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  1. Numerous studies have shown that Id-1 (Inhibitor of differentiation 1) is upregulated in several cancers and associated with tumor malignant characters. However, the clinical significance and biological role o...

    Authors: Jie Li, Yingjie Li, Bin Wang, Yongfu Ma and Ping Chen
    Citation: Journal of Biomedical Science 2017 24:95
    Content type: Research Published on:

  2. Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and cerebrospinal fluid of infected patients with brainst...

    Authors: Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang and Shun-Hua Chen
    Citation: Journal of Biomedical Science 2017 24:94
    Content type: Research Published on:

  4. Beta-thalassemia is common in the Mediterranean area as well as the Middle East and India. Official report in Iran revealed the average prevalence rate of carriers about 4%. More than 20 restriction fragment l...

    Authors: Mohammad Bagher Hashemi-Soteh, Seyed Saeed Mousavi and Alireza Tafazoli
    Citation: Journal of Biomedical Science 2017 24:92
    Content type: Research Published on:

  5. A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical man...

    Authors: Hiroya Matsumura, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Shunsuke Tomomori, Chikaaki Motoda, Michitaka Amioka, Naoya Hironobe, Masaaki Toshishige, Shinya Takahashi, Katsuhiko Imai, Taijiro Sueda, Kazuaki Chayama and Yasuki Kihara
    Citation: Journal of Biomedical Science 2017 24:91
    Content type: Research Published on:

  6. Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytoki...

    Authors: Isela Martínez-Reza, Lorenza Díaz and Rocío García-Becerra
    Citation: Journal of Biomedical Science 2017 24:90
    Content type: Review Published on:

  7. MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for...

    Authors: Che-Chung Yeh, Yanying Fan, Yi-Lin Yang and Michael J. Mann
    Citation: Journal of Biomedical Science 2017 24:89
    Content type: Research Published on:

  8. The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enh...

    Authors: Lorrany dos Santos Franco, Paloma Oliveira Vidal and Jaime Henrique Amorim
    Citation: Journal of Biomedical Science 2017 24:88
    Content type: Research Published on:

  9. Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellula...

    Authors: Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal and Stephen Myers
    Citation: Journal of Biomedical Science 2017 24:87
    Content type: Review Published on:

  11. This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascula...

    Authors: Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen and Li-Chin Sung
    Citation: Journal of Biomedical Science 2017 24:85
    Content type: Research Published on:

  12. Blood pressure control with renin-angiotensin system (RAS) blockade has remained the gold standard for treating patients with proteinuric chronic kidney disease (CKD) up to date. Nevertheless, RAS blockade slo...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin and Tun-Jun Tsai
    Citation: Journal of Biomedical Science 2017 24:84
    Content type: Review Published on:

  13. Cells adapt to hypoxia by transcriptional induction of genes that participate in regulation of angiogenesis, glucose metabolism and cell proliferation. The primary factors mediating cell response to low oxygen...

    Authors: Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Anna Lipińska, Lech Pomorski, Marek Wieczorek, Magdalena Bryś, Ewa Forma and Anna Krześlak
    Citation: Journal of Biomedical Science 2017 24:83
    Content type: Research Published on:

  14. Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric infl...

    Authors: Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2017 24:82
    Content type: Research Published on:

  15. Luteinizing hormone-releasing hormone (LH-RH) agonists are the standard for androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. Current guidelines recommend serum testosterone measurement to ...

    Authors: Juan Morote, Imma Comas, Roser Ferrer, Jacques Planas, Anna Celma and Lucas Regis
    Citation: Journal of Biomedical Science 2017 24:81
    Content type: Research Published on:

  17. Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+

    Authors: Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya
    Citation: Journal of Biomedical Science 2017 24:79
    Content type: Research Published on:

  18. Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely...

    Authors: Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G. Weiss, Daniela Panáková and Stéphanie Lucas
    Citation: Journal of Biomedical Science 2017 24:78
    Content type: Research Published on:

  19. Several tumour necrosis factor (TNF) based therapeutics have already been approved for human use and several others are emerging. Therefore, we determined the mRNA expression levels of the TNF superfamily liga...

    Authors: Satish Kumar Devarapu, Julia Felicitas Grill, Junhui Xie, Marc Weidenbusch, Mohsen Honarpisheh, Volker Vielhauer, Hans-Joachim Anders and Shrikant R. Mulay
    Citation: Journal of Biomedical Science 2017 24:77
    Content type: Research Published on:

  20. Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer’s disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, R...

    Authors: Waqar Ahmad, Bushra Ijaz, Khadija Shabbiri, Fayyaz Ahmed and Sidra Rehman
    Citation: Journal of Biomedical Science 2017 24:76
    Content type: Review Published on:

  21. Matrix metalloproteinases (MMPs) are known to play an important role in the degradation of the extracellular matrix and the pathological progression of osteoarthritis (OA). The natural polyphenolic compound ro...

    Authors: Seong-Hui Eo and Song Ja Kim
    Citation: Journal of Biomedical Science 2017 24:75
    Content type: Research Published on:

  23. Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2–3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiova...

    Authors: Maria Joao Paiva-Lopes and José Delgado Alves
    Citation: Journal of Biomedical Science 2017 24:73
    Content type: Review Published on:

  24. The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide. Its biological activity is also largely det...

    Authors: Miroslava Majzúnová, Zuzana Pakanová, Peter Kvasnička, Peter Bališ, Soňa Čačányiová and Ima Dovinová
    Citation: Journal of Biomedical Science 2017 24:72
    Content type: Research Published on:

  25. Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in ...

    Authors: Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang and Nigel H. Greig
    Citation: Journal of Biomedical Science 2017 24:71
    Content type: Review Published on:

  26. Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence....

    Authors: Chih-Hao Wang and Yau-Huei Wei
    Citation: Journal of Biomedical Science 2017 24:70
    Content type: Review Published on:

  28. The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...

    Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen and Yijuang Chern
    Citation: Journal of Biomedical Science 2017 24:68
    Content type: Research Published on:

  29. The aim of this study was to determine the biofilm formation, the extracellular enzymatic activities of 182 clinical isolates of the Candida parapsilosis complex.

    Authors: Sourour Neji, Ines Hadrich, Houaida Trabelsi, Salma Abbes, Fatma Cheikhrouhou, Hayet Sellami, Fattouma Makni and Ali Ayadi
    Citation: Journal of Biomedical Science 2017 24:67
    Content type: Research Published on:

  30. Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence repr...

    Authors: Omar A.H. Ahmed-Farid, Maha Nasr, Rania F. Ahmed and Rofanda M. Bakeer
    Citation: Journal of Biomedical Science 2017 24:66
    Content type: Research Published on:

  31. This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO...

    Authors: Yuling Zhou, Brett D. Hambly and Craig S. McLachlan
    Citation: Journal of Biomedical Science 2017 24:65
    Content type: Review Published on:

  32. Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excr...

    Authors: Leszek Szablewski
    Citation: Journal of Biomedical Science 2017 24:64
    Content type: Review Published on:

  33. Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular biology has been extensively studied resulting in identification of a complex nature of TRIM28 protein. In this revie...

    Authors: Patrycja Czerwińska, Sylwia Mazurek and Maciej Wiznerowicz
    Citation: Journal of Biomedical Science 2017 24:63
    Content type: Review Published on:

  34. Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-cateni...

    Authors: Jia-Feng Wu, Hsiu-Hao Chang, Meng-Yao Lu, Shiann-Tarng Jou, Kai-Chi Chang, Yen-Hsuan Ni and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2017 24:62
    Content type: Research Published on:

  35. Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

    Authors: Hong-Yi Chang, Hsin-Mei Chang, Tsung-Jung Wu, Chang-Yao Chaing, Tzong-Shin Tzai, Hong-Lin Cheng, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2017 24:61
    Content type: Research Published on:

  37. Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...

    Authors: Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen
    Citation: Journal of Biomedical Science 2017 24:59
    Content type: Review Published on:

  38. Vibrio vulnificus is a marine bacterial species that causes opportunistic infections manifested by serious skin lesions and fulminant septicemia in humans. We have previously shown tha...

    Authors: Chun-Liang Chen, Shu-Chun Chien, Tzeng-Horng Leu, Hans I-Chen Harn, Ming-Jer Tang and Lien-I Hor
    Citation: Journal of Biomedical Science 2017 24:58
    Content type: Research Published on:

  39. Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU m...

    Authors: Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth…
    Citation: Journal of Biomedical Science 2017 24:57
    Content type: Research Published on:

  40. Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Authors: Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri
    Citation: Journal of Biomedical Science 2017 24:56
    Content type: Review Published on:

  41. Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG’s effect on warts...

    Authors: Yu-Wen Chu, Shu-Ting Liu, Ya-Lan Yang, Shih-Ming Huang and Wei-Ming Wang
    Citation: Journal of Biomedical Science 2017 24:55
    Content type: Research Published on:

  42. An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cy...

    Authors: Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto and Lien-I Hor
    Citation: Journal of Biomedical Science 2017 24:54
    Content type: Research Published on:

  44. Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary ar...

    Authors: Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao and Liangxing Wang
    Citation: Journal of Biomedical Science 2017 24:52
    Content type: Research Published on:

  45. Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...

    Authors: Yu-Tang Chin, Le-Ming Wang, Meng-Ti Hsieh, Ya-Jung Shih, André Wendindondé Nana, Chun A. Changou, Yu-Chen S. H. Yang, Hsien-Chung Chiu, Earl Fu, Paul J. Davis, Heng-Yuan Tang and Hung-Yun Lin
    Citation: Journal of Biomedical Science 2017 24:51
    Content type: Research Published on:

  46. Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence show...

    Authors: Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu and Christopher W. K. Lai
    Citation: Journal of Biomedical Science 2017 24:50
    Content type: Review Published on:

  47. B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified with...

    Authors: Shin-Huei Fu, Li-Tzu Yeh, Chin-Chen Chu, B. Lin-Ju Yen and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2017 24:49
    Content type: Review Published on:

  49. Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with cognitive impairment. AD is the most common neurodegenerative disease worldwide,...

    Authors: Shih-Ya Hung and Wen-Mei Fu
    Citation: Journal of Biomedical Science 2017 24:47
    Content type: Review Published on:
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Journal of Biomedical Science

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