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  1. Matrix metalloproteinases (MMPs) are known to play an important role in the degradation of the extracellular matrix and the pathological progression of osteoarthritis (OA). The natural polyphenolic compound ro...

    Authors: Seong-Hui Eo and Song Ja Kim
    Citation: Journal of Biomedical Science 2017 24:75
    Content type: Research Published on:

  3. Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2–3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiova...

    Authors: Maria Joao Paiva-Lopes and José Delgado Alves
    Citation: Journal of Biomedical Science 2017 24:73
    Content type: Review Published on:

  4. The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide. Its biological activity is also largely det...

    Authors: Miroslava Majzúnová, Zuzana Pakanová, Peter Kvasnička, Peter Bališ, Soňa Čačányiová and Ima Dovinová
    Citation: Journal of Biomedical Science 2017 24:72
    Content type: Research Published on:

  5. Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in ...

    Authors: Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang and Nigel H. Greig
    Citation: Journal of Biomedical Science 2017 24:71
    Content type: Review Published on:

  6. Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence....

    Authors: Chih-Hao Wang and Yau-Huei Wei
    Citation: Journal of Biomedical Science 2017 24:70
    Content type: Review Published on:

  8. The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...

    Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen and Yijuang Chern
    Citation: Journal of Biomedical Science 2017 24:68
    Content type: Research Published on:

  9. The aim of this study was to determine the biofilm formation, the extracellular enzymatic activities of 182 clinical isolates of the Candida parapsilosis complex.

    Authors: Sourour Neji, Ines Hadrich, Houaida Trabelsi, Salma Abbes, Fatma Cheikhrouhou, Hayet Sellami, Fattouma Makni and Ali Ayadi
    Citation: Journal of Biomedical Science 2017 24:67
    Content type: Research Published on:

  10. Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence repr...

    Authors: Omar A.H. Ahmed-Farid, Maha Nasr, Rania F. Ahmed and Rofanda M. Bakeer
    Citation: Journal of Biomedical Science 2017 24:66
    Content type: Research Published on:

  11. This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO...

    Authors: Yuling Zhou, Brett D. Hambly and Craig S. McLachlan
    Citation: Journal of Biomedical Science 2017 24:65
    Content type: Review Published on:

  12. Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excr...

    Authors: Leszek Szablewski
    Citation: Journal of Biomedical Science 2017 24:64
    Content type: Review Published on:

  13. Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular biology has been extensively studied resulting in identification of a complex nature of TRIM28 protein. In this revie...

    Authors: Patrycja Czerwińska, Sylwia Mazurek and Maciej Wiznerowicz
    Citation: Journal of Biomedical Science 2017 24:63
    Content type: Review Published on:

  14. Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-cateni...

    Authors: Jia-Feng Wu, Hsiu-Hao Chang, Meng-Yao Lu, Shiann-Tarng Jou, Kai-Chi Chang, Yen-Hsuan Ni and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2017 24:62
    Content type: Research Published on:

  15. Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

    Authors: Hong-Yi Chang, Hsin-Mei Chang, Tsung-Jung Wu, Chang-Yao Chaing, Tzong-Shin Tzai, Hong-Lin Cheng, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2017 24:61
    Content type: Research Published on:

  17. Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...

    Authors: Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen
    Citation: Journal of Biomedical Science 2017 24:59
    Content type: Review Published on:

  18. Vibrio vulnificus is a marine bacterial species that causes opportunistic infections manifested by serious skin lesions and fulminant septicemia in humans. We have previously shown tha...

    Authors: Chun-Liang Chen, Shu-Chun Chien, Tzeng-Horng Leu, Hans I-Chen Harn, Ming-Jer Tang and Lien-I Hor
    Citation: Journal of Biomedical Science 2017 24:58
    Content type: Research Published on:

  19. Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU m...

    Authors: Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth…
    Citation: Journal of Biomedical Science 2017 24:57
    Content type: Research Published on:

  20. Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Authors: Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri
    Citation: Journal of Biomedical Science 2017 24:56
    Content type: Review Published on:

  21. Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG’s effect on warts...

    Authors: Yu-Wen Chu, Shu-Ting Liu, Ya-Lan Yang, Shih-Ming Huang and Wei-Ming Wang
    Citation: Journal of Biomedical Science 2017 24:55
    Content type: Research Published on:

  22. An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cy...

    Authors: Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto and Lien-I Hor
    Citation: Journal of Biomedical Science 2017 24:54
    Content type: Research Published on:

  24. Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary ar...

    Authors: Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao and Liangxing Wang
    Citation: Journal of Biomedical Science 2017 24:52
    Content type: Research Published on:

  25. Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...

    Authors: Yu-Tang Chin, Le-Ming Wang, Meng-Ti Hsieh, Ya-Jung Shih, André Wendindondé Nana, Chun A. Changou, Yu-Chen S. H. Yang, Hsien-Chung Chiu, Earl Fu, Paul J. Davis, Heng-Yuan Tang and Hung-Yun Lin
    Citation: Journal of Biomedical Science 2017 24:51
    Content type: Research Published on:

  26. Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence show...

    Authors: Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu and Christopher W. K. Lai
    Citation: Journal of Biomedical Science 2017 24:50
    Content type: Review Published on:

  27. B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified with...

    Authors: Shin-Huei Fu, Li-Tzu Yeh, Chin-Chen Chu, B. Lin-Ju Yen and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2017 24:49
    Content type: Review Published on:

  29. Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with cognitive impairment. AD is the most common neurodegenerative disease worldwide,...

    Authors: Shih-Ya Hung and Wen-Mei Fu
    Citation: Journal of Biomedical Science 2017 24:47
    Content type: Review Published on:

  31. Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human...

    Authors: Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang and Sheng-Ping L. Hwang
    Citation: Journal of Biomedical Science 2017 24:45
    Content type: Research Published on:

  32. The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate ...

    Authors: Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger and Marcel A. G. van der Heyden
    Citation: Journal of Biomedical Science 2017 24:44
    Content type: Research Published on:

  33. Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythr...

    Authors: Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2017 24:43
    Content type: Research Published on:

  34. Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects periphe...

    Authors: Peggy Sfyri and Antonios Matsakas
    Citation: Journal of Biomedical Science 2017 24:42
    Content type: Review Published on:

  35. Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF...

    Authors: Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara and Masafumi Kawamura
    Citation: Journal of Biomedical Science 2017 24:41
    Content type: Research Published on:

  36. Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. ...

    Authors: Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin and Hui-Yee Chee
    Citation: Journal of Biomedical Science 2017 24:40
    Content type: Research Published on:

  38. Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Authors: Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu
    Citation: Journal of Biomedical Science 2017 24:38
    Content type: Research Published on:

  39. Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung cancer. Late stage of diagnosis and lack of effec...

    Authors: Chantal Hoi Yin Cheung and Hsueh-Fen Juan
    Citation: Journal of Biomedical Science 2017 24:37
    Content type: Review Published on:

  40. The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial fo...

    Authors: Pey Yee Lee, Siok-Fong Chin, Hui-min Neoh and Rahman Jamal
    Citation: Journal of Biomedical Science 2017 24:36
    Content type: Review Published on:

  41. Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effect...

    Authors: Hwei-Fang Tsai and Ping-Ning Hsu
    Citation: Journal of Biomedical Science 2017 24:35
    Content type: Review Published on:

  42. Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears ...

    Authors: May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang and Henrich Cheng
    Citation: Journal of Biomedical Science 2017 24:34
    Content type: Research Published on:

  43. The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen
    Citation: Journal of Biomedical Science 2017 24:33
    Content type: Research Published on:

  45. In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Authors: Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon
    Citation: Journal of Biomedical Science 2017 24:31
    Content type: Research Published on:

  46. The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen
    Citation: Journal of Biomedical Science 2017 24:30
    Content type: Research Published on:

  47. Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Authors: Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2017 24:29
    Content type: Research Published on:

  49. Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate
    Citation: Journal of Biomedical Science 2017 24:27
    Content type: Research Published on:

  50. Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Authors: Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo
    Citation: Journal of Biomedical Science 2017 24:26
    Content type: Review Published on:
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Journal of Biomedical Science

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