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  1. The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in ...

    Authors: Zhengquan Wu, Bernd Uhl, Olivier Gires and Christoph A. Reichel
    Citation: Journal of Biomedical Science 2023 30:21
    Content type: Research Published on:

  2. Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer patients remain refractory to the ICB therapy, which is largely attributed...

    Authors: Ning Ma, Rong Hua, Yang Yang, Zhi-Chao Liu, Jie Pan, Bo-Yao Yu, Yi-Feng Sun, Dong Xie, Yan Wang and Zhi-Gang Li
    Citation: Journal of Biomedical Science 2023 30:20
    Content type: Research Published on:

  3. Lactobacilli are essential microbiota that maintain a healthy, balanced vaginal environment. Vaginitis is a common infection in women during their reproductive years. Many factors are associated with vaginitis...

    Authors: Ameda Abdullah Bnfaga, Kai Wei Lee, Leslie Thian Lung Than and Syafinaz Amin-Nordin
    Citation: Journal of Biomedical Science 2023 30:19
    Content type: Research Published on:

  4. Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosine (m6A) modification is a type of RNA modification that regulates metabolism of mRNAs. Pre...

    Authors: Dipayan Bose, Xiang Lin, Le Gao, Zhi Wei, Yonggang Pei and Erle S. Robertson
    Citation: Journal of Biomedical Science 2023 30:18
    Content type: Research Published on:

  5. E26 transformation-specific (ETS) transcription variant 5 (ETV5), also known as ETS-related molecule (ERM), exerts versatile functions in normal physiological processes, including branching morphogenesis, neur...

    Authors: Yi Wei, Shenqi Han, Jingyuan Wen, Jingyu Liao, Junnan Liang, Jingjing Yu, Xiaoping Chen, Shuai Xiang, Zhao Huang and Bixiang Zhang
    Citation: Journal of Biomedical Science 2023 30:17
    Content type: Review Published on:

  6. Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs al...

    Authors: Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang and Nigel H. Greig
    Citation: Journal of Biomedical Science 2023 30:16
    Content type: Research Published on:

  7. Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by typical manifestations such as oral herpes and rashes on the hands and feet. These s...

    Authors: Peiyu Zhu, Wangquan Ji, Dong Li, Zijie Li, Yu Chen, Bowen Dai, Shujie Han, Shuaiyin Chen, Yuefei Jin and Guangcai Duan
    Citation: Journal of Biomedical Science 2023 30:15
    Content type: Review Published on:

  8. Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly con...

    Authors: Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu and Ai-Li Shiau
    Citation: Journal of Biomedical Science 2023 30:14
    Content type: Research Published on:

  9. Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood...

    Authors: Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu…
    Citation: Journal of Biomedical Science 2023 30:13
    Content type: Research Published on:

  10. Zika virus (ZIKV) infection is clinically known to induce testicular swelling, termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain unclear. Previous reports suggested t...

    Authors: Hsin-Wei Wang, Hsing-Han Li, Shih-Cheng Wu, Cheng-Kang Tang, Hui-Ying Yu, Ya-Chen Chang, Pei-Shan Sung, Wei-Liang Liu, Matthew P. Su, Guann-Yi Yu, Li-Rung Huang, Chun-Hong Chen and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2023 30:12
    Content type: Research Published on:

  12. The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to investigate M splicing in various human influenza A viruses and characterize...

    Authors: Yi-Ju Han, Kuo-Ming Lee, Guan-Hong Wu, Yu-Nong Gong, Avijit Dutta and Shin-Ru Shih
    Citation: Journal of Biomedical Science 2023 30:10
    Content type: Research Published on:

  13. Pseudomonas aeruginosa intestinal carriage rates are significantly higher in immunosuppressed individuals and hospitalized patients who therefore have increased risk of infections and antibiotic-associated diarrh...

    Authors: Rajendra Prasad Janapatla, Anna Dudek, Chyi-Liang Chen, Chih-Hsien Chuang, Kun-Yi Chien, Ye Feng, Yuan-Ming Yeh, Yi-Hsin Wang, Hsin-Ju Chang, Yuan-Chuan Lee and Cheng-Hsun Chiu
    Citation: Journal of Biomedical Science 2023 30:9
    Content type: Research Published on:

  14. Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which ag...

    Authors: Jiajing Yan, Yibing Chen, Minhua Luo, Xinyu Hu, Hongsheng Li, Quentin Liu and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2023 30:8
    Content type: Review Published on:

  16. This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic cataractogenesis. Novel evidence in our model...

    Authors: Ehsan Ranaei Pirmardan, Yuanlin Zhang, Aliaa Barakat, Marzieh Naseri, Christoph Russmann and Ali Hafezi-Moghadam
    Citation: Journal of Biomedical Science 2023 30:6
    Content type: Research Published on:

  17. Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasion. However, co-evolution and co-adaptation between viruses and autophagy have armed vir...

    Authors: Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen and Hongbo Zhou
    Citation: Journal of Biomedical Science 2023 30:5
    Content type: Review Published on:

  18. The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory. The understanding of potential molecular targets is necessary for clinic...

    Authors: Onsurang Wattanathamsan, Naphat Chantaravisoot, Piriya Wongkongkathep, Sakkarin Kungsukool, Paninee Chetprayoon, Pithi Chanvorachote, Chanida Vinayanuwattikun and Varisa Pongrakhananon
    Citation: Journal of Biomedical Science 2023 30:4
    Content type: Research Published on:

  19. The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal cells. The dynamic cellular composition and functional charac...

    Authors: Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin and Hsing-Chen Tsai
    Citation: Journal of Biomedical Science 2023 30:3
    Content type: Review Published on:

  20. Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well eluci...

    Authors: Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho and Yun-Sil Lee
    Citation: Journal of Biomedical Science 2023 30:2
    Content type: Research Published on:

  22. Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted therapy. Although the study of interplay between cancer cells with their microenvironme...

    Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2023 30:54

  23. The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics. Therefore, it would be of gr...

    Authors: Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu and Han-Chung Wu
    Citation: Journal of Biomedical Science 2022 29:108
    Content type: Research Published on:

  24. Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcr...

    Authors: Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard and Yvon Trottier
    Citation: Journal of Biomedical Science 2022 29:107
    Content type: Research Published on:

  25. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcri...

    Authors: Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu and Junghee Lee
    Citation: Journal of Biomedical Science 2022 29:106
    Content type: Research Published on:

  26. In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein call...

    Authors: Sheng-Hung Wang, Jing-Yan Cheng, Hsiu-Hui Tsai, Tzu-Chi Lo, Jung-Tung Hung, Chun-Cheng Lin, Chien-Wei Lee, Yi-Hsuan Ho, Huan-Hsien Kuo, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2022 29:105
    Content type: Research Published on:

  27. Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...

    Authors: Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang, Mei-Lin Yang, Wan-Ting Shen, Jing-Ting Fu, Shih-Yao Chen, Wei-Yun Huang, Chien-Hui Ou, Yuh-Shyan Tsai, Feng-Chih Kuo, Ai-Li Shiau, Gia-Shing Shieh and Chao-Liang Wu
    Citation: Journal of Biomedical Science 2022 29:104
    Content type: Research Published on:

  28. Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...

    Authors: Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu and Sheng-Hui Lan
    Citation: Journal of Biomedical Science 2022 29:103
    Content type: Research Published on:

  29. yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria–host interactions...

    Authors: Hung-Hao Fan, Shiuh-Bin Fang, Yu-Chu Chang, Sheng-Tung Huang, Chih-Hung Huang, Pei-Ru Chang, Wei-Chiao Chang, Lauderdale Tsai-Ling Yang, Pei-Chun Lin and Hung-Yen Cheng
    Citation: Journal of Biomedical Science 2022 29:102
    Content type: Research Published on:

  30. Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear. Decidualization is critical for the establishment and maintenance of norma...

    Authors: Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang and Meirong Du
    Citation: Journal of Biomedical Science 2022 29:101
    Content type: Research Published on:

  31. Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endo...

    Authors: Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O’Malley and Sang Jun Han
    Citation: Journal of Biomedical Science 2022 29:100
    Content type: Research Published on:

  32. Sorafenib (SOR) is the first line treatment for advanced hepatocellular carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages (TAMs) have been reported to affect the progression of ...

    Authors: Hao-Chen Wang, Lin-Ya Haung, Chih-Jung Wang, Ying-Jui Chao, Ya-Chin Hou, Chia-Jui Yen and Yan-Shen Shan
    Citation: Journal of Biomedical Science 2022 29:99
    Content type: Research Published on:

  33. Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal ...

    Authors: Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2022 29:98
    Content type: Research Published on:

  34. The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during ch...

    Authors: Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee and Simanti Datta
    Citation: Journal of Biomedical Science 2022 29:97
    Content type: Research Published on:

  35. In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of th...

    Authors: Wan-Chen Hsieh, Bugi Ratno Budiarto, Yi-Fu Wang, Chih-Yu Lin, Mao-Chun Gwo, Dorothy Kazuno So, Yi-Shiuan Tzeng and Shih-Yu Chen
    Citation: Journal of Biomedical Science 2022 29:96
    Content type: Review Published on:

  36. Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial...

    Authors: Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2022 29:95
    Content type: Research Published on:

  37. Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are ...

    Authors: Makoto Kurano, Daisuke Jubishi, Koh Okamoto, Hideki Hashimoto, Eri Sakai, Yoshifumi Morita, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya and Yutaka Yatomi
    Citation: Journal of Biomedical Science 2022 29:94
    Content type: Research Published on:

  39. Phosphatase and tensin homolog (PTEN) is a tumor suppressor. Low PTEN expression has been observed in pancreatic neuroendocrine tumors (pNETs) and is associated with increased liver metastasis and poor surviva...

    Authors: Tsung-Ming Chang, Pei-Yi Chu, Hui-You Lin, Kuo-Wei Huang, Wen-Chun Hung, Yan-Shen Shan, Li-Tzong Chen and Hui-Jen Tsai
    Citation: Journal of Biomedical Science 2022 29:92
    Content type: Research Published on:

  41. Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall 5-year survival rate of less than 20%. The standard first-line therapy for advanc...

    Authors: Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:90
    Content type: Research Published on:

  42. Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, we integrated correlative metabolomics and transcriptomics of Pseudomonas aeruginosa to elucid...

    Authors: Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T. Tsuji, Darren J. Creek, Tony Velkov and Jian Li
    Citation: Journal of Biomedical Science 2022 29:89
    Content type: Research Published on:

  43. Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been reported to be enriched in colorectal cancer (CRC) in multiple studies. ...

    Authors: Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang and Ling-Hui Li
    Citation: Journal of Biomedical Science 2022 29:88
    Content type: Research Published on:

  44. Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably severe pulmonary symptoms, cardi...

    Authors: Alain C. Borczuk and Rhonda K. Yantiss
    Citation: Journal of Biomedical Science 2022 29:87
    Content type: Review Published on:

  45. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. P...

    Authors: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2022 29:86
    Content type: Review Published on:

  46. Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observe...

    Authors: Benjamin Chun-Kit Tong, Alexis Shiying Huang, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li and King-Ho Cheung
    Citation: Journal of Biomedical Science 2022 29:85
    Content type: Research Published on:

  49. Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid development and deployment of effective COVID-19 vaccines have suc...

    Authors: Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2022 29:82
    Content type: Review Published on:

  50. Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. ...

    Authors: Jing Lu, Francesco Annunziata, Dovydas Sirvinskas, Omid Omrani, Huahui Li, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Lisa Adam and Francesco Neri
    Citation: Journal of Biomedical Science 2022 29:81
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127