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835 result(s) for 'review' within Journal of Biomedical Science

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  1. Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to be...

    Authors: Shania Abbas, Syed Tasleem Raza, Faisal Ahmed, Absar Ahmad, Saliha Rizvi and Farzana Mahdi
    Citation: Journal of Biomedical Science 2013 20:80
    Content type: Review Published on:

  3. The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair the ...

    Authors: Chiao-Chi V Chen, Yu-Chen Chen, Han-Yun Hsiao, Chen Chang and Yijuang Chern
    Citation: Journal of Biomedical Science 2013 20:47
    Content type: Review Published on:

  4. MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to invol...

    Authors: Pravin Kumar Singh, Ajay Vir Singh and Devendra Singh Chauhan
    Citation: Journal of Biomedical Science 2013 20:14
    Content type: Review Published on:

  5. The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a sing...

    Authors: Valentina Arrè, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro
    Citation: Journal of Biomedical Science 2023 30:90
    Content type: Review Published on:

  6. Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by typical manifestations such as oral herpes and rashes on the hands and feet. These s...

    Authors: Peiyu Zhu, Wangquan Ji, Dong Li, Zijie Li, Yu Chen, Bowen Dai, Shujie Han, Shuaiyin Chen, Yuefei Jin and Guangcai Duan
    Citation: Journal of Biomedical Science 2023 30:15
    Content type: Review Published on:

  8. Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population.

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
    Content type: Research Published on:

  9. Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically ex...

    Authors: Yongsheng Xie, Yingcong Wang, Zhijian Xu, Yumeng Lu, Dongliang Song, Lu Gao, Dandan Yu, Bo Li, Gege Chen, Hui Zhang, Qilin Feng, Yong Zhang, Ke Hu, Cheng Huang, Yu Peng, Xiaosong Wu…
    Citation: Journal of Biomedical Science 2022 29:32
    Content type: Research Published on:

  11. A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brai...

    Authors: Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang and Jinquan Cai
    Citation: Journal of Biomedical Science 2021 28:30
    Content type: Review Published on:

  12. Enterovirus 71 (EV-71) is the main etiological agent of hand, foot and mouth disease (HFMD). Recent EV-71 outbreaks in Asia-Pacific were not limited to mild HFMD, but were associated with severe neurological comp...

    Authors: Chee Wah Tan, Jeffrey Kam Fatt Lai, I-Ching Sam and Yoke Fun Chan
    Citation: Journal of Biomedical Science 2014 21:14
    Content type: Review Published on:

  13. Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the ...

    Authors: Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang and Christine Neuveut
    Citation: Journal of Biomedical Science 2012 19:92
    Content type: Review Published on:

  14. Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggra...

    Authors: Jiajing Yan, Yibing Chen, Minhua Luo, Xinyu Hu, Hongsheng Li, Quentin Liu and Zhengzhi Zou
    Citation: Journal of Biomedical Science 2023 30:8
    Content type: Review Published on:

  15. We provide a multidimensional sequence of events that describe the electromagnetic field (EMF) stimulation and biological system interaction. We describe this process from the quantum to the molecular, cellular, ...

    Authors: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki and Maher Rizkalla
    Citation: Journal of Biomedical Science 2022 29:39
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:67

  16. O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible modification is catalysed by a uniq...

    Authors: Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud and Patrick Pagesy
    Citation: Journal of Biomedical Science 2022 29:64
    Content type: Review Published on:

  17. All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling and degradation. The vesicular trafficking and secretion pathway...

    Authors: I.-Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:56
    Content type: Review Published on:

  18. A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model. We investigated the neuroprotective effects of ADNF-9 against al...

    Authors: Youssef Sari, Zaneer M Segu, Ahmed YoussefAgha, Jonathan A Karty and Dragan Isailovic
    Citation: Journal of Biomedical Science 2011 18:77
    Content type: Research Published on:

  19. Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome.

    Authors: Tzu-Chun Tsai, Jen-Kann Lu, Sie-Lin Choo, Shu-Yu Yeh, Ren-Bing Tang, Hsin-Yu Lee and Jen-Her Lu
    Citation: Journal of Biomedical Science 2012 19:63
    Content type: Research Published on:

  20. Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regene...

    Authors: Ih-Jen Su, Lily Hui-Ching Wang, Wen-Chuan Hsieh, Han-Chieh Wu, Chiao-Fang Teng, Hung-Wen Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2014 21:98
    Content type: Review Published on:

  22. The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources. Among these, urine-derived induced pluripot...

    Authors: Xiya Yin, Qingfeng Li, Yan Shu, Hongbing Wang, Biju Thomas, Joshua T. Maxwell and Yuanyuan Zhang
    Citation: Journal of Biomedical Science 2024 31:47
    Content type: Review Published on:

  23. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intrigui...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang
    Citation: Journal of Biomedical Science 2009 16:96
    Content type: Review Published on:

  24. Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening co...

    Authors: Chanon Piamsiri, Chayodom Maneechote, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Biomedical Science 2021 28:25
    Content type: Review Published on:

  25. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious di...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2020 27:72
    Content type: Review Published on:

  26. Clustered Regularly Interspaced Short Palindromic repeats (CRISPR)-Cas systems rapidly raised from a bacterial genetic curiosity to the most popular tool for genetic modifications which revolutionized the stud...

    Authors: Rima Zein-Eddine, Guislaine Refrégier, Jorge Cervantes and Noemí Kaoru Yokobori
    Citation: Journal of Biomedical Science 2023 30:34
    Content type: Review Published on:

  27. The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidati...

    Authors: Cheng-Liang Kuo, Ananth Ponneri Babuharisankar, Ying-Chen Lin, Hui-Wen Lien, Yu Kang Lo, Han-Yu Chou, Vidhya Tangeda, Li-Chun Cheng, An Ning Cheng and Alan Yueh-Luen Lee
    Citation: Journal of Biomedical Science 2022 29:74
    Content type: Review Published on:

  28. Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied. In the context of the current global antimicrobial resistance ...

    Authors: Claudia C. Paredes-Amaya, María Teresa Ulloa and Víctor Antonio García-Angulo
    Citation: Journal of Biomedical Science 2023 30:67
    Content type: Review Published on:

  29. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasion a...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra
    Citation: Journal of Biomedical Science 2010 17:10
    Content type: Review Published on:

  30. Cyclooxygenase-2(COX-2) overexpression promotes inflammation and tumorigenesis. COX-2 expression in response to diverse stimuli is tightly controlled to avoid persistent overexpression. 5-methoxyindole metabolite...

    Authors: Kenneth K Wu, Huei-Hsuan Cheng and Tzu-Ching Chang
    Citation: Journal of Biomedical Science 2014 21:17
    Content type: Review Published on:

  31. Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation. The size of the autoph...

    Authors: Yo-hei Yamamoto and Takeshi Noda
    Citation: Journal of Biomedical Science 2020 27:97
    Content type: Review Published on:

  32. Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in thes...

    Authors: Yung-Chun Chuang, Shu-Ying Wang, Yee-Shin Lin, Hong-Ru Chen and Trai-Ming Yeh
    Citation: Journal of Biomedical Science 2013 20:42
    Content type: Review Published on:

  33. Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In...

    Authors: Yi-Heng Li, Cheng-Hsiang Kuo, Guey-Yueh Shi and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2012 19:34
    Content type: Review Published on:

  34. It is important to develop innovative therapies for advanced stage cancers in addition to the conventional therapies including chemotherapy, radiation and surgery. Antigen-specific immunotherapy has emerged as...

    Authors: Chi-Mu Chuang, Archana Monie, Annie Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2009 16:49
    Content type: Research Published on:

  35. Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...

    Authors: Xia Wang, Yadi Wang, Yue Wang, Jian Cheng, Yanyun Wang and Minwen Ha
    Citation: Journal of Biomedical Science 2013 20:5
    Content type: Research Published on:

  36. Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, ...

    Authors: Chia-Hung Chien, Wei-Ting Hsueh, Jian-Ying Chuang and Kwang-Yu Chang
    Citation: Journal of Biomedical Science 2021 28:18
    Content type: Review Published on:

  37. Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA ...

    Authors: Chia-Ling Hsu, Shin Yen Chong, Chia-Yeh Lin and Cheng-Fu Kao
    Citation: Journal of Biomedical Science 2021 28:48
    Content type: Review Published on:

  39. In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (BM),...

    Authors: Pei-Min Chen, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu and B-Linju Yen
    Citation: Journal of Biomedical Science 2011 18:49
    Content type: Review Published on:

  41. Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by ...

    Authors: Thierry Burnouf, Ming-Li Chou, David J. Lundy, Er-Yuan Chuang, Ching-Li Tseng and Hadi Goubran
    Citation: Journal of Biomedical Science 2023 30:79
    Content type: Review Published on:

  43. Due to differences in genetic background, it is unclear whether the genetic loci identified by the previous genome-wide association studies (GWAS) of pancreatic cancer also play significant roles in the develo...

    Authors: Yan-Shen Shan, Li-Tzong Chen, Jin-Shang Wu, Yin-Fan Chang, Chih-Ting Lee, Chih-Hsing Wu, Nai-Jung Chiang, Hsin-En Huang, Chia-Jui Yen, Ying-Jui Chao, Hui-Jen Tsai, Chiung-Yu Chen, Jui-Wen Kang, Chin-Fu Kuo, Chia-Rung Tsai, Ya-Ling Weng…
    Citation: Journal of Biomedical Science 2020 27:69
    Content type: Research Published on:

  44. Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies...

    Authors: Maryam Hajiabbas, Claudia D’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi and Christine Delporte
    Citation: Journal of Biomedical Science 2022 29:35
    Content type: Review Published on:

  45. Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) has...

    Authors: Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund and Thomas G Jensen
    Citation: Journal of Biomedical Science 2011 18:10
    Content type: Review Published on:

  46. The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah
    Citation: Journal of Biomedical Science 2009 16:54
    Content type: Review Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  47. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De
    Citation: Journal of Biomedical Science 2009 16:93
    Content type: Review Published on:

  48. Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w...

    Authors: Pu-Sheng Hsu, Shu-Han Yu, Yi-Tzang Tsai, Jen-Yun Chang, Li-Kuang Tsai, Chih-Hung Ye, Ning-Yu Song, Lih-Chiao Yau and Shau-Ping Lin
    Citation: Journal of Biomedical Science 2021 28:58
    Content type: Review Published on:

  49. An important role in atherogenesis is played by oxidative stress, which may be induced by common risk factors. Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidenc...

    Authors: Paolo Puddu, Giovanni M Puddu, Eleonora Cravero, Susanna De Pascalis and Antonio Muscari
    Citation: Journal of Biomedical Science 2009 16:112
    Content type: Review Published on:

  50. Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and has a high mortality rate worldwide. Sorafenib is the only systemic treatment demonstrating a statistically significant but modest ove...

    Authors: You-Liang Lai, Kai-Hung Wang, Hsing-Pang Hsieh and Wan-Ching Yen
    Citation: Journal of Biomedical Science 2022 29:5
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127