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  1. Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human...

    Authors: Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang and Sheng-Ping L. Hwang
    Citation: Journal of Biomedical Science 2017 24:45
    Content type: Research Published on:

  2. The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate ...

    Authors: Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger and Marcel A. G. van der Heyden
    Citation: Journal of Biomedical Science 2017 24:44
    Content type: Research Published on:

  3. Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythr...

    Authors: Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2017 24:43
    Content type: Research Published on:

  4. Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects periphe...

    Authors: Peggy Sfyri and Antonios Matsakas
    Citation: Journal of Biomedical Science 2017 24:42
    Content type: Review Published on:

  5. Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF...

    Authors: Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara and Masafumi Kawamura
    Citation: Journal of Biomedical Science 2017 24:41
    Content type: Research Published on:

  6. Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. ...

    Authors: Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin and Hui-Yee Chee
    Citation: Journal of Biomedical Science 2017 24:40
    Content type: Research Published on:

  8. Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Authors: Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu
    Citation: Journal of Biomedical Science 2017 24:38
    Content type: Research Published on:

  9. Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung cancer. Late stage of diagnosis and lack of effec...

    Authors: Chantal Hoi Yin Cheung and Hsueh-Fen Juan
    Citation: Journal of Biomedical Science 2017 24:37
    Content type: Review Published on:

  10. The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial fo...

    Authors: Pey Yee Lee, Siok-Fong Chin, Hui-min Neoh and Rahman Jamal
    Citation: Journal of Biomedical Science 2017 24:36
    Content type: Review Published on:

  11. Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effect...

    Authors: Hwei-Fang Tsai and Ping-Ning Hsu
    Citation: Journal of Biomedical Science 2017 24:35
    Content type: Review Published on:

  12. Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears ...

    Authors: May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang and Henrich Cheng
    Citation: Journal of Biomedical Science 2017 24:34
    Content type: Research Published on:

  13. The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen
    Citation: Journal of Biomedical Science 2017 24:33
    Content type: Research Published on:

  15. In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Authors: Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon
    Citation: Journal of Biomedical Science 2017 24:31
    Content type: Research Published on:

  16. The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen
    Citation: Journal of Biomedical Science 2017 24:30
    Content type: Research Published on:

  17. Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Authors: Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2017 24:29
    Content type: Research Published on:

  19. Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate
    Citation: Journal of Biomedical Science 2017 24:27
    Content type: Research Published on:

  20. Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Authors: Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo
    Citation: Journal of Biomedical Science 2017 24:26
    Content type: Review Published on:

  21. Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Authors: Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou
    Citation: Journal of Biomedical Science 2017 24:25
    Content type: Research Published on:

  22. Malfunctioning of the serotonergic system in Parkinson’s disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 re...

    Authors: Kryspin Andrzejewski, Katarzyna Kaczyńska and Małgorzata Zaremba
    Citation: Journal of Biomedical Science 2017 24:24
    Content type: Research Published on:

  23. GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin
    Citation: Journal of Biomedical Science 2017 24:23
    Content type: Research Published on:

  25. Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Authors: Susan Marqus, Elena Pirogova and Terrence J. Piva
    Citation: Journal of Biomedical Science 2017 24:21
    Content type: Review Published on:

  26. The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Authors: Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo
    Citation: Journal of Biomedical Science 2017 24:20
    Content type: Research Published on:

  28. Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-...

    Authors: Mei-Yi Lee, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng, Ming-Huan Chan and Hwei-Hsien Chen
    Citation: Journal of Biomedical Science 2017 24:18
    Content type: Research Published on:

  29. Multi voxel magnetic resonance spectroscopic imaging (MRSI) is an important imaging tool that combines imaging and spectroscopic techniques. MRSI of the human brain has been beneficially applied to different c...

    Authors: Oun Al-iedani, Jeannette Lechner-Scott, Karen Ribbons and Saadallah Ramadan
    Citation: Journal of Biomedical Science 2017 24:17
    Content type: Review Published on:

  30. Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulce...

    Authors: Manish Suthar, Saniya Gupta, Suhail Bukhari and Venkatesh Ponemone
    Citation: Journal of Biomedical Science 2017 24:16
    Content type: Research Published on:

  31. Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    Authors: S. M. Chiavenna, J. P. Jaworski and A. Vendrell
    Citation: Journal of Biomedical Science 2017 24:15
    Content type: Review Published on:

  32. Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Authors: Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini
    Citation: Journal of Biomedical Science 2017 24:14
    Content type: Review Published on:

  33. Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Authors: Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov
    Citation: Journal of Biomedical Science 2017 24:13
    Content type: Review Published on:

  34. Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Authors: Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf
    Citation: Journal of Biomedical Science 2017 24:12
    Content type: Research Published on:

  36. Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Authors: Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai
    Citation: Journal of Biomedical Science 2017 24:10
    Content type: Review Published on:

  37. Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Authors: Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee
    Citation: Journal of Biomedical Science 2017 24:9
    Content type: Review Published on:

  38. Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynam...

    Authors: Sean P. Nassoiy, Kenneth L. Byron and Matthias Majetschak
    Citation: Journal of Biomedical Science 2017 24:8
    Content type: Research Published on:

  39. Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils ar...

    Authors: Bill Cheng, H. C. Chen, I. W. Chou, Tony W. H. Tang and Patrick C. H. Hsieh
    Citation: Journal of Biomedical Science 2017 24:7
    Content type: Review Published on:

  40. The DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squam...

    Authors: Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang and Gang Kuang
    Citation: Journal of Biomedical Science 2017 24:6
    Content type: Research Published on:

  41. Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, wh...

    Authors: Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2017 24:5
    Content type: Review Published on:

  43. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxi...

    Authors: Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz and Daria Mochly-Rosen
    Citation: Journal of Biomedical Science 2017 24:3
    Content type: Research Published on:

  44. Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of vi...

    Authors: Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai and Jen-Yang Chen
    Citation: Journal of Biomedical Science 2017 24:2
    Content type: Research Published on:

  45. Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on...

    Authors: Xiaochen Yan, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2017 24:1
    Content type: Research Published on:

  47. Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Authors: Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara
    Citation: Journal of Biomedical Science 2016 23:89
    Content type: Research Published on:

  48. Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resul...

    Authors: Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj
    Citation: Journal of Biomedical Science 2016 23:88
    Content type: Review Published on:

  50. The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for adv...

    Authors: Bin-Chi Liao, Chia-Chi Lin, Jih-Hsiang Lee and James Chih-Hsin Yang
    Citation: Journal of Biomedical Science 2016 23:86
    Content type: Review Published on:
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Journal of Biomedical Science

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