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  1. Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained el...

    Authors: Qing Yong Ng, Vikneswari Mahendran, Ze Qin Lim, Jasmine Hwee Yee Tan, Joel Jie Feng Wong, Justin Jang Hann Chu, Vincent T. K. Chow, Newman Siu Kwan Sze and Sylvie Alonso
    Citation: Journal of Biomedical Science 2024 31:65
    Content type: Research Published on:

  2. The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins to exit the ER and reach ...

    Authors: Nesrin Gariballa, Feda Mohamed, Sally Badawi and Bassam R. Ali
    Citation: Journal of Biomedical Science 2024 31:64
    Content type: Review Published on:

  4. Ovarian carcinoma (OC) is a fatal malignancy, with most patients experiencing recurrence and resistance to chemotherapy. In contrast to hematogenous metastasizing tumors, ovarian cancer cells disseminate withi...

    Authors: Chang-Ni Lin, Yu-Ling Liang, Hsing-Fen Tsai, Pei-Ying Wu, Lan-Yin Huang, Yu-Han Lin, Chieh-Yi Kang, Chao-Ling Yao, Meng-Ru Shen and Keng-Fu Hsu
    Citation: Journal of Biomedical Science 2024 31:62
    Content type: Research Published on:

  5. Authors: B. Linju Yen, Li‑Tzu Wang, Hsiu‑Huang Wang, Chin‑Pao Hung, Pei‑Ju Hsu, Chia‑Chi Chang, Chien‑Yu Liao, Huey‑Kang Sytwu and Men‑Luh Yen
    Citation: Journal of Biomedical Science 2024 31:61
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2024 31:49

  6. Flavivirus is a challenge all over the world. The replication of flavivirus takes place within membranous replication compartments (RCs) derived from endoplasmic reticulum (ER). Flavivirus NS1 proteins have be...

    Authors: Shuhan Huang, Pan-Deng Shi, Xiao-Xuan Fan, Yang Yang, Cheng-Feng Qin, Hui Zhao, Lei Shi and Yali Ci
    Citation: Journal of Biomedical Science 2024 31:60
    Content type: Research Published on:

  7. Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by great heterogeneity of genomic aberrations, mutated genes, and cell types contribution, making therapy and patients ...

    Authors: Nicola Mosca, Nicola Alessio, Alessandra Di Paola, Maria Maddalena Marrapodi, Umberto Galderisi, Aniello Russo, Francesca Rossi and Nicoletta Potenza
    Citation: Journal of Biomedical Science 2024 31:59
    Content type: Review Published on:

  8. A vaccine against Trypanosoma cruzi, the agent of Chagas disease, would be an excellent additional tool for disease control. A recombinant vaccine based on Tc24 and TSA1 parasite antigens was found to be safe and...

    Authors: Eric Dumonteil, Weihong Tu, Hans Desale, Kelly Goff, Preston Marx, Jaime Ortega-Lopez and Claudia Herrera
    Citation: Journal of Biomedical Science 2024 31:58
    Content type: Research Published on:

  9. Severe infection and sepsis are medical emergencies. High morbidity and mortality are linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and multiple organ dysfunction. Males ap...

    Authors: Geoffrey P. Dobson, Hayley L. Letson and Jodie L. Morris
    Citation: Journal of Biomedical Science 2024 31:57
    Content type: Review Published on:

  10. Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in life-threatening conditions with a large spectrum of pathology. Monoclo...

    Authors: Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller…
    Citation: Journal of Biomedical Science 2024 31:56
    Content type: Research Published on:

  11. Radioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1) plays an important role in repairing DNA damage and maintaining genomic...

    Authors: Yunshang Chen, Xue Feng, Zilong Wu, Yongqiang Yang, Xinrui Rao, Rui Meng, Sheng Zhang, Xiaorong Dong, Shuangbing Xu, Gang Wu and Xiaohua Jie
    Citation: Journal of Biomedical Science 2024 31:55
    Content type: Research Published on:

  12. Alcohol-related liver disease (ALD) is a major health concern worldwide, but effective therapeutics for ALD are still lacking. Tumor necrosis factor-inducible gene 6 protein (TSG-6), a cytokine released from m...

    Authors: Jinsol Han, Chanbin Lee, Hayeong Jeong, Seunghee Jeon, Myunggyo Lee, Haeseung Lee, Yung Hyun Choi and Youngmi Jung
    Citation: Journal of Biomedical Science 2024 31:54
    Content type: Research Published on:

  15. The fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants have been identified in fusiform intracranial aneurysms, the molecular...

    Authors: Li Hao, Xiaolong Ya, Jiaye Wu, Chuming Tao, Ruochen Ma, Zhiyao Zheng, Siqi Mou, Yiming Ling, Yingxi Yang, Jiguang Wang, Yan Zhang, Qing Lin and Jizong Zhao
    Citation: Journal of Biomedical Science 2024 31:51
    Content type: Research Published on:

  16. G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) genome. Howev...

    Authors: Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard and Tao Jia
    Citation: Journal of Biomedical Science 2024 31:50
    Content type: Research Published on:

  17. The impact of global overconsumption of simple sugars on bone health, which peaks in adolescence/early adulthood and correlates with osteoporosis (OP) and fracture risk decades, is unclear. Mesenchymal stromal...

    Authors: B. Linju Yen, Li-Tzu Wang, Hsiu-Huang Wang, Chin-Pao Hung, Pei-Ju Hsu, Chia-Chi Chang, Chien-Yu Liao, Huey-Kang Sytwu and Men-Luh Yen
    Citation: Journal of Biomedical Science 2024 31:49
    Content type: Research Published on:

  18. Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), loom as threats to vision, causing detrimental effects on the structure and function of the retina...

    Authors: Beatriz Martins, Maria Pires, António Francisco Ambrósio, Henrique Girão and Rosa Fernandes
    Citation: Journal of Biomedical Science 2024 31:48
    Content type: Review Published on:

  19. The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources. Among these, urine-derived induced pluri...

    Authors: Xiya Yin, Qingfeng Li, Yan Shu, Hongbing Wang, Biju Thomas, Joshua T. Maxwell and Yuanyuan Zhang
    Citation: Journal of Biomedical Science 2024 31:47
    Content type: Review Published on:

  20. Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated wi...

    Authors: Hao-Wei Lee, Szu-Jung Chen, Kuen-Jer Tsai, Kuei-Sen Hsu, Yi-Fan Chen, Chih-Hua Chang, Hsiao-Han Lin, Wen-Yun Hsueh, Hsing-Pang Hsieh, Yueh-Feng Lee, Huai-Chueh Chiang and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2024 31:46
    Content type: Research Published on:

  21. Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and l...

    Authors: Alexandra Tikhomirova, Emmylee R. McNabb, Luca Petterlin, Georgia L. Bellamy, Kyaw H. Lin, Christopher A. Santoso, Ella S. Daye, Fatimah M. Alhaddad, Kah Peng Lee and Anna Roujeinikova
    Citation: Journal of Biomedical Science 2024 31:45
    Content type: Review Published on:

  22. Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucosi...

    Authors: Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le, Tsai-Chen Yang, Chou-Yu Kuo, Ai-Feng Feng, Kwok-Kong Tony Mong and Chun-Hung Lin
    Citation: Journal of Biomedical Science 2024 31:44
    Content type: Research Published on:

  23. Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each yea...

    Authors: Saumya Sinha, Kinjal Singh, Y. S. Ravi Kumar, Riya Roy, Sushant Phadnis, Varsha Meena, Sankar Bhattacharyya and Bhupendra Verma
    Citation: Journal of Biomedical Science 2024 31:43
    Content type: Review Published on:

  24. Myocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients with myocarditis originate from the right ventricular outflow tract (RV...

    Authors: Chye-Gen Chin, Yao-Chang Chen, Fong-Jhih Lin, Yung-Kuo Lin, Yen-Yu Lu, Tzu-Yu Cheng, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2024 31:42
    Content type: Research Published on:

  25. Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable disease flares and organ damage. This research investigates the potential of aberrant sign...

    Authors: Chin-Man Wang, Yeong-Jian Jan Wu, Jian-Wen Zheng, Li Yu Huang, Keng Poo Tan and Ji-Yih Chen
    Citation: Journal of Biomedical Science 2024 31:41
    Content type: Research Published on:

  26. Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked to a significant burden of disease. Despite substantial efforts in laboratory and ...

    Authors: Mohammed A. Gafar, Calvin A. Omolo, Eman Elhassan, Usri H. Ibrahim and Thirumala Govender
    Citation: Journal of Biomedical Science 2024 31:40
    Content type: Review Published on:

  27. High levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease severity of COVID-19 patients. Human angiotensin-converting enzyme 2 (ACE2) ...

    Authors: Kun-Han Hsieh, Chiao-Hsuan Chao, Yi-Ling Cheng, Yen-Chung Lai, Yung-Chun Chuang, Jen-Ren Wang, Sui-Yuan Chang, Yuan-Pin Hung, Yi-Ming Arthur Chen, Wei-Lun Liu, Woei-Jer Chuang and Trai-Ming Yeh
    Citation: Journal of Biomedical Science 2024 31:39
    Content type: Research Published on:

  28. Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research sugges...

    Authors: Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer and Yuan-Hao Chen
    Citation: Journal of Biomedical Science 2024 31:38
    Content type: Research Published on:

  29. Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly the striatum and the cortex. Alterations in the neurovascular co...

    Authors: Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, Jan Warnking, Isabel Pintelon, Dorian Pustina, Roger Cachope, Ladislav Mrzljak, Ignacio Muñoz-Sanjuan, Emmanuel L. Barbier, Winnok H. De Vos, Annemie Van der Linden and Marleen Verhoye
    Citation: Journal of Biomedical Science 2024 31:37
    Content type: Research Published on:

  30. This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-P...

    Authors: Jeonghyun Lim, Heejoon Myung, Daejin Lim and Miryoung Song
    Citation: Journal of Biomedical Science 2024 31:36
    Content type: Research Published on:

  33. T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that ...

    Authors: I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu
    Citation: Journal of Biomedical Science 2024 31:33
    Content type: Research Published on:

  34. The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR–Cas9. Despite its promise, off-target activity of Cas9 posed a great disadvantage for g...

    Authors: Rio Hermantara, Laura Richmond, Aqeel Faisal Taqi, Sabari Chilaka, Valentine Jeantet, Ileana Guerrini, Katherine West and Adam West
    Citation: Journal of Biomedical Science 2024 31:32
    Content type: Research Published on:

  35. The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The estrous/menstrual cycles are associated with drastic functional and mo...

    Authors: Mikhail S. Chesnokov, Aygun R. Mamedova, Boris Zhivotovsky and Gelina S. Kopeina
    Citation: Journal of Biomedical Science 2024 31:31
    Content type: Review Published on:

  36. Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The mi...

    Authors: Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S. Lee, Yen-Han Tseng…
    Citation: Journal of Biomedical Science 2024 31:30
    Content type: Research Published on:

  38. Ticks are vectors of various pathogens, including tick-borne encephalitis virus causing TBE and bacteria such as Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum causing e.g. viral-bacterial co-infec...

    Authors: Marta Dobrzyńska, Anna Moniuszko-Malinowska, Piotr Radziwon, Sławomir Pancewicz, Agnieszka Gęgotek and Elżbieta Skrzydlewska
    Citation: Journal of Biomedical Science 2024 31:28
    Content type: Research Published on:

  39. Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression patterns render them attractive biomarkers and therapeutic targets. Yet, the functional ...

    Authors: Joshua M. Hazan, Raziel Amador, Tahleel Ali-Nasser, Tamar Lahav, Stav Roni Shotan, Miryam Steinberg, Ziv Cohen, Dvir Aran, David Meiri, Yehuda G. Assaraf, Roderic Guigó and Assaf C. Bester
    Citation: Journal of Biomedical Science 2024 31:27
    Content type: Research Published on:

  40. Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infe...

    Authors: Lea A. Tölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers and Nikolai Siemens
    Citation: Journal of Biomedical Science 2024 31:26
    Content type: Research Published on:

  41. Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compar...

    Authors: Shiliang Xu, Lingxia Wang, Yuexin Zhao, Tong Mo, Bo Wang, Jun Lin and Huan Yang
    Citation: Journal of Biomedical Science 2024 31:25
    Content type: Review Published on:

  42. Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functio...

    Authors: Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan and Eng-King Tan
    Citation: Journal of Biomedical Science 2024 31:24
    Content type: Research Published on:

  43. Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This subtype accounts for the most aggressive BC, possesses high tu...

    Authors: Arpita Poddar, Farah Ahmady, Sushma R. Rao, Revati Sharma, George Kannourakis, Prashanth Prithviraj and Aparna Jayachandran
    Citation: Journal of Biomedical Science 2024 31:23
    Content type: Review Published on:

  45. Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population.

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
    Content type: Research Published on:

  46. Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). However, th...

    Authors: Wan-Ting Kuo, I-Ying Kuo, Hung-Chia Hsieh, Ssu-Ting Wu, Wu-Chou Su and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2024 31:20
    Content type: Research Published on:

  47. Previous research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendritic cells (DCs) from bone marrow progenitors, with a limited understanding of how thes...

    Authors: Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2024 31:19
    Content type: Research Published on:

  48. Mycobacterium abscessus, a fast-growing non-tuberculous mycobacterium, is an emerging opportunistic pathogen responsible for chronic bronchopulmonary infections in people with respiratory diseases such as cystic ...

    Authors: Magali Casanova, Marc Maresca, Isabelle Poncin, Vanessa Point, Hamza Olleik, Céline Boidin-Wichlacz, Aurélie Tasiemski, Kamel Mabrouk, Jean-François Cavalier and Stéphane Canaan
    Citation: Journal of Biomedical Science 2024 31:18
    Content type: Research Published on:

  49. MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor (ICI) treatment for different malignancies by various pancancer studies. Specifically, ...

    Authors: Dantong Sun, Haili Qian, Junling Li and Puyuan Xing
    Citation: Journal of Biomedical Science 2024 31:17
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127