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  1. The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic a...

    Authors: Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng and Jiu-Yao Wang
    Citation: Journal of Biomedical Science 2022 29:75
  2. The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidati...

    Authors: Cheng-Liang Kuo, Ananth Ponneri Babuharisankar, Ying-Chen Lin, Hui-Wen Lien, Yu Kang Lo, Han-Yu Chou, Vidhya Tangeda, Li-Chun Cheng, An Ning Cheng and Alan Yueh-Luen Lee
    Citation: Journal of Biomedical Science 2022 29:74
  3. Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory effects. Long noncoding RNAs (lncRNAs) have important functions in the immun...

    Authors: Jiajie Lin, Zhongyu Xie, Zhaoqiang Zhang, Ming Li, Guiwen Ye, Wenhui Yu, Jinteng Li, Feng Ye, Zepeng Su, Yunshu Che, Peitao Xu, Chenying Zeng, Peng Wang, Yanfeng Wu and Huiyong Shen
    Citation: Journal of Biomedical Science 2022 29:73
  4. Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes...

    Authors: Jayaprakash Mandal, Prativa Mandal, Tian-Li Wang and Ie-Ming Shih
    Citation: Journal of Biomedical Science 2022 29:71
  5. Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) and improving immune su...

    Authors: Li-Mei Chen, Pao-Pao Yang, Aushia Tanzih Al Haq, Pai-An Hwang, You-Chen Lai, Yueh-Shan Weng, Michelle Audrey Chen and Hsin-Ling Hsu
    Citation: Journal of Biomedical Science 2022 29:70
  6. The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-co...

    Authors: Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-yang Ding and Bixiang Zhang
    Citation: Journal of Biomedical Science 2022 29:69
  7. The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed...

    Authors: Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I.-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao…
    Citation: Journal of Biomedical Science 2022 29:68
  8. Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical ...

    Authors: Kunal Nepali, Ram Sharma, Sachin Sharma, Amandeep Thakur and Jing-Ping Liou
    Citation: Journal of Biomedical Science 2022 29:65
  9. O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible modification is catalysed by a uniq...

    Authors: Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud and Patrick Pagesy
    Citation: Journal of Biomedical Science 2022 29:64
  10. Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldwide. Fibrosis is defined by excessive extracellular matrix deposition at fibrotic foci in the organ...

    Authors: Chen-Ting Hung, Yi-Wei Tsai, Yu-Shuo Wu, Chih-Fan Yeh and Kai-Chien Yang
    Citation: Journal of Biomedical Science 2022 29:63
  11. Increasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated expression of miRNAs and increased formation of neut...

    Authors: Yu-Tung Hsieh, Yu-Chi Chou, Pin-Yu Kuo, Hung-Wen Tsai, Yi-Ting Yen, Ai-Li Shiau and Chrong-Reen Wang
    Citation: Journal of Biomedical Science 2022 29:62
  12. CYP11A1 is a protein located in the inner membrane of mitochondria catalyzing the first step of steroid synthesis. As a marker gene for steroid-producing cells, the abundance of CYP11A1 characterizes the exten...

    Authors: Karen G. Rosal, Wei-Yi Chen and Bon-chu Chung
    Citation: Journal of Biomedical Science 2022 29:61
  13. Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been s...

    Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang and Hongsheng Wang
    Citation: Journal of Biomedical Science 2022 29:58
  14. For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of can...

    Authors: Yu-Jui Kung, Brandon Lam, Ssu-Hsueh Tseng, Alana MacDonald, Hsin-Fang Tu, Suyang Wang, John Lin, Ya Chea Tsai, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2022 29:57
  15. All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling and degradation. The vesicular trafficking and secretion path...

    Authors: I.-Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:56
  16. Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate immunity to viral nucleic acids mediates ...

    Authors: Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing and Zhiqiang Zhang
    Citation: Journal of Biomedical Science 2022 29:55
  17. The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse l...

    Authors: Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu and Ting-Fen Tsai
    Citation: Journal of Biomedical Science 2022 29:53
  18. Coronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS). Rec...

    Authors: Pei-Shan Sung, Shao-Ping Yang, Yu-Chun Peng, Cheng-Pu Sun, Mi-Hwa Tao and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:52
  19. Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and...

    Authors: Ming-Chia Chu, Han-Fang Wu, Chi-Wei Lee, Yueh-Jung Chung, Hsiang Chi, Po See Chen and Hui-Ching Lin
    Citation: Journal of Biomedical Science 2022 29:51
  20. Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (...

    Authors: Tsung-Chih Tsai, Yi-Syuan Fang, Yu-Chieh Hung, Ling-Chien Hung and Kuei-Sen Hsu
    Citation: Journal of Biomedical Science 2022 29:50
  21. With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing effi...

    Authors: I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin…
    Citation: Journal of Biomedical Science 2022 29:49
  22. Many countries in Asia and Latin America are currently facing a double burden of outbreaks due to dengue and COVID-19. Here we discuss the similarities and differences between the two infections so that lesson...

    Authors: Gathsaurie Neelika Malavige, Chandima Jeewandara and Graham S. Ogg
    Citation: Journal of Biomedical Science 2022 29:48
  23. The lack of better understanding of the pathophysiology and cellular mechanisms associated with high mortality seen in hepatic encephalopathy (HE), a neurological complication arising from acute hepatic failur...

    Authors: Ching-Yi Tsai, Jacqueline C. C. Wu, Chiung-Ju Wu and Samuel H. H. Chan
    Citation: Journal of Biomedical Science 2022 29:47
  24. The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transit...

    Authors: Jia-Huang Chen, Chia-Hsien Wu, Jia-Rong Jheng, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu and Chih-Kang Chiang
    Citation: Journal of Biomedical Science 2022 29:46
  25. In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular ...

    Authors: Adelfia Talà, Flora Guerra, Matteo Calcagnile, Roberta Romano, Silvia Caterina Resta, Aurora Paiano, Mario Chiariello, Graziano Pizzolante, Cecilia Bucci and Pietro Alifano
    Citation: Journal of Biomedical Science 2022 29:45
  26. Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found ...

    Authors: Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin and Chiaho Shih
    Citation: Journal of Biomedical Science 2022 29:44
  27. Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genet...

    Authors: Yu-Wen Hsu, Henry Sung-Ching Wong, Wan-Chen Huang, Yi-Hung Yeh, Chwan-Deng Hsiao, Wei-Chiao Chang and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:43
  28. The development of drug resistance in oral squamous cell carcinoma (OSCC) that frequently leads to recurrence and metastasis after initial treatment remains an unresolved challenge. Presence of cancer stem cel...

    Authors: Te-Hsuan Jang, Wei-Chieh Huang, Shiao-Lin Tung, Sheng-Chieh Lin, Po-Ming Chen, Chun-Yu Cho, Ya-Yu Yang, Tzu-Chen Yen, Guo-Hsuen Lo, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:42
  29. Heteronemin (Haimian jing) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticancer properties. It inhibits cancer cell proliferation via different mechanisms, such as ...

    Authors: Kuan Wang, Yi-Fong Chen, Yu-Chen S. H. Yang, Haw-Ming Huang, Sheng-Yang Lee, Ya-Jung Shih, Zi-Lin Li, Jacqueline Whang-Peng, Hung-Yun Lin and Paul J. Davis
    Citation: Journal of Biomedical Science 2022 29:41
  30. Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DU...

    Authors: Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan and Yi-Rong Chen
    Citation: Journal of Biomedical Science 2022 29:40
  31. We provide a multidimensional sequence of events that describe the electromagnetic field (EMF) stimulation and biological system interaction. We describe this process from the quantum to the molecular, cellula...

    Authors: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki and Maher Rizkalla
    Citation: Journal of Biomedical Science 2022 29:39

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:67

  32. The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechani...

    Authors: Anushka Deshpande, Prithviraj Manohar Vijaya Shetty, Norbert Frey and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2022 29:38
  33. Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co...

    Authors: Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I. Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu and Hsin-Wei Chen
    Citation: Journal of Biomedical Science 2022 29:37
  34. Dry eye disease (DED) is a common disease in ophthalmology, affecting millions of people worldwide. Recent studies have shown that inflammation is the core mechanism of DED. IL-20 is a proinflammatory cytokine...

    Authors: Hsiao-Hsuan Wang, Wei-Yu Chen, Yi-Hsun Huang, Sheng-Min Hsu, Yeou-Ping Tsao, Yu-Hsiang Hsu and Ming-Shi Chang
    Citation: Journal of Biomedical Science 2022 29:36
  35. Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strateg...

    Authors: Maryam Hajiabbas, Claudia D’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi and Christine Delporte
    Citation: Journal of Biomedical Science 2022 29:35
  36. Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for ...

    Authors: Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin and Chong Zhang
    Citation: Journal of Biomedical Science 2022 29:34
  37. The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The fu...

    Authors: Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang and Wai Kit Chu
    Citation: Journal of Biomedical Science 2022 29:33
  38. Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically ex...

    Authors: Yongsheng Xie, Yingcong Wang, Zhijian Xu, Yumeng Lu, Dongliang Song, Lu Gao, Dandan Yu, Bo Li, Gege Chen, Hui Zhang, Qilin Feng, Yong Zhang, Ke Hu, Cheng Huang, Yu Peng, Xiaosong Wu…
    Citation: Journal of Biomedical Science 2022 29:32
  39. Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) si...

    Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo and Hee-Sook Jun
    Citation: Journal of Biomedical Science 2022 29:31
  40. Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio...

    Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, Fei-Yun Chen, Hsin-Yi Chen and Ruey-Hwa Chen
    Citation: Journal of Biomedical Science 2022 29:30

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:59

  41. Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine de...

    Authors: Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung and Wen-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:29
  42. Curiosity on toxin–antitoxin modules has increased intensely over recent years as it is ubiquitously present in many bacterial genomes, including pathogens like Methicillin-resistant Staphylococcus aureus (MRSA)....

    Authors: Sonia Jain, Arghya Bhowmick, Bohyun Jeong, Taeok Bae and Abhrajyoti Ghosh
    Citation: Journal of Biomedical Science 2022 29:28
  43. The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflamm...

    Authors: Yiran Wang, Mandi Wu, Yichen Li, Ho Him Yuen and Ming-Liang He
    Citation: Journal of Biomedical Science 2022 29:27
  44. Stenotrophomonas maltophilia, a member of γ-proteobacteria, is a ubiquitous environmental bacterium that is recognized as an opportunistic nosocomial pathogen. FecABCD system contributes to ferric citrate acquisi...

    Authors: Chun-Hsing Liao, Hsu-Feng Lu, Hsin-Hui Huang, Yu Chen, Li-Hua Li, Yi-Tsung Lin and Tsuey-Ching Yang
    Citation: Journal of Biomedical Science 2022 29:26

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