Skip to main content

Articles

792 result(s) for 'cancer' within Journal of Biomedical Science

Page 5 of 16

  1. Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O...-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common

    Authors: Aishwarya Gondane, Samuel Girmay, Alma Helevä, Satu Pallasaho, Massimo Loda and Harri M. Itkonen
    Citation: Journal of Biomedical Science 2022 29:13
    Content type: Research Published on:

  2. Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular ...

    Authors: Anna M Czarnecka, Jerzy S Czarnecki, Wojciech Kukwa, Francesco Cappello, Anna Ścińska and Andrzej Kukwa
    Citation: Journal of Biomedical Science 2010 17:31
    Content type: Review Published on:

  3. mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e...

    Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:84
    Content type: Review Published on:

  4. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. PARP...

    Authors: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2022 29:86
    Content type: Review Published on:

  5. Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...

    Authors: Yih-Fung Chen, Ying-Ting Chen, Wen-Tai Chiu and Meng-Ru Shen
    Citation: Journal of Biomedical Science 2013 20:23
    Content type: Review Published on:

  6. Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules ... of altering the tumor microenvironment and ther...

    Authors: Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo and Tang-Long Shen
    Citation: Journal of Biomedical Science 2019 26:35
    Content type: Review Published on:

  7. Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therap...

    Authors: Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska and Łukasz Opaliński
    Citation: Journal of Biomedical Science 2021 28:69
    Content type: Research Published on:

  8. Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nuclea...

    Authors: Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang and Shaw-Jenq Tsai
    Citation: Journal of Biomedical Science 2020 27:63
    Content type: Review Published on:

  9. X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these...

    Authors: Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng and Euphemia Leung
    Citation: Journal of Biomedical Science 2020 27:31
    Content type: Review Published on:

  10. Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate ... smoking is the primary risk factor for lung cancer, only 7% of femal...

    Authors: Liang-Chuan Lai, Mong-Hsun Tsai, Pei-Chun Chen, Lee H Chen, Jen-Hao Hsiao, Shin-Kuang Chen, Tzu-Pin Lu, Jang-Ming Lee, Chung-Ping Hsu, Chuhsing K Hsiao and Eric Y Chuang
    Citation: Journal of Biomedical Science 2014 21:24
    Content type: Research Published on:

  11. Liver cancer is the predominant cause of cancer mortality in males of Southern China and...in situ hepatoma model. The liver tumor nodule formation is inhibited by the CD8+...T cells, and a tumor antigen-specific...

    Authors: Huan-Yao Lei and Chih-Peng Chang
    Citation: Journal of Biomedical Science 2009 16:10
    Content type: Review Published on:

  12. Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases ... 125 deaths worldwide. About 90% of these cancers are of squamous cell origin (HNSCC...

    Authors: Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo and Chamindie Punyadeera
    Citation: Journal of Biomedical Science 2023 30:65
    Content type: Review Published on:

  13. The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications h...

    Authors: Carlotta Camilli, Alexandra E. Hoeh, Giulia De Rossi, Stephen E. Moss and John Greenwood
    Citation: Journal of Biomedical Science 2022 29:6
    Content type: Review Published on:

  16. Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has ... if let-7d and miR-205 together influence cancer cells.

    Authors: Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak and Katarzyna Lamperska
    Citation: Journal of Biomedical Science 2019 26:17
    Content type: Research Published on:

  17. Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be...

    Authors: Pablo Matar, Laura Alaniz, Viviana Rozados, Jorge B Aquino, Mariana Malvicini, Catalina Atorrasagasti, Manuel Gidekel, Marcelo Silva, O Graciela Scharovsky and Guillermo Mazzolini
    Citation: Journal of Biomedical Science 2009 16:30
    Content type: Review Published on:

  18. All cells, including prokaryotes and eukaryotes, could release extracellular vesicles (EVs). EVs contain many cellular components, including RNA, and surface proteins, and are essential for maintaining normal ...

    Authors: Fusheng Zhang, Jinshuai Guo, Zhenghou Zhang, Meiqi Duan, Guang Wang, Yiping Qian, Haiying Zhao, Zhi Yang and Xiaofeng Jiang
    Citation: Journal of Biomedical Science 2022 29:14
    Content type: Review Published on:

  19. Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading...

    Authors: Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin and Chong Zhang
    Citation: Journal of Biomedical Science 2022 29:34
    Content type: Research Published on:

  20. Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. Ide...

    Authors: Jing Lu, Francesco Annunziata, Dovydas Sirvinskas, Omid Omrani, Huahui Li, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Lisa Adam and Francesco Neri
    Citation: Journal of Biomedical Science 2022 29:81
    Content type: Research Published on:

  21. In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of the m...

    Authors: Wan-Chen Hsieh, Bugi Ratno Budiarto, Yi-Fu Wang, Chih-Yu Lin, Mao-Chun Gwo, Dorothy Kazuno So, Yi-Shiuan Tzeng and Shih-Yu Chen
    Citation: Journal of Biomedical Science 2022 29:96
    Content type: Review Published on:

  22. In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor pa...

    Authors: Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2019 26:78
    Content type: Review Published on:

  25. Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while...

    Authors: Juan de los Santos-Jiménez, José A. Campos-Sandoval, Clara Márquez-Torres, Nieves Urbano-Polo, David Brøndegaard, Mercedes Martín-Rufián, Carolina Lobo, Ana Peñalver, María C. Gómez-García, Janet Martín-Campos, Carolina Cardona, Laura Castilla, Felipe da Costa Souza, Tzuling Cheng, Juan A. Segura, Francisco J. Alonso…
    Citation: Journal of Biomedical Science 2021 28:14
    Content type: Research Published on:

  28. SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles...

    Authors: Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang, Shengbai Sun, Zehua Bian, Xue Wang, Chaoqun Li, Yuan Yin, Shengling Huang, Leyuan Zhou, Bojian Fei and Zhaohui Huang
    Citation: Journal of Biomedical Science 2022 29:4
    Content type: Research Published on:

  29. Arsenic exposure is an important public health issue worldwide. Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed. Inorganic arsenic is methylated ...

    Authors: Ling-I Hsu, Wu-Ping Chen, Tse-Yen Yang, Yu-Hsin Chen, Wann-Cheng Lo, Yuan-Hung Wang, Ya-Tang Liao, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2011 18:51
    Content type: Research Published on:

  30. Hormone-refractory prostate cancer (HRPC), which is resistant to hormone ... to inhibit HRPC growth and ultimately to kill cancers is highly demanded.

    Authors: Chia-Chun Yu, Shih-Ping Liu, Jui-Ling Hsu, John TA Hsu, Konstantin V Kudryavtsev and Jih-Hwa Guh
    Citation: Journal of Biomedical Science 2015 22:2
    Content type: Research Published on:

  31. The Maillard reaction is a chemical reaction occurring between a reducing sugar and an amino acid, generally requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and an...

    Authors: Jung-Il Chae, RaHam Lee, JinHyoung Cho, JinTae Hong and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2014 21:4
    Content type: Research Published on:

  32. Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical ... intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppre...

    Authors: Kyung-Ae Lee, Jung-Il Chae and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2012 19:60
    Content type: Research Published on:

  33. Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade. In this study, we established a screening model to discover nov...

    Authors: Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh and Michael Hsiao
    Citation: Journal of Biomedical Science 2021 28:29
    Content type: Research Published on:

  36. Our findings suggest that ARID1A protein transcriptionally modulates DUSP4 expression by remodeling chromatin, subsequently inactivating the MAPK pathway, leading to tumor suppression. The ARID1A-DUSP4-MAPK ax...

    Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang
    Citation: Journal of Biomedical Science 2023 30:94
    Content type: Research Published on:

  39. Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause ... a necessary cause for the development of cervical cancer. In addition, genetic and epigenetic alterations ... for progre...

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik
    Citation: Journal of Biomedical Science 2019 26:28
    Content type: Review Published on:

    The Retraction Note to this article has been published in Journal of Biomedical Science 2019 26:50

  40. It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatically...

    Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li and Han-Chung Wu
    Citation: Journal of Biomedical Science 2020 27:1
    Content type: Review Published on:

  41. To better evaluate and improve the efficacy of dendritic cell (DC)-based cancer immunotherapy, we conducted a clinical study of patients with advanced colorectal cancer using carcinoembryonic antigen (CEA)-pulsed...

    Authors: Ko-Jiunn Liu, Tsu-Yi Chao, Jang-Yang Chang, Ann-Lii Cheng, Hui-Ju Ch’ang, Woei-Yau Kao, Yu-Chen Wu, Wei-Lan Yu, Tsai-Rong Chung and Jacqueline Whang-Peng
    Citation: Journal of Biomedical Science 2016 23:64
    Content type: Research Published on:

  42. Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal fac...

    Authors: Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2022 29:98
    Content type: Research Published on:

  43. MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor (ICI) treatment for different malignancies by various pancancer studies. Specifically, ...

    Authors: Dantong Sun, Haili Qian, Junling Li and Puyuan Xing
    Citation: Journal of Biomedical Science 2024 31:17
    Content type: Review Published on:

  44. RMS-RR cell lines, characterized by a more aggressive and in vitro pro-metastatic phenotype, showed a higher ability to i) detoxify from reactive oxygen species; ii) repair DNA damage by differently activating no...

    Authors: Francesco Petragnano, Ilaria Pietrantoni, Simona Camero, Silvia Codenotti, Luisa Milazzo, Francesca Vulcano, Giampiero Macioce, Ilenia Giordani, Paolo Tini, Sara Cheleschi, Giovanni Luca Gravina, Claudio Festuccia, Alessandra Rossetti, Simona Delle Monache, Alessandra Ordinelli, Carmela Ciccarelli…
    Citation: Journal of Biomedical Science 2020 27:90
    Content type: Research Published on:

  45. Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall...

    Authors: Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:90
    Content type: Research Published on:

  46. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasio...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra
    Citation: Journal of Biomedical Science 2010 17:10
    Content type: Review Published on:

  47. Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector expressing IL15...

    Authors: Giou-Teng Yiang, Horng-Jyh Harn, Yung-Luen Yu, Sheng-Chuan Hu, Yu-Ting Hung, Chia-Jung Hsieh, Shinn-Zong Lin and Chyou-Wei Wei
    Citation: Journal of Biomedical Science 2009 16:47
    Content type: Research Published on:

  48. Esophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility. Mi...

    Authors: Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and Hung-Chi Cheng
    Citation: Journal of Biomedical Science 2020 27:102
    Content type: Research Published on:

  49. Human Papillomavirus type 18 (HPV18) is a high-risk HPV that is commonly associated with cervical cancer. HPV18 oncogenes E6 and E7 are associated...

    Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2022 29:80
    Content type: Research Published on:

  50. The aim of the study was to investigate the effect of dietary supplementation with zinc and polyphenol compounds, i.e. resveratrol and genistein, on the effectiveness of chemically induced mammary cancer and the ...

    Authors: Barbara Bobrowska-Korczak, Dorota Skrajnowska and Andrzej Tokarz
    Citation: Journal of Biomedical Science 2012 19:43
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    11.0 - 2-year Impact Factor
    10.9 - 5-year Impact Factor
    2.367 - SNIP (Source Normalized Impact per Paper)
    2.520 - SJR (SCImago Journal Rank)

    2023 Speed
    14 days submission to first editorial decision for all manuscripts (Median)
    107 days submission to accept (Median)

    2023 Usage 
    1,698,723 downloads
    3,813 Altmetric mentions 

Journal of Biomedical Science

ISSN: 1423-0127