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  1. GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23). Here, we identify three novel mutations in the GLB1 gene from tw...

    Authors: Chi-Fan Yang, Jer-Yuarn Wu and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:79
    Content type: Research Published on:

  2. Diabetes and stress stimulate hippocampal 5-HT synthesis, metabolism and release. The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the ...

    Authors: Pretty Mary Abraham, Korah P Kuruvilla, Jobin Mathew, Anitha Malat, Shilpa Joy and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:78
    Content type: Research Published on:

  3. Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection is well associated with NPC and has been implicated in its pathogenesis. Moreover, var...

    Authors: Peter Han-Chung Yee and Sai-Peng Sim
    Citation: Journal of Biomedical Science 2010 17:77
    Content type: Research Published on:

  5. We postulated that combining high-dose simvastatin with bone marrow derived-mesenchymal stem cells (MSCs) delivery may give better prognosis in a mouse hindlimb ischemia model.

    Authors: Yong Li, Dingguo Zhang, Yuqing Zhang, Guoping He and Fumin Zhang
    Citation: Journal of Biomedical Science 2010 17:75
    Content type: Research Published on:

  6. Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal ad...

    Authors: Xiaojun Liu, Min Zhang, Vay Liang W Go and Shen Hu
    Citation: Journal of Biomedical Science 2010 17:74
    Content type: Research Published on:

  7. Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, t...

    Authors: Aleksandra Klemba, Magdalena Kowalewska, Wojciech Kukwa, Katarzyna Tonska, Aleksandra Szybinska, Malgorzata Mossakowska, Anna Scinska, Paweł Golik, Kamil Koper, Jakub Radziszewski, Andrzej Kukwa, Anna M Czarnecka and Ewa Bartnik
    Citation: Journal of Biomedical Science 2010 17:73
    Content type: Research Published on:

  8. Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem de...

    Authors: Kuang-Yu Dai, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2010 17:72
    Content type: Research Published on:

  9. l-Dopa has been used for Parkinson's disease management for a long time. However, its wide variety in the rate and the extent of absorption remained challenge in designing suitable therapeutic regime. We report.....

    Authors: Chun-Li Wang, Yang-Bin Fan, Hsiao-Hwa Lu, Tung-Hu Tsai, Ming-Cheng Tsai and Hui-Po Wang
    Citation: Journal of Biomedical Science 2010 17:71
    Content type: Research Published on:

  10. Arsenic is a strong stimulus of heme oxygenase (HO)-1 expression in experimental studies in response to oxidative stress caused by a stimulus. A functional GT-repeat polymorphism in the HO-1 gene promoter was ...

    Authors: Meei-Maan Wu, Hung-Yi Chiou, Te-Chang Lee, Chi-Ling Chen, Ling-I Hsu, Yuan-Hung Wang, Wen-Ling Huang, Yi-Chen Hsieh, Tse-Yen Yang, Cheng-Yeh Lee, Ping-Keung Yip, Chih-Hao Wang, Yu-Mei Hsueh and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2010 17:70
    Content type: Research Published on:

  12. The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied wit...

    Authors: Wanisa Salaemae, Muhammad Junaid, Chanan Angsuthanasombat and Gerd Katzenmeier
    Citation: Journal of Biomedical Science 2010 17:68
    Content type: Research Published on:

  13. The prevalence of metabolic syndrome (MS) in children and adolescents has been increasing at an alarming rate. MS risks during childhood and adolescence adversely affect health conditions in later life. Thus, ...

    Authors: Megumi Ishikawa, Shiho Arai, Mio Takano, Atsumi Hamada, Kazuhiro Kunimasa and Mari Mori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S47
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  14. It has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabet...

    Authors: Shumei Lin, Jiancheng Yang, Gaofeng Wu, Mei Liu, Xinhong Luan, Qiufeng Lv, He Zhao and Jianmin Hu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S46
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  15. Pigmentation in human skin is an important defense mechanism against sunlight or oxidative stress. Despite the protective role of melanin, abnormal hyperpigmentation such as freckles and chloasma sometimes can...

    Authors: Ji Sun Yu and An Keun Kim
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S45
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  16. Calculus Bovis (:C.Bovis) is one of the most precious and commonly-used medicinal materials in Japan and China. As the natural occurrence is very rare, a source of supply for C. Bovis is far behind the actual nee...

    Authors: Kyoko Takahashi, Yuko Azuma, Kayoko Shimada, Tadashi Saito, Masaya Kawase and Stephen W Schaffer
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S44
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  17. Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of...

    Authors: Mari Mori, Hideki Mori, Atsumi Hamada and Yukio Yamori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S43
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  18. Lotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in...

    Authors: Huan Du, Jeong-Soon You, Xu Zhao, Ji-Yeon Park, Sung-Hoon Kim and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S42
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  19. Constipation is a common gastrointestinal symptom in Korea as well as in Western countries. This study was performed to investigate the dietary taurine intake, nutrient status, and life stress of functional co...

    Authors: Jeong-Soon You, Ji-Yeon Park and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S41
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  20. The purpose of this study was to investigate the dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students.

    Authors: Ji-Yeon Park, Jeong-Soon You and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S40
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  21. Nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxi...

    Authors: Huan Du, Xu Zhao, Jeong-Soon You, Ji-Yeon Park, Sung-Hoon Kim and Kyung-Ja Chang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S39
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  22. In the present study, we investigated the changes of uptake and efflux transport of taurine under various stress conditions using rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT cells), as in...

    Authors: Na-Young Lee and Young-Sook Kang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S37
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  23. In 1889 Dr. John Bland-Sutton, a prominent London surgeon, was consulted about fatal rickets in over 20 successive litters of lion cubs born at the London Zoo. He evaluated the diet and found the cause of rick...

    Authors: Russell W Chesney and Gail Hedberg
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S36
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  24. Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination f...

    Authors: Atsumi Hamada, Mari Mori, Hideki Mori, Alfa Muhihi, Marina Njelekela, Zablon Masesa, Jacob Mtabaji and Yukio Yamori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S34
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  25. Taurine plays an important role in reducing physiological stress. Recent studies indicated that taurine may serve as an anti-obesity agent at the cellular level. This study characterizes taurine’s potential an...

    Authors: Hye Min Kim, Chang-Hee Do and Dong Hee Lee
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S33
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  26. Taurine possesses membrane stabilization, osmoregulatory and antioxidant properties, aspects of relevance to ischemic injury. We tested the hypothesis that body taurine status is a determinant of renal ischemi...

    Authors: Mahmood S Mozaffari, Rafik Abdelsayed, Champa Patel, Hereward Wimborne, Jun Yao Liu and Stephen W Schaffer
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S32
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  27. Perinatal taurine exposure influences renal function in adult female offspring. This study tests the hypothesis that prenatal rather than postnatal taurine exposure alters renal function in adult conscious mal...

    Authors: Sanya Roysommuti, Pisamai Malila, Dusit Jirakulsomchok and J Michael Wyss
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S31
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  28. Perinatal taurine depletion leads to several physiological impairments in adult life, in part, due to taurine’s effects on the renin-angiotensin system, a crucial regulator of growth and differentiation during...

    Authors: Atcharaporn Thaeomor, J Michael Wyss, Dusit Jirakulsomchok and Sanya Roysommuti
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S30
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  29. Perinatal taurine exposure has long-term effects on the arterial pressure and renal function. This study tests its influence on renal potassium excretion in young adult, conscious rats. Female Sprague-Dawley r...

    Authors: Sanya Roysommuti, Pisamai Malila, Wichaporn Lerdweeraphon, Dusit Jirakulsomchok and J Michael Wyss
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S29
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  30. Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. We have demonstrated that cisplatin down-regulates the expression of the taurine transporter gene (Ta...

    Authors: Xiaobin Han and Russell W Chesney
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S28
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  31. Adiponectin greatly stimulated the expression of matrix metalloproteinases (MMPs) in fibroblast-like synoviocytes (FLSs) as did IL-1β. We wondered whether taurine chloramine (TauCl) inhibits the production of ...

    Authors: Kyoung Soo Kim, Hyun-Mi Choi, Da Hee Oh, Chaekyun Kim, Jin Seok Jeong, Myung Chul Yoo and Hyung-In Yang
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S27
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  32. ER stress is a strong indicator of whether or not a cell is undergoing physiological stress. C. elegans is a practical system of characterizing the effect of ER stress at the in vivo or organismal level.

    Authors: Hye Min Kim, Chang-Hee Do and Dong Hee Lee
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S26
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  33. The β-amino acid, taurine, is a nutritional requirement in some species. In these species, the depletion of intracellular stores of taurine leads to the development of severe organ dysfunction. The basis under...

    Authors: Chian Ju Jong, Takashi Ito, Mahmood Mozaffari, Junichi Azuma and Stephen Schaffer
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S25
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  34. Taurine is present in lymphocytes and seems to modulate certain immune cell functions. Among the effects of taurine on these cells are protection against antioxidants and regulation of inflammatory aspects of ...

    Authors: Fili Fazzino, Francisco Obregón and Lucimey Lima
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S24
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  35. The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Tauri...

    Authors: Svend Høime Hansen, Mogens Larsen Andersen, Claus Cornett, Robert Gradinaru and Niels Grunnet
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S23
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  36. Perinatal taurine depletion and high sugar diets blunted baroreflex function and heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders and taurine treat...

    Authors: Supaporn Kulthinee, J Michael Wyss, Dusit Jirakulsomchok and Sanya Roysommuti
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S22
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  37. Since taurine (T) administration was proven to decrease blood pressure (BP) and stroke mortality in stroke-prone spontaneously hypertension rates (SHRSP) in the 1980’s and our WHO-coordinated CARDIAC (Cardiova...

    Authors: Yukio Yamori, Takashi Taguchi, Hideki Mori and Mari Mori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S21
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  38. Taurine, a sulfur-containing β-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardia...

    Authors: Takashi Ito, Shohei Oishi, Mika Takai, Yasushi Kimura, Yoriko Uozumi, Yasushi Fujio, Stephen W Schaffer and Junichi Azuma
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S20
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  39. Both taurine, an inhibitory neurotransmitter and granulocyte colony-stimulating factor (G-CSF), a growth factor, possess neuroprotective and neurotrophic properties in vitro. However, the mechanisms of their u...

    Authors: Chunliu Pan, Amit Gupta, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S18
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  40. Taurine is a free amino acid present in high concentrations in a variety of organs of mammalians. As an antioxidant, taurine has been found to protect cells against oxidative stress, but the underlying mechani...

    Authors: Chunliu Pan, Grace S Giraldo, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S17
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  41. Fragile X Syndrome is the most common known genetic cause of autism. The Fmr1-KO mouse, lacks the fragile X mental retardation protein (FMRP), and is used as a model of the syndrome. The core behavioral deficits ...

    Authors: Abdeslem El Idrissi, Lorenz S Neuwirth and William L’Amoreaux
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S15
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  42. Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Chronic supplementation of taurine in drinking water to mice increases brain excitability ...

    Authors: William J L’Amoreaux, Alexandra Marsillo and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S14
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  43. Taurine and zinc exert neurotrophic effects in the central nervous system. Current studies demonstrate that Na+/Cl- dependent neurotransmitter transporters, similar to that of taurine, are modulated by micromolar...

    Authors: Sonia Nusetti, Mary Urbina and Lucimey Lima
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S13
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  44. Pancreatic β-cells release insulin via an electrogenic response triggered by an increase in plasma glucose concentrations. The critical plasma glucose concentration has been determined to be ~3 mM, at which ti...

    Authors: William J L’Amoreaux, Christina Cuttitta, Allison Santora, Jonathan F Blaize, Janto Tachjadi and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S11
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  45. Hippocampal slices swell and release taurine during oxidative stress. The influence of cellular signalling pathways on this process is unclear. Glutamate signalling can facilitate volume regulation in other CN...

    Authors: Brian Tucker and James E Olson
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S10
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  46. It has been demonstrated that taurine is one of the most abundant free amino acids in the male reproductive system, and can be biosynthesized by male reproductive organs. But the effect of taurine on male repr...

    Authors: Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lv, Shumei Lin and Jianmin Hu
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  47. The fragile X mouse model shows an increase in seizure susceptibility, indicating an involvement of the GABAergic system via an alteration in cellular excitability. In the brain, we have previously described a...

    Authors: Abdeslem El Idrissi, Xin Yan, Francoise Sidime and William L’Amoreaux
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S8
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  48. Arsenic exposure induces overproduction of reactive nitrogen species (RNS) in brain tissue and results in nucleic acid damage to the nerve cells. The 8-nitroguanine is one of the major products formed by the r...

    Authors: Ning Ma, Mikio Sasoh, Shosuke Kawanishi, Hiromichi Sugiura and Fengyuan Piao
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  50. Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating c...

    Authors: Jang-Yen Wu and Howard Prentice
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S1
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

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