Skip to main content

Articles

Page 19 of 32

  1. 5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how ...

    Authors: Ching-Chia Chang Chien and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:42
    Content type: Research Published on:

  2. Down syndrome (DS) is one of the commonest disorders with huge medical and social cost. DS is associated with number of phenotypes including congenital heart defects, leukemia, Alzeihmer’s disease, Hirschsprun...

    Authors: Ambreen Asim, Ashok Kumar, Srinivasan Muthuswamy, Shalu Jain and Sarita Agarwal
    Citation: Journal of Biomedical Science 2015 22:41
    Content type: Review Published on:

  3. The NF-κB signaling pathway plays a role in local and remote tissue damage following ischemia-reperfusion (I/R) injury to skeletal muscles. Evidence suggests that exosomes can act as intercellular communicator...

    Authors: Johnson Chia-Shen Yang, Ming-Wei Lin, Cheng-Shyuan Rau, Seng-Feng Jeng, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2015 22:40
    Content type: Research Published on:

  5. EGFR, a receptor tyrosine kinase (RTK), is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have been widely used in the treatment of many cancers, ...

    Authors: Chi-Yuan Chen, Zhu-Yun Yu, Yen-Shu Chuang, Rui-Mei Huang and Tzu-Chien V Wang
    Citation: Journal of Biomedical Science 2015 22:38
    Content type: Research Published on:

  6. Parkinson’s disease is the second most common neurodegenerative disorders after Alzheimer’s disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. N...

    Authors: Yun-Lian Lin, Huey-Jen Tsay, Tzu-Hsuan Lai, Tsai-Teng Tzeng and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2015 22:37
    Content type: Research Published on:

  8. The purpose of this study was to evaluate the efficacy of a multi-layered conductive nanofibrous hollow conduit in combination with olfactory ensheathing cells (OEC) to promote peripheral nerve regeneration. W...

    Authors: Mahboubeh Kabiri, Saeed Oraee-Yazdani, Abbas Shafiee, Hana Hanaee-Ahvaz, Masumeh Dodel, Mohammad Vaseei and Masoud Soleimani
    Citation: Journal of Biomedical Science 2015 22:35
    Content type: Research Published on:

  9. Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are systemic autoimmune connective tissue diseases that share overlapping clinico-pathological features. It is highly probable that there is an o...

    Authors: Puleng Matatiele, Mohamed Tikly, Gareth Tarr and Mary Gulumian
    Citation: Journal of Biomedical Science 2015 22:34
    Content type: Research Published on:

  10. MSP58 is a nucleolar protein associated with rRNA transcription and cell proliferation. Its mechanism of translocation into the nucleus or the nucleolus, however, is not entirely known. In order to address thi...

    Authors: Chuan-Pin Yang, Chi-Wu Chiang, Chang-Han Chen, Yi-Chao Lee, Mei-Hsiang Wu, Yi-Huan Tsou, Yu-San Yang, Wen-Chang Chang and Ding-Yen Lin
    Citation: Journal of Biomedical Science 2015 22:33
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2015 22:60

  11. Cytochrome P450 metabolizes many drugs in the liver. Three genotypes of CYP2C19 with extensive, intermediate, and poor metabolizing activity, respectively, have been identified in peripheral blood of transplan...

    Authors: King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto and Chao-Long Chen
    Citation: Journal of Biomedical Science 2015 22:32
    Content type: Review Published on:

  12. Adenoviral vector is an efficient tool for gene transfer. Protein expression is regulated by a number of factors, but the regulation by gene copy number remains to be investigated further.

    Authors: Yi-Chen Tsai, Tsung-Huang Tsai, Chen-Ping Chang, Shu-Fen Chen, Yen-Ming Lee and Song-Kun Shyue
    Citation: Journal of Biomedical Science 2015 22:31
    Content type: Research Published on:

  13. Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-a...

    Authors: Hsiu-Ting Tseng, Young Joo Park, Yoon Kwang Lee and David D Moore
    Citation: Journal of Biomedical Science 2015 22:30
    Content type: Research Published on:

  14. Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, t...

    Authors: María B Mazzucco, Laura B Talarico, Sezen Vatansever, Ana C Carro, Mirta L Fascio, Norma B D’Accorso, Cybele C García and Elsa B Damonte
    Citation: Journal of Biomedical Science 2015 22:29
    Content type: Research Published on:

  15. Identifying the drug-deliverables that target autophagy is crucial to finding a cure for pancreatic cancer (PC), as activated autophagy is associated with poor patient outcomes. Our recent studies recognized t...

    Authors: Sheeja Aravindan, Satish Kumar Ramraj, Somasundaram T Somasundaram and Natarajan Aravindan
    Citation: Journal of Biomedical Science 2015 22:28
    Content type: Research Published on:

  16. ESBL-producing bacteria are a clinical problem in the management of diseases caused by these pathogens. Worldwide, systemic infections with BL enzymes are evolving by mutations from classical bla genes in an inte...

    Authors: Amel Bourouis, Mouhamed Ben moussa and Omrane Belhadj
    Citation: Journal of Biomedical Science 2015 22:27
    Content type: Research Published on:

  17. Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effec...

    Authors: Rishi Kumar Gara, Vikas Kumar Srivastava, Shivali Duggal, Jaspreet Kaur Bagga, MLB Bhatt, Sabyasachi Sanyal and Durga Prasad Mishra
    Citation: Journal of Biomedical Science 2015 22:26
    Content type: Research Published on:

  18. Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplant...

    Authors: Krissanapong Manotham, Supreecha Chattong and Anant Setpakdee
    Citation: Journal of Biomedical Science 2015 22:25
    Content type: Research Published on:

  19. Experimental models of pneumonia with penicillin non-susceptible Streptococcus pneumoniae (PNSSP) are hard to reproduce because the majority of strains with clinical relevance (like serotypes 6B, 9 V and 19 F) ha...

    Authors: Andres F Zuluaga, Beatriz E Salazar, Maria Agudelo, Carlos A Rodriguez and Omar Vesga
    Citation: Journal of Biomedical Science 2015 22:24
    Content type: Research Published on:

  20. The estimated glomerular filtration rate (eGFR) is a well-known measure of kidney function and is commonly used for the diagnosis and management of patients with chronic kidney disease. The inter-individual va...

    Authors: Farook Thameem, V Saroja Voruganti, John Blangero, Anthony G Comuzzie and Hanna E Abboud
    Citation: Journal of Biomedical Science 2015 22:23
    Content type: Research Published on:

  21. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells. In addition to its primary rol...

    Authors: Lee-Young Chau
    Citation: Journal of Biomedical Science 2015 22:22
    Content type: Review Published on:

  24. Heroin use among young women of reproductive age has drawn much attention around the world. Although methadone is widely used in maintenance therapy for heroin/morphine addiction, the long-term effects of pren...

    Authors: Yao-Chang Chiang, Li-Ci Ye, Kuei-Ying Hsu, Chien-Wei Liao, Tsai-Wei Hung, Wan-Jou Lo, Ing-Kang Ho and Pao-Luh Tao
    Citation: Journal of Biomedical Science 2015 22:19
    Content type: Research Published on:

  25. Coronary heart disease is a leading cause of death in the world and therapy to reduce injury is still needed. The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial i...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, His-Lin Chiu and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:18
    Content type: Research Published on:

  27. Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after H. pylori infection. The stu...

    Authors: Yu-Ching Tsai, Wei-Hsin Hsiao, Sheng-Hsiang Lin, Hsiao-Bai Yang, Hsiu-Chi Cheng, Wei-Lun Chang, Cheng-Chan Lu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2015 22:16
    Content type: Research Published on:

  28. Novel pentacycloundecane (PCU)-lactone-CO-EAIS peptide inhibitors were designed, synthesized, and evaluated against wild-type C-South African (C-SA) HIV-1 protease. Three compounds are reported herein, two of ...

    Authors: Bahareh Honarparvar, Sachin A Pawar, Cláudio Nahum Alves, Jerônimo Lameira, Glenn EM Maguire, José Rogério A Silva, Thavendran Govender and Hendrik G Kruger
    Citation: Journal of Biomedical Science 2015 22:15
    Content type: Research Published on:

  29. One of the most important manifestations of perinatal asphyxia is the occurrence of seizures, which are treated with antiepileptic drugs, such as carbamazepine. These early seizures, combined with pharmacologi...

    Authors: Silvia J López-Pérez, Alberto Morales-Villagrán and Laura Medina-Ceja
    Citation: Journal of Biomedical Science 2015 22:14
    Content type: Research Published on:

  30. Candida tropicalis is an increasingly important human pathogen associated with high mortality rates; however, little is known regarding the virulence properties of C. tropicalis, particularly t...

    Authors: Marcia Cristina Furlaneto, Daniel Favero, Emanuele Julio Galvão França and Luciana Furlaneto-Maia
    Citation: Journal of Biomedical Science 2015 22:13
    Content type: Research Published on:

  31. Polyunsaturated fatty acids (PUFAs) are nutrients necessary for life. The liver is the essential metabolic center, which aids in maintaining health via diverse biological actions. In the present work, a proteo...

    Authors: Chun-Ying Huang, Wei-Ming Chen, Yeou-Guang Tsay, Shu-Chen Hsieh, Yun Lin, Wen-Jane Lee, Wayne Huey-Herng Sheu and An-Na Chiang
    Citation: Journal of Biomedical Science 2015 22:12
    Content type: Research Published on:

  32. Telomerase deficiency has been associated with inadequate differentiation of mesenchymal stem cells. However, the effect of telomerase deficiency on differential regulation of osteoblast specific genes, based ...

    Authors: Hamid Saeed and Mehwish Iqtedar
    Citation: Journal of Biomedical Science 2015 22:11
    Content type: Research Published on:

  33. Argininosuccinate synthetase (ASS) participates in urea and nitric oxide production and is a rate-limiting enzyme in arginine biosynthesis. Regulation of ASS expression appears complex and dynamic. In addition to...

    Authors: Shih-Chang Shiue, Miao-Zeng Huang, Ting-Fen Tsai, Alice Chien Chang, Kong Bung Choo, Chiu-Jung Huang and Tsung-Sheng Su
    Citation: Journal of Biomedical Science 2015 22:10
    Content type: Research Published on:

  34. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been found highly conserved among species. MiRNAs are able to negatively regulate gene expression through base pairing of 3’ UTRs of...

    Authors: Shih-Hsuan Chan and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2015 22:9
    Content type: Review Published on:

  35. Intermittent hypobaric hypoxia (IHH) induces changes in the redox status and structure in rat testis. These effects may be present in people at high altitudes, such as athletes and miners. Polyunsaturated fatt...

    Authors: Rodrigo L Castillo, Andrea B Zepeda, Stefania E Short, Elías Figueroa, Eduardo Bustos-Obregon and Jorge G Farías
    Citation: Journal of Biomedical Science 2015 22:8
    Content type: Research Published on:

  36. Bortezomib, a proteasome inhibitor and suberoylanilide hydroxamic acid (SAHA, also known as Vorinostat), a histone deacetylase inhibitor, have been recognized as potent chemotherapeutic drugs. Bortezomib and S...

    Authors: Zhuomin Huang, Shiwen Peng, Jayne Knoff, Sung Yong Lee, Benjamin Yang, Tzyy-Choou Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2015 22:7
    Content type: Research Published on:

  38. Leptin, produced mainly by white adipose tissue, is a hormone that promotes vascular smooth muscle cell (VSMC) migration and proliferation, a process involved in the pathophysiology of atherosclerosis. Leptin ...

    Authors: Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2015 22:5
    Content type: Research Published on:

  39. Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual a...

    Authors: Nithya Subramanian, Jagat R Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rupinder K Kanwar, Sailaja Eluchuri and Subramanian Krishnakumar
    Citation: Journal of Biomedical Science 2015 22:4
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:100

  40. Hormone-refractory prostate cancer (HRPC), which is resistant to hormone therapy, is a major obstacle in clinical treatment. An approach to inhibit HRPC growth and ultimately to kill cancers is highly demanded.

    Authors: Chia-Chun Yu, Shih-Ping Liu, Jui-Ling Hsu, John TA Hsu, Konstantin V Kudryavtsev and Jih-Hwa Guh
    Citation: Journal of Biomedical Science 2015 22:2
    Content type: Research Published on:

  41. We profiled the expression of circulating microRNAs (miRNAs) in mice using Illumina small RNA deep sequencing in order to identify the miRNAs that may potentially be used as biomarkers to distinguish between g...

    Authors: Cheng-Shyuan Rau, Shao-Chun Wu, Johnson Chia-Shen Yang, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2015 22:1
    Content type: Research Published on:

  42. Lymphangiogenesis is one of the major causes of corneal graft rejection. Among the lymphangiogenic factors, vascular endothelial growth factor (VEGF)-C and -D are considered to be the most potent. Both bind to...

    Authors: Minkoo Seo, Jun-Sub Choi, Chang Rae Rho, Choun-Ki Joo and Suk Kyeong Lee
    Citation: Journal of Biomedical Science 2015 22:3
    Content type: Research Published on:

  43. Although cigarette smoke is known to be a complex mixture of over 4000 substances that can lead to damage through active or passive smoking, its mechanisms and biochemical consequences in pregnancy and neonate...

    Authors: Ednildes de Almeida Olympio Rua, Marcella Leite Porto, Jean Pierre Louzada Ramos, Breno Valentim Nogueira, Silvana dos Santos Meyrelles, Elisardo Corral Vasquez and Thiago de Melo Costa Pereira
    Citation: Journal of Biomedical Science 2014 21:105
    Content type: Research Published on:

  44. Surgery has wide ranging immunomodulatory properties of which the mechanism is poorly understood. In order to investigate how different types of surgery influence inflammation, we designed a longitudinal obser...

    Authors: Jaap Willem Hol, Robert J Stolker, Markus Klimek, Dirk L Stronks and Durk Fekkes
    Citation: Journal of Biomedical Science 2014 21:102
    Content type: Research Published on:

  46. Use of the chemotherapeutic drug doxorubicin (DOX) is associated with serious cardiotoxicity, as it increases levels of reactive oxygen species (ROS). N-3 polyunsaturated fatty acid dietary supplements can be ...

    Authors: Hsiu-Ching Hsu, Ching-Yi Chen and Ming-Fong Chen
    Citation: Journal of Biomedical Science 2014 21:101
    Content type: Research Published on:

  47. Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these patho...

    Authors: Sue-Jane Lin, Ming Lo, Rei-Lin Kuo, Shin-Ru Shih, David M Ojcius, Jean Lu, Chien-Kuo Lee, Hui-Chen Chen, Meei Yun Lin, Chuen-Miin Leu, Chia-Ni Lin and Ching-Hwa Tsai
    Citation: Journal of Biomedical Science 2014 21:99
    Content type: Research Published on:

  48. Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as wi...

    Authors: Francesca Bonafè, Marco Govoni, Emanuele Giordano, Claudio Marcello Caldarera, Carlo Guarnieri and Claudio Muscari
    Citation: Journal of Biomedical Science 2014 21:100
    Content type: Review Published on:

  49. Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regene...

    Authors: Ih-Jen Su, Lily Hui-Ching Wang, Wen-Chuan Hsieh, Han-Chieh Wu, Chiao-Fang Teng, Hung-Wen Tsai and Wenya Huang
    Citation: Journal of Biomedical Science 2014 21:98
    Content type: Review Published on:

  50. Hyperglycemia increases the risk of gastric cancer in H. pylori-infected patients. High glucose could increase endothelial permeability and cancer-associated signaling. These suggest high glucose may affect H. py...

    Authors: Shew-Meei Sheu, Hsin Cheng, Cheng-Ye Kao, Yao-Jong Yang, Jiunn-Jong Wu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2014 21:96
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2023 Citation Impact
    9.0 - 2-year Impact Factor
    10.7 - 5-year Impact Factor
    2.014 - SNIP (Source Normalized Impact per Paper)
    2.606 - SJR (SCImago Journal Rank)

    2023 Speed
    14 days submission to first editorial decision for all manuscripts (Median)
    107 days submission to accept (Median)

    2023 Usage 
    1,698,723 downloads
    3,813 Altmetric mentions 

Journal of Biomedical Science

ISSN: 1423-0127