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  1. The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of ...

    Authors: Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen and Huey-Ling Chen
    Citation: Journal of Biomedical Science 2021 28:19
  2. Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, ...

    Authors: Chia-Hung Chien, Wei-Ting Hsueh, Jian-Ying Chuang and Kwang-Yu Chang
    Citation: Journal of Biomedical Science 2021 28:18
  3. Innate immunity is the first line of host defense against viral infection. After invading into the cells, pathogen-associated-molecular-patterns derived from viruses are recognized by pattern recognition recep...

    Authors: Rongzhao Zhang, Zhixin Li, Yan-Dong Tang, Chenhe Su and Chunfu Zheng
    Citation: Journal of Biomedical Science 2021 28:17
  4. Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins...

    Authors: Ming-Hsiang Hong, I-Chun Weng, Fang-Yen Li, Wei-Han Lin and Fu-Tong Liu
    Citation: Journal of Biomedical Science 2021 28:16
  5. Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs in up to a third of patients, is relatively neglected as research focus, despite its significant...

    Authors: T. Ollewagen, K. H. Myburgh, M. van de Vyver and C. Smith
    Citation: Journal of Biomedical Science 2021 28:15
  6. Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have...

    Authors: Juan de los Santos-Jiménez, José A. Campos-Sandoval, Clara Márquez-Torres, Nieves Urbano-Polo, David Brøndegaard, Mercedes Martín-Rufián, Carolina Lobo, Ana Peñalver, María C. Gómez-García, Janet Martín-Campos, Carolina Cardona, Laura Castilla, Felipe da Costa Souza, Tzuling Cheng, Juan A. Segura, Francisco J. Alonso…
    Citation: Journal of Biomedical Science 2021 28:14
  7. Although the availability of therapeutic options including temozolomide, radiotherapy and some target agents following neurosurgery, the prognosis of glioma patients remains poor. Thus, there is an urgent nee...

    Authors: Hong-Qing Cai, Min-Jie Zhang, Zhi-Jian Cheng, Jing Yu, Qing Yuan, Jin Zhang, Yan Cai, Li-Yan Yang, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang and Jing-Hai Wan
    Citation: Journal of Biomedical Science 2021 28:13
  8. Helicobacter pylori-mediated gastric carcinogenesis is initiated by a plethora of signaling events in the infected gastric epithelial cells (GECs). The E3 ubiquitin ligase seven in absentia homolog 2 (Siah2) is i...

    Authors: Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh and Asima Bhattacharyya
    Citation: Journal of Biomedical Science 2021 28:12
  9. Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the app...

    Authors: Tomasz Klaus and Sameer Deshmukh
    Citation: Journal of Biomedical Science 2021 28:11
  10. Viruses from the genus Enterovirus (EV) of the Picornaviridae family are known to cause diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis and myocarditis. The capsid of EV is...

    Authors: Mohd Ishtiaq Anasir, Faisal Zarif and Chit Laa Poh
    Citation: Journal of Biomedical Science 2021 28:10
  11. Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse ...

    Authors: Ioannis P. Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E. Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N. Pavlakis and Meletios A. Dimopoulos
    Citation: Journal of Biomedical Science 2021 28:9
  12. Congenital myopathy (CM) is a group of clinically and genetically heterogeneous muscle disorders, characterized by muscle weakness and hypotonia from birth. Currently, no definite treatment exists for CM. A de...

    Authors: Po-Jui Hsu, Horng-Dar Wang, Yung-Che Tseng, Shao-Wei Pan, Bonifasius Putera Sampurna, Yuh-Jyh Jong and Chiou-Hwa Yuh
    Citation: Journal of Biomedical Science 2021 28:8
  13. The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish...

    Authors: Ming-Wei Kuo, Hsiu-Hui Tsai, Sheng-Hung Wang, Yi-Yin Chen, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2021 28:7
  14. The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin...

    Authors: Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker and Lee-Young Chau
    Citation: Journal of Biomedical Science 2021 28:5
  15. Circular RNAs (circRNAs) have caught increasing attentions and interests for their important involvement in cancer initiation and progression. This study aims to investigate the biological functions of circNOL...

    Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu
    Citation: Journal of Biomedical Science 2021 28:4

    The Correction to this article has been published in Journal of Biomedical Science 2021 28:31

  16. Successful pregnancy is supported by a healthy maternal–fetal interface (i.e., the decidual tissues) which holds the conceptus and safeguards it against stressors from the beginning of pregnancy. Any disturban...

    Authors: Paz de la Torre, Miguel Fernández-de la Torre and Ana I. Flores
    Citation: Journal of Biomedical Science 2021 28:3
  17. The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after treatment with DNA damage agents. O6-methylguanine DNA methyltransferase (MGMT...

    Authors: Shang-Hung Chen, Wen-Tsung Huang, Wan-Chen Kao, Sheng-Yen Hsiao, Hsin-Yi Pan, Chin-Wen Fang, Yow-Ling Shiue, Chia-Lin Chou and Chien-Feng Li
    Citation: Journal of Biomedical Science 2021 28:2
  18. Emergence of Candida glabrata, which causes potential life-threatening invasive candidiasis, has been widely associated with high morbidity and mortality. In order to cause disease in vivo, a robust and highly ef...

    Authors: Shu Yih Chew, Alistair J. P. Brown, Benjamin Yii Chung Lau, Yoke Kqueen Cheah, Kok Lian Ho, Doblin Sandai, Hassan Yahaya and Leslie Thian Lung Than
    Citation: Journal of Biomedical Science 2021 28:1
  19. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the most challenging pandemic in this century. Cons...

    Authors: Yen-Der Li, Wei-Yu Chi, Jun-Han Su, Louise Ferrall, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2020 27:104
  20. Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morph...

    Authors: Hsiao-Tang Hu, Tzyy-Nan Huang and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2020 27:103
  21. Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover...

    Authors: Maria García-Ricobaraza, Mercedes García-Bermúdez, Francisco J. Torres-Espinola, M. Teresa Segura Moreno, Mathieu N. Bleyere, Ligia E. Díaz-Prieto, Esther Nova, Ascensión Marcos and Cristina Campoy
    Citation: Journal of Biomedical Science 2020 27:101
  22. Esophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility....

    Authors: Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and Hung-Chi Cheng
    Citation: Journal of Biomedical Science 2020 27:102
  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nithya Subramanian, Jagat R. Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rupinder K. Kanwar, Sailaja Eluchuri and Subramanian Krishnakumar
    Citation: Journal of Biomedical Science 2020 27:100

    The original article was published in Journal of Biomedical Science 2015 22:4

  24. Global ischemia is the resulting effect of a cardiopulmonary arrest (CPA). Presently there is no effective treatment to address neurological deficits in patients who survived a CPA. Granulocyte-colony stimulat...

    Authors: Janet M. Menzie-Suderam, Jigar Modi, Hongyaun Xu, Andrew Bent, Paula Trujillo, Kristen Medley, Eugenia Jimenez, Jessica Shen, Michael Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2020 27:99
  25. Post-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent addition of a small chemi...

    Authors: Prithviraj Manohar Vijaya Shetty, Ashraf Yusuf Rangrez and Norbert Frey
    Citation: Journal of Biomedical Science 2020 27:98
  26. A lung transplant is the last resort treatment for many patients with advanced lung disease. The majority of donated lungs come from donors following brain death (BD). The endothelin axis is upregulated in the...

    Authors: K. Walweel, K. Skeggs, A. C. Boon, L. E. See Hoe, M. Bouquet, N. G. Obonyo, S. E. Pedersen, S. D. Diab, M. R. Passmore, K. Hyslop, E. S. Wood, J. Reid, S. M. Colombo, N. J. Bartnikowski, M. A. Wells, D. Black…
    Citation: Journal of Biomedical Science 2020 27:96
  27. The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell research initiatives and provide a platform for researchers interested in utilizing induced pluripotent...

    Authors: Ching-Ying Huang, Ling-Hui Li, Wan-Tseng Hsu, Yu-Che Cheng, Martin W. Nicholson, Chun-Lin Liu, Chien-Yu Ting, Hui-Wen Ko, Shih-Han Syu, Cheng-Hao Wen, Zhuge Yan, Hsiang-Po Huang, Hong-Lin Su, Po-Min Chiang, Chia-Ning Shen, Hsin-Fu Chen…
    Citation: Journal of Biomedical Science 2020 27:92
  28. Preconditioning before bone marrow transplantation such as irradiation causes vascular endothelial cells damage and promoting the repair of damaged endothelial cells is beneficial for hematopoietic reconstitut...

    Authors: Wen Ju, Wenyi Lu, Lan Ding, Yurong Bao, Fei Hong, Yuting Chen, Hui Gao, Xiaoqi Xu, Guozhang Wang, Weiwei Wang, Xi Zhang, Chunling Fu, Kunming Qi, Zhenyu Li, Kailin Xu, Jianlin Qiao…
    Citation: Journal of Biomedical Science 2020 27:91
  29. The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is ess...

    Authors: Francesco Petragnano, Ilaria Pietrantoni, Simona Camero, Silvia Codenotti, Luisa Milazzo, Francesca Vulcano, Giampiero Macioce, Ilenia Giordani, Paolo Tini, Sara Cheleschi, Giovanni Luca Gravina, Claudio Festuccia, Alessandra Rossetti, Simona Delle Monache, Alessandra Ordinelli, Carmela Ciccarelli…
    Citation: Journal of Biomedical Science 2020 27:90
  30. Salmonella enterica serotype Typhimurium is a nontyphoidal and common foodborne pathogen that causes serious threat to humans. There is no licensed vaccine to prevent the nontyphoid bacterial infection caused by

    Authors: Tzu-Wei Chiu, Chi-Jiun Peng, Ming-Cheng Chen, Mei-Hua Hsu, Yi-Hua Liang, Cheng-Hsun Chiu, Jim-Min Fang and Yuan Chuan Lee
    Citation: Journal of Biomedical Science 2020 27:89
  31. Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV program...

    Authors: Ching-Fen Shen, Shih-Min Wang, Hsin Chi, Yi-Chuan Huang, Li-Min Huang, Yhu-Chering Huang, Hsiao-Chuan Lin, Yu-Huai Ho, Chao A. Hsiung and Ching-Chuan Liu
    Citation: Journal of Biomedical Science 2020 27:88
  32. The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The act...

    Authors: Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki and Hideki Shibata
    Citation: Journal of Biomedical Science 2020 27:87
  33. Extraintestinal pathogenic E. coli (ExPEC) is a common gram-negative organism causing various infections, including urinary tract infections (UTIs), bacteremia, and neonatal meningitis. The cjrABC-senB gene clust...

    Authors: Wen-Chun Huang, Yi-Jyun Liao, Masayuki Hashimoto, Kuan-Fu Chen, Chishih Chu, Po-Chuen Hsu, Shuying Wang and Ching-Hao Teng
    Citation: Journal of Biomedical Science 2020 27:86
  34. Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic pepti...

    Authors: Iosu Rázquin-Olazarán, Hawraa Shahrour and Guillermo Martínez-de-Tejada
    Citation: Journal of Biomedical Science 2020 27:85
  35. Precision medicine is becoming the standard of care in anti-cancer treatment. The personalized precision management of cancer patients highly relies on the improvement of new technology in next generation sequ...

    Authors: Wen-Chi Yang, Feng-Ming Hsu and Pan-Chyr Yang
    Citation: Journal of Biomedical Science 2020 27:82
  36. Recent trials have shown promise in intra-arterial thrombectomy after the first 6–24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management....

    Authors: Duen-Pang Kuo, Po-Chih Kuo, Yung-Chieh Chen, Yu-Chieh Jill Kao, Ching-Yen Lee, Hsiao-Wen Chung and Cheng-Yu Chen
    Citation: Journal of Biomedical Science 2020 27:80
  37. 5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methylt...

    Authors: Kenneth K. Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee and Jun-Yang Liou
    Citation: Journal of Biomedical Science 2020 27:79
  38. N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein.....

    Authors: Ying-Nai Wang, Heng-Huan Lee, Jennifer L. Hsu, Dihua Yu and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2020 27:77
  39. Monoclonal antibodies (mAbs) are a major targeted therapy for malignancies, infectious diseases, autoimmune diseases, transplant rejection and chronic inflammatory diseases due to their antigen specificity and...

    Authors: Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang and Tian-Lu Cheng
    Citation: Journal of Biomedical Science 2020 27:76
  40. ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to the tumorigenesis of lung cancer, howeve...

    Authors: Chantal Hoi Yin Cheung, Chia-Lang Hsu, Tsai-Yu Lin, Wei-Ting Chen, Yi-Ching Wang, Hsuan-Cheng Huang and Hsueh-Fen Juan
    Citation: Journal of Biomedical Science 2020 27:75
  41. Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have ...

    Authors: Radha Gopalaswamy, Sivakumar Shanmugam, Rajesh Mondal and Selvakumar Subbian
    Citation: Journal of Biomedical Science 2020 27:74

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