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  1. The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural developme...

    Authors: Shu-Fen Chen, Yu-Chen Tsai and Seng-Sheen Fan
    Citation: Journal of Biomedical Science 2012 19:101
    Content type: Research Published on:

  2. Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we ...

    Authors: Shih-Hung Chan, Jyh-Hong Chen, Yi-Heng Li and Liang-Miin Tsai
    Citation: Journal of Biomedical Science 2012 19:100
    Content type: Research Published on:

  3. The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on ...

    Authors: Ruofeng Qiu, Anping Cai, Yugang Dong, Yingling Zhou, Danqing Yu, Yuli Huang, Dongdan Zheng, Shaoqi Rao, Yingqing Feng and Weiyi Mai
    Citation: Journal of Biomedical Science 2012 19:99
    Content type: Research Published on:

  4. Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induce...

    Authors: Jyh-Hwa Kau, Yung-Luen Shih, Te-Sheng Lien, Chin-Cheng Lee, Hsin-Hsien Huang, Hung-Chi Lin, Der-Shan Sun and Hsin-Hou Chang
    Citation: Journal of Biomedical Science 2012 19:98
    Content type: Research Published on:

  5. Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpos...

    Authors: Yu-Huei Liu, Ching-Chu Chen, Li-Ling Liao, Lei Wan, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2012 19:97
    Content type: Research Published on:

  6. Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitoge...

    Authors: Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:96
    Content type: Research Published on:

  7. Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and abdominal wall defects. Secondary features that are fr...

    Authors: Katherine Marie Robbins, Zhiyuan Chen, Kevin Dale Wells and Rocío Melissa Rivera
    Citation: Journal of Biomedical Science 2012 19:95
    Content type: Research Published on:

  9. Tissue engineering scaffold constitutes a new strategy of myocardial repair. Here, we studied the contribution of a patch using autologous mesenchymal stem cells (MSCs) seeded on collagen-1 scaffold on the car...

    Authors: Pablo Maureira, Pierre-Yves Marie, Fengxu Yu, Sylvain Poussier, Yihua Liu, Frederique Groubatch, Aude Falanga and Nguyen Tran
    Citation: Journal of Biomedical Science 2012 19:93
    Content type: Research Published on:

  10. Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...

    Authors: Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang and Christine Neuveut
    Citation: Journal of Biomedical Science 2012 19:92
    Content type: Review Published on:

  11. The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC. In...

    Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2012 19:91
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:21

  12. MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the func...

    Authors: Pai-Sheng Chen, Jen-Liang Su and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2012 19:90
    Content type: Review Published on:

  13. Several low-molecular-weight phenolic acids are present in the blood of septic patients at high levels. The microbial origin of the most of phenolic acids in the human body was shown previously, but pathophysi...

    Authors: Natalia Beloborodova, Iskander Bairamov, Andrei Olenin, Victoria Shubina, Vera Teplova and Nadezhda Fedotcheva
    Citation: Journal of Biomedical Science 2012 19:89
    Content type: Research Published on:

  16. Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumb...

    Authors: Hsing-Yu Weng, Ming-Jen Hsu, Ching-Chung Wang, Bing-Chang Chen, Chuang-Ye Hong, Mei-Chieh Chen, Wen-Ta Chiu and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2012 19:86
    Content type: Research Published on:

  17. MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged Arginine r...

    Authors: Shin-Yi Jou, Chien-Chih Chang, Chun-Hsien Wu, Mei-Ru Chen, Ching-Hwa Tsai, Wen-Hui Chuang, Yun-Hui Chen, Ann-Lii Cheng and Shin-Lian Doong
    Citation: Journal of Biomedical Science 2012 19:85
    Content type: Research Published on:

  19. Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been i...

    Authors: Mohamed Fouda Salama, Henry K Bayele and Surjit SK Srai
    Citation: Journal of Biomedical Science 2012 19:83
    Content type: Research Published on:

  20. The root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and anti-inf...

    Authors: Hyeong Sim Choi, Hye-Sook Seo, Ji Hye Kim, Jae-Young Um, Yong Cheol Shin and Seong-Gyu Ko
    Citation: Journal of Biomedical Science 2012 19:82
    Content type: Research Published on:

  21. Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and int...

    Authors: Ruey-Hwa Chen, Yu-Ru Lee and Wei-Chien Yuan
    Citation: Journal of Biomedical Science 2012 19:81
    Content type: Review Published on:

  22. Daidzein, a phytoestrogen found in isoflavone, is known to exert neurotrophic and neuroprotective effects on the nervous system. Using primary rat dorsal root ganglion (DRG) neuronal cultures, we have examined...

    Authors: Shih-Hung Yang, Chih-Chen Liao, Ying Chen, Jhih-Pu Syu, Chung-Jiuan Jeng and Seu-Mei Wang
    Citation: Journal of Biomedical Science 2012 19:80
    Content type: Research Published on:

  23. Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly...

    Authors: Li-Jing Chen, Seh Hong Lim, Yi-Ting Yeh, Sheng-Chieh Lien and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2012 19:79
    Content type: Review Published on:

  24. Epilepsy is a neurological disorder produced by an imbalance between excitatory and inhibitory neurotransmission, in which transporters of both glutamate and GABA have been implicated. Hence, at different time...

    Authors: Laura Medina-Ceja, Flavio Sandoval-García, Alberto Morales-Villagrán and Silvia J López-Pérez
    Citation: Journal of Biomedical Science 2012 19:78
    Content type: Research Published on:

  26. Estrogen acts on the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ER)β-dependent mechanism. We investigated in...

    Authors: Kay LH Wu, Chen-Hsiu Chen and Cheng-Dean Shih
    Citation: Journal of Biomedical Science 2012 19:76
    Content type: Research Published on:

  27. TRPM7 (T ransient R eceptor P otential of the M elastatin subfamily) proteins are highly expressed in the heart, however, electrophysiological studies, demonstrating and characterizing these channels in human car...

    Authors: Regina Macianskiene, Irma Martisiene, Danguole Zablockaite and Vida Gendviliene
    Citation: Journal of Biomedical Science 2012 19:75
    Content type: Research Published on:

  28. Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a...

    Authors: Kaiyu Zhou, Gang Wu, Yifei Li, Liang Zhao, Rong Zhou, Qi Zhu, Xupei Huang, Dezhi Mu and Yimin Hua
    Citation: Journal of Biomedical Science 2012 19:74
    Content type: Research Published on:

  29. Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalitie...

    Authors: Jun-Xia Deng, Xiao-Jing Nie, Ying-Feng Lei, Chao-Feng Ma, Dong-Liang Xu, Biao Li, Zhi-Kai Xu and Guo-Cheng Zhang
    Citation: Journal of Biomedical Science 2012 19:73
    Content type: Research Published on:

  30. PUMA (p53-up-regulated modulator of apoptosis), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of PUMA in cardiomyocytes under mechanical stress is little k...

    Authors: Wen-Pin Cheng, Gong-Jhe Wu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2012 19:72
    Content type: Research Published on:

  31. Endoplasmic reticulum (ER) and mitochondria have been implicated in the pathology of renal ischemia/reperfusion (I/R). In the present study, we investigated whether the use of ischemic postconditioning (IPostC...

    Authors: Asma Mahfoudh-Boussaid, Mohamed Amine Zaouali, Thierry Hauet, Kaouther Hadj-Ayed, Abdel-Hédi Miled, Sonia Ghoul-Mazgar, Dalila Saidane-Mosbahi, Joan Rosello-Catafau and Hassen Ben Abdennebi
    Citation: Journal of Biomedical Science 2012 19:71
    Content type: Research Published on:

  33. Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This stud...

    Authors: Ching-Hua Hsieh, Cheng-Shyuan Rau, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng and Johnson Chia-Shen Yang
    Citation: Journal of Biomedical Science 2012 19:69
    Content type: Research Published on:

  34. The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.

    Authors: Luciano da Silva Lopes, Rosemarie Brandin Marques, Heliana Barros Fernandes, Sergio da Silva Pereira, Mariane CC Ayres, Mariana Helena Chaves and Fernanda RC Almeida
    Citation: Journal of Biomedical Science 2012 19:68
    Content type: Research Published on:

  36. The roles of circulating endothelial progenitor cell (EPC) and mononuclear cell apoptosis (MCA) in liver cirrhosis (LC) patients are unknown. Moreover, vascular endothelial growth factor (VEGF) and stromal cel...

    Authors: Chih-Hung Chen, Li-Teh Chang, Wei-Chih Tung, Yung-Lung Chen, Chia-Lo Chang, Steve Leu, Cheuk-Kwan Sun, Tzu-Hsien Tsai, I-Ting Tsai, Hsueh-Wen Chang and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2012 19:66
    Content type: Research Published on:

  37. Cancer is an international health problem, and the search for effective treatments is still in progress. Peptide therapy is focused on the development of short peptides with strong tumoricidal activity and low...

    Authors: Nahlah M Almansour, Elena Pirogova, Peter J Coloe, Irena Cosic and Taghrid S Istivan
    Citation: Journal of Biomedical Science 2012 19:65
    Content type: Research Published on:

  38. Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen spe...

    Authors: Shih-Hung Chan, Ushio Kikkawa, Hidenori Matsuzaki, Jyh-Hong Chen and Wen-Chang Chang
    Citation: Journal of Biomedical Science 2012 19:64
    Content type: Research Published on:

  39. Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome.

    Authors: Tzu-Chun Tsai, Jen-Kann Lu, Sie-Lin Choo, Shu-Yu Yeh, Ren-Bing Tang, Hsin-Yu Lee and Jen-Her Lu
    Citation: Journal of Biomedical Science 2012 19:63
    Content type: Research Published on:

  41. Rabies is known to be lethal in human. Treatment with passive immunity for the rabies is effective only when the patients have not shown the central nerve system (CNS) signs. The blood–brain barrier (BBB) is a...

    Authors: Pi-Hung Liao, Hui-Hua Yang, Ping-Tse Chou, Ming-Hseng Wang, Po-Chun Chu, Hao-Li Liu and Li-Kuang Chen
    Citation: Journal of Biomedical Science 2012 19:61
    Content type: Research Published on:

  42. Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for tr...

    Authors: Kyung-Ae Lee, Jung-Il Chae and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2012 19:60
    Content type: Research Published on:

  43. The phosphoinositide 3-kinases (PI3K/Akt) dependent signaling pathway plays an important role in cardiac function, specifically cardiac contractility. We have reported that sepsis decreases myocardial Akt acti...

    Authors: Bridget M Graves, Thomas Simerly, Chuanfu Li, David L Williams and Robert Wondergem
    Citation: Journal of Biomedical Science 2012 19:59
    Content type: Research Published on:

  44. Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections. This research evaluates how probiotic lac...

    Authors: R Doug Wagner and Shemedia J Johnson
    Citation: Journal of Biomedical Science 2012 19:58
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:84

  45. Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis ...

    Authors: Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung and Hsuan Liu
    Citation: Journal of Biomedical Science 2012 19:57
    Content type: Research Published on:

  46. Maternal epileptic seizures during pregnancy can affect the hippocampal neurons in the offspring. The polysialylated neural cell adhesion molecule (PSA-NCAM), which is expressed in the developing central nervo...

    Authors: Aliakbar Rajabzadeh, Alireza Ebrahimzadeh Bideskan, Alireza Fazel, Mojtaba Sankian, Houshang Rafatpanah and Hossein Haghir
    Citation: Journal of Biomedical Science 2012 19:56
    Content type: Research Published on:

  47. N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in m...

    Authors: Tsung-Chieh Chen, José Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh and Bai-Chuang Shyu
    Citation: Journal of Biomedical Science 2012 19:55
    Content type: Research Published on:

  48. The Aim of this study is to study the minimum zinc dependent metalloprotease catalytic folding motif, helix B Met loop-helix C, with proteolytic catalytic activities in metzincin super family. The metzincin su...

    Authors: Wei-Hsuan Yu, Po-Tsang Huang, Kuo-Long Lou, Shuan-Su C Yu and Chen Lin
    Citation: Journal of Biomedical Science 2012 19:54
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2012 19:87

  49. We aimed to examine the expression level of Nucleophosmin (NPM1) protein in colon cancer tissues and to investigate the potential role of NPM1 in the regulation of cell migration and invasiveness.

    Authors: Yan Liu, Fei Zhang, Xiao-fang Zhang, Li-sha Qi, Lei Yang, Hua Guo and Ning Zhang
    Citation: Journal of Biomedical Science 2012 19:53
    Content type: Research Published on:

  50. Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulatio...

    Authors: Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen and Horng-Dar Wang
    Citation: Journal of Biomedical Science 2012 19:52
    Content type: Research Published on:
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Journal of Biomedical Science

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