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  2. Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem. C-phycocyanin (Cpc) i...

    Authors: Li-Chen Wu, Yu-Yun Lin, Szu-Yen Yang, Yu-Ting Weng and Yi-Ting Tsai
    Citation: Journal of Biomedical Science 2011 18:74
    Content type: Research Published on:

  3. The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant ...

    Authors: Jenher Lu, Tzuchun Tsai, Sielin Choo, Shuyu Yeh, Renbing Tang, Anhang Yang, Hsinyu Lee and Jennkan Lu
    Citation: Journal of Biomedical Science 2011 18:73
    Content type: Research Published on:

  4. Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drink...

    Authors: Yu-Jun Lai, Chung-Lieh Hung, Ray-Ching Hong, Ya-Ming Tseng, Cheng-I Lin, Yu-Shien Ko, Cheng-Ho Tsai and Hung-I Yeh
    Citation: Journal of Biomedical Science 2011 18:72
    Content type: Research Published on:

  5. Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway. Presuming a major role of complement as an effecter in peptid...

    Authors: Yu-Huei Liu, Lei Wan, Chwen-Tzuei Chang, Wen-Ling Liao, Wen-Chi Chen, Yuhsin Tsai, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2011 18:71
    Content type: Research Published on:

  6. β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos wit...

    Authors: Yi-Ting Wu, Che Yi Lin, Ming-Yuan Tsai, Yi-Hua Chen, Yu-Fen Lu, Chang-Jen Huang, Chao-Min Cheng and Sheng-Ping L Hwang
    Citation: Journal of Biomedical Science 2011 18:70
    Content type: Research Published on:

  7. Perinatal brain injury is the leading cause of subsequent neurological disability in both term and preterm baby. Glutamate excitotoxicity is one of the major factors involved in perinatal hypoxic-ischemic ence...

    Authors: Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Ching-Jung Lai, Pen Jung Wang and Ted H Chiu
    Citation: Journal of Biomedical Science 2011 18:69
    Content type: Research Published on:

  8. The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia ...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Pei-Hsuan Chen, Ching-Mei Hsu and Lee-Wei Chen
    Citation: Journal of Biomedical Science 2011 18:68
    Content type: Research Published on:

  9. Although recent studies have highlighted the role of epicardial cells during cardiac development and regeneration, their cardiomyogenic potential is still controversial due to the question of lineage tracing o...

    Authors: Bin Zeng, Xiao-feng Ren, Feng Cao, Xiao-yang Zhou and Jing Zhang
    Citation: Journal of Biomedical Science 2011 18:67
    Content type: Research Published on:

  11. Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therap...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai
    Citation: Journal of Biomedical Science 2011 18:65
    Content type: Research Published on:

  12. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2011 18:64
    Content type: Research Published on:

  13. Prostate cancer is the most frequently diagnosed non-cutaneous tumor of men in Western countries. While surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary ...

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su
    Citation: Journal of Biomedical Science 2011 18:63
    Content type: Review Published on:

  14. Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Authors: Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki, Yu Sogo, Atsuo Ito and Akira Matsumura
    Citation: Journal of Biomedical Science 2011 18:62
    Content type: Research Published on:

  15. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang
    Citation: Journal of Biomedical Science 2011 18:61
    Content type: Research Published on:

  16. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi
    Citation: Journal of Biomedical Science 2011 18:60
    Content type: Research Published on:

  17. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li
    Citation: Journal of Biomedical Science 2011 18:59
    Content type: Research Published on:

  18. Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. R...

    Authors: Shan-shan Liu, Xiang-mei Chen, Hong-xia Zheng, Shu-liang Shi and Yu Li
    Citation: Journal of Biomedical Science 2011 18:58
    Content type: Research Published on:

  19. High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...

    Authors: Ke Chen, ping jin, Hong-hui He, Yan-hong Xie, Xiao-yun Xie and Zhao-hui Mo
    Citation: Journal of Biomedical Science 2011 18:57
    Content type: Research Published on:

  20. Notch and TLR pathways were found to act cooperatively to activate Notch target genes and to increase the production of TLR-induced cytokines in macrophages. However, the mechanism of LPS-induced Notch activat...

    Authors: Po-Nien Tsao, Shu-Chen Wei, Miao-Tzu Huang, Ming-Cheng Lee, Hung-Chieh Chou, Chien-Yi Chen and Wu-Shiun Hsieh
    Citation: Journal of Biomedical Science 2011 18:56
    Content type: Research Published on:

  21. Sphingosylphosphorylcholine (SPC) acts as a potent lipid mediator and signaling molecule in various cell types. In the present study, we investigated the effects of SPC on melanogenesis and SPC-modulated signa...

    Authors: Hyo-Soon Jeong, Seung Hoon Lee, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung-Chan Park and Dong-Seok Kim
    Citation: Journal of Biomedical Science 2011 18:55
    Content type: Research Published on:

  22. Spinocerebellar ataxia (SCA) refers to a disease entity in which polyglutamine aggregates are over-produced in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and...

    Authors: You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bing-Wen Soong, Jennifer H Ho and Oscar K Lee
    Citation: Journal of Biomedical Science 2011 18:54
    Content type: Research Published on:

  23. Postconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of precondit...

    Authors: Yikui Tian, Wenjuan Zhang, Dachuan Xia, Paul Modi, Degang Liang and Minxin Wei
    Citation: Journal of Biomedical Science 2011 18:53
    Content type: Research Published on:

  24. Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers...

    Authors: Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen and Jungshan Chang
    Citation: Journal of Biomedical Science 2011 18:52
    Content type: Research Published on:

  25. Arsenic exposure is an important public health issue worldwide. Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed. Inorganic arsenic is methylat...

    Authors: Ling-I Hsu, Wu-Ping Chen, Tse-Yen Yang, Yu-Hsin Chen, Wann-Cheng Lo, Yuan-Hung Wang, Ya-Tang Liao, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2011 18:51
    Content type: Research Published on:

  26. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq
    Citation: Journal of Biomedical Science 2011 18:50
    Content type: Research Published on:

  27. In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (B...

    Authors: Pei-Min Chen, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu and B-Linju Yen
    Citation: Journal of Biomedical Science 2011 18:49
    Content type: Review Published on:

  28. At the beginning of neurogenesis, massive brain cell death occurs and more than 50% of cells are eliminated by apoptosis along with neuronal differentiation. However, few studies were conducted so far regardin...

    Authors: Hyo Sang Go, Jung Eun Seo, Ki Chan Kim, So Min Han, Pitna Kim, Young Sun Kang, Seol Heui Han, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2011 18:48
    Content type: Research Published on:

  29. Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to possess an insulin-like property in diabetes. In...

    Authors: Chih-Chun Chang, Chieh-Yu Chang, Yang-Tzu Wu, Jiung-Pang Huang, Tzung-Hai Yen and Li-Man Hung
    Citation: Journal of Biomedical Science 2011 18:47
    Content type: Research Published on:

  30. Methionine Sulfoxide Reductase A (MsrA), an enzyme in the Msr gene family, is important in the cellular anti-oxidative stress defense mechanism. It acts by reducing the oxidized methionine sulfoxide in protein...

    Authors: Pingping Jia, Chi Zhang, Yuanyuan Jia, Keith A Webster, Xupei Huang, Andrei A Kochegarov, Sharon L Lemanski and Larry F Lemanski
    Citation: Journal of Biomedical Science 2011 18:46
    Content type: Research Published on:

  31. Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling path...

    Authors: Karen F Chambers, Joanna F Pearson, Davide Pellacani, Naveed Aziz, Miodrag Gužvić, Christoph A Klein and Shona H Lang
    Citation: Journal of Biomedical Science 2011 18:45
    Content type: Research Published on:

  32. Damage-associated molecular patterns (DAMPs) are associated with immunogenic cell death and have the ability to enhance maturation and antigen presentation of dendritic cells (DCs). Specific microtubule-depoly...

    Authors: Chih-Chun Wen, Hui-Ming Chen, Swey-Shen Chen, Li-Ting Huang, Wei-Ting Chang, Wen-Chi Wei, Li-Chen Chou, Palanisamy Arulselvan, Jin-Bin Wu, Sheng-Chu Kuo and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2011 18:44
    Content type: Research Published on:

  33. Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteina...

    Authors: Ta-Liang Chen, Yung-Feng Lin, Chao-Wen Cheng, Shi-Yun Chen, Ming-Thau Sheu, Ting-Kai Leung, Cheng-Hong Qin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2011 18:43
    Content type: Research Published on:

  34. The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally ...

    Authors: Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh and Li-Mei Pai
    Citation: Journal of Biomedical Science 2011 18:42
    Content type: Research Published on:

  35. The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden. Two seasons existed, one of increased deprivation...

    Authors: Pa T Ngom, Juan Solon, Sophie E Moore, Gareth Morgan, Andrew M Prentice and Richard Aspinall
    Citation: Journal of Biomedical Science 2011 18:41
    Content type: Research Published on:

  36. Carbon monoxide (CO) is a toxic gas, which also acts in the organism as a neurotransmitter. It is generated as a by-product of heme breakdown catalyzed by heme oxygenase. We have investigated changes in electr...

    Authors: Denis V Abramochkin, Nail N Haertdinov, Maria V Porokhnya, Andrew L Zefirov and Gusel F Sitdikova
    Citation: Journal of Biomedical Science 2011 18:40
    Content type: Research Published on:

  37. Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact ro...

    Authors: Ling-fang He, Ting-ting Wang, Qian-ying Gao, Guang-feng Zhao, Ya-hong Huang, Li-ke Yu and Ya-yi Hou
    Citation: Journal of Biomedical Science 2011 18:39
    Content type: Research Published on:

  38. Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one ...

    Authors: Lorenzo A Calò, Luciana Bordin, Paul A Davis, Elisa Pagnin, Lucia Dal Maso, Gian Paolo Rossi, Achille C Pessina and Giulio Clari
    Citation: Journal of Biomedical Science 2011 18:38
    Content type: Research Published on:

  39. It is of growing interest to develop novel approaches to initiate differentiation of mesenchymal stem cells (MSCs) into cardiomyocytes. The purpose of this investigation was to determine if Sphingosine-1-phosp...

    Authors: Zhenqiang Zhao, Zhibin Chen, Xiubo Zhao, Fang Pan, Meihua Cai, Tan Wang, Henggui Zhang, Jian R Lu and Ming Lei
    Citation: Journal of Biomedical Science 2011 18:37
    Content type: Research Published on:

  40. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as repr...

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen
    Citation: Journal of Biomedical Science 2011 18:36
    Content type: Research Published on:

  41. Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to prote...

    Authors: Jian Xiao, Xiaoyan Zhu, Bin He, Yufeng Zhang, Bo Kang, Zhinong Wang and Xin Ni
    Citation: Journal of Biomedical Science 2011 18:35
    Content type: Research Published on:

  42. Mu opioid receptor (MOR), which plays key roles in analgesia and also has effects on learning and memory, was reported to distribute abundantly in the patches of the neostriatum. The marginal division (MrD) of...

    Authors: Chuanxing Wang, Si Yun Shu, Zhouyi Guo, Ye Feng Cai, Xinmin Bao, Changchun Zeng, Bingyi Wu, Ziyou Hu and Xuemei Liu
    Citation: Journal of Biomedical Science 2011 18:34
    Content type: Research Published on:

  44. Adrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS). We previously demonstrated...

    Authors: David HT Yen, Lih-Chi Chen, Yuh-Chiang Shen, Ying-Chen Chiu, I-Chun Ho, Ya-Jou Lou, I-Chin Chen and Jiin-Cherng Yen
    Citation: Journal of Biomedical Science 2011 18:32
    Content type: Research Published on:

  45. Hypoxia during the first week of life can induce neuronal death in vulnerable brain regions usually associated with an impairment of cognitive function that can be detected later in life. The neurobiological c...

    Authors: Thoppil R Anju, Sadanandan Jayanarayanan and Cheramadatikudiyil S Paulose
    Citation: Journal of Biomedical Science 2011 18:31
    Content type: Research Published on:

  47. NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex...

    Authors: Hsin-Yu Liu, Pin-Chao Liao, Kai-Tun Chuang and Mou-Chieh Kao
    Citation: Journal of Biomedical Science 2011 18:29
    Content type: Research Published on:

  48. Natural products have played a significant role in drug discovery and development. Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been suggested to conn...

    Authors: I-Ni Hsieh, Anita Shin-Yuan Chang, Che-Ming Teng, Chien-Chih Chen and Chia-Ron Yang
    Citation: Journal of Biomedical Science 2011 18:28
    Content type: Research Published on:

  49. Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effect...

    Authors: Bao-Wei Wang, Chiu-Mei Lin, Gong-Jhe Wu and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2011 18:27
    Content type: Research Published on:

  50. Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients ...

    Authors: Wei S Lian, Heng Lin, Winston TK Cheng, Tateki Kikuchi and Ching F Cheng
    Citation: Journal of Biomedical Science 2011 18:26
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127