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  1. Content type: Research

    LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined.

    Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong and Jian Zhang

    Citation: Journal of Biomedical Science 2018 25:18

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  2. Content type: Research

    Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed 99mT...

    Authors: Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr

    Citation: Journal of Biomedical Science 2018 25:17

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  3. Content type: Research

    Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed ...

    Authors: Lan Zhao, Alvin H. W. Fong, Na Liu and William C. S. Cho

    Citation: Journal of Biomedical Science 2018 25:16

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  4. Content type: Research

    Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has dev...

    Authors: Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam and Shamala Devi Sekaran

    Citation: Journal of Biomedical Science 2018 25:15

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  5. Content type: Research

    Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastic...

    Authors: Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu and Meei Jyh Jiang

    Citation: Journal of Biomedical Science 2018 25:14

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  6. Content type: Research

    Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, the precise underlying pathogenic mechanisms have not been elucidated. In the present study, t...

    Authors: Xiaoling Yuan, Tao Hu, Hanwen He, Huan Qiu, Xuan Wu, Jingxian Chen, Minmin Wang, Cheng Chen and Shenghai Huang

    Citation: Journal of Biomedical Science 2018 25:13

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  7. Content type: Research

    Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mec...

    Authors: Sajal K. Ghosh, Abhishek Ganta and Remco A. Spanjaard

    Citation: Journal of Biomedical Science 2018 25:12

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  8. Content type: Research

    Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms of lncRNA H19 in vascular sm...

    Authors: Lei Zhang, Hailing Cheng, Yuxia Yue, Shuangzhan Li, Daping Zhang and Ruili He

    Citation: Journal of Biomedical Science 2018 25:11

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  9. Content type: Research

    Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tole...

    Authors: Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Zu-Min Xing, Han-Wen Chen and Yi-Wen Zhang

    Citation: Journal of Biomedical Science 2018 25:10

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  10. Content type: Research

    Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) i...

    Authors: Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan and Jim-Tong Horng

    Citation: Journal of Biomedical Science 2018 25:9

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  11. Content type: Research

    Intake of ethanol (alcohol) has been shown to influence cardiovascular function; the underlying brain mechanism remains unclear. Noting that nitric oxide (NO) system in the CNS is involved in the regulation of...

    Authors: Jiro Hasegawa Situmorang, Hsun-Hsun Lin, Hsuan Lo and Chih-Chia Lai

    Citation: Journal of Biomedical Science 2018 25:8

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  12. Content type: Research

    Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrade...

    Authors: Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen and Marianne M. Stanford

    Citation: Journal of Biomedical Science 2018 25:7

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  13. Content type: Research

    Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essenti...

    Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and Lee-Young Chau

    Citation: Journal of Biomedical Science 2018 25:6

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  14. Content type: Research

    Mesenchymal stem cells (MSC) are used for several therapeutic applications to improve the functions of bone, cardiac, nervous tissue as well as to facilitate the repopulation of hematopoietic stem cells. MSC g...

    Authors: Chinnapaka Somaiah, Atul Kumar, Renu Sharma, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, Sewali Deka Talukdar and Bithiah Grace Jaganathan

    Citation: Journal of Biomedical Science 2018 25:5

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  15. Content type: Research

    Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic ...

    Authors: Zhenyu Tang, Zongming Gong and Xiaoliang Sun

    Citation: Journal of Biomedical Science 2018 25:4

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  16. Content type: Review

    The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling me...

    Authors: Yu-Tzu Shih and Yi-Ping Hsueh

    Citation: Journal of Biomedical Science 2018 25:2

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  17. Content type: Research

    Atherosclerosis occurs in arterial curvatures and branches, where the flow is disturbed with low and oscillatory shear stress (OSS). The remodeling and alterations of extracellular matrices (ECMs) and their co...

    Authors: Tung-Lin Yang, Pei-Ling Lee, Ding-Yu Lee, Wei-Li Wang, Shu-Yi Wei, Chih-I Lee and Jeng-Jiann Chiu

    Citation: Journal of Biomedical Science 2018 25:1

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  18. Content type: Research

    Numerous studies have shown that Id-1 (Inhibitor of differentiation 1) is upregulated in several cancers and associated with tumor malignant characters. However, the clinical significance and biological role o...

    Authors: Jie Li, Yingjie Li, Bin Wang, Yongfu Ma and Ping Chen

    Citation: Journal of Biomedical Science 2017 24:95

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  19. Content type: Research

    Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and cerebrospinal fluid of infected patients with brainst...

    Authors: Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang and Shun-Hua Chen

    Citation: Journal of Biomedical Science 2017 24:94

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  20. Content type: Research

    Beta-thalassemia is common in the Mediterranean area as well as the Middle East and India. Official report in Iran revealed the average prevalence rate of carriers about 4%. More than 20 restriction fragment l...

    Authors: Mohammad Bagher Hashemi-Soteh, Seyed Saeed Mousavi and Alireza Tafazoli

    Citation: Journal of Biomedical Science 2017 24:92

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  21. Content type: Research

    A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical man...

    Authors: Hiroya Matsumura, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Shunsuke Tomomori, Chikaaki Motoda, Michitaka Amioka, Naoya Hironobe, Masaaki Toshishige, Shinya Takahashi, Katsuhiko Imai, Taijiro Sueda, Kazuaki Chayama and Yasuki Kihara

    Citation: Journal of Biomedical Science 2017 24:91

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  22. Content type: Review

    Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytoki...

    Authors: Isela Martínez-Reza, Lorenza Díaz and Rocío García-Becerra

    Citation: Journal of Biomedical Science 2017 24:90

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  23. Content type: Research

    MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for...

    Authors: Che-Chung Yeh, Yanying Fan, Yi-Lin Yang and Michael J. Mann

    Citation: Journal of Biomedical Science 2017 24:89

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  24. Content type: Research

    The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enh...

    Authors: Lorrany dos Santos Franco, Paloma Oliveira Vidal and Jaime Henrique Amorim

    Citation: Journal of Biomedical Science 2017 24:88

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  25. Content type: Review

    Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc’s dynamic role as an insulin mimetic and a cellula...

    Authors: Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal and Stephen Myers

    Citation: Journal of Biomedical Science 2017 24:87

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  26. Content type: Research

    This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascula...

    Authors: Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen and Li-Chin Sung

    Citation: Journal of Biomedical Science 2017 24:85

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  27. Content type: Review

    Blood pressure control with renin-angiotensin system (RAS) blockade has remained the gold standard for treating patients with proteinuric chronic kidney disease (CKD) up to date. Nevertheless, RAS blockade slo...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin and Tun-Jun Tsai

    Citation: Journal of Biomedical Science 2017 24:84

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  28. Content type: Research

    Cells adapt to hypoxia by transcriptional induction of genes that participate in regulation of angiogenesis, glucose metabolism and cell proliferation. The primary factors mediating cell response to low oxygen...

    Authors: Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Anna Lipińska, Lech Pomorski, Marek Wieczorek, Magdalena Bryś, Ewa Forma and Anna Krześlak

    Citation: Journal of Biomedical Science 2017 24:83

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  29. Content type: Research

    Both H. pylori infection and diabetes increase the risk of gastric cancer. This study investigated whether patients with type 2 diabetes mellitus (T2DM) and H. pylori infection had more severe corpus gastric infl...

    Authors: Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2017 24:82

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  30. Content type: Research

    Luteinizing hormone-releasing hormone (LH-RH) agonists are the standard for androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. Current guidelines recommend serum testosterone measurement to ...

    Authors: Juan Morote, Imma Comas, Roser Ferrer, Jacques Planas, Anna Celma and Lucas Regis

    Citation: Journal of Biomedical Science 2017 24:81

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  31. Content type: Research

    Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+

    Authors: Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya

    Citation: Journal of Biomedical Science 2017 24:79

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  32. Content type: Research

    Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely...

    Authors: Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G. Weiss, Daniela Panáková and Stéphanie Lucas

    Citation: Journal of Biomedical Science 2017 24:78

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  33. Content type: Research

    Several tumour necrosis factor (TNF) based therapeutics have already been approved for human use and several others are emerging. Therefore, we determined the mRNA expression levels of the TNF superfamily liga...

    Authors: Satish Kumar Devarapu, Julia Felicitas Grill, Junhui Xie, Marc Weidenbusch, Mohsen Honarpisheh, Volker Vielhauer, Hans-Joachim Anders and Shrikant R. Mulay

    Citation: Journal of Biomedical Science 2017 24:77

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  34. Content type: Review

    Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer’s disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, R...

    Authors: Waqar Ahmad, Bushra Ijaz, Khadija Shabbiri, Fayyaz Ahmed and Sidra Rehman

    Citation: Journal of Biomedical Science 2017 24:76

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  35. Content type: Research

    Matrix metalloproteinases (MMPs) are known to play an important role in the degradation of the extracellular matrix and the pathological progression of osteoarthritis (OA). The natural polyphenolic compound ro...

    Authors: Seong-Hui Eo and Song Ja Kim

    Citation: Journal of Biomedical Science 2017 24:75

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  36. Content type: Review

    Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2–3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiova...

    Authors: Maria Joao Paiva-Lopes and José Delgado Alves

    Citation: Journal of Biomedical Science 2017 24:73

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  37. Content type: Research

    The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide. Its biological activity is also largely det...

    Authors: Miroslava Majzúnová, Zuzana Pakanová, Peter Kvasnička, Peter Bališ, Soňa Čačányiová and Ima Dovinová

    Citation: Journal of Biomedical Science 2017 24:72

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  38. Content type: Review

    Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in ...

    Authors: Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang and Nigel H. Greig

    Citation: Journal of Biomedical Science 2017 24:71

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  39. Content type: Review

    Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence....

    Authors: Chih-Hao Wang and Yau-Huei Wei

    Citation: Journal of Biomedical Science 2017 24:70

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  40. Content type: Research

    The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...

    Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen and Yijuang Chern

    Citation: Journal of Biomedical Science 2017 24:68

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  41. Content type: Research

    The aim of this study was to determine the biofilm formation, the extracellular enzymatic activities of 182 clinical isolates of the Candida parapsilosis complex.

    Authors: Sourour Neji, Ines Hadrich, Houaida Trabelsi, Salma Abbes, Fatma Cheikhrouhou, Hayet Sellami, Fattouma Makni and Ali Ayadi

    Citation: Journal of Biomedical Science 2017 24:67

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  42. Content type: Research

    Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence repr...

    Authors: Omar A.H. Ahmed-Farid, Maha Nasr, Rania F. Ahmed and Rofanda M. Bakeer

    Citation: Journal of Biomedical Science 2017 24:66

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  43. Content type: Review

    This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO...

    Authors: Yuling Zhou, Brett D. Hambly and Craig S. McLachlan

    Citation: Journal of Biomedical Science 2017 24:65

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  44. Content type: Review

    Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excr...

    Authors: Leszek Szablewski

    Citation: Journal of Biomedical Science 2017 24:64

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