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356 result(s) for 'screening test' within Journal of Biomedical Science

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  1. The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncR...

    Authors: Ming-Che Kuo, Sam Chi-Hao Liu, Ya-Fang Hsu and Ruey-Meei Wu
    Citation: Journal of Biomedical Science 2021 28:78
    Content type: Review Published on:

  2. Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin,...

    Authors: Chung-Yin Wu, Chih-Ta Lin, Min-Zu Wu and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2011 18:1
    Content type: Research Published on:

  3. Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade. In this study, we established a screening model to discover nov...

    Authors: Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh and Michael Hsiao
    Citation: Journal of Biomedical Science 2021 28:29
    Content type: Research Published on:

  4. The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural developme...

    Authors: Shu-Fen Chen, Yu-Chen Tsai and Seng-Sheen Fan
    Citation: Journal of Biomedical Science 2012 19:101
    Content type: Research Published on:

  5. Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and int...

    Authors: Ruey-Hwa Chen, Yu-Ru Lee and Wei-Chien Yuan
    Citation: Journal of Biomedical Science 2012 19:81
    Content type: Review Published on:

  6. Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Understanding of the etiologi...

    Authors: Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang and Yong Poovorawan
    Citation: Journal of Biomedical Science 2014 21:16
    Content type: Research Published on:

  8. Somatic mutations of the epidermal growth factor receptor (EGFR) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the mu...

    Authors: Tiffany Ng Shi Yeen, Rajadurai Pathmanathan, Mohd Sidik Shiran, Fattah Azman Ahmad Zaid and Yoke Kqueen Cheah
    Citation: Journal of Biomedical Science 2013 20:22
    Content type: Research Published on:

  10. Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl− cotransporter NKCC2. We recently established the mutant mouse line Slc1...

    Authors: Elisabeth Kemter, Birgit Rathkolb, Lore Becker, Ines Bolle, Dirk H Busch, Claudia Dalke, Ralf Elvert, Jack Favor, Jochen Graw, Wolfgang Hans, Boris Ivandic, Svetoslav Kalaydjiev, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Anja Schrewe…
    Citation: Journal of Biomedical Science 2014 21:68
    Content type: Research Published on:

  11. Lactobacilli are essential microbiota that maintain a healthy, balanced vaginal environment. Vaginitis is a common infection in women during their reproductive years. Many factors are associated with vaginitis...

    Authors: Ameda Abdullah Bnfaga, Kai Wei Lee, Leslie Thian Lung Than and Syafinaz Amin-Nordin
    Citation: Journal of Biomedical Science 2023 30:19
    Content type: Research Published on:

  12. Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essenti...

    Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu and Lee-Young Chau
    Citation: Journal of Biomedical Science 2018 25:6
    Content type: Research Published on:

  13. Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalitie...

    Authors: Jun-Xia Deng, Xiao-Jing Nie, Ying-Feng Lei, Chao-Feng Ma, Dong-Liang Xu, Biao Li, Zhi-Kai Xu and Guo-Cheng Zhang
    Citation: Journal of Biomedical Science 2012 19:73
    Content type: Research Published on:

  14. The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved ...

    Authors: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau and Ruey-Bing Yang
    Citation: Journal of Biomedical Science 2023 30:33
    Content type: Review Published on:

  15. Recently accumulated evidence suggests that Raf kinase inhibitor protein (RKIP) participates in regulation of many signaling pathways and plays an important role in tumorigenesis and tumor metastasis. However,...

    Authors: Fang Nie, Jianguo Cao, Jinlu Tong, Mingming Zhu, Yuan Gao and Zhihua Ran
    Citation: Journal of Biomedical Science 2015 22:56
    Content type: Research Published on:

  16. A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immuno...

    Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye and Ping Lan
    Citation: Journal of Biomedical Science 2023 30:47
    Content type: Research Published on:

  17. Human Papillomavirus type 18 (HPV18) is a high-risk HPV that is commonly associated with cervical cancer. HPV18 oncogenes E6 and E7 are associated with the malignant transformation of cells, thus the identific...

    Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2022 29:80
    Content type: Research Published on:

  18. The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed...

    Authors: Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I.-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao…
    Citation: Journal of Biomedical Science 2022 29:68
    Content type: Review Published on:

  19. Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are l...

    Authors: Daniel B. Rodrigues, Rui L. Reis and Rogério P. Pirraco
    Citation: Journal of Biomedical Science 2024 31:13
    Content type: Review Published on:

  21. Antibodies against spliceosome Sm proteins (anti-Sm autoantibodies) are specific to the autoimmune disease systemic lupus erythematosus (SLE). Anti-Sm autosera have been reported to specifically recognize Sm D...

    Authors: Hong-How Chang, Huan-Hsuan Hu, Yu-Jen Lee, Hung-Ming Wei, Ming-Chun Fan-June, Tsai-Ching Hsu, Gregory J Tsay and Chuan Li
    Citation: Journal of Biomedical Science 2013 20:27
    Content type: Research Published on:

  22. This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhib...

    Authors: Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata and Ebthag M. Awad
    Citation: Journal of Biomedical Science 2019 26:69
    Content type: Research Published on:

  23. Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been s...

    Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang and Hongsheng Wang
    Citation: Journal of Biomedical Science 2022 29:58
    Content type: Research Published on:

  24. Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inf...

    Authors: Wen-Chi Wei, Sheng-Yen Lin, Yi-Jyun Chen, Chih-Chun Wen, Chiung-Yao Huang, Arulselvan Palanisamy, Ning-Sun Yang and Jyh-Horng Sheu
    Citation: Journal of Biomedical Science 2011 18:94
    Content type: Research Published on:

  25. Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown.

    Authors: Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang and Tsung-I. Hsu
    Citation: Journal of Biomedical Science 2022 29:21
    Content type: Research Published on:

  28. Esophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility....

    Authors: Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and Hung-Chi Cheng
    Citation: Journal of Biomedical Science 2020 27:102
    Content type: Research Published on:

  29. Two isoforms of Rho-associated protein kinase (ROCK), ROCKI and ROCKII, play a pivotal role in regulation of cytoskeleton and are involved in multiple cellular processes in mammalian cells. Knockout mice exper...

    Authors: Hsiang-Hao Chuang, Shao-Wei Liang, Zee-Fen Chang and Hsiao-Hui Lee
    Citation: Journal of Biomedical Science 2013 20:83
    Content type: Research Published on:

  30. Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into saliva and milk. Although CA VI was first described as ...

    Authors: Maarit Patrikainen, Peiwen Pan, Natalia Kulesskaya, Vootele Voikar and Seppo Parkkila
    Citation: Journal of Biomedical Science 2014 21:82
    Content type: Research Published on:

  31. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP). The aim of...

    Authors: Leo Tsui, Shwu-Fen Chang, Hsiang-Po Huang, Tsorng-Harn Fong and I-Jong Wang
    Citation: Journal of Biomedical Science 2016 23:2
    Content type: Research Published on:

  32. Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs al...

    Authors: Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang and Nigel H. Greig
    Citation: Journal of Biomedical Science 2023 30:16
    Content type: Research Published on:

  34. Parkinson's disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. Genetic association studies have linked 13 h...

    Authors: Shahrooz Vahedi, Mehrnoosh Rajabian, Arman Misaghian, Daniel Grbec, Horst H Simon and Kambiz N Alavian
    Citation: Journal of Biomedical Science 2010 17:66
    Content type: Research Published on:

  35. Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers...

    Authors: Shu-Lin Liu, Chun-Chia Cheng, Chun-Chao Chang, Fu-Der Mai, Chia-Chi Wang, Shui-Cheng Lee, Ai-Sheng Ho, Ling-Yun Chen and Jungshan Chang
    Citation: Journal of Biomedical Science 2011 18:52
    Content type: Research Published on:

  36. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang
    Citation: Journal of Biomedical Science 2020 27:42
    Content type: Research Published on:

  37. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as repr...

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen
    Citation: Journal of Biomedical Science 2011 18:36
    Content type: Research Published on:

  38. Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

    Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji
    Citation: Journal of Biomedical Science 2021 28:44
    Content type: Research Published on:

  39. KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at...

    Authors: Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen and Ming-Hsien Chien
    Citation: Journal of Biomedical Science 2023 30:68
    Content type: Research Published on:

  40. The tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the interaction between tumor and immune cells. The aim of this study was to...

    Authors: Changwu Wu, Siming Gong, Yingjuan Duan, Chao Deng, Sonja Kallendrusch, Laura Berninghausen, Georg Osterhoff and Nikolas Schopow
    Citation: Journal of Biomedical Science 2023 30:23
    Content type: Research Published on:

  41. Hematological and biochemical abnormalities are among the most common clinicopathological manifestations of HIV patients on ART. Consequently, the development and assessment of indigenous antiretroviral drugs ...

    Authors: Bartholomew Okecuhukwu Ibeh, Olushola D Omodamiro, Urenna Ibeh and Josiah Bitrus Habu
    Citation: Journal of Biomedical Science 2013 20:73
    Content type: Research Published on:

  42. Dengue is an important mosquito-borne viral infection that affects millions of persons worldwide. Early diagnosis is necessary to effect appropriate management and decrease mortality. Immunochromatographic tes...

    Authors: Ivan E. Vickers, Kevin M. Harvey, Michelle G. Brown, Kereann Nelson, Marion Bullock DuCasse and John F. Lindo
    Citation: Journal of Biomedical Science 2015 22:55
    Content type: Research Published on:

  43. Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, wit...

    Authors: Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2019 26:91
    Content type: Research Published on:

  45. Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Authors: Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri
    Citation: Journal of Biomedical Science 2017 24:56
    Content type: Review Published on:

  46. Hyperglycemia increases the risk of gastric cancer in H. pylori-infected patients. High glucose could increase endothelial permeability and cancer-associated signaling. These suggest high glucose may affect H. py...

    Authors: Shew-Meei Sheu, Hsin Cheng, Cheng-Ye Kao, Yao-Jong Yang, Jiunn-Jong Wu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2014 21:96
    Content type: Research Published on:

  47. Dry eye disease (DED) is a common disease in ophthalmology, affecting millions of people worldwide. Recent studies have shown that inflammation is the core mechanism of DED. IL-20 is a proinflammatory cytokine...

    Authors: Hsiao-Hsuan Wang, Wei-Yu Chen, Yi-Hsun Huang, Sheng-Min Hsu, Yeou-Ping Tsao, Yu-Hsiang Hsu and Ming-Shi Chang
    Citation: Journal of Biomedical Science 2022 29:36
    Content type: Research Published on:

  48. Beta-thalassemia is common in the Mediterranean area as well as the Middle East and India. Official report in Iran revealed the average prevalence rate of carriers about 4%. More than 20 restriction fragment l...

    Authors: Mohammad Bagher Hashemi-Soteh, Seyed Saeed Mousavi and Alireza Tafazoli
    Citation: Journal of Biomedical Science 2017 24:92
    Content type: Research Published on:

  49. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang
    Citation: Journal of Biomedical Science 2020 27:11
    Content type: Research Published on:

  50. Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and postt...

    Authors: Fangfang Wang and Youwei Zhang
    Citation: Journal of Biomedical Science 2024 31:11
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127