical Science 2019 26:64

    Content type: Review

    Published on:

  30. Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the cure rates for AML patients remain low, and the notorious adverse effects of chemotherapeutic drugs drastically reduce the life qual...

    Authors: Szu-Yuan Wu, Yu-Ching Wen, Chia-Chi Ku, Yi-Chieh Yang, Jyh-Ming Chow, Shun-Fa Yang, Wei-Jiunn Lee and Ming-Hsien Chien

    Citation: Journal of Biomedical Science 2019 26:63

    Content type: Research

    Published on:

  31. Loss of ovarian function, as in menopause or after ovariectomy (OVX), is closely associated with obesity and white adipose tissue (WAT) inflammation. Estrogen replacement protects against postmenopausal obesit...

    Authors: Hsin-Hsueh Shen, Chien-Yi Yang, Ching-Wen Kung, Shu-Ying Chen, Hong-Min Wu, Pao-Yun Cheng, Kwok-Keung Lam and Yen-Mei Lee

    Citation: Journal of Biomedical Science 2019 26:62

    Content type: Research

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  32. Among older adults, arterial aging is the major factor contributing to increased risk for cardiovascular disease–related morbidity and mortality. The chronic vascular inflammation that accompanies aging causes...

    Authors: Hou-Yu Chiang, Pao-Hsien Chu and Ting-Hein Lee

    Citation: Journal of Biomedical Science 2019 26:61

    Content type: Research

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  33. Thrombomodulin (TM), an integral membrane protein, has long been known for its anticoagulant activity. Recent studies showed that TM displays multifaceted activities, including the involvement in cell adhesion...

    Authors: Gang-Hui Lee, Chia-Lin Chang, Wen-Tai Chiu, Tsun-Hsien Hsiao, Po-Yuan Chen, Kuan-Chieh Wang, Cheng-Hsiang Kuo, Bing-Hung Chen, Guey-Yueh Shi, Hua-Lin Wu and Tzu-Fun Fu

    Citation: Journal of Biomedical Science 2019 26:60

    Content type: Research

    Published on:

  34. Increasing evidences have shown strong associations between gut microbiota and many human diseases, and understanding the dynamic crosstalks of host-microbe interaction in the gut has become necessary for the ...

    Authors: Cherng-Shyang Chang and Cheng-Yuan Kao

    Citation: Journal of Biomedical Science 2019 26:59

    Content type: Review

    Published on:

  35. Multiple interplays between viral and host factors are involved in influenza virus replication and pathogenesis. Several small RNAs have recently emerged as important regulators of host response to viral infec...

    Authors: Yuag-Meng Liu, Chung-Hsin Tseng, Yi-Chun Chen, Wen-Ya Yu, Meng-Yen Ho, Chia-Yin Ho, Michael M. C. Lai and Wen-Chi Su

    Citation: Journal of Biomedical Science 2019 26:58

    Content type: Research

    Published on:

  36. During recent 20 years, enterovirus A71 (EV-A71) has emerged as a major concern among pediatric infectious diseases, particularly in the Asia-Pacific region. The clinical manifestations of EV-A71 include uncom...

    Authors: Luan-Yin Chang, Hsiang-Yuan Lin, Susan Shur-Fen Gau, Chin-Yu Lu, Shao-Hsuan Hsia, Yhu-Chering Huang, Li-Min Huang and Tzou-Yien Lin

    Citation: Journal of Biomedical Science 2019 26:57

    Content type: Review

    Published on:

  38. Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza A/H1N1 viruses conta...

    Authors: Ruey-Wen Lin, Guang-Wu Chen, Hsiang-Hsuan Sung, Ren-Jye Lin, Li-Chen Yen, Yu-Ling Tseng, Yung-Kun Chang, Shu-Pei Lien, Shin-Ru Shih and Ching-Len Liao

    Citation: Journal of Biomedical Science 2019 26:55

    Content type: Research

    Published on:

  39. After publication of this article [1], it was brought to our attention that there are some errors in the section of ‘Authors’ contributions’.

    Authors: Mohsen Keshavarz, Farid Solaymani-Mohammadi, Seyed Mohammad Miri and Amir Ghaemi

    Citation: Journal of Biomedical Science 2019 26:54

    Content type: Correction

    Published on:

    The original article was published in Journal of Biomedical Science 2019 26:48

  40. Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades that contribute to secondary neuronal damage. Tropomyosin-related kinase receptor B (TrkB) signaling plays a crucial role in prom...

    Authors: Chun-Hu Wu, Chien-Cheng Chen, Tai-Ho Hung, Yen-Chieh Chuang, Min Chao, Song-Kun Shyue and Szu-Fu Chen

    Citation: Journal of Biomedical Science 2019 26:53

    Content type: Research

    Published on:

  41. Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is oft...

    Authors: Shu Yih Chew, Wallace Jeng Yang Chee and Leslie Thian Lung Than

    Citation: Journal of Biomedical Science 2019 26:52

    Content type: Review

    Published on:

  42. Identifying bone anabolic agents is a superior strategy for the treatment of osteoporosis. Naturally, derived coumarin derivatives have shown osteoanabolic effect in vitro and in vivo. In this study, we invest...

    Authors: Basem M. Abdallah and Enas M. Ali

    Citation: Journal of Biomedical Science 2019 26:51

    Content type: Research

    Published on:

  43. The Editor-in-Chief has retracted this article [1] due to significant overlap with previously published articles [2–5]. Both authors agree with this retraction.

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik

    Citation: Journal of Biomedical Science 2019 26:50

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Biomedical Science 2019 26:28

  44. Human enteroviruses contain over 100 serotypes. We have routinely conducted enterovirus surveillance in northern Taiwan; but about 10% of isolates could not be serotyped using traditional assays. Next-generati...

    Authors: Yeh-Sheng Chien, Shu-Ting Luo, Kuo-Chien Tsao, Yhu-Chering Huang, Wan-Yu Chung, Yu-Chieh Liao, Yi Tan, Suman R. Das and Min-Shi Lee

    Citation: Journal of Biomedical Science 2019 26:49

    Content type: Research

    Published on:

  45. Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intri...

    Authors: Mohsen Keshavarz, Farid Solaymani-Mohammadi, Seyed Mohammad Miri and Amir Ghaemi

    Citation: Journal of Biomedical Science 2019 26:48

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:54

  47. Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory respo...

    Authors: Fu-Chen Yang, Po-Yuan Chiu, Yun Chen, Tak W. Mak and Nien-Jung Chen

    Citation: Journal of Biomedical Science 2019 26:46

    Content type: Research

    Published on:

  49. Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of...

    Authors: Chia-Jui Yen, Shu-Ting Yang, Ruo-Yu Chen, Wenya Huang, Kazuaki Chayama, Ming-Hao Lee, Shiang-Jie Yang, Hong-Sheng Lai, Hsin-Yi Yen, Yu-Wei Hsiao, Ju-Ming Wang, Yih-Jyh Lin and Liang-Yi Hung

    Citation: Journal of Biomedical Science 2019 26:44

    Content type: Research

    Published on:

  50. Stroke is the second most common cause of deaths worldwide. After an ischemic stroke, the proliferated reactive astrocytes in the peri-infarct areas play a beneficial role in neuronal survival. As such, astroc...

    Authors: Sujira Mukda, Ching-Yi Tsai, Steve Leu, Jenq-Lin Yang and Samuel H. H. Chan

    Citation: Journal of Biomedical Science 2019 26:43

    Content type: Research

    Published on:

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Journal of Biomedical Science

ISSN: 1423-0127