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  3. Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been s...

    Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang and Hongsheng Wang
    Citation: Journal of Biomedical Science 2022 29:58
    Content type: Research Published on:

  4. For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of can...

    Authors: Yu-Jui Kung, Brandon Lam, Ssu-Hsueh Tseng, Alana MacDonald, Hsin-Fang Tu, Suyang Wang, John Lin, Ya Chea Tsai, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2022 29:57
    Content type: Research Published on:

  5. All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling and degradation. The vesicular trafficking and secretion path...

    Authors: I.-Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:56
    Content type: Review Published on:

  6. Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate immunity to viral nucleic acids mediates ...

    Authors: Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing and Zhiqiang Zhang
    Citation: Journal of Biomedical Science 2022 29:55
    Content type: Research Published on:

  8. The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse l...

    Authors: Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu and Ting-Fen Tsai
    Citation: Journal of Biomedical Science 2022 29:53
    Content type: Research Published on:

  9. Coronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS). Rec...

    Authors: Pei-Shan Sung, Shao-Ping Yang, Yu-Chun Peng, Cheng-Pu Sun, Mi-Hwa Tao and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:52
    Content type: Research Published on:

  10. Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and...

    Authors: Ming-Chia Chu, Han-Fang Wu, Chi-Wei Lee, Yueh-Jung Chung, Hsiang Chi, Po See Chen and Hui-Ching Lin
    Citation: Journal of Biomedical Science 2022 29:51
    Content type: Research Published on:

  11. Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (...

    Authors: Tsung-Chih Tsai, Yi-Syuan Fang, Yu-Chieh Hung, Ling-Chien Hung and Kuei-Sen Hsu
    Citation: Journal of Biomedical Science 2022 29:50
    Content type: Research Published on:

  12. With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing effi...

    Authors: I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin…
    Citation: Journal of Biomedical Science 2022 29:49
    Content type: Research Published on:

  13. Many countries in Asia and Latin America are currently facing a double burden of outbreaks due to dengue and COVID-19. Here we discuss the similarities and differences between the two infections so that lesson...

    Authors: Gathsaurie Neelika Malavige, Chandima Jeewandara and Graham S. Ogg
    Citation: Journal of Biomedical Science 2022 29:48
    Content type: Review Published on:

  14. The lack of better understanding of the pathophysiology and cellular mechanisms associated with high mortality seen in hepatic encephalopathy (HE), a neurological complication arising from acute hepatic failur...

    Authors: Ching-Yi Tsai, Jacqueline C. C. Wu, Chiung-Ju Wu and Samuel H. H. Chan
    Citation: Journal of Biomedical Science 2022 29:47
    Content type: Research Published on:

  15. The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transit...

    Authors: Jia-Huang Chen, Chia-Hsien Wu, Jia-Rong Jheng, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu and Chih-Kang Chiang
    Citation: Journal of Biomedical Science 2022 29:46
    Content type: Research Published on:

  16. In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular ...

    Authors: Adelfia Talà, Flora Guerra, Matteo Calcagnile, Roberta Romano, Silvia Caterina Resta, Aurora Paiano, Mario Chiariello, Graziano Pizzolante, Cecilia Bucci and Pietro Alifano
    Citation: Journal of Biomedical Science 2022 29:45
    Content type: Research Published on:

  17. Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found ...

    Authors: Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin and Chiaho Shih
    Citation: Journal of Biomedical Science 2022 29:44
    Content type: Research Published on:

  18. Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genet...

    Authors: Yu-Wen Hsu, Henry Sung-Ching Wong, Wan-Chen Huang, Yi-Hung Yeh, Chwan-Deng Hsiao, Wei-Chiao Chang and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:43
    Content type: Research Published on:

  19. The development of drug resistance in oral squamous cell carcinoma (OSCC) that frequently leads to recurrence and metastasis after initial treatment remains an unresolved challenge. Presence of cancer stem cel...

    Authors: Te-Hsuan Jang, Wei-Chieh Huang, Shiao-Lin Tung, Sheng-Chieh Lin, Po-Ming Chen, Chun-Yu Cho, Ya-Yu Yang, Tzu-Chen Yen, Guo-Hsuen Lo, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:42
    Content type: Research Published on:

  20. Heteronemin (Haimian jing) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticancer properties. It inhibits cancer cell proliferation via different mechanisms, such as ...

    Authors: Kuan Wang, Yi-Fong Chen, Yu-Chen S. H. Yang, Haw-Ming Huang, Sheng-Yang Lee, Ya-Jung Shih, Zi-Lin Li, Jacqueline Whang-Peng, Hung-Yun Lin and Paul J. Davis
    Citation: Journal of Biomedical Science 2022 29:41
    Content type: Review Published on:

  21. Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DU...

    Authors: Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan and Yi-Rong Chen
    Citation: Journal of Biomedical Science 2022 29:40
    Content type: Research Published on:

  22. We provide a multidimensional sequence of events that describe the electromagnetic field (EMF) stimulation and biological system interaction. We describe this process from the quantum to the molecular, cellula...

    Authors: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki and Maher Rizkalla
    Citation: Journal of Biomedical Science 2022 29:39
    Content type: Review Published on:

  23. The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechani...

    Authors: Anushka Deshpande, Prithviraj Manohar Vijaya Shetty, Norbert Frey and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2022 29:38
    Content type: Review Published on:

  24. Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co...

    Authors: Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I. Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu and Hsin-Wei Chen
    Citation: Journal of Biomedical Science 2022 29:37
    Content type: Research Published on:

  25. Dry eye disease (DED) is a common disease in ophthalmology, affecting millions of people worldwide. Recent studies have shown that inflammation is the core mechanism of DED. IL-20 is a proinflammatory cytokine...

    Authors: Hsiao-Hsuan Wang, Wei-Yu Chen, Yi-Hsun Huang, Sheng-Min Hsu, Yeou-Ping Tsao, Yu-Hsiang Hsu and Ming-Shi Chang
    Citation: Journal of Biomedical Science 2022 29:36
    Content type: Research Published on:

  26. Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strateg...

    Authors: Maryam Hajiabbas, Claudia D’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi and Christine Delporte
    Citation: Journal of Biomedical Science 2022 29:35
    Content type: Review Published on:

  27. Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for ...

    Authors: Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin and Chong Zhang
    Citation: Journal of Biomedical Science 2022 29:34
    Content type: Research Published on:

  28. The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The fu...

    Authors: Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang and Wai Kit Chu
    Citation: Journal of Biomedical Science 2022 29:33
    Content type: Review Published on:

  29. Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically ex...

    Authors: Yongsheng Xie, Yingcong Wang, Zhijian Xu, Yumeng Lu, Dongliang Song, Lu Gao, Dandan Yu, Bo Li, Gege Chen, Hui Zhang, Qilin Feng, Yong Zhang, Ke Hu, Cheng Huang, Yu Peng, Xiaosong Wu…
    Citation: Journal of Biomedical Science 2022 29:32
    Content type: Research Published on:

  30. Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) si...

    Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo and Hee-Sook Jun
    Citation: Journal of Biomedical Science 2022 29:31
    Content type: Research Published on:

  31. Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio...

    Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, Fei-Yun Chen, Hsin-Yi Chen and Ruey-Hwa Chen
    Citation: Journal of Biomedical Science 2022 29:30
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:59

  32. Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine de...

    Authors: Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung and Wen-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:29
    Content type: Research Published on:

  33. Curiosity on toxin–antitoxin modules has increased intensely over recent years as it is ubiquitously present in many bacterial genomes, including pathogens like Methicillin-resistant Staphylococcus aureus (MRSA)....

    Authors: Sonia Jain, Arghya Bhowmick, Bohyun Jeong, Taeok Bae and Abhrajyoti Ghosh
    Citation: Journal of Biomedical Science 2022 29:28
    Content type: Research Published on:

  34. The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflamm...

    Authors: Yiran Wang, Mandi Wu, Yichen Li, Ho Him Yuen and Ming-Liang He
    Citation: Journal of Biomedical Science 2022 29:27
    Content type: Review Published on:

  35. Stenotrophomonas maltophilia, a member of γ-proteobacteria, is a ubiquitous environmental bacterium that is recognized as an opportunistic nosocomial pathogen. FecABCD system contributes to ferric citrate acquisi...

    Authors: Chun-Hsing Liao, Hsu-Feng Lu, Hsin-Hui Huang, Yu Chen, Li-Hua Li, Yi-Tsung Lin and Tsuey-Ching Yang
    Citation: Journal of Biomedical Science 2022 29:26
    Content type: Research Published on:

  36. Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells ...

    Authors: Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne and Shaw-Fang Yet
    Citation: Journal of Biomedical Science 2022 29:25
    Content type: Research Published on:

  37. Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial–mesenchymal transition (EMT) process. Centrosome is an organelle that functions as the ma...

    Authors: Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou and Tang K. Tang
    Citation: Journal of Biomedical Science 2022 29:24
    Content type: Research Published on:

  38. Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of p...

    Authors: Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knežević, Cyprian Winogradow, Karolina Amaro, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Justyna Rękas and Andrzej Górski
    Citation: Journal of Biomedical Science 2022 29:23
    Content type: Review Published on:

  40. Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown.

    Authors: Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang and Tsung-I. Hsu
    Citation: Journal of Biomedical Science 2022 29:21
    Content type: Research Published on:

  41. Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for patients with CRC are still needed. Recently, fluorescent chemical probes have been developed for cancer imaging ...

    Authors: Pei-Hsuan Chou, Cong-Kai Luo, Niaz Wali, Wen-Yen Lin, Shang-Kok Ng, Chun-Hao Wang, Mingtao Zhao, Sheng-Wei Lin, Pei-Ming Yang, Pin-Jung Liu, Jiun-Jie Shie and Tzu-Tang Wei
    Citation: Journal of Biomedical Science 2022 29:20
    Content type: Research Published on:

  42. A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as me...

    Authors: Alyssa Zi-Xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-Fen Pung and Teck Yew Low
    Citation: Journal of Biomedical Science 2022 29:19
    Content type: Review Published on:

  44. Androgenetic alopecia (AGA) is a genetic disorder caused by dihydrotestosterone (DHT), accompanied by the senescence of androgen-sensitive dermal papilla cells (DPCs) located in the base of hair follicles. DHT...

    Authors: Young Hyun Jung, Chang Woo Chae, Gee Euhn Choi, Him Cha Shin, Jae Ryong Lim, Han Seung Chang, Joonmo Park, Ji Hyeon Cho, Mo Ran Park, Hyun Jik Lee and Ho Jae Han
    Citation: Journal of Biomedical Science 2022 29:17
    Content type: Research Published on:

  45. Docetaxel has been approved by USFDA as a first-line treatment for castration-resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy along with docetaxel result in superior ...

    Authors: Yu-Ke Fu, Bi-Juan Wang, Jen-Chih Tseng, Shih-Han Huang, Ching-Yu Lin, Ying-Yu Kuo, Tzyh-Chyuan Hour and Chih-Pin Chuu
    Citation: Journal of Biomedical Science 2022 29:16
    Content type: Research Published on:

  47. All cells, including prokaryotes and eukaryotes, could release extracellular vesicles (EVs). EVs contain many cellular components, including RNA, and surface proteins, and are essential for maintaining normal ...

    Authors: Fusheng Zhang, Jinshuai Guo, Zhenghou Zhang, Meiqi Duan, Guang Wang, Yiping Qian, Haiying Zhao, Zhi Yang and Xiaofeng Jiang
    Citation: Journal of Biomedical Science 2022 29:14
    Content type: Review Published on:

  48. Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common can...

    Authors: Aishwarya Gondane, Samuel Girmay, Alma Helevä, Satu Pallasaho, Massimo Loda and Harri M. Itkonen
    Citation: Journal of Biomedical Science 2022 29:13
    Content type: Research Published on:

  49. Obesity is nowadays considered a pandemic which prevalence’s has been steadily increasingly in western countries. It is a dynamic, complex, and multifactorial disease which propitiates the development of sever...

    Authors: José Antônio Fagundes Assumpção, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martín Hernan Bonamino and Kelly Grace Magalhães
    Citation: Journal of Biomedical Science 2022 29:12
    Content type: Review Published on:

  50. The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly. An exuberant inadequate immune response is behind most of the pathology caused by the H...

    Authors: María Martín-Vicente, Salvador Resino and Isidoro Martínez
    Citation: Journal of Biomedical Science 2022 29:11
    Content type: Review Published on:
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ISSN: 1423-0127