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356 result(s) for 'screening test' within Journal of Biomedical Science

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  1. Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have l...

    Authors: Yothin Teethaisong, Nongluk Autarkool, Kittipot Sirichaiwetchakoon, Pongrit Krubphachaya, Sajeera Kupittayanant and Griangsak Eumkeb
    Citation: Journal of Biomedical Science 2014 21:90
    Content type: Research Published on:

  2. Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembr...

    Authors: Jehad M Al-Shuneigat, Samir S Mahgoub and Fazlul Huq
    Citation: Journal of Biomedical Science 2011 18:50
    Content type: Research Published on:

  3. The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Authors: Stacy L. McAllister, Katherine Sun and Eric R. Gross
    Citation: Journal of Biomedical Science 2016 23:80
    Content type: Review Published on:

  4. Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree ... but not type II, IFNs. Through inheritance test, genetic mappin...

    Authors: Lan-Sun Chen, Pei-Chi Wei, Taming Liu, Chung-Hsuan Kao, Li-Mei Pai and Chien-Kuo Lee
    Citation: Journal of Biomedical Science 2009 16:22
    Content type: Research Published on:

  5. G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) genome. Howev...

    Authors: Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard and Tao Jia
    Citation: Journal of Biomedical Science 2024 31:50
    Content type: Research Published on:

  6. The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse l...

    Authors: Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu and Ting-Fen Tsai
    Citation: Journal of Biomedical Science 2022 29:53
    Content type: Research Published on:

  7. Compared with the prior MALDI-TOF and machine learning studies of CRKP, the amount of data in our study was more sufficient and allowing us to conduct external validation. With better generalization abilities, ou...

    Authors: Yu-Ming Zhang, Mei-Fen Tsao, Ching-Yu Chang, Kuan-Ting Lin, Joseph Jordan Keller and Hsiu-Chen Lin
    Citation: Journal of Biomedical Science 2023 30:25
    Content type: Research Published on:

  8. Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Authors: Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini
    Citation: Journal of Biomedical Science 2017 24:14
    Content type: Review Published on:

  9. Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine de...

    Authors: Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung and Wen-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:29
    Content type: Research Published on:

  10. Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin...

    Authors: Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo and Chamindie Punyadeera
    Citation: Journal of Biomedical Science 2023 30:65
    Content type: Review Published on:

  12. The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish...

    Authors: Ming-Wei Kuo, Hsiu-Hui Tsai, Sheng-Hung Wang, Yi-Yin Chen, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2021 28:7
    Content type: Research Published on:

  13. Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its se...

    Authors: You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen and Wun-Chang Ko
    Citation: Journal of Biomedical Science 2011 18:84
    Content type: Research Published on:

  15. Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, t...

    Authors: Aleksandra Klemba, Magdalena Kowalewska, Wojciech Kukwa, Katarzyna Tonska, Aleksandra Szybinska, Malgorzata Mossakowska, Anna Scinska, Paweł Golik, Kamil Koper, Jakub Radziszewski, Andrzej Kukwa, Anna M Czarnecka and Ewa Bartnik
    Citation: Journal of Biomedical Science 2010 17:73
    Content type: Research Published on:

  16. Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co...

    Authors: Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I. Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu and Hsin-Wei Chen
    Citation: Journal of Biomedical Science 2022 29:37
    Content type: Research Published on:

  17. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
    Content type: Research Published on:

  18. The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of ...

    Authors: Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen and Huey-Ling Chen
    Citation: Journal of Biomedical Science 2021 28:19
    Content type: Research Published on:

  19. Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important consequences for disease diagnosis and treatment. In addition to the many genetic and non-genetic (e.g., epige...

    Authors: Y. Henry Sun, Yueh-Lin Wu and Ben-Yang Liao
    Citation: Journal of Biomedical Science 2023 30:58
    Content type: Review Published on:

  20. The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic sign...

    Authors: Gordana Đorđević, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac and Nives Jonjić
    Citation: Journal of Biomedical Science 2012 19:40
    Content type: Research Published on:

  21. Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. Few studies are available that describe this association with bladder cancer either related or unrelated to ...

    Authors: Fathia El-Sharkawi, Mahmoud El Sabah, Zeinab Hassan and Hussein Khaled
    Citation: Journal of Biomedical Science 2014 21:72
    Content type: Research Published on:

  22. One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropria...

    Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek and Thomas E. Prisinzano
    Citation: Journal of Biomedical Science 2021 28:62
    Content type: Research Published on:

  23. Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer patients remain refractory to the ICB therapy, which is largely attributed...

    Authors: Ning Ma, Rong Hua, Yang Yang, Zhi-Chao Liu, Jie Pan, Bo-Yao Yu, Yi-Feng Sun, Dong Xie, Yan Wang and Zhi-Gang Li
    Citation: Journal of Biomedical Science 2023 30:20
    Content type: Research Published on:

  24. It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatica...

    Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li and Han-Chung Wu
    Citation: Journal of Biomedical Science 2020 27:1
    Content type: Review Published on:

  25. The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candid...

    Authors: Ahmed S Abdel-Moneim, Ahmad E Abdel-Ghany and Salama AS Shany
    Citation: Journal of Biomedical Science 2010 17:25
    Content type: Research Published on:

  27. Genome editing technologies hold great promise for numerous applications including the understanding of cellular and disease mechanisms and the development of gene and cellular therapies. Achieving high editin...

    Authors: Nanna S. Mikkelsen and Rasmus O. Bak
    Citation: Journal of Biomedical Science 2023 30:51
    Content type: Review Published on:

  28. Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona...

    Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin
    Citation: Journal of Biomedical Science 2021 28:65
    Content type: Research Published on:

  29. Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Authors: Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng
    Citation: Journal of Biomedical Science 2015 22:102
    Content type: Research Published on:

  30. H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadheri...

    Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2019 26:4
    Content type: Research Published on:

  31. The COVID-19 pandemic continues to pose a significant worldwide threat to human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic antibodies and the ability to evade vaccination...

    Authors: Hsiao-Ling Chiang, Kang-Hao Liang, Ruei-Min Lu, Ting-Wen Kuo, Yi‑Ling Lin and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:59
    Content type: Research Published on:

  32. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2020 27:72
    Content type: Review Published on:

  33. Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making ...

    Authors: Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2013 20:88
    Content type: Review Published on:

  34. Among the various types of dementia, Alzheimer’s disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central ne...

    Authors: Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado and Jaderson Costa Da Costa
    Citation: Journal of Biomedical Science 2019 26:15
    Content type: Review Published on:

  35. Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNALys gene, and usually manifested as complex neur...

    Authors: Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma and Yau-Huei Wei
    Citation: Journal of Biomedical Science 2023 30:70
    Content type: Research Published on:

  36. Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the app...

    Authors: Tomasz Klaus and Sameer Deshmukh
    Citation: Journal of Biomedical Science 2021 28:11
    Content type: Review Published on:

  37. Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...

    Authors: Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen
    Citation: Journal of Biomedical Science 2017 24:59
    Content type: Review Published on:

  38. Pseudomonas aeruginosa intestinal carriage rates are significantly higher in immunosuppressed individuals and hospitalized patients who therefore have increased risk of infections and antibiotic-associated diarrh...

    Authors: Rajendra Prasad Janapatla, Anna Dudek, Chyi-Liang Chen, Chih-Hsien Chuang, Kun-Yi Chien, Ye Feng, Yuan-Ming Yeh, Yi-Hsin Wang, Hsin-Ju Chang, Yuan-Chuan Lee and Cheng-Hsun Chiu
    Citation: Journal of Biomedical Science 2023 30:9
    Content type: Research Published on:

  39. Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Authors: Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou
    Citation: Journal of Biomedical Science 2015 22:105
    Content type: Research Published on:

  40. Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we ...

    Authors: Shih-Hung Chan, Jyh-Hong Chen, Yi-Heng Li and Liang-Miin Tsai
    Citation: Journal of Biomedical Science 2012 19:100
    Content type: Research Published on:

  41. Zinc finger protein 179 (Znf179), also known as ring finger protein 112 (Rnf112), is a member of the RING finger protein family and plays an important role in neuronal differentiation. To investigate novel mec...

    Authors: Ding-Yen Lin, Chi-Chen Huang, Ya-Ting Hsieh, Hsin-Chuan Lin, Ping-Chieh Pao, Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Hung, Ju-Ming Wang, Wen-Chang Chang and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2013 20:98
    Content type: Research Published on:

  42. Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, t...

    Authors: María B Mazzucco, Laura B Talarico, Sezen Vatansever, Ana C Carro, Mirta L Fascio, Norma B D’Accorso, Cybele C García and Elsa B Damonte
    Citation: Journal of Biomedical Science 2015 22:29
    Content type: Research Published on:

  43. The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic a...

    Authors: Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng and Jiu-Yao Wang
    Citation: Journal of Biomedical Science 2022 29:75
    Content type: Research Published on:

  45. Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU m...

    Authors: Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth…
    Citation: Journal of Biomedical Science 2017 24:57
    Content type: Research Published on:

  46. T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that ...

    Authors: I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu
    Citation: Journal of Biomedical Science 2024 31:33
    Content type: Research Published on:

  47. In this study, conducted in the Lisbon area, staphylococci isolated (n...= 53) from diabetic foot ulcers were identified, genotyped and screened for virulence and antimicrobial resistance traits. Genetic ... for ...

    Authors: Carla Mottola, Teresa Semedo-Lemsaddek, João J. Mendes, José Melo-Cristino, Luís Tavares, Patrícia Cavaco-Silva and Manuela Oliveira
    Citation: Journal of Biomedical Science 2016 23:33
    Content type: Research Published on:

  48. Progressive micro-vascular vaso-degeneration is the major factor in progression of diabetic complications. Adrenomedullin (AM) and basic-Fibroblast growth factor (b-FGF) are strongly correlated with angiogenes...

    Authors: Fawziah A Alrouq, Abeer A Al-Masri, Laila M AL-Dokhi, Khalid A Alregaiey, Nervana M Bayoumy and Faten A Zakareia
    Citation: Journal of Biomedical Science 2014 21:94
    Content type: Research Published on:

  49. Opioids have been used for the management of pain and coadministration of two opioids may induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, the ant...

    Authors: Hugo F Miranda, Viviana Noriega, Pilar Zanetta, Juan Carlos Prieto, Juan Carlos Prieto-Rayo, Nicolás Aranda and Fernando Sierralta
    Citation: Journal of Biomedical Science 2014 21:62
    Content type: Research Published on:

  50. Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endo...

    Authors: Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O’Malley and Sang Jun Han
    Citation: Journal of Biomedical Science 2022 29:100
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127