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  2. Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNALys gene, and usually manifested as complex neur...

    Authors: Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma and Yau-Huei Wei
    Citation: Journal of Biomedical Science 2023 30:70
    Content type: Research Published on:

  3. Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. ...

    Authors: Howida M. Nail, Chien-Chih Chiu, Chung-Hang Leung, Mahmoud M. M. Ahmed and Hui-Min David Wang
    Citation: Journal of Biomedical Science 2023 30:69
    Content type: Review Published on:

  4. KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at...

    Authors: Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen and Ming-Hsien Chien
    Citation: Journal of Biomedical Science 2023 30:68
    Content type: Research Published on:

  5. Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied. In the context of the current global antimicrobial resistan...

    Authors: Claudia C. Paredes-Amaya, María Teresa Ulloa and Víctor Antonio García-Angulo
    Citation: Journal of Biomedical Science 2023 30:67
    Content type: Review Published on:

  6. Parkinson’s disease (PD) is the second most frequent age-related neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both environmental and genetic aspects are involved in the ...

    Authors: Jun Sung Park, Kyonghwan Choe, Hyeon Jin Lee, Tae Ju Park and Myeong Ok Kim
    Citation: Journal of Biomedical Science 2023 30:66
    Content type: Research Published on:

  7. Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin...

    Authors: Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo and Chamindie Punyadeera
    Citation: Journal of Biomedical Science 2023 30:65
    Content type: Review Published on:

  8. Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger associated molecular patterns (...

    Authors: Reiner Kunze, Silvia Fischer, Hugo H. Marti and Klaus T. Preissner
    Citation: Journal of Biomedical Science 2023 30:64
    Content type: Review Published on:

  9. Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p....

    Authors: Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo and Min-Xin Guan
    Citation: Journal of Biomedical Science 2023 30:63
    Content type: Research Published on:

  10. Excess polymorphonuclear neutrophil (PMN) recruitment or excessive neutrophil extracellular trap (NET) formation can lead to the development of multiple organ dysfunction during sepsis. M2 macrophage-derived e...

    Authors: Yang Jiao, Ti Zhang, Mei Liu, Luyang Zhou, Mengzhi Qi, Xin Xie, Xueyin Shi, Xiaoping Gu and Zhengliang Ma
    Citation: Journal of Biomedical Science 2023 30:62
    Content type: Research Published on:

  12. Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. In combination with immune checkpoint blockade (ICB), epigenetic modification-...

    Authors: M A A Mamun, Yu Zhang, Jin-Yuan Zhao, Dan-Dan Shen, Ting Guo, Yi-Chao Zheng, Li-Juan Zhao and Hong-Min Liu
    Citation: Journal of Biomedical Science 2023 30:60
    Content type: Review Published on:

  13. The COVID-19 pandemic continues to pose a significant worldwide threat to human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic antibodies and the ability to evade vaccination...

    Authors: Hsiao-Ling Chiang, Kang-Hao Liang, Ruei-Min Lu, Ting-Wen Kuo, Yi‑Ling Lin and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:59
    Content type: Research Published on:

  14. Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important consequences for disease diagnosis and treatment. In addition to the many genetic and non-genetic (e.g., epige...

    Authors: Y. Henry Sun, Yueh-Lin Wu and Ben-Yang Liao
    Citation: Journal of Biomedical Science 2023 30:58
    Content type: Review Published on:

  15. Supplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation attenuates respiratory viral infection in mice and exhibits anti-inflammatory eff...

    Authors: Chung-Ming Chen, Yu-Chen S. H. Yang, Hsiu-Chu Chou and Shan Lin
    Citation: Journal of Biomedical Science 2023 30:57
    Content type: Research Published on:

  16. The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transme...

    Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala and Dinakar M. Salunke
    Citation: Journal of Biomedical Science 2023 30:56
    Content type: Research Published on:

  17. Sustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly activated by cAMP (Epac1 and Epac2) as key mediators. This study aimed to e...

    Authors: Yi-Hsin Chan, Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen and Yung-Hsin Yeh
    Citation: Journal of Biomedical Science 2023 30:55
    Content type: Research Published on:

  18. Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2023 30:54
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2022 29:109

  20. Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/o...

    Authors: Patience Shumba, Thomas Sura, Kirsten Moll, Bhavya Chakrakodi, Lea A. Tölken, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
    Citation: Journal of Biomedical Science 2023 30:52
    Content type: Research Published on:

  21. Genome editing technologies hold great promise for numerous applications including the understanding of cellular and disease mechanisms and the development of gene and cellular therapies. Achieving high editin...

    Authors: Nanna S. Mikkelsen and Rasmus O. Bak
    Citation: Journal of Biomedical Science 2023 30:51
    Content type: Review Published on:

  22. Sotorasib is the first KRASG12C inhibitor approved by the US Food and Drug Administration for treating KRASG12C-mutant non-small-cell lung cancer (NSCLC). Clinical trials on the therapeutic use of sotorasib for c...

    Authors: Li-Wen Chiou, Chien-Hui Chan, Yu-Ling Jhuang, Ching-Yao Yang and Yung-Ming Jeng
    Citation: Journal of Biomedical Science 2023 30:50
    Content type: Research Published on:

  23. The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interacti...

    Authors: Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka and Raymond Kaempfer
    Citation: Journal of Biomedical Science 2023 30:49
    Content type: Research Published on:

  25. A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immuno...

    Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye and Ping Lan
    Citation: Journal of Biomedical Science 2023 30:47
    Content type: Research Published on:

  26. Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) vi...

    Authors: Monika Kumari, Shih-Chieh Su, Kang-Hao Liang, Hsiu-Ting Lin, Yu-Feng Lu, Kai-Chi Chen, Wan-Yu Chen and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:46
    Content type: Research Published on:

  27. Emerging research has reported that circular RNAs (circRNAs) play important roles in cardiac cell death after myocardial ischemia and reperfusion (I/R). Ferroptosis, a new form of cell death discovered in rece...

    Authors: Jie Ju, Xin-Min Li, Xue-Mei Zhao, Fu-Hai Li, Shao-Cong Wang, Kai Wang, Rui-Feng Li, Lu-Yu Zhou, Lin Liang, Yin Wang, Yu-Hui Zhang and Kun Wang
    Citation: Journal of Biomedical Science 2023 30:45
    Content type: Research Published on:

  28. Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation...

    Authors: Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang and Hai Hu
    Citation: Journal of Biomedical Science 2023 30:44
    Content type: Research Published on:

  30. The global burden of invasive fungal infections (IFIs) has shown an upsurge in recent years due to the higher load of immunocompromised patients suffering from various diseases. The role of early and accurate ...

    Authors: Wenjie Fang, Junqi Wu, Mingrong Cheng, Xinlin Zhu, Mingwei Du, Chang Chen, Wanqing Liao, Kangkang Zhi and Weihua Pan
    Citation: Journal of Biomedical Science 2023 30:42
    Content type: Review Published on:

  31. Flavivirus causes many serious public health problems worldwide. However, licensed DENV vaccine has restrictions on its use, and there is currently no approved ZIKV vaccine. Development of a potent and safe fl...

    Authors: Li-Chen Yen, Hsin-Wei Chen, Chia-Lo Ho, Chang-Chi Lin, Yi-Ling Lin, Qiao-Wen Yang, Kuo-Chou Chiu, Shu-Pei Lien, Ren-Jye Lin and Ching-Len Liao
    Citation: Journal of Biomedical Science 2023 30:41
    Content type: Research Published on:

  32. Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fib...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2023 30:40
    Content type: Research Published on:

  33. Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10) contributes to distant migration of PDAC. The role of KLF1...

    Authors: Yi-Chih Tsai, Kung Hung Cheng, Shih Sheng Jiang, John R. Hawse, Shun En Chuang, Su Liang Chen, Tze-Sing Huang and Hui-Ju Ch’ang
    Citation: Journal of Biomedical Science 2023 30:39
    Content type: Research Published on:

  34. The intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key player in the colonic microbiota that reside...

    Authors: Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris and Qiaozhu Su
    Citation: Journal of Biomedical Science 2023 30:38
    Content type: Research Published on:

  35. We investigated the presence of heteroresistance against both tigecycline and colistin in Acinetobacter baumannii and then evaluated the effectiveness of combined antibiotic treatment given the existence of discr...

    Authors: Jeongwoo Jo, Ki Tae Kwon and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:37
    Content type: Research Published on:

  36. Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment a...

    Authors: Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson and James R. Connor
    Citation: Journal of Biomedical Science 2023 30:36
    Content type: Research Published on:

  37. Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by laborious cell cul...

    Authors: Yi-Jou Chen, Michael Chen, Tian-Lu Cheng, Yi-Shan Tsai, Chang-Hung Wang, Che-Yi Chen, Tung-Yun Wu, Shey-Cherng Tzou, Kai-Hung Wang, Jing-Jy Cheng, An-Pei Kao, Shyr-Yi Lin and Kuo-Hsiang Chuang
    Citation: Journal of Biomedical Science 2023 30:35
    Content type: Research Published on:

  38. Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the stud...

    Authors: Rima Zein-Eddine, Guislaine Refrégier, Jorge Cervantes and Noemí Kaoru Yokobori
    Citation: Journal of Biomedical Science 2023 30:34
    Content type: Review Published on:

  39. The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved ...

    Authors: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau and Ruey-Bing Yang
    Citation: Journal of Biomedical Science 2023 30:33
    Content type: Review Published on:

  40. Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as...

    Authors: Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung and David K. Ann
    Citation: Journal of Biomedical Science 2023 30:32
    Content type: Research Published on:

  41. Klebsiella pneumoniae capsular types K1, K2, K5, K20, K54, and K57 are prevalent hypervirulent types associated with community infections, and worrisomely, hypervirulent strains that acquired drug resistance have...

    Authors: Jia-Wen Wu, Jin-Town Wang, Tzu-Lung Lin, Ya-Zhu Liu, Lii-Tzu Wu and Yi-Jiun Pan
    Citation: Journal of Biomedical Science 2023 30:31
    Content type: Research Published on:

  42. The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. T...

    Authors: Jaung-Geng Lin, Guan-Jhong Huang and Yi-Chang Su
    Citation: Journal of Biomedical Science 2023 30:30
    Content type: Review Published on:

  43. Gram-positive (G+) bacterial infection is a great burden to both healthcare and community medical resources. As a result of the increasing prevalence of multidrug-resistant G+ bacteria such as methicillin-resista...

    Authors: He Liu, Zhen Hu, Mengyang Li, Yi Yang, Shuguang Lu and Xiancai Rao
    Citation: Journal of Biomedical Science 2023 30:29
    Content type: Review Published on:

  44. Ingestion of alcoholic beverages is a known trigger of migraine attacks. However, whether and how ethanol exerts its pro-migraine action remains poorly known. Ethanol stimulates the transient receptor potentia...

    Authors: Lorenzo Landini, Daniel Souza Monteiro de Araujo, Martina Chieca, Gaetano De Siena, Elisa Bellantoni, Pierangelo Geppetti, Romina Nassini and Francesco De Logu
    Citation: Journal of Biomedical Science 2023 30:28
    Content type: Research Published on:

  45. Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-t...

    Authors: Yu-Ling Tseng, Po-Chao Lu, Chi-Chang Lee, Ruei-Yu He, Yung-An Huang, Yin-Chen Tseng, Ting-Jen Rachel Cheng, Joseph Jen-Tse Huang and Jim-Min Fang
    Citation: Journal of Biomedical Science 2023 30:27
    Content type: Research Published on:

  46. Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. ...

    Authors: Dong Suk Yoon, Yoorim Choi, Kyoung-Mi Lee, Eun Ae Ko, Eun-Ji Kim, Kwang Hwan Park and Jin Woo Lee
    Citation: Journal of Biomedical Science 2023 30:26
    Content type: Research Published on:

  47. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a clinically critical pathogen that causes severe infection. Due to improper antibiotic administration, the prevalence of CRKP infection has been increasing co...

    Authors: Yu-Ming Zhang, Mei-Fen Tsao, Ching-Yu Chang, Kuan-Ting Lin, Joseph Jordan Keller and Hsiu-Chen Lin
    Citation: Journal of Biomedical Science 2023 30:25
    Content type: Research Published on:

  48. Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased...

    Authors: Lisa J. Ioannidis, Stephanie I. Studniberg, Emily M. Eriksson, Suhendro Suwarto, Dionisius Denis, Yang Liao, Wei Shi, Alexandra L. Garnham, R. Tedjo Sasmono and Diana S. Hansen
    Citation: Journal of Biomedical Science 2023 30:24
    Content type: Research Published on:

  49. The tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the interaction between tumor and immune cells. The aim of this study was to...

    Authors: Changwu Wu, Siming Gong, Yingjuan Duan, Chao Deng, Sonja Kallendrusch, Laura Berninghausen, Georg Osterhoff and Nikolas Schopow
    Citation: Journal of Biomedical Science 2023 30:23
    Content type: Research Published on:

  50. The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS). In this s...

    Authors: Suyeon Park, Hyunkeun Kim and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:22
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127