Taylor F, Levine L: Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost. J Sex Med. 2010, 7: 269-276. 10.1111/j.1743-6109.2009.01454.x.
Article
CAS
PubMed
Google Scholar
Mancini A, Leone E, Festa R, Grande G, Silvestrini A, de Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E: Effects of testosterone on antioxidant systems in male secondary hypogonadism. J Androl. 2008, 29: 622-629. 10.2164/jandrol.107.004838.
Article
CAS
PubMed
Google Scholar
Cheng YS, Dai DZ, Dai Y: Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. Reprod Toxicol. 2010, 29: 421-426. 10.1016/j.reprotox.2010.03.001.
Article
CAS
PubMed
Google Scholar
Esteva S, Pedret R, Fort N, Torrella JR, Pages T, Viscor G: Oxidative stress status in rats after intermittent exposure to hypobaric hypoxia. Wilderness Environ Med. 2010, 21: 325-331. 10.1016/j.wem.2010.09.004.
Article
PubMed
Google Scholar
Blokhina O, Fagerstedt KV: Oxidative metabolism, ROS and NO under oxygen deprivation. Plant Physiol Biochem. 2010, 48: 359-373. 10.1016/j.plaphy.2010.01.007.
Article
CAS
PubMed
Google Scholar
Gorlach A, Klappa P, Kietzmann T: The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal. 2006, 8: 1391-1418. 10.1089/ars.2006.8.1391.
Article
PubMed
Google Scholar
Dara L, Ji C, Kaplowitz N: The contribution of ER stress to liver diseases. Hepatology. 2011
Google Scholar
Gewandter JS, Staversky RJ, O'Reilly MA: Hyperoxia augments ER-stress-induced cell death independent of BiP loss. Free Radic Biol Med. 2009, 47: 1742-1752. 10.1016/j.freeradbiomed.2009.09.022.
Article
PubMed Central
CAS
PubMed
Google Scholar
Collodel G, Moretti E, Fontani V, Rinaldi S, Aravagli L, Sarago G, Capitani S, Anichini C: Effect of emotional stress on sperm quality. Indian J Med Res. 2008, 128: 254-261.
PubMed
Google Scholar
Gundogan M, Yeni D, Avdatek F, Fidan AF: Influence of sperm concentration on the motility, morphology, membrane and DNA integrity along with oxidative stress parameters of ram sperm during liquid storage. Anim Reprod Sci. 2010, 122: 200-207. 10.1016/j.anireprosci.2010.08.012.
Article
CAS
PubMed
Google Scholar
Zhang TT, Cui B, Dai DZ, Tang XY: Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. J Cardiovasc Pharmacol. 2005, 46: 727-734. 10.1097/01.fjc.0000184470.58047.79.
Article
CAS
PubMed
Google Scholar
Cui B, Feng Y, Dai DZ, Dai Y: CPU0213, a novel endothelin receptor antagonist, relieves hypoxic pulmonary hypertension in rats by suppressing excessive ET-ROS pathway. Drug Dev Res. 2007, 68: 42-50. 10.1002/ddr.20164.
Article
CAS
Google Scholar
Qi MY, Xia HJ, Dai DZ, Dai Y: A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. J Cardiovasc Pharmacol. 2006, 47: 729-735. 10.1097/01.fjc.0000211765.52012.aa.
Article
CAS
PubMed
Google Scholar
Feng Y, Tang XY, Dai DZ, Dai Y: Reversal of isoproterenol-induced downregulation of phospholamban and FKBP12.6 by CPU0213-mediated antagonism of endothelin receptors. Acta Pharmacol Sin. 2007, 28: 1746-1754. 10.1111/j.1745-7254.2007.00650.x.
Article
CAS
PubMed
Google Scholar
Desai N, Sabanegh E, Kim T, Agarwal A: Free radical theory of aging: implications in male infertility. Urology. 2010, 75: 14-19. 10.1016/j.urology.2009.05.025.
Article
PubMed
Google Scholar
Zhang K: Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int J Clin Exp Med. 2010, 3: 33-40.
PubMed Central
CAS
PubMed
Google Scholar
Kim J, Choi TG, Ding Y, Kim Y, Ha KS, Lee KH, Kang I, Ha J, Kaufman RJ, Lee J, Choe W, Kim SS: Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci. 2008, 121: 3636-3648. 10.1242/jcs.028654.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dai DZ: CPU86017: a novel Class III antiarrhythmic agent with multiple actions at ion channels. Cardiovasc Drug Rev. 2006, 24: 101-115. 10.1111/j.1527-3466.2006.00101.x.
Article
CAS
PubMed
Google Scholar
Li N, Dai DZ, Dai Y: CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. Naunyn Schmiedebergs Arch Pharmacol. 2008, 378: 541-552. 10.1007/s00210-008-0309-4.
Article
CAS
PubMed
Google Scholar
Hirenallur SD, Haworth ST, Leming JT, Chang J, Hernandez G, Gordon JB, Rusch NJ: Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008, 295: L915-924. 10.1152/ajplung.90286.2008.
Article
Google Scholar
Feng Y, Zhang Q, Dai DZ, Ying HJ, Dai Y: Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Clin Exp Pharmacol Physiol. 2007, 34: 1131-1137.
CAS
PubMed
Google Scholar
Zhang GL, Dai DZ, Xi T, Cong XD, Zhang Y, Dai Y: Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein. Acta Pharmacol Sin. 2011, 32: 223-229. 10.1038/aps.2010.177.
Article
PubMed Central
PubMed
Google Scholar
Wang YX, Zheng YM: Role of ROS signaling in differential hypoxic Ca2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells. Respir Physiol Neurobiol. 2010, 174: 192-200. 10.1016/j.resp.2010.08.008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang Y, Gao M, Guo Y, Qiao J: Calcium antagonists, diltiazem and nifedipine, protect broilers against low temperature-induced pulmonary hypertension and pulmonary vascular remodeling. Anim Sci J. 2010, 81: 494-500. 10.1111/j.1740-0929.2010.00762.x.
Article
CAS
PubMed
Google Scholar
Dandona P, Dhindsa S, Chaudhuri A, Bhatia V, Topiwala S: Hypogonadotrophic hypogonadism in type 2 diabetes. Aging Male. 2008, 11: 107-117. 10.1080/13685530802317934.
Article
CAS
PubMed
Google Scholar
Miller WL: StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import. Mol Endocrinol. 2007, 21: 589-601.
Article
CAS
PubMed
Google Scholar
Martin LJ, Tremblay JJ: Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1. J Mol Endocrinol. 2008, 41: 165-175. 10.1677/JME-07-0145.
Article
CAS
PubMed
Google Scholar
Luo DY, Yang G, Liu JJ, Yang YR, Dong Q: Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian J Androl. 2011, 13: 287-291. 10.1038/aja.2010.111.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX: Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes. Arch Toxicol. 2010, 84: 53-61. 10.1007/s00204-009-0479-y.
Article
CAS
PubMed
Google Scholar
Schlinger BA, Pradhan DS, Soma KK: 3beta-HSD activates DHEA in the songbird brain. Neurochem Int. 2008, 52: 611-620. 10.1016/j.neuint.2007.05.003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li J, Lee AS: Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med. 2006, 6: 45-54. 10.2174/156652406775574523.
Article
CAS
PubMed
Google Scholar
Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE: Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. J Biol Chem. 2008, 283: 469-475.
Article
CAS
PubMed
Google Scholar
Ron D, Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007, 8: 519-529. 10.1038/nrm2199.
Article
CAS
PubMed
Google Scholar
Hu C, Cong XD, Dai DZ, Zhang Y, Zhang GL, Dai Y: Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue. Naunyn Schmiedebergs Arch Pharmacol. 2011, 383: 309-319. 10.1007/s00210-010-0593-7.
Article
CAS
PubMed
Google Scholar
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D: CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004, 18: 3066-3077. 10.1101/gad.1250704.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K: Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One. 2010, 5: e11865-10.1371/journal.pone.0011865.
Article
PubMed Central
PubMed
Google Scholar
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A: ER stress triggers apoptosis by activating BH3-only protein Bim. Cell. 2007, 129: 1337-1349. 10.1016/j.cell.2007.04.027.
Article
CAS
PubMed
Google Scholar
Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010, 30: 16938-16948. 10.1523/JNEUROSCI.1598-10.2010.
Article
CAS
PubMed
Google Scholar