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  1. Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progres...

    Authors: María Belén Vecchione, Natalia Laufer, Omar Sued, Marcelo Corti, Horacio Salomon and Maria Florencia Quiroga

    Citation: Journal of Biomedical Science 2020 27:20

    Content type: Research

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  2. Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Prese...

    Authors: Li-Kai Huang, Shu-Ping Chao and Chaur-Jong Hu

    Citation: Journal of Biomedical Science 2020 27:18

    Content type: Review

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  3. Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replicati...

    Authors: Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih and Jen-Ren Wang

    Citation: Journal of Biomedical Science 2020 27:17

    Content type: Research

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  4. Over-stimulation of dopamine signaling is thought to underlie the pathophysiology of a list of mental disorders, such as psychosis, mania and attention-deficit/hyperactivity disorder. These disorders are frequ...

    Authors: Pi-Kai Chang, Jung Chu, Ya-Ting Tsai, Yan-Heng Lai and Jin-Chung Chen

    Citation: Journal of Biomedical Science 2020 27:16

    Content type: Research

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  6. Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections...

    Authors: Wen-Chun Huang, Chung-Yen Lin, Masayuki Hashimoto, Jiunn-Jong Wu, Ming-Cheng Wang, Wei-Hung Lin, Chang-Shi Chen and Ching-Hao Teng

    Citation: Journal of Biomedical Science 2020 27:14

    Content type: Research

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  7. Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to d...

    Authors: Torsten Voigtländer, Jochen Metzger, Holger Husi, Martha M. Kirstein, Martin Pejchinovski, Agnieszka Latosinska, Maria Frantzi, William Mullen, Thorsten Book, Harald Mischak and Michael P. Manns

    Citation: Journal of Biomedical Science 2020 27:13

    Content type: Research

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  8. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang

    Citation: Journal of Biomedical Science 2020 27:11

    Content type: Research

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  11. Bacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host. In ...

    Authors: Haejeong Lee, Juyoun Shin, Yeun-Jun Chung, Myungseo Park, Kyeong Jin Kang, Jin Yang Baek, Dongwoo Shin, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song and Kwan Soo Ko

    Citation: Journal of Biomedical Science 2020 27:8

    Content type: Research

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  12. Today, the treatment of bacterial infections is a major challenge, due to growing rate of multidrug-resistant bacteria, complication of treatment and increased healthcare costs. Moreover, new treatments for ba...

    Authors: Shima Afrasiabi, Maryam Pourhajibagher, Reza Raoofian, Maryam Tabarzad and Abbas Bahador

    Citation: Journal of Biomedical Science 2020 27:6

    Content type: Review

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  13. Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal and there is currently no effective antiviral agent or vaccine. The only licensed vaccine, Dengvaxia, has low efficacy...

    Authors: Rui Rui Wong, Noraini Abd-Aziz, Sarah Affendi and Chit Laa Poh

    Citation: Journal of Biomedical Science 2020 27:4

    Content type: Review

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  14. Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated in several solid tumors. We have prev...

    Authors: Jing-You Guo, Chu-Hsuan Chiu, Mei-Jung Wang, Fu-An Li and Jeou-Yuan Chen

    Citation: Journal of Biomedical Science 2020 27:2

    Content type: Research

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  15. It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatica...

    Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li and Han-Chung Wu

    Citation: Journal of Biomedical Science 2020 27:1

    Content type: Review

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  16. In the original publication of this article [1] the name of the fifth author is uncorrect. The correct name of the fifth author should be Wei-Chiao Chang rather than Wei-Chao Chang. The original publication ha...

    Authors: Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang and Yun Yen

    Citation: Journal of Biomedical Science 2019 26:98

    Content type: Correction

    Published on:

    The original article was published in Journal of Biomedical Science 2019 26:96

  17. Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodie...

    Authors: Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman and Shie-Liang Hsieh

    Citation: Journal of Biomedical Science 2019 26:97

    Content type: Research

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  18. Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic...

    Authors: Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang and Yun Yen

    Citation: Journal of Biomedical Science 2019 26:96

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:98

  20. Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain ...

    Authors: Yu-Jia Wang, Henry Sung-Ching Wong, Chung-Che Wu, Yung-Hsiao Chiang, Wen-Ta Chiu, Kai-Yun Chen and Wei-Chiao Chang

    Citation: Journal of Biomedical Science 2019 26:94

    Content type: Research

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  21. Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and Chi...

    Authors: An-Ting Liou, Chun-Che Liao, Shu-Fan Chou, Ya-Shu Chang, Chih-Shin Chang and Chiaho Shih

    Citation: Journal of Biomedical Science 2019 26:93

    Content type: Research

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  22. Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms a...

    Authors: Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori, Mehrnaz Mehrabani and Saeedeh Salimi

    Citation: Journal of Biomedical Science 2019 26:92

    Content type: Research

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  23. Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, wit...

    Authors: Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang and Fuu-Jen Tsai

    Citation: Journal of Biomedical Science 2019 26:91

    Content type: Research

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  24. Toll-like receptors (TLRs) are well known as critical pattern recognition receptors that trigger innate immune responses. In addition, TLRs are expressed in neurons and may act as the gears in the neuronal det...

    Authors: Chiung-Ya Chen, Yi-Chun Shih, Yun-Fen Hung and Yi-Ping Hsueh

    Citation: Journal of Biomedical Science 2019 26:90

    Content type: Review

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  25. Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying stra...

    Authors: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum and Thierry Burnouf

    Citation: Journal of Biomedical Science 2019 26:89

    Content type: Research

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  26. Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review intr...

    Authors: Jyong-Huei Lee, Kuan-Lun Ho and Shih-Kang Fan

    Citation: Journal of Biomedical Science 2019 26:88

    Content type: Review

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  27. The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based d...

    Authors: Ching-Ying Huang, Chun-Lin Liu, Chien-Yu Ting, Yueh-Ting Chiu, Yu-Che Cheng, Martin W. Nicholson and Patrick C. H. Hsieh

    Citation: Journal of Biomedical Science 2019 26:87

    Content type: Review

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  31. Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and ...

    Authors: María Ángeles JIMÉNEZ-SOUSA, José Luis JIMÉNEZ, Amanda FERNÁNDEZ-RODRÍGUEZ, José María BELLÓN, Carmen RODRÍGUEZ, Melchor RIERA, Joaquín PORTILLA, Ángeles CASTRO, María Ángeles MUÑOZ-FERNÁNDEZ and Salvador RESINO

    Citation: Journal of Biomedical Science 2019 26:83

    Content type: Research

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  32. MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and identified as an upstream activator of the MAPK J...

    Authors: Huai-Chia Chuang and Tse-Hua Tan

    Citation: Journal of Biomedical Science 2019 26:82

    Content type: Review

    Published on:

  34. Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degr...

    Authors: Ruey-Hwa Chen, Yu-Hsuan Chen and Tzu-Yu Huang

    Citation: Journal of Biomedical Science 2019 26:80

    Content type: Review

    Published on:

  36. In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor...

    Authors: Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang and Zhengzhi Zou

    Citation: Journal of Biomedical Science 2019 26:78

    Content type: Review

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  37. Intratumor subsets with tumor-initiating features in glioblastoma are likely to survive treatment. Our goal is to identify the key factor in the process by which cells develop temozolomide (TMZ) resistance.

    Authors: Chia-Hung Chien, Jian-Ying Chuang, Shun-Tai Yang, Wen-Bin Yang, Pin-Yuan Chen, Tsung-I Hsu, Chih-Yuan Huang, Wei-Lun Lo, Ka-Yen Yang, Ming-Sheng Liu, Jui-Mei Chu, Pei-Hsuan Chung, Jr-Jiun Liu, Shao-Wen Chou, Shang-Hung Chen and Kwang-Yu Chang

    Citation: Journal of Biomedical Science 2019 26:77

    Content type: Research

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  38. The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses ...

    Authors: Daria Mezhenskaya, Irina Isakova-Sivak and Larisa Rudenko

    Citation: Journal of Biomedical Science 2019 26:76

    Content type: Review

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  39. Enterovirus A71 (EV-A71) is one of the common causative pathogens for hand foot and mouth disease (HFMD) affecting young children. HFMD outbreak can result in a substantial pediatric hospitalization and burden...

    Authors: Jiratchaya Puenpa, Nasamon Wanlapakorn, Sompong Vongpunsawad and Yong Poovorawan

    Citation: Journal of Biomedical Science 2019 26:75

    Content type: Review

    Published on:

  40. Complex regional pain syndrome (CRPS) is related to microcirculation impairment caused by tissue hypoxia and peripheral cytokine overproduction in the affected human limb and chronic post-ischemic pain (CPIP) ...

    Authors: Hung-Tsung Hsiao, Yuan-Yuarn Liu, Jeffrey Chi-Fei Wang, Ya-Chi Lin and Yen-Chin Liu

    Citation: Journal of Biomedical Science 2019 26:74

    Content type: Research

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  41. Soft materials have been developed very rapidly in the biomedical field over the past 10 years because of advances in medical devices, cell therapy, and 3D printing for precision medicine. Smart polymers are o...

    Authors: Hung-Jin Huang, Yu-Liang Tsai, Shih-Ho Lin and Shan-hui Hsu

    Citation: Journal of Biomedical Science 2019 26:73

    Content type: Review

    Published on:

  42. Transforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis. Currently, there are no effective agents targeting TGF-β s...

    Authors: Ying-Jen Chen, Shih-Ming Huang, Ming-Cheng Tai, Jiann-Torng Chen and Chang-Min Liang

    Citation: Journal of Biomedical Science 2019 26:72

    Content type: Research

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  43. Atrial fibrillation (AF) frequently coexists with congestive heart failure (HF) and arginine vasopressin (AVP) V1 receptor antagonists are used to treat hyponatremia in HF. However, the role of AVP in HF-induc...

    Authors: Jen-Hung Huang, Yao-Chang Chen, Yen-Yu Lu, Yung-Kuo Lin, Shih-Ann Chen and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2019 26:71

    Content type: Research

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  44. Currently available anti-influenza drugs are often associated with limitations such as toxicity and the appearance of drug-resistant strains. Therefore, there is a pressing need for the development of novel, s...

    Authors: Hadi Ghaffari, Ahmad Tavakoli, Abdolvahab Moradi, Alijan Tabarraei, Farah Bokharaei-Salim, Masoumeh Zahmatkeshan, Mohammad Farahmand, Davod Javanmard, Seyed Jalal Kiani, Maryam Esghaei, Vahid Pirhajati-Mahabadi, Seyed Hamidreza Monavari and Angila Ataei-Pirkooh

    Citation: Journal of Biomedical Science 2019 26:70

    Content type: Research

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  45. This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhib...

    Authors: Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata and Ebthag M. Awad

    Citation: Journal of Biomedical Science 2019 26:69

    Content type: Research

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  46. Increasing evidence suggests that high glucose (HG) causes abnormalities in endothelial and vascular smooth muscle cell function (VSMC) and contributes to atherosclerosis. Receptor for advanced glycation end-p...

    Authors: Sheng-Chiang Su, Yi-Jen Hung, Chia-Luen Huang, Yi-Shing Shieh, Chu-Yen Chien, Chi-Fu Chiang, Jhih-Syuan Liu, Chieh-Hua Lu, Chang-Hsun Hsieh, Chien-Ming Lin and Chien-Hsing Lee

    Citation: Journal of Biomedical Science 2019 26:68

    Content type: Research

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  47. Different neurological disorders frequently display antibodies against several self-glycans. Increasing evidence supports their pathogenic role; however, far less is known about their origin. Meanwhile, antibo...

    Authors: Ricardo Dante Lardone, Fernando José Irazoqui and Gustavo Alejandro Nores

    Citation: Journal of Biomedical Science 2019 26:67

    Content type: Research

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  48. After the publication of this article [1], the authors would like to clarify that some immunoblotting data in Figs. 2f, 3a and 4b were obtained from the same samples but individual SDS-PAGE gels.

    Authors: Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu and Wan-Wan Lin

    Citation: Journal of Biomedical Science 2019 26:66

    Content type: Correction

    Published on:

    The original article was published in Journal of Biomedical Science 2019 26:40

  49. Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or sev...

    Authors: Jing-Yi Lin, Yu-An Kung and Shin-Ru Shih

    Citation: Journal of Biomedical Science 2019 26:65

    Content type: Review

    Published on:

  50. Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activat...

    Authors: Dong-Yan Tsai, Kuo-Hsuan Hung, Chia-Wei Chang and Kuo-I Lin

    Citation: Journal of Biomedical Science 2019 26:64

    Content type: Review

    Published on:

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ISSN: 1423-0127