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  1. Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal cells under appropriate cellular conditions and transplanted in brain injury and neurodegenerative diseases animal models for neurore...

    Authors: Min Gong, Yang Bi, Wei Jiang, Yun Zhang, Li Chen, Nali Hou, Youxue Liu, Xiaoping Wei, Jie Chen and Tingyu Li
    Citation: Journal of Biomedical Science 2011 18:87
  2. Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its se...

    Authors: You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen and Wun-Chang Ko
    Citation: Journal of Biomedical Science 2011 18:84
  3. Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction. We previously report...

    Authors: Sang Won Park, Xine Shen, Lu-Tai Tien, Richard Roman and Tangeng Ma
    Citation: Journal of Biomedical Science 2011 18:83
  4. Peripheral tissue inflammation initiates hyperalgesia accompanied by tissue acidosis, nociceptor activation, and inflammation mediators. Recent studies have suggested a significantly increased expression of ac...

    Authors: Wei-Hsin Chen, Ching-Liang Hsieh, Chun-Ping Huang, Tzu-Jou Lin, Jason TC Tzen, Tin-Yun Ho and Yi-Wen Lin
    Citation: Journal of Biomedical Science 2011 18:82
  5. MiR-1 (microRNA-1) has been used as a positive control in some microRNA experiments. We found that miR-1 transfection of nasopharyngeal carcinoma cells reveals a typical apoptotic process as shown by time-laps...

    Authors: Cheng-Der Wu, Yuan-Sung Kuo, Han-Chung Wu and Chin-Tarng Lin
    Citation: Journal of Biomedical Science 2011 18:80
  6. Ischemic postconditioning (IPO) has been demonstrated to attenuate ischemia/reperfusion (I/R) injury in the heart and brain, its roles to liver remain to be defined. The study was undertaken to determine if IP...

    Authors: Jia Y Guo, Tong Yang, Xiang G Sun, Ni Y Zhou, Fu S Li, Dan Long, Tao Lin, Ping Y Li and Li Feng
    Citation: Journal of Biomedical Science 2011 18:79
  7. A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model. We investigated the neuroprotective effects of ADNF-9 against al...

    Authors: Youssef Sari, Zaneer M Segu, Ahmed YoussefAgha, Jonathan A Karty and Dragan Isailovic
    Citation: Journal of Biomedical Science 2011 18:77
  8. Accumulation of amyloid β-peptide (Aβ) in the plaques is one of the major pathological features in Alzheimer's disease (AD). Sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme...

    Authors: Anne Jämsä, Oscar Belda, Michael Edlund and Erik Lindström
    Citation: Journal of Biomedical Science 2011 18:76
  9. Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem. C-phycocyanin (Cpc) i...

    Authors: Li-Chen Wu, Yu-Yun Lin, Szu-Yen Yang, Yu-Ting Weng and Yi-Ting Tsai
    Citation: Journal of Biomedical Science 2011 18:74
  10. The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant ...

    Authors: Jenher Lu, Tzuchun Tsai, Sielin Choo, Shuyu Yeh, Renbing Tang, Anhang Yang, Hsinyu Lee and Jennkan Lu
    Citation: Journal of Biomedical Science 2011 18:73
  11. Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drink...

    Authors: Yu-Jun Lai, Chung-Lieh Hung, Ray-Ching Hong, Ya-Ming Tseng, Cheng-I Lin, Yu-Shien Ko, Cheng-Ho Tsai and Hung-I Yeh
    Citation: Journal of Biomedical Science 2011 18:72
  12. Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway. Presuming a major role of complement as an effecter in peptid...

    Authors: Yu-Huei Liu, Lei Wan, Chwen-Tzuei Chang, Wen-Ling Liao, Wen-Chi Chen, Yuhsin Tsai, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2011 18:71
  13. β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos wit...

    Authors: Yi-Ting Wu, Che Yi Lin, Ming-Yuan Tsai, Yi-Hua Chen, Yu-Fen Lu, Chang-Jen Huang, Chao-Min Cheng and Sheng-Ping L Hwang
    Citation: Journal of Biomedical Science 2011 18:70
  14. Perinatal brain injury is the leading cause of subsequent neurological disability in both term and preterm baby. Glutamate excitotoxicity is one of the major factors involved in perinatal hypoxic-ischemic ence...

    Authors: Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Ching-Jung Lai, Pen Jung Wang and Ted H Chiu
    Citation: Journal of Biomedical Science 2011 18:69
  15. The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia ...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Pei-Hsuan Chen, Ching-Mei Hsu and Lee-Wei Chen
    Citation: Journal of Biomedical Science 2011 18:68
  16. Although recent studies have highlighted the role of epicardial cells during cardiac development and regeneration, their cardiomyogenic potential is still controversial due to the question of lineage tracing o...

    Authors: Bin Zeng, Xiao-feng Ren, Feng Cao, Xiao-yang Zhou and Jing Zhang
    Citation: Journal of Biomedical Science 2011 18:67
  17. Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therap...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai
    Citation: Journal of Biomedical Science 2011 18:65
  18. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Pao-Luh Tao, Chien-Fang Chen and Eagle Yi-Kung Huang
    Citation: Journal of Biomedical Science 2011 18:64
  19. Prostate cancer is the most frequently diagnosed non-cutaneous tumor of men in Western countries. While surgery is often successful for organ-confined prostate cancer, androgen ablation therapy is the primary ...

    Authors: Chih-Pin Chuu, John M Kokontis, Richard A Hiipakka, Junichi Fukuchi, Hui-Ping Lin, Ching-Yu Lin, Chiech Huo and Liang-Cheng Su
    Citation: Journal of Biomedical Science 2011 18:63
  20. Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Authors: Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki, Yu Sogo, Atsuo Ito and Akira Matsumura
    Citation: Journal of Biomedical Science 2011 18:62
  21. Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prosta...

    Authors: Hsi-Hsien Hsu, Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Li-Mien Chen, Wei-Kung Chen, Jin-Ming Hwang, Fuu-Jen Tsai, Chung-Jung Liu and Chih-Yang Huang
    Citation: Journal of Biomedical Science 2011 18:61
  22. The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

    Authors: Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada, Atsushi Yoshiki, Katsueki Ogiwara, Atsushi Kimura and Takayuki Takahashi
    Citation: Journal of Biomedical Science 2011 18:60
  23. Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering.

    Authors: Xu-Fang Yang, Xu He, Jian He, Li-Hong Zhang, Xue-Jin Su, Zhi-Yong Dong, Yun-Jian Xu, Yan Li and Yu-Lin Li
    Citation: Journal of Biomedical Science 2011 18:59
  24. Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. R...

    Authors: Shan-shan Liu, Xiang-mei Chen, Hong-xia Zheng, Shu-liang Shi and Yu Li
    Citation: Journal of Biomedical Science 2011 18:58
  25. High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Ins...

    Authors: Ke Chen, ping jin, Hong-hui He, Yan-hong Xie, Xiao-yun Xie and Zhao-hui Mo
    Citation: Journal of Biomedical Science 2011 18:57
  26. Notch and TLR pathways were found to act cooperatively to activate Notch target genes and to increase the production of TLR-induced cytokines in macrophages. However, the mechanism of LPS-induced Notch activat...

    Authors: Po-Nien Tsao, Shu-Chen Wei, Miao-Tzu Huang, Ming-Cheng Lee, Hung-Chieh Chou, Chien-Yi Chen and Wu-Shiun Hsieh
    Citation: Journal of Biomedical Science 2011 18:56
  27. Sphingosylphosphorylcholine (SPC) acts as a potent lipid mediator and signaling molecule in various cell types. In the present study, we investigated the effects of SPC on melanogenesis and SPC-modulated signa...

    Authors: Hyo-Soon Jeong, Seung Hoon Lee, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung-Chan Park and Dong-Seok Kim
    Citation: Journal of Biomedical Science 2011 18:55
  28. Spinocerebellar ataxia (SCA) refers to a disease entity in which polyglutamine aggregates are over-produced in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and...

    Authors: You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bing-Wen Soong, Jennifer H Ho and Oscar K Lee
    Citation: Journal of Biomedical Science 2011 18:54
  29. Postconditioning (PostC) inhibits myocardial apoptosis after ischemia-reperfusion (I/R) injury. The JAK2-STAT3 pathway has anti-apoptotic effects and plays an essential role in the late protection of precondit...

    Authors: Yikui Tian, Wenjuan Zhang, Dachuan Xia, Paul Modi, Degang Liang and Minxin Wei
    Citation: Journal of Biomedical Science 2011 18:53
  30. Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers...

    Authors: Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen and Jungshan Chang
    Citation: Journal of Biomedical Science 2011 18:52
  31. Arsenic exposure is an important public health issue worldwide. Dose-response relationship between arsenic exposure and risk of urothelial carcinoma (UC) is consistently observed. Inorganic arsenic is methylat...

    Authors: Ling-I Hsu, Wu-Ping Chen, Tse-Yen Yang, Yu-Hsin Chen, Wann-Cheng Lo, Yuan-Hung Wang, Ya-Tang Liao, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2011 18:51
  32. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq
    Citation: Journal of Biomedical Science 2011 18:50
  33. In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (B...

    Authors: Pei-Min Chen, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu and B-Linju Yen
    Citation: Journal of Biomedical Science 2011 18:49
  34. At the beginning of neurogenesis, massive brain cell death occurs and more than 50% of cells are eliminated by apoptosis along with neuronal differentiation. However, few studies were conducted so far regardin...

    Authors: Hyo Sang Go, Jung Eun Seo, Ki Chan Kim, So Min Han, Pitna Kim, Young Sun Kang, Seol Heui Han, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2011 18:48
  35. Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been indicated to possess an insulin-like property in diabetes. In...

    Authors: Chih-Chun Chang, Chieh-Yu Chang, Yang-Tzu Wu, Jiung-Pang Huang, Tzung-Hai Yen and Li-Man Hung
    Citation: Journal of Biomedical Science 2011 18:47
  36. Methionine Sulfoxide Reductase A (MsrA), an enzyme in the Msr gene family, is important in the cellular anti-oxidative stress defense mechanism. It acts by reducing the oxidized methionine sulfoxide in protein...

    Authors: Pingping Jia, Chi Zhang, Yuanyuan Jia, Keith A Webster, Xupei Huang, Andrei A Kochegarov, Sharon L Lemanski and Larry F Lemanski
    Citation: Journal of Biomedical Science 2011 18:46
  37. Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling path...

    Authors: Karen F Chambers, Joanna F Pearson, Davide Pellacani, Naveed Aziz, Miodrag Gužvić, Christoph A Klein and Shona H Lang
    Citation: Journal of Biomedical Science 2011 18:45
  38. Damage-associated molecular patterns (DAMPs) are associated with immunogenic cell death and have the ability to enhance maturation and antigen presentation of dendritic cells (DCs). Specific microtubule-depoly...

    Authors: Chih-Chun Wen, Hui-Ming Chen, Swey-Shen Chen, Li-Ting Huang, Wei-Ting Chang, Wen-Chi Wei, Li-Chen Chou, Palanisamy Arulselvan, Jin-Bin Wu, Sheng-Chu Kuo and Ning-Sun Yang
    Citation: Journal of Biomedical Science 2011 18:44
  39. Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteina...

    Authors: Ta-Liang Chen, Yung-Feng Lin, Chao-Wen Cheng, Shi-Yun Chen, Ming-Thau Sheu, Ting-Kai Leung, Cheng-Hong Qin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2011 18:43
  40. The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally ...

    Authors: Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh and Li-Mei Pai
    Citation: Journal of Biomedical Science 2011 18:42
  41. The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden. Two seasons existed, one of increased deprivation...

    Authors: Pa T Ngom, Juan Solon, Sophie E Moore, Gareth Morgan, Andrew M Prentice and Richard Aspinall
    Citation: Journal of Biomedical Science 2011 18:41
  42. Carbon monoxide (CO) is a toxic gas, which also acts in the organism as a neurotransmitter. It is generated as a by-product of heme breakdown catalyzed by heme oxygenase. We have investigated changes in electr...

    Authors: Denis V Abramochkin, Nail N Haertdinov, Maria V Porokhnya, Andrew L Zefirov and Gusel F Sitdikova
    Citation: Journal of Biomedical Science 2011 18:40
  43. Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact ro...

    Authors: Ling-fang He, Ting-ting Wang, Qian-ying Gao, Guang-feng Zhao, Ya-hong Huang, Li-ke Yu and Ya-yi Hou
    Citation: Journal of Biomedical Science 2011 18:39
  44. Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one ...

    Authors: Lorenzo A Calò, Luciana Bordin, Paul A Davis, Elisa Pagnin, Lucia Dal Maso, Gian Paolo Rossi, Achille C Pessina and Giulio Clari
    Citation: Journal of Biomedical Science 2011 18:38
  45. It is of growing interest to develop novel approaches to initiate differentiation of mesenchymal stem cells (MSCs) into cardiomyocytes. The purpose of this investigation was to determine if Sphingosine-1-phosp...

    Authors: Zhenqiang Zhao, Zhibin Chen, Xiubo Zhao, Fang Pan, Meihua Cai, Tan Wang, Henggui Zhang, Jian R Lu and Ming Lei
    Citation: Journal of Biomedical Science 2011 18:37

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